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Genomics and introgression： Discovery and mapping of thousands of species-diagnostic SNPs using RAD sequencing

current Zoology 2015年第1期61卷 146-154页

作者： Brian K. HAND Tyler D. HETHER Ryan P. KOVAcH clint c. MUHLFELD Stephen J. AMISH Matthew c. boyer Sean M. O'ROURKE Michael R. MILLER Winsor H. LOWE Paul A. HOHENLOHE Gordon LUIKART Flathead Lake Biological Station Fish and Wildlife Genomics Group University of Montana Poison MT 59860 USA Institute for Bioinformatics and Evolutionary Studies Department of Biological Sciences University of Idaho Moscow ID 83844 USA U. S. Geological Survey Northem Rocky Mountain Science Center Glacier National Park West Glacier Montana 59936 USA Fish and Wildlife Genomics Group Division of Biological Sciences The University of Montana Missoula Montana 59812USA Montana Fish Wildlife and Parks Kalispell Montana 59901 USA Department of Animal Science University of California Davis One Shields Avenue Davis CA 95616 USA University of Montana Division of Biological Sciences Missoula Montana 59812 USA

Invasive hybridization and introgression pose a serious threat to the persistence of many native species. Understand- ing the effects of hybridization on native populations （e.g., fitness consequences） requires numerous species-diagnostic loci dis- tributed genome-wide. Here we used RAD sequencing to discover thousands of single-nucleotide polymorphisms （SNPs） that are diagnostic between rainbow trout （RBT, Oncorhynchus mykiss）, the world＇s most widely introduced fish, and native westslope cutthroat trout （WcT, （9. clarkii lewisi） in the northern Rocky Mountains, USA. We advanced previous work that identified 4,914 species-diagnostic loci by using longer sequence reads （100 bp vs. 60 bp） and a larger set of individuals （n = 84）. We sequenced RAD libraries for individuals from diverse sampling sources, including native populations of WcT and hatchery broodstocks of WcT and RBT. We also took advantage of a newly released reference genome assembly for RBT to align our RAD loci. In total, we discovered 16,788 putatively diagnostic SNPs, 10,267 of which we mapped to anchored chromosome locations on the RBT genome. A small portion of previously discovered putative diagnostic loci （325 of 4,914） were no longer diagnostic （i.e., fixed between species） based on our wider survey of non-hybridized RBT and WcT individuals. Our study suggests that RAD loci mapped to a draft genome assembly could provide the marker density required to identify genes and chromosomal regions in- fluencing selection in admixed populations of conservation concern and evolutionary interest [current Zoology 61 （1）： 146-154, 2015].

关键词： conservation genetics Hybridization Invasive species Next generation sequencing Salmonid fish SNP discovery

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TMT激光导引星系统设计

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光电工程 2018年第3期45卷 107-115页

作者：李敏江长春魏凯凡木文芮道满唐金龙 boyer c Wang L Q Trubey M 中国科学院自适应光学重点实验室四川成都610209 中国科学院光电技术研究所四川成都610209 三十米望远镜美国加利福尼亚州帕萨迪纳91107

激光导引星系统(LGSF)是美国30 m望远镜(TMT)的组成部分之一,在满足TMT对科学目标高分辨力成像和光谱探测的性能需求方面,LGSF具有重要的作用。LGSF主要负责为窄视场红外自适应光学系统(NFIRAOS)和下一代TMT-AO系统提供人造钠导星。本... 详细信息

激光导引星系统(LGSF)是美国30 m望远镜(TMT)的组成部分之一,在满足TMT对科学目标高分辨力成像和光谱探测的性能需求方面,LGSF具有重要的作用。LGSF主要负责为窄视场红外自适应光学系统(NFIRAOS)和下一代TMT-AO系统提供人造钠导星。本文主要讨论LGSF以下几部分:设计概述,LGSF星群模式,LGSF波前误差分配,发射系统设计。

关键词：激光导引星系统 30m望远镜星群波前误差分配

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Effects of Unstable Footwear on Stance Pattern

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Journal of Biosciences and Medicines 2014年第3期2卷 20-24页

作者： M. A. choukou S. Ghouli F. c. boyer R. Taiar Laboratoire de Biomécanique GRESPI Université de Reims-Champagne Ardenne Reims France

Inadequate safety shoe wearing is thought to be responsible of many musculoskeletal disorders. A new concept of unstable footwear is proposed to reduce mechanical stresses during work. Major expectations argue for a better ankle dynamic behavior leading to an increased muscular activity. The aim of this study was to evaluate the variation of stance characteristics while walking on level ground as a function of the models of safety shoes. Twenty healthy males (aged 23.6 ± 7) were asked to make six gait cycles on a walking track while barefoot, shod with low cost safety footwear, high cost one, and equipped by Masa? Barefoot Technology shoes (the most unstable footwear). Stance phases (heel strike, flat foot and toe-off) have been normalized as percentages of the maximum value of ground reaction force recorded during each step. The highest significant percentages have been observed in Masa? Barefoot Technology shoes condition and only during heel strike (8% to 10.1% higher) and toe-off (10% to 11.3% higher). In contrast, the temporal durations of the three stance phases were not significantly different between the four conditions. The convexity of safety shoe induces less stability increasing the adaptation of the muscle activity of the wearer at heel-strike and toe-off in order to regain stable gait pattern.

关键词： Gait Barefoot convex Shoes Pain

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煤层甲烷气体的工业开采

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国外煤田地质 1997年第3期 19-22页

作者： boyer,c 马宝军

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Impact of ribavirin dose on retreatment of chronic hepatitis c patients

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World Journal of Gastroenterology 2012年第23期18卷 2966-2972页

作者： christiane Stern Michelle Martinot-Peignoux Marie Pierre Ripault Nathalie boyer corinne castelnau Dominique Valla Patrick Marcellin Service d'Hépatologie and INSERM U773-cRB3 H pital Beaujon University Paris-Diderot

AIM: To study the efficacy and factors associated with a sustained virological response (SVR) in chronic hepatitis c (cHc) relapsing patients. METHODS: Out of 1228 cHc patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV), 165 (13%) had a relapse. Among these, 62 patients were retreated with PEG-IFN-2a or-2b and RBV. clinical, biological, virological and histological data were collected. Initial doses and treatment modifications were recorded. The efficacy of retreatment and predictive factors for SVR were analyzed. RESULTS: An SVR was achieved in 42% of patients. SVR was higher in young (course was associated with higher SVR rates (53% vs 28%, P = 0.04). Also, a better SVR rate was observed with RBV dose/body weight > 15.2 mg/kg per day (70% vs 35%, P = 0.04). In logistic regression, predictors of a response were age (P = 0.018), genotype (P = 0.048) and initial RBV dose/body weight (P = 0.022). None of the patients without a complete early virological response achieved an SVR (negative predictive value = 100%). cONcLUSION: Retreatment with PEG-IFN/RBV is effective in genotype 2 or 3 relapsers, especially in young patients. A high dose of RBV seems to be important for the retreatment response.

关键词： chronic hepatitis c Relapse Retreatment Ribavirin Pegylated interferon

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Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

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Machine learning empowers efficient design of ternary organic solar cells with PM6 donor

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Journal of Energy chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram D.Dongale Santosh S.Sutar Atul c.Khot Tae Geun Kim School of Electrical Engineering Korea University computational Electronics and Nanoscience Research Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao chavan School of Rural Development Shivaji University

Organic solar cells(OScs) hold great potential as a photovoltaic technology for practical ***, the traditional experimental trial-and-error method for designing and engineering OScs can be complex, expensive, and time-consuming. Machine learning(ML) techniques enable the proficient extraction of information from datasets, allowing the development of realistic models that are capable of predicting the efficacy of materials with commendable accuracy. The PM6 donor has great potential for high-performance OScs. However, it is crucial for the rational design of a ternary blend to accurately forecast the power conversion efficiency(PcE) of ternary OScs(TOScs) based on a PM6 ***, we collected the device parameters of PM6-based TOScs and evaluated the feature importance of their molecule descriptors to develop predictive models. In this study, we used five different ML algorithms for analysis and prediction. For the analysis, the classification and regression tree provided different rules, heuristics, and patterns from the heterogeneous dataset. The random forest algorithm outperforms other prediction ML algorithms in predicting the output performance of PM6-based TOScs. Finally, we validated the ML outcomes by fabricating PM6-based TOScs. Our study presents a rapid strategy for assessing a high PcE while elucidating the substantial influence of diverse descriptors.

关键词： Random forests

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