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Influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study

World Journal of Gastrointestinal Surgery 2024年第2期16卷 331-344页

作者： Miran Bezjak Ivan Stresec Branislav Kocman Stipislav Jadrijević Tajana Filipec Kanizaj Miro Antonijević Bojana Dalbelo bašić Danko Mikulić Department of Surgery University Hospital MerkurZagreb 10000Croatia Department of Electronics MicroelectronicsComputer and Intelligent SystemsFaculty of Electrical Engineering and ComputingZagreb 10000Croatia Department of Gastroenterology University Hospital MerkurZagreb 10000Croatia Development of Software Nanobit Ltd.Zagreb 10000Croatia

baCKGROUND The growing disparity between the rising demand for liver transplantation(LT)and the limited availability of donor organs has prompted a greater reliance on older liver ***,utilizing livers from elderly donors has been associated with outcomes inferior to those achieved with grafts from younger *** accounting for additional risk factors,we hypothesize that the utili-zation of older liver grafts has a relatively minor impact on both patient survival and graft *** To evaluate the impact of donor age on LT outcomes using multivariate analysis and comparing young and elderly donor *** In the period from April 2013 to December 2018,656 adult liver transplants were performed at the University Hospital *** multivariate Cox propor-tional hazards models were developed to independently assess the significance of donor *** age was treated as a continuous *** approach involved univariate and multivariate analysis,including variable selection and assessment of interactions and ***,to exemplify the similarity of using young and old donor liver grafts,the group of 87 recipients of elderly donor liver grafts(≥75 years)was compared to a group of 124 recipients of young liver grafts(≤45 years)from the *** rates of the two groups were estimated using the Kaplan-Meier method and the log-rank test was used to test the differences between *** Using multivariate Cox analysis,we found no statistical significance in the role of donor age within the constructed *** when retained during the entire model development,the donor age's impact on survival remained insignificant and transformations and interactions yielded no substantial effects on *** insigni-ficance and low coefficient values suggest that donor age does not impact patient survival in our ***,there was no statistical evidence that the five developed models did not adhe

关键词： Liver transplantation Elderly donors Survival analysis Postoperative complications Cox proportional hazard models

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Performance Evaluation of Novel Eco-Materials Composed of Millet Husks, Rice Husks, and Polystyrene

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Open Journal of Composite Materials 2024年第1期14卷 33-43页

作者： Paul Damien Amadji Edem Chabi Valéry Kouandété Doko Céphas Houndedji Emmanuel Olodo Laboratory of Applied Energy and Mechanics (LEMA) Polytechnic School of Abomey-Calavi University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Rural Engineering School of Rural Engineering National University of Agriculture Kétou Benin

Managing agricultural waste and expanded polystyrene (EPS) poses significant environmental and economic challenges. This study aims to create composites from millet husks, rice husks, and recycled EPS, using a manufacturing method that involves dissolving the polystyrene in a solvent followed by cold pressing. Various particle sizes and two binder dosages were investigated to assess their influence on the physico-mechanical properties of the composites. The mechanical properties obtained range from 2.54 to 4.47 MPa for the Modulus of Rupture (MOR) and from 686 to 1400 MPa for the Modulus of Elasticity in Bending (MOE). The results indicate that these composites have potential for applications in the construction sector, particularly for wood structures and interior decoration. Moreover, surface treatments could enhance their durability and mechanical properties. This research contributes to the valorization of agricultural and plastic waste as eco-friendly and economical construction materials.

关键词： Bio-based Composites Millet Husk Rice Husk Expanded Polystyrene Waste Valorization Sustainable Construction

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舞蹈高等教育面向未来发展的八个引擎

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北京舞蹈学院学报 2024年第1期 1-7页

作者：巴图北京舞蹈学院北京100081

在北京舞蹈学院建校70周年之际,文章提出舞蹈高等教育面向未来发展的八个引擎,即先进舞蹈文化之光的映照、优质舞蹈教育供给的扩容、贤哲云集的变量效应、自觉的舞蹈学术驱动、学院风格的艺术创作、更有效能的舞蹈教育国际化、舞蹈教育... 详细信息

在北京舞蹈学院建校70周年之际,文章提出舞蹈高等教育面向未来发展的八个引擎,即先进舞蹈文化之光的映照、优质舞蹈教育供给的扩容、贤哲云集的变量效应、自觉的舞蹈学术驱动、学院风格的艺术创作、更有效能的舞蹈教育国际化、舞蹈教育的数字化赋能、舞蹈课堂中的革命风暴。

关键词：舞蹈高等教育未来发展引擎

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新文科建设背景下中国教育人类学学科建设研究

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西北民族研究 2024年第1期 75-88页

作者：巴战龙北京师范大学社会学院北京100875

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会... 详细信息

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会组织为核心的学科创新生态系统。为实现“世界水平、中国特色”的学科建设目标和任务,中国教育人类学界需要齐心协力,从开发和健全学会组织功能、激励和加强高等学校教学、构建和密织学术合作网络、加强和提升学术创新能力、普及和传播学科视角方法等五个方面着手构建学科创新生态系统。通过不懈努力将教育人类学打造成文科教育中国范式的典型案例和示范学科,真正开创出国际学界公认和国内学界自豪的“教育人类学的中国时代”。

关键词：创新生态系统新文科建设学科建设教育人类学

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根茎克隆植物芦苇应对风沙活动过程的生长和生殖的权衡关系

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Journal of Plant Ecology 2024年第1期17卷 68-77页

作者： Chaoqun ba Shanshan Zhai Jianqiang Qian Bo Liu Jinlei Zhu Zhimin Liu Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China College of Forestry Henan Agricultural UniversityZhengzhou 450002China College of Life Science Qufu Normal UniversityQufu 273165China Institute of Ecological Conservation and Restoration Chinese Academy of ForestryBeijing 100093China

生长和繁殖之间的权衡是克隆植物适应性策略的重要组成部分。根茎型沙生植物通过权衡策略应对风沙过程(埋沙和风蚀)对它们在流动沙丘上的定居尤为重要。尽管根茎型物种对风沙过程的响应已经有了部分研究,但这些克隆物种如何通过生长和... 详细信息

生长和繁殖之间的权衡是克隆植物适应性策略的重要组成部分。根茎型沙生植物通过权衡策略应对风沙过程(埋沙和风蚀)对它们在流动沙丘上的定居尤为重要。尽管根茎型物种对风沙过程的响应已经有了部分研究,但这些克隆物种如何通过生长和繁殖中的潜在权衡关系来应对风沙过程仍不清楚。在本研究中,我们采用了野外调查和生物量建模的手段,评估了芦苇(Phragmites communis)在沙埋和风蚀条件下,营养生长和生殖生长以及分株数量和大小之间的权衡关系。研究结果表明,沙埋促进了种子生物量和生殖努力(RE)的增加;风蚀减少了RE,但对种子生物量没有显著影响。沙埋增加了分株的生物量,而风蚀增加了分株种群密度并加速了分株的成熟。这些研究表明,根茎型沙地植物通过调整其生长策略来应对风沙过程,即在沙埋条件下,增加生殖生长和分株大小,而在风蚀条件下,增加营养生长和分株数量。

关键词：适应策略沙埋风蚀芦苇(Phragmites communis) 有性生长无性生长根茎

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Spatial Morphology Evolution Characteristics Analysis of the Resident Population Distribution in Henan, China

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Journal of Geoscience and Environment Protection 2024年第3期12卷 163-180页

作者： Kaiguang Zhang Hongling Meng Mingting ba Danhuan Wen School of Geography and Tourism Zhengzhou Normal University Zhengzhou China

The population spatial distribution pattern and its evolving pattern play an important role in regional allocation of social resources and production factors, formulation of regional development plans, construction of a better life society, and promotion of regional economic development. based on the resident population statistics data of Henan province from 2006 to 2021, with county as the basic study unit, the paper studies the spatial morphology characteristics and its evolution patterns of resident population distribution, by using spatial analysis methods such as population distribution center, standard deviation ellipse, and spatial auto correlation analysis. The results show that: the resident population spatial distribution shows unbalanced state, the population agglomeration areas mainly distribute in the northeast part and north part, where the resident population growth rate is significantly higher than other regions, over time, this trend is gradually becoming significant. The resident population distribution has a trend of centripetal concentration, with the degree and trend of centripetal gradually strengthening. The resident population distribution has obvious directional characteristics, but the significance is not high, the weighted resident population average center is approximately located at (4.13740˚N, 113.8935˚E), and the azimuth of the distribution axis is approximately 11.19˚. The population distribution has obvious agglomeration characteristics, with the built-up areas of Zhengzhou and Luoyang as their centers, where have a significant siphon effect on the surrounding population. The southern and southwestern regions in the province form a relatively stable belt area of Low-Low agglomeration areas.

关键词： Resident Population Spatial Distribution Spatial Morphology Temporal and Spatial Evolution Center Migration Standard Deviation Ellipse Spatial Autocorrelation

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现代性与多样性的关系--教育人类学的根本研究论题刍议

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西南民族大学学报（人文社会科学版） 2024年第5期45卷 16-26页

作者：巴战龙北京师范大学社会学院北京100875

作为学科界说的新范式,“新教育人类学”建立在两个基本假设--教育人类学既是一门社会科学,又是教育诸学科中最为基础的学科--之上,主张教育人类学的根本研究论题是现代性与多样性的关系问题。尽管学界关于“何谓现代性”至今仍是聚讼... 详细信息

作为学科界说的新范式,“新教育人类学”建立在两个基本假设--教育人类学既是一门社会科学,又是教育诸学科中最为基础的学科--之上,主张教育人类学的根本研究论题是现代性与多样性的关系问题。尽管学界关于“何谓现代性”至今仍是聚讼纷纷、莫衷一是,但在反思性继承社会科学已有经验和成果的基础上,教育人类学至少可以从同一性与多样性和不平等与多样性两个主题出发对现代性与多样性的关系问题展开探索和论述,进而转换研究视角和理论观念,努力做出新时代“标志性研究成果”。

关键词：现代性多样性理论构建新教育人类学

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Levels of evidence and grades of recommendation supporting European society for medical oncology clinical practice guidelines

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Oncology Research 2024年第5期32卷 807-815页

作者： MARKO SKELIN BRUNA PERKOV-STIPIČIN SANJA VUŠKOVIĆ MARINAŠANDRK PLEHAČEK ANE baŠIĆ DAVIDŠARČEVIĆ MAJA ILIĆ IVAN KREČAK Pharmacy Department General Hospital ofŠibenik-Knin CountyŠibenikCroatia Faculty of Medicine University of RijekaRijekaCroatia Undergraduate Study in Nursing University of Applied SciencesŠibenikCroatia Department of Oncology University Hospital Center ZagrebZagrebCroatia Pharmacies Joukhadar Sveta NedeljaCroatia Pharmacies Prima Pharme ZagrebCroatia Pharmacy Department General Hospital ZadarZadarCroatia Pharmacy Department General Hospital PulaPulaCroatia Department of Internal Medicine General Hospital ofŠibenik-Knin CountyŠibenikCroatia

background:The European Society for Medical Oncology(ESMO)guidelines are among the most comprehensive and widely used clinical practice guidelines(CPGs)***,the level of scientific evidence supporting ESMO CPG recommendations has not been systematically *** study assessed ESMO CPG levels of evidence(LOE)and grades of recommendations(GOR),as well as their trends over time across various cancer ***:We manually extracted every recommendation with the Infectious Diseases Society of America(IDSA)classification from each *** examined the distribution of LOE and GOR in all available ESMO CPG guidelines across different topics and cancer ***:Among the 1,823 recommendations in the current CPG,30%were classified as LOEⅠ,and 43%were classified as GOR ***,there was a slight decrease in LOEⅠ(−2%)and an increase in the proportion of GOR A(+1%)in the current CPG compared to previous *** proportion of GOR A recommendations based on higher levels of evidence such as randomized trials(LOEⅠ–Ⅱ)shows a decrease(71%vs.63%,p=0.009)while recommendations based on lower levels of evidence(LOEⅢ–Ⅴ)show an increase(29%vs.37%,p=0.01)between previous and current *** the current versions,the highest proportion of LOEⅠ(42%)was found in recommendations related to pharmacotherapy,while the highest proportion of GOR A recommendations was found in the areas of pathology(50%)and diagnostic(50%)*** variability in LOEⅠand GOR A recommendations and their changes over time was observed across different cancer ***:One-third of the current ESMO CPG recommendations are supported by the highest level of *** well-designed randomized clinical trials are needed to increase the proportion of LOEⅠand GOR A recommendations,ultimately leading to improved outcomes for cancer patients.

关键词： ESMO guidelines Clinical practice guidelines Level of evidence Grade of recommendation

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Mid-infrared computational temporal ghost imaging

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Light(Science & Applications) 2024年第6期13卷 1088-1097页

作者： Han Wu Bo Hu Lu Chen Fei Peng Zinan Wang Goery Genty Houkun Liang College of Electronics and Information Engineering Sichuan UniversityChengduSichuan610064China College of Electrical Engineering Sichuan UniversityChengduSichuan610064China Key Lab of Optical Fiber Sensing&Communications University of Electronic Science&Technology of ChinaChengduSichuan611731China Laboratory of Photonics Tampere UniversityFI-33014TampereFinland

Ghost imaging in the time domain allows for reconstructing fast temporal objects using a slow *** technique involves correlating random or pre-programmed probing temporal intensity patterns with the integrated signal measured after modulation by the temporal ***,the implementation of temporal ghost imaging necessitates ultrafast detectors or modulators for measuring or pre-programming the probing intensity patterns,which are not available in all spectral regions especially in the mid-infrared ***,we demonstrate a frequency downconversion temporal ghost imaging scheme that enables to extend the operation regime to arbitrary wavelengths regions where fast modulators and detectors are not *** approach modulates a signal with temporal intensity patterns in the near-infrared and transfers the patterns to an idler via difference-frequency generation in a nonlinear crystal at a wavelength where the temporal object can be *** a proof-of-concept,we demonstrate computational temporal ghost imaging in the mid-infrared with operating wavelength that can be tuned from 3.2 to 4.3μ*** scheme is flexible and can be extended to other *** results introduce new possibilities for scan-free pump-probe imaging and the study of ultrafast dynamics in spectral regions where ultrafast modulation or detection is challenging such as the mid-infrared and THz regions.

关键词： ghost Ghost scheme

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Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation

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World Journal of Diabetes 2024年第5期15卷 958-976页

作者： Hong Xu Li-Bo Zhang Yi-Yi Luo Ling Wang Ye-Pin Zhang Pei-Qi Chen Xue-Ying ba Jian Han Heng Luo Department of Ophthalmology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Precision Medicine Center of Chuxiong Yi Autonomous Prefecture The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Endocrinology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Pathology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina

baCKGROUND Synaptotagmins(SYTs)are a family of 17 membrane transporters that function as calcium ion sensors during the release of Ca2+-dependent neurotransmitters and ***,few studies have reported whether members of the SYT family play a role in glucose uptake in diabetic retinopathy(DR)through Ca2+/glucose transporter-1(GLUT1)and the possible regulatory mechanism of *** To elucidate the role of the SYT family in the regulation of glucose transport in retinal pigment epithelial cells and explore its potential as a therapeutic target for the clinical management of *** DR was induced by streptozotocin in C57BL/6J mice and by high glucose medium in human retinal pigment epithelial cells(ARPE-19).Bioinformatics analysis,reverse transcriptase-polymerase chain reaction,Western blot,flow cytometry,ELISA,HE staining,and TUNEL staining were used for *** Six differentially expressed proteins(SYT2,SYT3,SYT4,SYT7,SYT11,and SYT13)were found between the DR and control groups,and SYT4 was highly *** induces SYT4 overexpression,manipulates Ca2+influx to induce GLUT1 fusion with the plasma membrane,promotes abnormal expression of the glucose transporter GLUT1 and excessive glucose uptake,induces ARPE-19 cell apoptosis,and promotes DR *** deficiency inhibits the proteasomal degradation of SYT4 in DR,resulting in SYT4 accumulation and enhanced GLUT1 fusion with the plasma membrane,and these effects were blocked by oe-Parkin ***,dysregulation of the myelin transcription factor 1(Myt1)-induced transcription of SYT4 in DR further activated the SYT4-mediated stimulus-secretion coupling process,and this process was inhibited in the oe-MYT1-treated *** Our study reveals the key role of SYT4 in regulating glucose transport in retinal pigment epithelial cells during the pathogenesis of DR and the underlying mechanism and suggests potential therapeutic targets for clinical DR.

关键词： Diabetic retinopathy Glucose transporter-1 Synaptotagmin 4 Parkin Myelin transcription factor 1

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