检索结果-南通市图书馆

Natural Resources 2019年第9期10卷 358-366页

作者： charles K. Mullins Michael J. bradley Lashé D. Mullins James N. Maples Division of Humanities and Social Sciences Alice Lloyd College Pippa Passes USA Department of Recreation and Park Administration Eastern Kentucky University Richmond USA Department of Anthropology Sociology and Social Work Eastern Kentucky University Richmond USA

Sinkers are quicksand enthusiasts that crave the sensation of being trapped in deep mud while being sucked downward. Although humans have been interested in quicksand over the years (particularly through film), there remains a void of research into the meaning and value in the lives of those who engage in a recreational pursuit of quicksand, most notably the community of individuals who self-describe as sinkers. The purpose of this exploratory study was to examine if sinking can contribute to a participant’s understanding of history and natural resources at state parks. In order to obtain a better understanding of the effects, a qualitative study was conducted in the summer of 2016 at Stephen c. Foster State Park, a state park adjacent to Okefenokee Swamp. The researchers exercised grounded theory techniques and inductive content analysis to analyze interview data and compile coded text into four main categories: learning, enjoyment, traveling, and economic impact. Findings suggest that participants believed their knowledge of park history and natural resources increased through a recreational pursuit of quicksand.

关键词： Quicksand Sinkers Sinking Qualitative Research Park Management History Natural Resources

Two disulfide mutants in domain I of <i>Bacillus thuringiensis</i>cry3Aa δ-endotoxin increase stability with no effect on toxicity

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Advances in Biological chemistry 2012年第2期2卷 123-131页

作者： Sheng-Jiun Wu Alvaro M. Florez bradley J. Homoelle Donald H. Dean Oscar Alzate Biochemistry Department Ohio State University Columbus USA Department of cell and Developmental Biology University of North Carolina Chapel Hill USA Laboratorio de Biología Molecular y Biotecnología Facultad de Medicina Universidad de Santander (UDES) Campus Univer- sitario Bucaramanga Colombia

To increase protein stability and test protein function, three double-cysteine mutations were individually introduced by protein engineering into the cysteine-free cry3Aa δ-endotoxin from Bacillus thuringiensis. These mutations were designed to create disulfide bonds between α-helices 2 and 5 (positions 110 - 193), and α-helices 5 and 7 (positions 195 - 276 and 198 - 276). comparison of the cD spectra of the wild-type and the double-cysteine mutant proteins indicates a tighter helical packing consistent with formation of at least two of the disulfide bonds between the central and the outer helices. Thermal stability analysis indi-cates that potential covalent linkages between the central α-helix 5 and the other helices increase resistance to thermal denaturation by 10?c to 14?c com-pared to the thermal stability of the wild-type protein. Spectroscopic analysis of the disulfide-specific absorbance band indicates that the double mutant proteins are more stable to temperature and denaturant (guanidine hydrochloride) than the wild-type protein, as a result of the formation of two of the disulfide bridges. These results indicate that the double muta-tions M110c/F193c and A198c/V276c successfully established disulfide bonds, resulting in a more stable structure of the entire toxin. Despite the increase in stability and structural changes introduced by the disulfide bonds, no effect on toxicity was observed. A possible mechanism involving the insertion of all of domain I of cry3Aa toxin into the target membrane accounts for these observations.

关键词： Disulfide Bonds cD Spectra cry3Aa Site Directed Mutagenesis

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基督教青年协会雷鸟营杜克能源馆

中外建筑 2011年第10期 10-17页

作者： bradley Wheeler Sigma Ning Stanley capps c design Inc.

在南加州的Wylie湖畔,由YMcA（基督教青年协会）赞助的雷鸟营耸立着一幢远离二十一世纪生活喧嚣的建筑——杜克能源馆。该馆在作为户外运动和康乐休闲处所的同时,也成为世上良好和有益身心的＂丰碑＂。首次体验c设计公司的建筑,让人联... 详细信息

在南加州的Wylie湖畔,由YMcA（基督教青年协会）赞助的雷鸟营耸立着一幢远离二十一世纪生活喧嚣的建筑——杜克能源馆。该馆在作为户外运动和康乐休闲处所的同时,也成为世上良好和有益身心的＂丰碑＂。首次体验c设计公司的建筑,让人联想到家庭烧烤以及周日下午远离光影交织的数码生活而漫步公园的情景。

关键词：基督教能源雷鸟协会数码生活户外运动南加州建筑

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阻塞性睡眠呼吸暂停是难治性高血压最常见的继发性病因

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中华高血压杂志 2012年第2期20卷 185-186页

作者： Pedrosa RP Drager LF Gonzaga cc Sousa MG de Paula LK Amaro Ac Amodeo c Bortolotto LA Krieger EM bradley TD Lorenzi-Filho G 叶鹏机构不详

该研究发现阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)是难治性高血压患者最常见的继发性病因,并且提出OSA的临床预测因子。该研究结果有助于发现和治疗OSA,并且对于难治性高血压的诊治有新的重要意义,值得在临床实践中参考。

关键词：阻塞性睡眠呼吸暂停难治性高血压继发性病因临床实践高血压患者预测因子 OSA

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儿童中枢听觉处理障碍的诊断方法及展望

中国听力语言康复科学杂志 2014年第2期12卷 113-118页

作者：马潇然 bradley McPherson[澳大利亚] 杨峰香港大学教育学院言语与听觉科学系香港999077 深圳市儿童医院深圳 518026

根据美国言语语言听力协会（American Speech-Language-Hearing Association，ASHA）对中枢听觉处理障碍[central Auditory Processing Disorder，（c）APD]的定义[1]，在以下项目中有一项或多项出现障碍，即可认为是中枢听觉处理障碍... 详细信息

根据美国言语语言听力协会（American Speech-Language-Hearing Association，ASHA）对中枢听觉处理障碍[central Auditory Processing Disorder，（c）APD]的定义[1]，在以下项目中有一项或多项出现障碍，即可认为是中枢听觉处理障碍，包括声源定位和优势偏向、听觉信号分辨、听觉模式识别、时间处理及在畸变信号或竞争信号下的听觉能力。英国听力学会（British Society of Audiology, BSA）定义（c）APD为损伤的大脑结构引起的障碍，同时强调其并非由注意力或记忆力等其他认知处理功能的异常所引起[2]。（c）APD最常见的症状为噪声下言语识别能力的下降和声源定位困难，它既存在于儿童中也存在于成人中。由于大部分（c）APD发现于儿童阶段，症状并不能随着个体自身的听觉神经发育和成熟而好转，因此，（c）APD的诊断正确性和康复效果将影响患者一生的学习和生活。目前，在中国（c）APD的临床诊断还处于起步阶段，筛查和诊断工具特别是听觉问卷和行为检查测试材料的开发鲜有报道。本文将重点讨论学龄儿童的（c）APD诊断方法，希望对该领域的发展起到借鉴和促进作用。

关键词：听觉处理学龄儿童诊断方法中枢英国听力学会听觉信号言语识别能力声源定位

世界家庭医生组织(WONcA)研究论文摘要汇编——全科药师在英国的角色演变:纵向研究

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中国全科医学 2018年第33期 4162-4162页

作者：本刊编辑部 bradley F SESTON E MANNALL c

背景为了解决日益增长的全科劳动力危机,NHS英格兰(NHSE)在2015年推出了全科临床药师计划。NHSE计划让药师去扮演更新的、面向患者的角色,目前其作用和所进行的活动缺乏洞察力。所有计划内的药师均参加了全科药师培训途径(GPPTP)。目的... 详细信息

背景为了解决日益增长的全科劳动力危机,NHS英格兰(NHSE)在2015年推出了全科临床药师计划。NHSE计划让药师去扮演更新的、面向患者的角色,目前其作用和所进行的活动缺乏洞察力。所有计划内的药师均参加了全科药师培训途径(GPPTP)。目的探讨临床药师在英国全科医学中的角色演变与整合。设计与场所在培训开始阶段(T1)和培训6个月(T2)里,对所有1期GPPTP注册者进行纵向调查。方法在T1和T2对所有1期GPPTP注册者(n=457)进行在线纵向调查,测量其感知知识、技能和信心、所进行的活动以及对全科整合、环境和支持的认知。进行描述性统计和非参数检验。结果回应率分别为46%(T1)和52%(T2);158名参与者完成了两份问卷。从T1到T2,除了处理急性或常见疾病之外,所有领域的感知知识、技能和信心水平均显著提高。实践范围显著增加,特别是面向患者的活动。与行政人员共享办公室很常见,13%的参与者报告没有指定的工作区域。在T2阶段,感知整合度相当高(中位数=5分,范围为1～7分),但是1/3的参与者认为全科的临床支持"太少"。结论结果提示,不仅仅是面对患者的角色延伸,还有实践环境和支持问题,药师可能希望在自己的发展中有更多的全科时间。实践需要实际的支持,而不是期望立即减少工作量。

关键词：临床药师 WONcA 角色演变纵向调查注册者

Developing one-dimensional implosions for inertial confinement fusion science

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High Power Laser Science and Engineering 2016年第4期4卷 1-7页

作者： J.L.Kline S.A.Yi A.N.Simakov R.E.Olson D.c.Wilson G.A.Kyrala T.S.Perry S.H.Batha E.L.Dewald J.E.Ralph D.J.Strozzi A.G.MacPhee D.A.callahan D.Hinkel O.A.Hurricane R.J.Leeper A.B.Zylstra R.R.Peterson B.M.Haines L.Yin P.A.bradley R.c.Shah T.Braun J.Biener B.J.Kozioziemski J.D.Sater M.M.Biener A.V.Hamza A.Nikroo L.F.Berzak Hopkins D.Ho S.LePape N.B.Meezan D.S.Montgomery W.S.Daughton E.c.Merritt T.cardenas E.S.Dodd Los Alamos National Laboratory Lawrence Livermore National Laboratory

Experiments on the National Ignition Facility show that multi-dimensional effects currently dominate the implosion performance. Low mode implosion symmetry and hydrodynamic instabilities seeded by capsule mounting features appear to be two key limiting factors for implosion performance. One reason these factors have a large impact on the performance of inertial confinement fusion implosions is the high convergence required to achieve high fusion *** tackle these problems, a predictable implosion platform is needed meaning experiments must trade-off high gain for performance. LANL has adopted three main approaches to develop a one-dimensional(1D) implosion platform where 1D means measured yield over the 1D clean calculation. A high adiabat, low convergence platform is being developed using beryllium capsules enabling larger case-to-capsule ratios to improve symmetry. The second approach is liquid fuel layers using wetted foam targets. With liquid fuel layers, the implosion convergence can be controlled via the initial vapor pressure set by the target fielding temperature. The last method is double shell targets. For double shells, the smaller inner shell houses the DT fuel and the convergence of this cavity is relatively small compared to hot spot ignition. However,double shell targets have a different set of trade-off versus advantages. Details for each of these approaches are described.

关键词： beryllium capsules double shells inertial confinement fusion liquid layers

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Multi-Agent Based Stochastic Dynamical Model to Measure community Resilience

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Journal of Social computing 2022年第3期3卷 262-286页

作者： Jaber Valinejad Lamine Mili c.Natalie Van Der Wal Data and System Science Lab Harvard Medical SchoolHarvard UniversityCambridgeMA 02138USA bradley Department of Electrical and computer Engineering Virginia TechNorthern Virginia CenterFalls ChurchVA 22043USA Department of Multi-Actor Systems Faculty of TechnologyPolicy and ManagementDelft University of TechnologyDelft2600 AAthe Netherlands.

Emergency services and utilities need appropriate planning tools to analyze and improve infrastructure and community resilience to *** as a key metric of community resilience is the social well-being of a community during a disaster,which is made up of mental and physical social *** factors influencing community resilience directly or indirectly are emotional health,emergency services,and the availability of critical infrastructures services,such as food,agriculture,water,transportation,electric power,and communications *** turns out that in computational social science literature dealing with community resilience,the role of these critical infrastructures along with some important social characteristics is not *** address these weaknesses,we develop a new multi-agent based stochastic dynamical model,standardized by overview,design concepts,details,and decision(ODD+D)protocol and derived from neuro-science,psychological and social sciences,to measure community resilience in terms of mental and physical *** this model,we analyze the micro-macro level dependence between the emergency services and power systems and social characteristics such as fear,risk perception,informationseeking behaviour,cooperation,flexibility,empathy,and experience,in an artificial ***,we simulate this model in two case studies and show that a high level of flexibility,experience,and cooperation enhances community *** for both theory and practice are discussed.

关键词： community resilience collective behavior emergency services power systems critical infrastructures artificial society overview,design concepts,details,and decision(ODD+D) cyber-physical-social system

Global land mapping of satellite-observed cO_(2)total columns using spatio-temporal geostatistics

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International Journal of Digital Earth 2017年第4期10卷 426-456页

作者： Zhao-cheng Zeng Liping Lei Kimberly Strong Dylan B.A.Jones Lijie Guo Min Liu Feng Deng Nicholas M.Deutscher Manvendra K.Dubey David W.T.Griffith Frank Hase bradley Henderson Rigel Kivi Rodica Lindenmaier Isamu Morino Hirofumi Ohyama christof Petri Ralf Sussmann Voltaire A.Velazco Paul O.Wennberg Hui Lin Institute of Space and Earth Information Science The Chinese University of Hong KongHong KongPeople’s Republic of China Key Laboratory of Digital Earth Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijingPeople’s Republic of China Department of Physics University of TorontoTorontoOntarioCanada Institute of Environmental Physics(IUP) University of BremenBremenGermany School of chemistry University of WollongongWollongongAustralia Los Alamos National Laboratory Los AlamosNMUSA Karlsruhe Institute of Technology Institute for Meteorology and Climate Research(IMK-ASF)Germany FMI Arctic Research center SodankyläFinland National Institute for Environmental Studies(NIES) TsukubaIbarakiJapan Earth Observation Research center Japan Aerospace Exploration Agency(JAXA)Tsukuba-cityIbarakiJapan Karlsruhe Institute of Technology IMK-IFUGarmisch-PartenkirchenGermany california Institute of Technology PasadenaCAUSA Department of Geography and Resource Management The Chinese University of Hong KongHong KongPeople’s Republic of China PNNL RichmondWA 99352USA. The Solar-Terrestrial Environment Laboratory Nagoya UniversityJapan

This study presents an approach for generating a global land mapping dataset of the satellite measurements of cO_(2)total column(XcO_(2))using spatio-temporal geostatistics,which makes full use of the joint spatial and temporal dependencies between *** mapping approach considers the latitude-zonal seasonal cycles and spatio-temporal correlation structure of XcO_(2),and obtains global land maps of XcO_(2),with a spatial grid resolution of 1°latitude by 1°longitude and temporal resolution of 3 *** evaluate the accuracy and uncertainty of the mapping dataset in the following three ways:(1)in cross-validation,the mapping approach results in a high correlation coefficient of 0.94 between the predictions and observations,(2)in comparison with ground truth provided by the Total carbon column Observing Network(TccON),the predicted XcO_(2)time series and those from TccON sites are in good agreement,with an overall bias of 0.01 ppm and a standard deviation of the difference of 1.22 ppm and(3)in comparison with model simulations,the spatio-temporal variability of XcO_(2)between the mapping dataset and simulations from the cT2013 and GEOS-chem are generally *** generated mapping XcO_(2)data in this study provides a new global geospatial dataset in global understanding of greenhouse gases dynamics and global warming.

关键词： XcO_(2) AcOS-GOSAT Spatio-temporal geostatistics global mapping geospatial dataset

Erbium-doped TeO2-coated Si3N4 waveguide amplifiers with 5 dB net gain:erratum

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Photonics Research 2020年第6期8卷 1022-1022页

作者： HENRY c.FRANKIS HAMIDU M.MBONDE DAWSON B.BONNEVILLE cHENGLIN ZHANG RIcHARD MATEMAN ARNE LEINSE JONATHAN D.B.bradley Department of Engineering Physics McMaster UniversityHamiltonOntario L8S 4L7Canada LioniX International BV Enschede AL 7500The Netherlands

This erratum corrects typos that appeared in ***.8,127(2020)in the text,a figure showing the experimental setup,and a table listing the absorption and emission cross section values used in simulations.

关键词： waveguide Erbium amplifiers