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In vitro immunotoxicity of untreated and treated urbanwastewaters using various treatment processes to rainbow trout leucocytes

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Journal of Environmental Sciences 2013年第7期25卷 1400-1407页

作者： Franois Gagné Marlène Fortier Michel Fournier Shirley-Anne Smyth Emerging Methods Aquatic Contaminants Research Division Water Science and Technology Environment Canada105 McGill Street Montral Qubec Canada INRS-Institut Armand-Frappier 531 boul.des Prairies Laval Qubec Canada Effluents and Wastewaters Aquatic Contaminants Research Division Water Science and Technology Environment Canada867 Lakeshore Road BurlingtonOntario Canada

Municipal effluents are known to impede the immune system of aquatic organisms. the purpose of this studywas to examine the immunotoxicity of urbanwastewaters before and after 6 treatment processes from 12 cities toward trout leucocytes. Freshly prepared trout leucocyteswere exposed to increasing concentrations of solid phase （C18） extracts ofwastewaters for24 hr at 15°C. Immunocompetencewasdetermined by following changes in leucocyte viability and the proportion of cells able to ingest at least one （immunoactivity） and at least three （immunoefficiency） fluorescent beads. the influentswere treated by sixdifferent treatment strategies consisting of facultative aerated lagoons, activated sludge, biological aerated filter, biological nutrient removal, chemically-assisted physical treatment and trickling filter/solid contact. Water quality parameters of thewastewaters revealed that the plants effectively removed total suspended solids and reduced the chemical oxygendemand. the results revealed that the effluents＇ immunotoxic propertieswere generally more influenced by the properties of the untreatedwastewaters than by the treatment processes. About half of the incoming influentsdecreased leucocyte viabilitywhile4 treatment plantswere able to reduce toxicity. the influents readily increased phagocytosis activity for 8/12 influentswhile itwasdecreased in4/12 influents. this increasewas abolished for4/12 of the effluents using treatments involving biological and oxidative processes. In conclusion, municipal effluents have the potential to alter the immune system in fish and more researchwill be needed to improve the treatments ofwastewaters to better protect the quality of the aquatic environment.

关键词： municipal effluents fish leucocytes viability phagocytosis

A Novel Approach for Fault Diagnosis in Wireless Sensor networks

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Communications and network 2013年第2期5卷 169-177页

作者： boul Chandra Garai Priyanka Das ISRO Satellite Centre Bangalore India

the following article has been retracted due to special reason of the author. this paper published in Vol.5 No. 2, 2013, has been removed from this site.

关键词： System-Level Fault Diagnosis testing by Comparison Wireless Sensor networks Distributed Diagnosis Intermittent and Permanent Faults Message Complexity Identifiability

用最初两叶鉴定小麦单株中特定的白粉病抗性基因

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国外作物育种 1996年第3期15卷 18-23页

作者： boul.,VL 谢国禄

卡尔古利区戈登迈尔：构造引起的含金变质流体的渗：位于...

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世界地质 1991年第2期10卷 121-135页

作者： boul.,Ca 李德伦

通过卡尔古利戈尔登迈尔构造控制中型和微型金矿化的构造分析,已经表明了矿物单纯的含金黄铁矿类型(开采量为70％)限于狭窄的强烈变形带内(韧性剪切带)和介于未变形岩石中有关的张性断裂的交叉系统中。事实上所有的韧性剪切带的矿脉构... 详细信息

通过卡尔古利戈尔登迈尔构造控制中型和微型金矿化的构造分析,已经表明了矿物单纯的含金黄铁矿类型(开采量为70％)限于狭窄的强烈变形带内(韧性剪切带)和介于未变形岩石中有关的张性断裂的交叉系统中。事实上所有的韧性剪切带的矿脉构造都分布于戈尔登迈尔粒玄岩中,因为在变形前它需要动力完全均匀。有人提出在几乎直立的区域褶皱事件中,在接近褶轴面方向上形成许多韧性剪切带,伴随与这个方向一致的倾角较缓的同步形成的两组共轭剪切带。动力分析说明,张性交错矿脉,可能与这三组韧性剪切带有空间的几何关系。戈尔登迈尔型矿化是同构造期形成的,在构造期后,原先的构造部位没有矿液沉淀。显微构造分析表明,在韧性剪切带内,在从物质转移占主导的韧性变形期间,韧性剪切带内强烈地改造了与金侵位有关的矿物。特别在微破裂内的破裂封闭系统中,颗粒的边缘和显微穿晶位置有大量的证据说明有助于韧性剪切带内块体的塑性流动。有人提出,在导致增大渗透性的每个破裂封闭循环系统中,建立高流体压梯度及考虑通过狭窄叶理带的流体的集中。这个构造引起的渗入机制使矿液在变形带中渗透,同时也控制了把溶解的矿物组份从高应力带运移到沉淀的场所的应变过程。因此,在剪切带演化的韧性期间产生矿化,虽然中型脉是存在于韧性剪切带内,它们不是金矿侵位事件必不可少的部分,在构造历史中大多数脉形成较晚。微型变形控制了在韧性剪切带中的金侵位,即使在缺少大型和中型的扩张部位,韧性剪切带也是一个很好的勘查靶区。

关键词：金矿床含金变质流体渗入

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管网参数的显法计算

国外建筑科学 1991年第2期6卷 53-56,70页

作者： boul.,PF 何体中

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植物抗虫遗传工程

国外生物科技 1989年第4期 20-23页

作者： boul.,D. 陆美琴

FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts

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World Journal of Gastroenterology 2012年第33期18卷 4533-4541页

作者： Cindy neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel Service de Gastroentérologie-Pancréatologie Hpital Beaujon 100 Boul-evard du Général Leclerc 92110 Clichy La Garenne AP-HP France Service d'Oncologie Médicale Hpital Saint Antoine 184 Rue du Faubourg Saint-Antoine 75012 Paris AP-HP France Unité de Biostatistique et d'Epidémiologie EA 4184 Centre Georges Franois Leclerc 1 Rue du Pr Marion 21079 Dijon France Service d'Oncologie Médicale Hpital Beau-jon 100 Boulevard du Général Leclerc 92110 Clichy La Garenne AP-HP France Département d'Oncologie Médicale Institut Mutualiste Montsouris 42 Boulevard Jourdan 75014 Paris France

AIM: to evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. MEtHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. tumor response, time to progression (ttP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULtS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median ttP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). the main reason for discontinuing FOLFIRI was tumor progression (90.3%). tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median ttP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. there was no toxic death. PS 2 was significantly associated w

关键词： Pancreatic cancer Pancreatic adenocarcinoma Metastases Chemotherapy 5-fluorouracil Irinotecan Camptothecin FOLFIRI regimen