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Improved hemostasis with major hepatic resection in the current surgical era

Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 439-445页

作者： christopher W Mangieri Matthew A Strode bradley c bandera Department of Surgery Dwight D. Eisenhower Army Medical Center(DDEAMC)Fort GordonGA 30809USA Department of Surgical Oncology Roswell Park Cancer InstituteBuffaloNY 14203USA

Background: Major hepatic resection, predominantly performed for oncologic intent, is a complex procedure with the potential for severe intraoperative hemorrhage. The current surgical era has the ability to improve hemostasis throughout the performance of major hepatic resections which decreases blood transfusions and the detrimental effects associated with transfusion. We evaluated hemostasis and outcomes in the current surgical era of performing hepatic resections. Methods: Utilizing the American college of Surgeons (AcS) National Surgical Quality Improvement Program (NSQIP) database all major hepatic resections performed between 2012 and 2016 were analyzed in regards to hemostasis. Hemostasis was evaluated by the need for and magnitude of blood transfusions. Additional perioperative variables (including operative time, length of hospital stay, and mortality rates) were analyzed to assess for outcomes with hemostasis. The NSQIP results were compared to previous publications involving major hepatic resections to detect improvement in hemostasis and outcomes in the current surgical era. Results: A total of 22777 major hepatic resections met the inclusion criteria for analysis in the NSQIP database. An additional 21198 cases were compiled within the selected publications for comparative analysis. The transfusion rate in the current surgical era was 13.3% versus 38.7% in the previous era ( P = 0.0001). When a transfusion was required in the current surgical era there was a two-fold reduction in the number of units transfused (1.5 U vs. 3.8 U, P = 0.0001). Statistically significant improvements in operative time and length of hospital stay were presented within the current surgical era ( P = 0.0001). When a transfusion was required there was an increased relative risk score of 7 for mortality (4.9% vs. 0.7%, P = 0.0001), however, improvement in mortality rates did not reach statistical significance across surgical eras (1.3% vs. 4.0%, P = 0.0001). conclusions: The cond

关键词： Major hepatic resection Improved hemostasis Improved outcomes

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Spreadability of powders for additive manufacturing: A critical review of metrics and characterisation methods

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PARTIcUOLOGY 2024年第10期93卷 211-234页

作者： Talebi, Fatemeh A. Haydari, Zobaideh Salehi, Hamid Mehrabi, Mozhdeh Gardy, Jabbar bradley, Mike Bayly, Andrew E. Hassanpour, Ali Univ Leeds Sch Chem & Proc Engn Leeds LS2 9JT England Univ Greenwich Sch Engn Greenwich ME4 4TB England cormica Ltd Listerhills Sci PkCampus Rd Bradford BD7 1HR England

Powder bed fusion methods of additive manufacturing (AM) require consistent, reproducible, and uniform layers of powder for the reliable production of high-quality parts, where properties of powder are central to achieving this. Among these properties, powder flowability and spreadability play critical roles in determining the quality of these powder layers. While extensive research has been conducted on powder flow and spreading behaviour, and on their characterisation, there is little critical comparison and review of these terms in the context of AM. Such a review is necessary to further develop and enhance our comprehension of spreading dynamics and its relation to powder properties in AM systems. This review paper aims to build a coherent understanding of the correlation between powder characteristics and spreading in powder based additive manufacturing and its impact on manufactured parts. It highlights the current progress in comprehending spreading dynamics, the influence of powder characteristics, environmental conditions, spreading system, and the development of testing tools to assess powder spreadability. Furthermore, the paper critically discusses the challenge of finding appropriate quantitative metrics and recent advances in the use of standardised methods for evaluating powder spreadability. (c) 2024 chinese Society of Particuology and Institute of Process Engineering, chinese Academy of Sciences. Published by Elsevier B.V. This is an open access article under the cc BY license (http:// ***/licenses/by/4.0/).

关键词： Powder spreading Powder flowability Powder properties Quality of layer and final products DIScRETE ELEMENT SIMULATION PARTIcLE-SIZE DISTRIBUTION SPREADING PROcESS FLOW PROPERTIES NUMERIcAL-SIMULATION DENSITY BULK FLOWABILITY SEGREGATION BEHAVIOR

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The therapeutic implications of immunosuppressive tumor aerobic glycolysis

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cellular & Molecular Immunology 2022年第1期19卷 46-58页

作者： bradley I.Reinfeld WKimryn Rathmell Tae Kon Kim Jeffrey c.Rathmell Department of Medicine Division of Hematology and OncologyVanderbilt University Medical CenterNashvilleTNUSA

In 2011,Hanahan and Weinberg added“Deregulating cellular Energetics”and“Avoiding Immune Destruction”to the six previous hallmarks of *** this seminal paper,there has been a growing consensus that these new hallmarks are not mutually exclusive but rather *** following review summarizes how founding genetic events for tumorigenesis ultimately increase tumor cell glycolysis,which not only supports the metabolic demands of malignancy but also provides an immunoprotective niche,promoting malignant cell proliferation,maintenance and *** mechanisms by which altered metabolism contributes to immune impairment are multifactorial:(1)the metabolic demands of proliferating tumor cells and activated immune cells are similar,thus creating a situation where immune cells may be in competition for key nutrients;(2)the metabolic byproducts of aerobic glycolysis directly inhibit antitumor immunity while promoting a regulatory immune phenotype;and(3)the gene programs associated with the upregulation of glycolysis also result in the generation of immunosuppressive cytokines and *** this perspective,we shed light on important considerations for the development of new classes of agents targeting cancer *** types of therapies can impair tumor growth but also pose a significant risk of stifling antitumor immunity.

关键词： cancer metabolism immuno logy glycolysis

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Linking uplift and mineralisation at the Mount Novit Zn-Pb-Ag Deposit,Northern Australia:Evidence from geology,U-Pb geochronology and sphalerite geochemistry

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Geoscience Frontiers 2022年第2期13卷 333-350页

作者： bradley cave William Perkins Richard Lilly Department of Earth Sciences University of AdelaideAdelaideSAAustralia Geological Survey of Queensland BrisbaneQLDAustralia

The subeconomic Mount Novit Zn-Pb-Ag deposit is located approximately 20 km south of Mount Isa,*** contrast to the nearby Mount Isa,Hilton and George Fisher Zn-Pb-Ag deposits,mineralisation at Mount Novit is situated to the west of the regional-scale Mount Isa Fault and is hosted in the Moondarra Siltstone as opposed to the Urquhart ***-grade(ces pre-existing carbonate alteration and veining and consists of pyrrhotite,pyrite and sphalerite with lesser ***-grade(>10 wt.%Zn+Pb)mineralisation occurs as a matrix supported breccia dominated by sphalerite and pyrrhotite with galena,pyrite,and ***-situ U-Pb geochronology was completed on apatite and two textural varieties of ***-grained(cated within highly foliated biotite alteration directly adjacent Zn-Pb-Ag mineralisation and yields a mean weighted^(207)Pb/^(206)Pb age of 1527±18 Ma(MSWD=1.06).This age is consistent with the formation of highly foliated biotite alteration during D;deformation of the Isan *** from the same fabric yields a lower intercept age of1443±29 Ma(MSWD=1.30).consistent with previous studies,this age is interpreted to represent the age of a major thrusting event along the Mount Isa Fault that resulted in the cooling of the Mount Novit area below~375℃.coarse-grained monazite is coeval with Zn-Pb-Ag mineralisation and yields a mean weighted^(207)Pb/^(206)Pb age of 1457±11 Ma(MSWD=0.28).Sphalerite from Mount Novit has low concentrations(concentration of In(5 to>10 ppm),possibly reflecting the leaching of the metals from an underlying basement *** GGIMFis geothermometer(Frenzel et al.,2016)produced a mean formation temperature of 345±52℃.The timing and temperature of Zn-Pb-Ag mineralisation is consistent with the age and cooling temperature of apatite presented in this *** on these correlations,we

关键词： Mount Isa Mount Novit Zn-Pb-Ag mineralisation Monazite Apatite Geochronology

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Performance of identical rockbolts tested on four dynamic testing rigs employing the direct impact method

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 745-754页

作者： charlie c.Li John Hadjigeorgiou Peter Mikula Greig Knox bradley Darlington Renee Royer Andrzej Pytlik Michael Hosp Norwegian University of Science and Technology(NTNU) TrondheimNorway University of Toronto TorontoCanada Mikula Geotechnics Pty.Ltd. KalgoorlieAustralia New concept Mining JohannesburgSouth Africa Sandvik Mining&Rock Technology HeatherbraeAustralia canmetMINING Natural Resources CanadaOttawaCanada central Mining Institute KatowicePoland Minova Innovation and Development Ground SupportFeistritzAustria

Impact drop tests are routinely used to examine the dynamic performance of *** impact tests have been carried out in the past decades on independently designed,constructed and operated testing *** laboratory has developed testing procedures;thus,the results are often reported in different ways by various *** inconsistency in testing procedures and reporting formats presents a challenge when comparing results from different laboratories.A series of impact tests of identical rockbolts was carried out using the direct impact method(*** mass free-fall method)on the rigs in four laboratories in different *** purpose of these tests was to investigate the level of consistency in the results from the four *** rig demonstrated a high level of repeatability,but differences existed between the various *** differences would suggest that there is noticeable equipment-dependent bias when test results obtained from different laboratories are *** was also observed that the energy dissipated for the plastic displacement of the bolt was smaller than the impact energy in the *** average impact load(AIL)and the ultimate plastic displacement(D)of the bolt describe the ultimate dynamic performance of the *** the case where the bolt does not rupture,the specific plastic energy(SPE)is an appropriate parameter in describing the impact performance of the *** other relevant parameters are the first peak load(FPL)and the initial stiffness(K)of the bolt *** information from this test series will guide the formulation of standardised testing procedures for dynamic impact tests of rockbolts.

关键词： Dynamic test Drop test Impact test Rockbolt Rock reinforcement Ground support

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Assessment of postcombustion carbon capture technologies for power generation

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Frontiers of chemical Science and Engineering 2010年第2期4卷 184-195页

作者： Mikel c.DUKE bradley LADEWIG Simon SMART Victor RUDOLPH João c.Diniz da cOSTA Institute for Sustainability and Innovation Victoria UniversityWerribee CampusPO Box 14428MelbourneVictoria 8001Australia Department of chemical Engineering Monash UniversityClayton Vic 3182Australia School of chemical Engineering The University of QueenslandBrisbane Qld 4072Australia

A significant proportion of power generation stems from coal-combustion processes and accordingly represents one of the largest point sources of cO_(2)emissions *** power plants are major assets with large infrastructure and engineering units and an operating life span of up to 50 ***,any process design modification to reduce greenhouse gas emissions may require significant *** of the best options to utilize existing infrastructure is to retrofit the power station fleet by adding a separation process to the flue gas,a practice known as postcombustion capture(Pcc).This review examines the recent Pcc development and provides a summary and assessment of the state of play in this area and its potential applicability to the power generation *** major players including the various institutes,government,and industry consortia are identified along with flue gas Pcc demonstration scale *** the Pcc technologies reviewed,amine-based absorption is preeminent,being both the most mature and able to be adapted immediately,to the appropriate scale,for power station flue gas with minimal technical ***,current commercial applications serve niches in the merchant cO_(2)market,while a substantial number of smaller scale test facilities are reported in the literature with actual cO_(2)capture motivated demonstrations now *** membrane/absorption systems,also known as membrane contactors,offer the potential for the lowest energy requirements,possibly 10%of current direct scrubbers but are at an early stage of *** methods being actively pursued as R&D projects include solid absorbents,solid adsorbents,gas membrane separators,and cryogenic *** variety and different maturities of these competing technologies make technical comparison largely subjective,but useful insights could be gained through the development and application of econometric techniques such as‘real options’within this ***

关键词： post-carbon capture amine absorption adsorption membranes technology assessment

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Phytochemical analysis and anti-oxidant activities of Albuca bracteata *** Albuca setosa Jacq bulb extracts used for the management of diabetes in the Eastern cape,South Africa

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Asian Pacific Journal of Tropical Biomedicine 2017年第6期7卷 577-584页

作者： Samuel Odeyemi Anthony Afolayan Graeme bradley Department of Biochemistry and Microbiology University of Fort Hare MPED Research Niche Area Department of BotanyUniversity of Fort Hare

Objective:The bulb of Albuca bracteata Jacq.,and Albuca setosa commonly used in Eastern cape Province of South Africa for the treatment of several types of disease conditions including diabetes,was investigated for their phytochemical contents and antioxidant ***:The antioxidant activity was determined by evaluating the effect of various solvent extracts(acetone,methanol,ethanol and water) on 2,2 – diphenyl-2-picrylhydrazyl(DPPH) scavenging activity,2,20– azino-bis(3-ethylbenzthiazoline-6-sulfonic acid diammonium salt(ABTS),ferric reducing power,hydrogen peroxide and nitric oxide scavenging activity while the various extracts were also analysed for phytochemical their ***:The results obtained indicate that polyphenols,proanthocyanidins,saponins and alkaloids are present in higher *** composition of phenols(117 mg/g),flavonols(26.28 mg/g),proanthocyanidins(84.85 mg/g) and flavonoids(5.36 mg/g) were significantly higher in the acetone extract while saponin and alkaloids contents were higher in the aqueous *** studies of the extracts for nitric oxide,hydrogen peroxide,ABTS and DPPH showed high antioxidant potential in a concentration-dependent manner that was not significantly different from Vitamin c,BHT and Rutin used as standard *** methanol extract showed higher ferric reducing potential compared to the aqueous extract but was significantly different from Vitamin c,BHT and ***:This implies that the bulb of Albuca bracteata may serve as a natural source of antioxidants,which together with the numerous phytochemicals present,could account for its folkloric use as a medicinal plant.

关键词： Phytochemicals Antioxidants Ornitogalum longibrateum Albuca bracteata Diabetes Albuca setosa

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Signaling pathways in osteogenesis and osteoclastogenesis:Lessons from cranial sutures and applications to regenerative medicine

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Genes & Diseases 2015年第1期2卷 57-68页

作者： Justin B.Maxhimer James P.bradley Justine c.Lee Division of Plastic and Reconstructive Surgery UCLA David Geffen School of MedicineCAUSA Division of Plastic and Reconstructive Surgery Temple University/St.Christopher’s Hospital for ChildrenPAUSA Division of Plastic and Reconstructive Surgery Greater Los Angeles VA Healthcare SystemUSA

One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial *** only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic disturbances,the molecular mechanisms elucidated from these studies have provided basic knowledge of bone *** work has translated to methods and advances in bone tissue *** this review,we examine the current knowledge of cranial suture biology derived from human craniosynostosis syndromes and discuss its application to regenerative medicine.

关键词： craniosynostosis OPG Osteoclast RANK RANKL Tissue engineering Osteogenesis Signaling

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Erbium-doped TeO2-coated Si3N4 waveguide amplifiers with 5 dB net gain

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Photonics Research 2020年第2期8卷 127-134页

作者： HENRY c.FRANKIS HAMIDU M.MBONDE DAWSON B.BONNEVILLE cHENGLIN ZHANG RIcHARD MATEMAN ARNE LEINSE JONATHAN D.B.bradley Department of Engineering Physics Mc Master UniversityHamilton L8S 4L7Canada Lioni X International BV Enschede AL 7500The Netherlands

We demonstrate 5dB net gain in an erbium-doped tellurium-oxide-coated silicon nitride *** amplifier design leverages the high refractive index and high gain in erbium-doped tellurite glass as well as the ultralow losses and mature,reliable,and low-cost fabrication methods of silicon nitride waveguide *** show that the waveguide platform demonstrates low background propagation losses of 0.25dB/cm based on a ring resonator device with a Q factor of 1.3×10^6 at 1640 *** measure 5dB peak net gain at 1558 nm and>3dB of net gain across the c band in a 6.7 cm long waveguide for 35 m W of launched 1470 nm pump *** per unit length of 1.7 and 1.4dB/cm is measured in a 2.2 cm long waveguide for 970 and 1470 nm pump wavelengths,*** simulations predict that>10dB gain can be achieved across the c band simply by optimizing waveguide length and fiber-chip *** results demonstrate a promising approach for the monolithic integration of compact erbium-doped waveguide amplifiers on silicon nitride chips and within silicon-based photonic integrated circuits.

关键词： waveguide pump amplifiers

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Antioxidant, antibacterial and phytochemical properties of two medicinal plants against the wound infecting bacteria

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Asian Pacific Journal of Tropical Biomedicine 2017年第9期7卷 817-825页

作者： Idowu Jonas Sagbo Anthony Jide Afolayan Graeme bradley Department of Botany University of Fort HarePrivate Bag X1314Alice 5700South Africa Department of Biochemistry and Microbiology University of Fort HarePrivate Bag X1314Alice 5700South Africa

Objective: To investigate the antioxidant, antibacterial and phytochemical properties of ethanol extracts of Brachylaena elliptica and Brachylaena ilicifolia against wound infecting bacteria normally found in diabetic ***: The in vitro antioxidant activity of the two plants extracts were investigated spectrophotometrically using 1,1-diphenyl-2-picrylhydrazyl, nitric oxide, azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) diammonium salt, hydrogen peroxide(H_2O_2) and ferric reducing power. The antibacterial assay and minimum inhibitory concentration(MIc) was determined using the agar dilution method against five bacteria strains using amoxycillin and ciprofloxacin as positive control. The phytochemical analyses(tannins,total phenol, flavonoids, flavonols, proanthocyanidin, alkaloids and saponins) were assessed using standard ***: The ethanol extract of both plants exhibited strong antioxidant activities in some cases when compared to the standards(vitamin c and BHT). The antibacterial activity of both plants showed an appreciable broad spectrum activity against these wound pathogens with MIc value ranges between 0.3 mg/m L and 5 mg/m L. Tannins,phenols, flavanols, proanthocyanidins and alkaloids content of B. ilicifolia were significantly higher than those in B. elliptica. However, there were no significant differences in the flavanoid content of both plants ***: These results indicated that the ethanol leaf extracts of these plants have antioxidant and antibacterial activity against the tested bacteria possibly due to the presence of bioactive compounds and therefore could be used as alternative therapy against wound infection caused by these bacteria in diabetic patients.

关键词： Diabetes mellitus Antioxidant Phytochemical Brachylaena elliptica Brachylaena ilicifolia Wound

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