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Transient expression of inactive RB in mesenchymal stem cells impairs their adipogenic potential and is associated with hypermethylation of the PPARγ2 promoter

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Genes & Diseases 2022年第1期9卷 165-175页

作者： Mikhail Baryshev Nikolai Petrov Vladimir Ryabov boris Popov Institute of Cytology Russian Academy of Sciences St.Petersburg4Tikhoretsky Av.194064St.PetersburgRussia Institute of Microbiology and Virology Riga Stradins UniversityRatsupites 5LV-1067RigaLatvia Developmental Therapeutics Branch National Cancer InstituteNational Institutes of HealthBethesdaMaryland 20892USA

The retinoblastoma gene product(pRb)is a chromatin-associated protein that can either suppress or promote activity of key regulators of tissue-specific *** found that twelve weeks after transfection of the exogenous active(ΔB/X andΔр34)or inactive(ΔS/N)forms of RB into the 10T1/2 mesenchymal stem cells and clonal selection not a single cell line did contain exogenous RB,despite being G-418 ***,the consequences of the transient production of exogenous RB had different effects on the cell ***ΔB/X andΔр34 cells transfected with active form of RB showed elevated levels of inducible adipocyte differentiation(AD).On the contrary,theΔS/N cells transfected with inactive RB mutant were insensitive to induction of AD associated with abolishing of expression of the PPARγ***,the PPARγ2 promoter in undifferentiatedΔS/N cells was hypermethylated,but all except−60 position CpG became mostly demethylated after cells exposure to *** conclude that while transient expression of inactive exogenous RB induces long term epigenetic alterations that prevent adipogenesis,production of active exogenous RBs results in an AD-promoting epigenetic *** results indicate that pRb is involved in the establishment of hereditary epigenetic memory at least by creating a methylation pattern of PPARγ2.

关键词： Adipogenic differentiation DNA methyltransferase 1 Mesenchymal stem cells MSCs RB Retinoblastoma susceptibility gene

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Multiple cycles of magnetic activity in the Sun and Sun-like stars and their evolution

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Research in Astronomy and Astrophysics 2018年第7期18卷 21-36页

作者： Elena Aleksandrovna Bruevich Vasily Vladimirovich Bruevich boris Pavlovich Artamonov Lomonosov Moscow State University Sternberg Astronomical Institute

The wavelet transform method for high-quality time-frequency analysis is applied to sets of observations of relative sunspot numbers and stellar chromosphere fluxes of 10 Sun-like stars. Wavelet analysis of solar data shows that in a certain interval of time there are several cycles of activity with pe- riods of duration which vary considerably from each other： from quasi-biennial cycles to lO0-yr cycles. Cyclic activity was detected in almost all Sun-like stars that we examined, even those that previously were not considered as stars with cyclic activity according to analysis using a Scargle periodogram. The durations of solar and stellar cycles significantly change during the observation period.

关键词： Sun activity - multiple cycles - Sun-like stars activity

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ZIKV viral proteins and their roles in virus-host interactions

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Science China(Life Sciences) 2021年第5期64卷 709-719页

作者： Moujian Guo Lixia Hui Yiwen Nie boris Tefsen Ying Wu State Key Laboratory of Virology School of Basic Medical SciencesWuhan UniversityWuhan 430071China Department of Biological Sciences Xi'an Jiaotong-Liverpool UniversitySuzhou 215123China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

The re-emergence of Zika virus(ZIKV) and its associated neonatal microcephaly and Guillain-Barré syndrome have led the World Health Organization to declare a global health emergency. Until today, many related studies have successively reported the role of various viral proteins of ZIKVin the process of ZIKVinfection and pathogenicity. These studies have provided significant insights for the treatment and prevention of ZIKV infection. Here we review the current research advances in the functional characterization of the interactions between each ZIKV viral protein and its host factors.

关键词： ZIKV viral protein host-virus interactions immune response pathogenicity

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pRb-E2F signaling in life of mesenchymal stem cells:Cell cycle,cell fate,and cell differentiation

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Genes & Diseases 2014年第2期1卷 174-187页

作者： boris Popov Nikolay Petrov Institute of Cytology Russian Academy of SciencesSt.Petersburg4Tikhoretsky Av.194064Russia

Mesenchymal stem cells(MSCs)are multipotent cells that can differentiate into various mesodermal lines forming fat,muscle,bone,and other lineages of connective *** possess plasticity and under special metabolic conditions may transform into cells of unusual phenotypes originating from ecto-and *** transplantation,MSCs release the humoral factors promoting regeneration of the damaged *** last five years,the numbers of registered clinical trials of MSCs have increased about 10 *** gives evidence that MSCs present a new promising resource for cell therapy of the most dangerous *** efficacy of the MSCs therapy is limited by low possibilities to regulate their conversion into cells of damaged tissues that is implemented by the pRb-E2F *** widely accepted viewpoint addresses pRb as ubiquitous regulator of cell cycle and tumor ***,current publications suggest that basic function of the pRb-E2F signaling in development is to regulate cell fate and *** facultative and constitutive chromatin modifications,pRb-E2F signaling promotes transient and stable cells quiescence,cell fate choice to differentiate,to senesce,or to *** of pRb is associated with cancer cell *** regulates cell fate by retaining quiescence of one cell population in favor of commitment of another or by suppression of genes of different cell *** is the founder member of the“pocket protein”family possessing functional *** increase in the efficacy of the MSCs based cell therapy will depend on precise understanding of various aspects of the pRb-E2F signaling.

关键词： Cell cycle Cell differentiation Cell fate Mesenchymal stem cells pRb-E2F signaling

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Hepatocellular carcinoma chemoprevention in chronic hepatitis B patients:all-in on statins?

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 676-678页

作者： JoséUrsic-Bedoya boris Guiu Department of Hepatology St-Eloi University HospitalMontpellierFrance Department of Radiology St-Eloi University HospitalMontpellierFrance

Chronic hepatitis B(CHB)affects approximately 257 million individuals worldwide,the highest prevalence being in Western Pacific WHO Region[6.2%(1)].In highly endemic CHB regions,the 5-year cumulative incidence of hepatocellular carcinoma(HCC)ranges from 3%to 17%,depending on the presence of cirrhosis(2).Antiviral treatment decreases the risk of HCC,without abolishing it completely(3).Paradoxically,by decreasing liver-related mortality,antiviral treatment in CHB patients causes an increase in HCC long-term incidence(4).

关键词： prevention patients mortality

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Capacitance,charge dynamics,and electrolyte-surface interactions in functionalized carbide-derived carbon electrodes

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Progress in Natural Science:Materials International 2015年第6期25卷 631-641页

作者： boris Dyatkin Eugene Mamontov Kevin M.Cook Yury Gogotsi Department of Materials Science & Engineering and A.J.Drexel Nanomaterials Institute Drexel University Spallation Neutron Source Oak Ridge National Laboratory Materials Engineering Division Naval Air Systems Command

This study analyzed the dynamics of ionic liquid electrolyte inside of defunctionalized,hydrogenated,and aminated pores of carbide-derived carbon supercapacitor *** approach tailors surface functionalities and tunes nanoporous structures to decouple the influence of pore wall composition on capacitance,ionic resistance,and long-term ***-elastic neutron scattering probes the self-diffusion properties and electrode-ion interactions of electrolyte molecules confined in functionalized ***-temperature ionic liquid interactions in confined pores are strongest when the hydrogen-containing groups are present on the *** property translates into higher capacitance and greater ion transport through pores during electrochemical *** hydrogenated pores,aminated pores do not favorably interact with ionic liquid ions and,subsequently,are outperformed by defunctionalized surfaces.

关键词： Supercapacitor Carbide-derived carbon Neutron scattering Energy storage Porous materials Surface chemistry

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Impact and Friction Sensitivity of Energetic Materials：Methodical Evaluation of Technological Safety Features

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火炸药学报 2015年第3期38卷 1-8页

作者： Aleksandr Smirnov Oleg Voronko boris Korsunsky Tatyana Pivina Bakhirev State Scientific Research Institute of Mechanical Engineering DzerzhinskNizhny Novgorod Region 606002Russia Institute of Problems of Chemical Physics Russian Academy of SciencesChernogolovkaMoscow Region142432Russia Zelinsky Institute of 0rganic Chemistry Russian Academy of SciencesMoscow119991Russia

Key methods developed and used in the USSR and in the Russian Federation to determine the impact and friction sensitivity of energetic materials and explosives have been *** methodologies and instruments that underlie the assessment of their production and handling safety have been *** of a large number of compounds have revealed relationships between their sensitivity parameters and structure of individual compounds and *** range of change of physical and chemical characteristics for the compounds we examined covers the entire region of their *** methodology and equations have been formulated to estimate the impact and friction sensitivity parameters of energetic materials and to evaluate the technological safety in *** developed methodology is characterized by high-accuracy calculations and prediction of sensitivity parameters.

关键词： energetic materials experimental testing friction sensitivity impact sensitivity regressive analysis safety in use methodical evaluation

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Crystal-field levels of Nd3+ in a new langasite compound Nd3CrGe3Be2O14

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Journal of Rare Earths 2019年第11期37卷 1250-1254页

作者： Sergei A.Klimin boris V.Mill Marina N.Popova Institute of Spectroscopy Russian Academy of SciencesTroitskMoscow 108840Russia Faculty of Physics M.V.Lomonosov Moscow State UniversityMoscow 119991Russia

We report on the crystal-field(CF)levels of Nd^3+in Nd3CrGe3Be2O14,a representative of recently synthesized Be-containing *** are the first in the family to contain two magnetic subsystems,1 D chromium and Kagome-like rare-earth ***-resolution broad-band temperature-dependent spectra allow us to find all five CF Kramers doublets of the ground 4I9/2 CF multiplet and 38 levels of the excited 4I11/2,13/2,15/2,4F3/2,4F5/2+2H9/2,4F7/2+4S3/2 and 4F9/2 CF *** data form a basis for a future exploration of this interesting two-sublattice magnet with frustrated *** transitions between Kramers doublets of Nd^3+indicate magnetic activity of 1D-chromium chains at T<20 K.

关键词： Langasite Two magnetic subsystems High-resolution spectroscopy Crystal-field levels Magnetic correlations Rare earths

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The key role of the hepatic veins collaterals in the modern liver surgery

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 643-644页

作者： Fabrizio Panaro boris Guiu Astrid Herrero Division of HBP Surgery&Transplantation Dept.of SurgerySt.Eloi HospitalMontpellier University Hospital-School of MedicineMontpellierFrance

Currently,the terminology for liver anatomy and resection was based on the updates of the Brisbane 2000 system(1).In this setting,Couinaud’s anatomical description serves as the backbone for the classification of resection(2).Based on this classification,an anatomic liver resection was defined as the complete removal of the liver parenchyma confined within the responsible portal *** subsegmentectomy is defined as the removal of the liver parenchyma within the portal territory of less than a Couinaud’s *** are also defined as cone units,and their areas can be intraoperatively assessed by using ischemic demarcation,indocyanine green(ICG)staining,or both.

关键词： anatomy surgery hepatic

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Liver venous deprivation:a bright future for liver metastases-but what about hepatocellular carcinoma?

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 270-272页

作者： boris Guiu Astrid Herrero Fabrizio Panaro Department of Radiology St-Eloi University HospitalMontpellierFrance Department of HBP Surgery&Transplantation St-Eloi University HospitalMontpellierFrance

Liver venous deprivation(LVD)refers to the percutaneous procedure aiming to simultaneously abrogate both portal inflow and hepatic venous outflow to accelerate liver regeneration of the future liver remnant(FLR),which limits patient drop-out from resection due either to insufficient FLR or tumor *** authors have designated the exact same technique under the acronym RASPE(Radiological Simultaneous Porto-hepatic Vein Embolization)(1)while others reported on‘double embolization’for designating portal vein embolization(PVE)and proximal embolization of one hepatic vein,keeping patent distal venous branches and veno-venous collaterals(2).

关键词： venous Liver deprivation

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