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Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated： a prospective study using patient-reported outcome measures

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Asian Journal of Andrology 2017年第1期19卷 62-66页

作者： Karan Wadhwa Lina Carmona-Echeveria Timur Kuru Gabriele Gaziev Eva Serrao Deepak Parasha Julia Frey Ivailo Dimov Jonas Seidenader Pete Acher Gordon Muir Andrew Doble Vincent Gnanapragasam boris hadaschik Christof Kastner Department of Urology Addenbrookes Hospital Cambridge UK Department of Urology University Hospital Heidelberg Germany Department of Biochemistry University of Cambridge Cambridge UK Cancer Research Centre and Statistics and Epidemiology Unit Division of Health Sciences Warwick Medical School University of Warwick Coventry UK Department of Urology Southend University Hospital Southend UK Department of Urology Kings College Hospital London UK CamPARI Prostate Cancer Clinic Addenbrookes Hospital Cambridge UK.

We aimed to determine short-term patient-reported outcomes in men having general anesthetic transperineal （TP） prostate biopsies. A prospective cohort study was performed in men having a diagnostic TP biopsy. This was done using a validated and adapted questionnaire immediately post-biopsy and at follow-up of between 7 and 14 days across three tertiary referral hospitals with a response rate of 51.6%. Immediately after biopsy 43/201 （21.4%） of men felt light-headed, syncopal, or suffered syncope. Fifty-three percent of men felt discomfort after biopsy （with 95% scoring 〈5 in a 0-10 scale）. Twelve out of 196 men （6.1%） felt pain immediately after the procedure. Despite a high incidence of symptoms （e.g., up to 75% had some hematuria, 47% suffered some pain）, it was not a moderate or serious problem for most, apart from hemoejaculate which 31 men suffered. Eleven men needed catheterization （5.5%）. There were no inpatient admissions due to complications （hematuria, sepsis）. On repeat questioning at a later time point, only 25/199 （12.6%） of men said repeat biopsy would be a significant problem despite a significant and marked reduction in erectile function after the procedure. From this study, we conclude that TP biopsy is well tolerated with similar side effect profiles and attitudes of men to repeat biopsy to men having TRUS biopsies. These data allow informed counseling of men prior to TP biopsy and a benchmark for tolerability with local anesthetic TP biopsies being developed for clinical use.

关键词： attitude to rebiopsy patient-reported outcome measures patient satisfaction prostate cancer diagnosis transperineal biopsies transrectal biopsies

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Prostate magnetic resonance imaging at 3 Tesla:Is administration of hyoscine-N-butyl-bromide mandatory?

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World Journal of Radiology 2013年第7期5卷 259-263页

作者： Matthias C Roethke Timur H Kuru Alexander Radbruch boris hadaschik Heinz-Peter Schlemmer Department of Radiology German Cancer Research Center Heidelberg (DKFZ) 69120 Heidelberg Germany Department of Urology Universityhospital Heidelberg 69120 Heidelberg Germany

AIM: To evaluate the value of administration of hyoscine-N-butyl-bromide (HBB) for image quality magnetic resonance imaging (MRI) of the prostate. METHODS: Seventy patients were retrospectively included in the study. Thirty-five patients were examined with administration of 40 milligrams of HBB (Buscopan ; Boehringer, Ingelheim, Germany); 35 patients were examined without HBB. A multiparametric MRI protocol was performed on a 3.0 Tesla scanner without using an endorectal coil. The following criteria were evaluated independently by two experienced radiologists on a five-point Likert scale: anatomical details (delineation between peripheral and transitional zone of the prostate, visualisation of the capsule, depiction of the neurovascular bundles); visualisation of lymph nodes; motion related artefacts; and overall image ***: Comparison of anatomical details between the two cohorts showed no statistically significant difference (3.9 ± 0.7 vs 4.0 ± 0.9, P = 0.54, and 3.8 ± 0.7 vs 4.2 ± 0.6, P = 0.07) for both readers. There was no significant advantage regarding depiction of local and iliac lymph nodes (3.9 ± 0.6 vs 4.2 ± 0.6, P = 0.07, and 3.8 ± 0.9 vs 4.1 ± 0.8, P = 0.19). Motion arte- facts were rated as 'none' to 'few' in both groups and showed no statistical difference (2.3 ± 1.0 vs 1.9 ± 0.9, P = 0.19, and 2.3 ± 1.1 vs 1.9 ± 0.7, P = 0.22). Overall image quality was rated 'good' in average for both cohorts without significant difference (4.0 ± 0.6 vs 4.0 ± 0.9, P = 0.78, and 3.8 ± 0.8 vs 4.2 ± 0.6, P = 0.09). CONCLUSION: The results demonstrated no significant effect of HBB administration on image quality. The study suggests that use of HBB is not mandatory for MRI of the prostate at 3.0 Tesla.

关键词： Butylscopolamine Buscopan Motion artefacts Magnetic resonance imaging Prostate cancer 3 Tesla

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Collecting Duct (Bellini Duct) Renal Cell Carcinoma: Oncologic Outcome and Therapeutic Management

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Journal of Cancer Therapy 2017年第5期8卷 413-422页

作者： Yuejun Du Sascha Pahernik Matthias Kwol Stefan Fuxius boris hadaschik Dogu Teber Stefan Duensing Annette Kaiser Markus Hohenfellner Carsten Grüllich Department of Urology Heidelberg University Hospital Heidelberg Germany Department of Urology Nanfang Hospital of Southern Medical University Guangzhou China Department of Urology Nuremberg General Hospital Paracelsus Medical University Nuremberg Germany Praxis for Onkologie Heidelberg Germany Section of Molecular Urooncology Department of Urology Heidelberg University Hospital Heidelberg Germany Clinic for Pathology Nuremberg General Hospital Paracelsus Medical University Nuremberg Germany Department of Medical Oncology National Center for Tumor Diseases Heidelberg University Hospital Heidelberg Germany

Objectives: To evaluate treatment and prognosis of collecting duct renal cell carcinoma (CDRCC) in three institutions. Methods: The data of CDRCC patients were collected retrospectively from 3 participating institutions. Results: A total of 24 patients were identified in 3 institutions with an incidence of 0.5% - 0.6%. Among them, the median age was 63.0 years and male gender was predominant (66.7%). At least 45.7% (11/24) of the patients were symptomatic at presentation. Moreover, distant metastasis at initial diagnosis was present in 13 patients (54.2%) and 6 patients (25.0%) developed distant metastasis during the course of disease. Almost all these patients were at high stage (87.5%) and poorly differentiated (79.2%). Besides, nodal involvement and major vein extension were observed in 14 (58.3%) and 10 (41.7%) patients, respectively. All the patients in this cohort underwent surgery with a median cancer specific survival of 11.3 months. Of the 14 patients with chemotherapy, gemcitabine/cisplatin was dominantly given in 6 patients (42.9%). Conclusions: CDRCC is rarely seen. Most of CDRCC patients had advanced stage, high nuclear grade, regional nodal involvement, distant metastasis at presentation and consequent poor prognosis. To date, no standard protocol for the treatment of CDRCC exists. Current standard in systemic therapy of CDRCC is chemotherapy with gemcitabine and cisplatin.

关键词： Bellini Duct Collecting Duct Prognosis Renal Cell Cancer Treatment

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天然气水合物储层性质对微波加热后储层温度的影响

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中国石油大学学报(自然科学版) 2025年

作者：樊燊王旱祥张辛刘延鑫孙秉宇葛家旺葛城才刘博 KHROUSTALEV boris 管冰中国石油大学(华东)海洋物探及勘探开发装备国家工程研究中心中国石油大学(华东)机电工程学院山东威马泵业股份有限公司

为了弥补降压法开采后期储层结冰、水合物二次生成等方面的不足,运用微波加热技术向储层进行能量补充。选用漏泄同轴天线作为微波加热装置,根据装置结构设计天然气水合物储层微波加热工艺方案,并且建立水合物储层微波加热仿真模型,通过... 详细信息

为了弥补降压法开采后期储层结冰、水合物二次生成等方面的不足,运用微波加热技术向储层进行能量补充。选用漏泄同轴天线作为微波加热装置,根据装置结构设计天然气水合物储层微波加热工艺方案,并且建立水合物储层微波加热仿真模型,通过试验验证仿真模型的准确性,并分析储层性质对微波加热后储层温度的影响规律。结果表明:储层微波加热工艺方案能够有效提升储层温度,储层初始温度为2℃,微波加热后储层最高温度为26.22℃,平均温度为5.19℃;储层温度随着损耗因子的增大而增大,随着介电常数的增大而减小;随着储层密度和比定压热容的增大,储层升温效果变差;随着储层导热系数的增大,储层温度分布更加均匀。

关键词：天然气水合物储层性质微波加热储层温度微波天线

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Surface-enhanced Raman scattering inside Au@Ag core/shell nanorods

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Nano Research 2016年第8期9卷 2303-2318页

作者： boris Khlebtsov Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences Saratov 410049 Russia Saratov National Research State University Saratov 410012 Russia

The design and synthesis of plasmonic nanoparticles with Raman-active molecules embedded inside them are of significant interest for sensing and imaging applications. However, direct synthesis of such nanostructures with controllable shape, size, and plasmonic properties remains extremely challenging. Here we report on the preparation of uniform Au@Ag core/sheU nanorods with controllable Ag shells of 1 to 25 nm in thickness. 1,4-Aminothiophenol （4-ATP） molecules, used as the Raman reporters, were located between the Au core and the Ag shell. Successful embedding of reporter molecules inside the core/shell nanoparticles was confirmed by the absence of selective oxidation of the amino groups, as measured by Raman spectroscopy. The dependence of Raman intensity on the location of the reporter molecules in the inside and outside of the nanorods was studied. The molecules in the interior showed strong and uniform Raman intensity, at least an order of magnitude higher than that of the molecules on the nanoparticle surface. In contrast to the usual surface-functionalized Raman tags, aggregation and clustering of nanoparticles with embedded molecules decreased the surface-enhanced Raman scattering （SERS） signal. The findings from this study provide the basis for a novel detection technique of low analyte concentration utilizing the high SERS response of molecules inside the core/shell metal nanostructures. As an example, we show robust SERS detection of thiram fungicide as low as 10-9 M in solutions.

关键词： surface-enhanced Ramanscattering (SERS) Au@Ag nanorods nanocuboids multipole plasmons

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On approach for obtaining approximate solution to highly nonlinear oscillatory system with singularity

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Acta Mechanica Sinica 2020年第4期36卷 910-917页

作者： Zvonko Rakaric boris Stojic Department of Mechanics Faculty of Technical SciencesUniversity of Novi Sad21000 Novi SadSerbia Department of Mechanization and Design Engineering Faculty of Technical SciencesUniversity of Novi Sad21000 Novi SadSerbia

This paper deals with further investigations of recently introduced so-called low-frequency pendulum mechanism,which represents an extended form of classical *** equation of motion,which is in Eksergian’s form,is a singular and highly nonlinear second order differential *** is transformed by suitable choice of a new “coordinates”into classical form of nonlinear conservative oscillator containing only inertial and restoring force ***,due to the singularity of coefficient of governing equation that shows hyperbolic growth,Laurent series expansion was *** these,we derived a nonsingular nonlinear differential equation,for which there exists an exact solution in the form of a Jacobi elliptic *** using this exact solution,and after returning to the original coordinate,both explicit expression for approximate natural period and solution of motion of mechanism were *** between approximate solution and solution is obtained by numerical integration of exact equation shows noticeable *** of impact of mechanism parameters on period is given.

关键词： Pendulum mechanism Low frequency Singularity Laurent series Jacobi elliptic function

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A Linear System Arising from a Polynomial Problem and Its Applications

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Chinese Annals of Mathematics,Series B 2007年第3期28卷 283-292页

作者： boris SHEKHTMAN Department of Mathematics University of South FloridaPHY1144202 E Fowler AvenueTampaFL 33620-5700USA.

A linear system arising from a polynomial problem in the approximation theory is studied, and the necessary and sufficient conditions for existence and uniqueness of its solutions are presented. Together with a class of determinant identities, the resulting theory is used to determine the unique solution to the polynomial problem. Some homogeneous polynomial identities as well as results on the structure of related polynomial ideals are just by-products.

关键词： Linear system Determinant identity Polynomial ideal in two variables

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The Log Minimal Model Program for Horospherical Varieties Via Moment Polytopes

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Acta Mathematica Sinica,English Series 2018年第3期34卷 542-562页

作者： boris PASQUIER Institut Montpelliérain Alexander Grothendieck CNRS Univ. Montpellier Laboratoire de Mathématiques et Applications CNRS Université de Poitiers

In a previous work, we described the Minimal Model Program in the family of Q-Gorenstein projective horospherical varieties, by studying certain continuous changes of moment polytopes of polarized horospherical varieties. Here, we summarize the results of the previous work and we explain how to generalize them in order to describe the Log Minimal Model Program for pairs（X, Δ） when X is a projective horospherical variety.

关键词： Log minimal model program horospherical varieties moment polytopes

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Chances and challenges in China

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Protein & Cell 2016年第4期7卷 233-235页

作者： boris Tefsen Department of Biological Sciences Xi'an Jiaotong-Liverpool University Suzhou China

So there I was, 35 years old and at the crossroads of my scientific career. The current academic system in the Netherlands, like in many other places around the world （Powell, 2015）, is not designed to have scientists staying in a postdoc position forever. So, you are either deemed good enough to become a permanent staff member, or you have to leave academia at some point and try your luck in a pharmaceutical company or elsewhere. I had not succeeded in the former, but I also did not want to do the latter, so I took a less threaded path and headed to China.

关键词： Chances challenges China

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The family of quantum droplets keeps expanding

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Frontiers of physics 2021年第2期16卷 9-12页

作者： boris A.Malomed Department of Physical Electronics School of Electrical EngineeringFaculty of Engineeringand Center for Light-Matter InteractionTel Aviv UniversityP.O.B.39040Tel AvivIsrael Instituto de Alta Investigacion Universidad de TarapacaCasilla 7DAricaChile

In the course of the past 25 years,several new quantum states of matter have been created in ultracold gases,starting from the celebrated Bose-Einstein condensates(BECs),which were first made in 1995,follow-ing the theoretical prediction published in 1924[1].This achievement was followed by the creation and detailed exploration of degenerate Fermi gases[2].

关键词： quantum gases expanding

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