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Recent Developments in Metallic Degradable Micromotors for Biomedical and Environmental Remediation Applications

Nano-Micro Letters 2024年第3期16卷 1-35页

作者： Sourav Dutta Seungmin Noh Roger Sanchis Gual Xiangzhong Chen Salvador Pané bradley j.Nelson Hongsoo Choi Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea DGIST‑ETH Microrobotics Research Center DGISTDaegu 42988Republic of Korea Multi‑Scale Robotics Lab Institute of Robotics and Intelligent SystemsETH Zurich8092 ZurichSwitzerland Institute of Optoelectronics State Key Laboratory of Photovoltaic Science and TechnologyShanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionFudan UniversityShanghai 200433People’s Republic of China

Synthetic micromotor has gained substantial attention in biomedicine and environmental ***-based degradable micromotor composed of magnesium(Mg),zinc(Zn),and iron(Fe)have promise due to their nontoxic fuel-free propulsion,favorable biocompatibility,and safe excretion of degradation products Recent advances in degradable metallic micromotor have shown their fast movement in complex biological media,efficient cargo delivery and favorable biocompatibility.A noteworthy number of degradable metal-based micromotors employ bubble propulsion,utilizing water as fuel to generate hydrogen *** novel feature has proj.cted degradable metallic micromotors for active in vivo drug delivery *** addition,understanding the degradation mechanism of these micromotors is also a key parameter for their design and *** propulsion efficiency and life span govern the overall performance of a degradable metallic *** we review the design and recent advancements of metallic degradable ***,we describe the controlled degradation,efficient in vivo drug delivery,and built-in acid neutralization capabilities of degradable micromotors with versatile biomedical ***,we discuss micromotors’efficacy in detecting and destroying environmental ***,we address the limitations and future research directions of degradable metallic micromotors.

关键词： Magnesium Zinc Iron Biodegradable microrobot Biomedical Environmental

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发育基因组解剖工程：寻找人类发育障碍基因的细胞遗传学方法

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中华口腔医学杂志 2009年第Z1期44卷 76-76页

作者： Cynthia C. Morton bradley j. quade j.mes F. Gusella Richard L .Maas David j. Harris BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA MassachusettsGeneralHospiatalBrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwom BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA MassachusettsGeneralHospiatalBrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwom BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA MassachusettsGeneralHospiatalBrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwom BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA MassachusettsGeneralHospiatalBrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwom BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA MassachusettsGeneralHospiatalBrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwom

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Surgeon preferences in the treatment of thumb carpometacarpal osteoarthritis

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World j.urnal of Orthopedics 2024年第5期15卷 435-443页

作者： Edward j.Wu bradley W Fossum Wyatt Vander Voort Christopher O Bayne Robert M Szabo Department of Orthopedic Surgery University of Minnesota Medical SchoolMinneapolisMN 55455United States Department of Orthopaedic Surgery UC Davis School of MedicineSacramentoCA 95817United States

BACKGROUND Primary thumb carpometacarpal(CMC)osteoarthritis is one of the most common conditions encountered by hand *** the vast number of operations that have been proposed,none have demonstrated results significantly superior to trapeziectomy *** The purpose of our study was to determine why surgeons opt for their technique in treating CMC *** A cross-sectional survey of active members of the American Society for Surgery of the Hand was conducted to evaluate the reasons behind their preferred technique in the treatment of isolated thumb CMC *** were contacted by email once and provided with a link to a de-identified survey consisting of 5 treatment questions and 5 demographic *** Of 950 responses were received.40.5%of surgeons preferred trapeziectomy+ligament reconstruction tendon interposition(LRTI),followed by trapeziectomy+suspensionplasty(28.2%),suture button suspension(5.9%),trapeziectomy alone(4.6%),prosthetic arthroplasty(3.2%),arthrodesis(1.1%),and other(6.6%).Proponents of trapeziectomy+LRTI cited familiarity(73.2%),exposure during fellowship(48.8%)and less proximal migration(60%)to be the main reasons affecting their *** who preferred trapeziectomy+suspensionplasty most reported simplicity(74.9%),fewer complications(45.3%),less proximal migration(43.8%),and avoidance of autogenous tissue harvest(42.7%).Advocates of suture button suspension cited avoidance of autogenous tissue harvest(80.4%),shorter immobilization(76.8%),and quicker recovery(73.2%)with their *** of trapeziectomy alone cited simplicity(97.7%),fewer complications(86.4%),and avoidance of autogenous tissue harvest(59.1%).In their comments,45%of surgeons choosing trapeziectomy alone cited evidence as an additional *** of prosthetic arthroplasty cited improved pinch strength(83.3%)and improved range of motion(63.3%),while those preferring arthrodesis cited better pinch strength(90%)and freque

关键词： Thumb carpometacarpal Osteoarthritis Trapeziectomy Ligament reconstruction tendon interposition Suspensionplasty Preferences Trends

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Long-term olfactory loss post-COVID-19:Pathobiology and potential therapeutic strategies

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World j.urnal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 148-155页

作者： Sarah Kim j.hn B.Finlay Tiffany Ko bradley j.Goldstein Department of Head and Neck Surgery&Communication Sciences Duke UniversityDurhamNorth CarolinaUSA Medical Scientist Training Program Duke UniversityDurhamNorth CarolinaUSA Department of Neurobiology Duke UniversityDurhamNorth CarolinaUSA

An acute loss of smell emerged as a striking symptom present in roughly half of the people infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus in the early phases of the COVID-19 *** most COVID-19 patients,olfaction recovers over the course of a few ***,a lasting partial or complete loss of smell,often associated with distorted olfactory perceptions termed parosmia,has emerged as a widespread problem impacting at least 5%-10%of those who experience anosmia due to *** inability to offer effective therapies to this hyposmic or anosmic population,comprising millions of patients,highlights an enormous unmet need for the medical ***,we summarize the current understanding of the pathobiology causing acute olfactory loss due to SARS-CoV-2 infection,focusing on how the virus interacts with the peripheral olfactory system,a maj.r site of viral *** also explore the problem of long-COVID olfactory dysfunction,which may accompany other persistent systemic disorders collectively termed postacute sequelae of ***,we discuss an emerging model focused on unresolved immune cell activity driving ongoing ***,we review current and future therapeutic approaches aimed at restoring olfactory function.

关键词： hyposmia inflammation long-COVID parosmia

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Magnetic Helical Micro-and Nanorobots:Toward Their Biomedical Applications

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Engineering 2015年第1期1卷 21-26页

作者： Famin Qiu bradley j.Nelson Institute of Robotics and Intelligent Systems(IRIS) ETH Zurich

Magnetic helical micro- and nanorobots can perform 3D navigation in various liquids with a sub- micrometer precision under low-strength rotating magnetic fields （〈 10 rer）. Since magnetic fields with low strengths are harmless to cells and tissues, magnetic helical micro/ nanorobots are promising tools for biomedical applications, such as minimally invasive surgery, cell manipulation and analysis, and targeted therapy. This review provides general information on magnetic helical micro/nanorobots, including their fabrication, motion control, and further functionalization for biomedical applications.

关键词： magnetic helical micro/nanorobots mobilemicro/nanorobots artificial bacterial flagella (ABFs) functionalization biomedical applications

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Arabidopsis FtsZ2-1 and FtsZ2-2 Are Functionally Redundant, But FtsZ-Based Plastid Division Is Not Essential for Chloroplast Partitioning or Plant Growth and Development

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Molecular Plant 2009年第6期2卷 1211-1222页

作者： Aaron j. Schmitz j.nathan M. Glynn bradley j.S.C. Olson Kevin D. Stokes Katherine W. Osteryoung Department of Plant Biology 166 Plant Biology Bldg Michigan State University East Lansing MI 48824-1312 USA Cell and Molecular Biology Program Michigan State University East Lansing MI 48824 USA Department of Energy-Plant Research Laboratory Michigan State University East Lansing MI 48824 USA Genetics Program Michigan State University East Lansing MI 48824 USA Biochemistry and Molecular Biology Program Michigan State University East Lansing MI 48824 USA Present address: The Salk Institute for Biological Studies Plant Molecular and Cellular Biology Laboratory La Jolla CA 92037 USA Present address: Mycobacteria and Brucella Section NVSL/APHIS/USDA 1920 Dayton Ave Ames IA 50010 USA

FtsZ1 and FtsZ2 are phylogenetically distinct families of FtsZ in plants that co-localize to mid-plastid rings and facilitate division of chloroplasts. In plants, altered levels of either FtsZ1 or FtsZ2 cause dose-dependent defects in chloroplast division; thus, studies on the functional relationship between FtsZgenes require careful manipulation of FtsZ levels in vivo. To define the functional relationship between the two FtsZ2 genes in Arabidopsis thaliana, FtsZ2-1 and FtsZ2-2, we expressed FtsZ2-1 in an ftsZ2-2 null mutant, and vice versa, and determined whether the chloroplast division defects were rescued in plants expressing different total levels of FtsZ2. Full rescue was observed when either the FtsZ2-1 or FtsZ2-2 level approximated total FtsZ2 levels in wild-type （WT）. Additionally, FtsZ2-2 interacts with ARC6, as shown previously for FtsZ2- 1. These data indicate that FtsZ2-1 and FtsZ2-2 are functionally redundant for chloroplast division in Arabidopsis. To rigorously validate the requirement of each FtsZ family for chloroplast division, we replaced FtsZ1 with FtsZ2 in vivo, and vice versa, while maintaining the FtsZ level in the transgenic plants equal to that of the total level in WT. Chloroplast division defects were not rescued, demonstrating conclusively that FtsZ1 and FtsZ2 are non-redundant for maintenance of WT chloroplast numbers. Finally, we generated ftsZtriple null mutants and show that plants completely devoid of FtsZ protein are viable and fertile. As plastids are presumably essential organelles, these findings suggest that an FtsZ-independent mode of plastid partitioning may occur in higher plants.

关键词： Chloroplast plastid division FtsZ ARC6 PDV1.

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Effect of Strain Path Reversal on Austenite Grain Subdivision and Deformation Induced Ferrite Transformation Studied by Hot Torsion

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j.urnal of Iron and Steel Research International 2011年第S1期18卷 233-237页

作者： Muszka Krzysztof Wynne bradley P Palmiere Eric j Institute for Microstructural and Mechanical Process Engineering The University of SheffieldMappin StreetSheffield S1 3JDUK

The effects of large strain and strain path reversal on the deformation microstructure evolution in austenite below the recrystallisation temperature were studied by hot torsion using a non-transforming Fe-30wt%Ni model austenitic *** show that the high angle boundaries (HABs) can be generated by both microstructure mechanism through dislocation accumulation and texture mechanism via subgrain ***,multiple strain path reversals lead to less well-developed HABs in the original grains compared to single reversal deformed to the same amount of total accumulative *** effect is attributed to the subgrain rotation mechanism being less effective at small *** comparison,the same hot torsion tests were conducted using a microalloyed steel at a temperature between Ae 3 and Ar *** single strain path reversal,substantial deformation-induced austenite-to-ferrite phase transformation was ***,a test with multiple strain path reversals but with the same total strain produces much lower levels of strain-induced ferrite *** difference is correlated to the observations made in the Fe-30wt%Ni model *** is believed that the different amount of strain-induced ferrite originated from the different levels of strain-induced HABs within the austenite which act as ferrite nucleation sites.

关键词： strain induced transformation ultra fine ferrite dislocation boundaries EBSD

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Intraspecific temporal resource partitioning at white-tailed deer feeding sites

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Current Zoology 2019年第2期65卷 139-146页

作者： David B. STONE j.mes A. MARTIN bradley S. COHEN Thomas j. PREBYL Charlie KILLMASTER Karl V. MILLER Warnell School of Forestry and Natural Resources University of Georgia Athens GA USA Savannah River Ecology Lab University of Georgia Aiken SC USA Department of Biology Tennessee Technological University Cookeville TN USA Georgia Department of Natural Resources Atlanta GA USA

Individuals may reduce competition by temporally partitioning their use of a shared resource. Behavioral differences between sexes in ungulates may encourage segregation as individuals attempt to avoid antagonistic interactions. However, dominant sex and age groups may reduce subordinates' access to food resources, regardless of the subordinate's sex. We hypothesized that white-tailed deer Odocoileus Virginian us temporally segregated at supplemental feedi ng sites based on social rank (subordinate: yearling males and adult females;dominant: adult males) and that segregation was affected by phase of the breeding season and diel cycle. If deer temporally segregate according to social rank, we predicted that the resulting activity patterns would manifest in one social class being relatively more susceptible to hunter-induced mortality. We used a multistate modeling approach to quantify temporal segregation and calculated the probability that a feeding site was in a particular state during diurnal and nocturnal hours for each of the 3 phases of the breeding season. We determined that transition probabilities differed by season and diel cycle and dominant and subordinate social classes clearly avoided each other, with <1% co-occurrenee at feedi ng sites. During the pre-breedi ng seas on, the probability of a subordi nate being present during diurnal hours was *** more likely than a dominant being present, but did not differ during nocturnal hours. There was no difference for dominants and subordinates during diurnal or no cturnal hours during the breedi ng season .In the post-breedi ng season, subordi nates were 1.7x more likely to occur at the feeding site than a dominant during diurnal hours but they did not differ during nocturnal hours. Our results indicate that dominance status influences temporal segregation at feeding sites and is affected by the phase of the breeding season. Therefore, the resulti ng activity patterns may in crease subordi nates' risk to human

关键词： competition multistate modeling predation risk supplemental feeding sites intraspecific temporal resource partitioning white-tailed deer

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Enhanced catalytic degradation of organic pollutants by multi-stimuli activated multiferroic nanoarchitectures

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Nano Research 2020年第8期13卷 2183-2191页

作者： Faj.r Mushtaq Xiangzhong Chen Harun Torlakcik bradley j.elson Salvador Pané Multi-Scale Robotics Lab(MSRL) Institute of Robotics and Intelligent Systems(IRIS)ETH ZurichCH-8092ZurichSwitzerland

Smart catalysts that can simultaneously utilize multiple energy sources will have a significant positive impact on the inefficiencies of conventional environmental remediation approaches,and will address their high energy *** this work,we have manufactured multiferroic magnetoelectric photocatalysts that can be simultaneously activated using multiple energy sources for the degradation of organic *** catalysts are composed of CoFe2O4@BiFeO3(CFO@BFO)nanooctahedrons(NOs),CFO@BFO nanocubes(NCs),and CFO@BFO nanowires(NWs),and were successful in harnessing energy from three different energy sources,including UV-vis light,acoustically mediated mechanical vibrations and magnetic *** CFO@BFO NOs displayed the most enhanced degradation,reaching 93%,96%,and 99%degradation of RhB dye within 1 h under light,ultrasound,and magnetic fields,*** these energy sources were used simultaneously,significantly increased reaction rates were observed compared to the single-energy source *** of radical trapping experiments indicate that radical species i.e.,OH·and O2·^-play a dominant role in catalytic degradation of organic pollutant,RhB,under all three *** results will contribute significantly to the development of new environmental technologies that are highly versatile in nature and able to adapt to changing environments to deliver efficient environmental remediation.

关键词： magnetoelectric photocatalysis nanoparticles water remediation piezoelectric

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Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes

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分子细胞生物学报:英文版 2012年第1期4卷 38-47页

作者： Cheng-Rui Li Bas j.G.Baaten Linda M.bradley Infectious and Inflammatory Disease Center Sanford-Burnham Medical Research Institute10901 North Torrey Pines RoadLa JollaCA 92037USA

Type 1 diabetes(T1D)results from autoimmune destruction of insulin-producing b-cells in the pancreatic *** is an immediate need to restore both b-cell function and immune tolerance to control disease progression and ultimately cure ***,there is no effective treatment strategy to restore glucose regulation in patients with ***3-expressing CD4^(+) regulatory T cells(Tregs)are potential candidates to control autoimmunity because they play a central role in maintaining ***,deficiencies in either naturally occurring Tregs(nTregs)themselves and/or their ability to control pathogenic effector T cells have been associated with ***,we hypothesize that nTregs can be replaced by FoxP3^(+) adaptive Tregs(aTregs),which are uniquely equipped to combat autoreactivity in *** nTregs,aTregs are stable and provide long-lived *** this review,we summarize the current understanding of aTregs and their potential for use as an immunological intervention to treat T1D.

关键词： type 1 diabetes adaptive regulatory T cells autoimmunity immunotherapy

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