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Cryptococcus and Cryptococcosis in Human and Animal Model:An Overview

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Advances in Microbiology 2020年第4期10卷 180-193页

作者： Eriques Goncalves da Silva Diniz Pereira Leite-Jr Margareth Léa da Silva Maia Sandra Marilia de Souza Silva Francisco de Assis Baroni Marcos Ereno Auler Amanda Latércia Tranches Dias Débora moreira Rinaldo Ferreira Gandra Regina Teixeira Barbieri Ramos André Gasparetto Elisangela Santana de Oliveira Dantas Valéria Tognato Costa Claudete Rodrigues Paula School of Dentistry University of Sao Paulo(USP)Sao PauloBrazil Specialized Medical Mycology Center Federal University of Mato Grosso(UFMT)CuiabáBrazil Federal University of ABC(UFABC) Santo AndréBrazil Rural Federal University of Rio de Janeiro(UFRRJ) Rio de JaneiroBrazil Faculty of Pharmacy University of the Western Center of Paraná(UNICENTRO)Campus CedetegGuarapuavaBrazil Federal University of Alfenas(UNIFAL) AlfenasBrazil University Hospital State University of West Paraná(UNIOESTE)CascavelBrazil Department of Dentistry State University of Maringa(UEM)MaringáBrazil Institute of Biosciences Federal University of Mato Grosso(UFMT)CuiabáBrazil

Background: Yeasts from the genus Cryptococcus (species C. neoformans and C. gattii) are opportunistic pathogens that afflict humans with low immunity caused by diseases such as AIDS or by the usage of immunosuppressive drugs. It is a fatal disease that has been studied around the whole world and its most fatal form is the brain cryptococcosis. Purpose: The present review describes the disease from pathogen isolation, the various clinical presentations of the disease, the most important virulence factors of yeast in human and animal model and their clinical issues. Methods: On this review, several published studies about the disease are presented. Results: Numerous researches have been done worldwide in order to find a kind of therapy that is more effective against the disease. Amphotericin B, in all forms is still the drug of choice in the treatment of the cryptococcosis. Fluconazole, as well as voriconazole in combination with amphotericin B, is recommended in the cases of treatment failure. Conclusion: This study presented has elucidated a little more about the disease. Further studies should be conducted to find more diagnoses that are accurate as well as more effective treatments for eradicating the disease. In this study, the bibliographic survey makes reference to the world literature;with regard to ecology, taxonomy, mains factors related to virulence, the clinical manifestations, the action of antifungal drugs and histopathological analysis used in an animal model, were the objectives deleterious aspects of this study, thus informing, in a simple way, the importance of this microorganism for research and researchers working with this global disease, called Cryptococcosis.

关键词： Cryptocococcus Cryptococcosis Animal Model Cryptococcus neoformans Cryptococcusgattii Virulence Related Factors

Characterization of Clinical and Environmental Isolates of <i>Cryptococcus neoformans</i>/<i>Cryptococcus gattii</i>Complex Maintained in Yeast Culture Collection in São Paulo, Brazil

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Open Journal of Epidemiology 2018年第2期8卷 76-92页

作者： Pedro Henrique Magalhã es Cardoso Bosco Christiano Maciel da Silva Jairo Ivo dos Santos Rennan Luiz Oliveira dos Santos Diniz Pereira Leite Jú nior Marcos Ereno Auler Luciana da Silva Ruiz Eriques Gonç alves da Silva Dé bora moreira Carina Domaneschi Francisco de Assis Baroni Marcia de Souza Carvalho Melhem Marilena dos Anjos Martins Claudete Rodrigues Paula Faculty of Veterinary Medicine and Zootechny-FMVZ-USP University of S&#227 o Paulo (USP) S&#227 o Paulo Brazil Faculty of Medicine/FMUSP University of S&#227 o Paulo (USP) S&#227 o Paulo Brazil Federal University of Santa Catarina (UFSC) Florian&oacute polis Brazil Faculty of Dentistry University of S&#227 o Paulo (FOUSP) S&#227 o Paulo Brazil Faculty of Medicine Federal University of Mato Grosso (UFMT) Cuiab&aacute Brazil Faculty of Pharmacy University of the Western Center of Paran&aacute (UNICENTRO) Guarapuava Brazil Institute Adolfo Lutz (IAL) Bauru Brazil Federal Rural University of Rio de Janeiro (UFRRJ) Serop&eacute dica Brazil Institute Adolfo Lutz (IAL) S&#227 o Paulo Brazil

Objective: As isolates of Cryptococcus are frequently kept collection stocks in institutions, sometimes without proper characterization, we sought to determine the genotype profiles, protease and phospholipase activities “in vitro” and the susceptibility testing for azoles and amphotericin B. Methodology: 84 isolates from several regions of Brazil (40 samples from clinical origin and 44 isolates from environmental origin) were maintained at the microorganism’s bank of the Biomedical Science Institute (ICB-USP) of the São Paulo University, in São Paulo, Brazil. This isolates was submitted fungal strains determination, DNA extraction and purification, determination of genotype by URA5 gene RFLP of CGB-positive isolates, protease and phospholipase activity and susceptibility to antifungals. Results: Of six CGB positive isolates tested by RFLP-PCR, only four presented a genomic profile consistent C. gattii species (VGII), while two other were C. neoformans (VNI and VNIII), indicating the existence of canavanine-resistante C. neoformans isolates in the culture collections. The clinical isolates secreted higher levels of phospholipase and environmental isolates but no differences were observed for the protease levels. Almost all isolates were sensible to azoles and amphotericin B. Conclusion: We point out in this research the existence of C. neoformans strains resistant to canavanine and intrinsic characteristic of C. gatti. These results demonstrate the importance to perform a detailed characterization of isolates kept in culture collections.

关键词： Cryptococcus Complex Genotyping Protease Phospholipase Etest Culture Collection

An investigation of ballistic response of reinforced and sandwich concrete panels using computational techniques

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Frontiers of Structural and Civil Engineering 2019年第5期13卷 1120-1137页

作者： Mohammad HANIFEHZADEH bora GENCTURK Sonny Astani Department of Civil and Environmental Engineering University of Southern CaliforniaLos AngelesCA 90007USA

Structural performance of nuclear containment structures and power plant facilities is of critical importance for public safety. The performance of concrete in a high-speed hard projectile impact is a complex problem due to a combination of multiple failure modes including brittle tensile fracture, crushing, and spalling. In this study, reinforced concrete (RC) and steel-concrete-steel sandwich (SCSS) panels are investigated under high-speed hard projectile impact. Two modeling techniques, smoothed particle hydrodynamics (SPH) and conventional finite element (FE) analysis with element erosion are used. Penetration depth and global deformation are compared between doubly RC and SCSS panels in order to identity the advantages of the presence of steel plates over the reinforcement layers. A parametric analysis of the front and rear plate thicknesses of the SCSS configuration showed that the SCSS panel with a thick front plate has the best performance in controlling the hard projectile. While a thick rear plate is effective in the case of a large and soft projectile as the plate reduces the rear deformation. The effects of the impact angle and impact velocity are also considered. It was observed that the impact angle for the flat nose missile is critical and the front steel plate is effective in minimizing penetration depth.

关键词： concrete panels projectile impact finite element modeling smoothed particle hydrodynamics strain rate effect

Experimental Study of Parameters of a Plasma Antenna

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Plasma Science and Technology 2010年第5期12卷 592-600页

作者： Rajneesh KUMAR Dhiraj bora Institute for Plasma Research ITER Organisation

A plasma column excited by a surface wave can act as a plasma antenna. Experiments are carried out to study the current and conductivity distributions, field, power patterns, directivity and efficiency of such a plasma antenna. In addition, an equivalent metallic copper antenna is built up and its antenna parameters are compared with that of the plasma antenna. Our findings indicate that the power content in the harmonics of the plasma antenna is more prominent as compared to the copper antenna （which only generates a fundamental frequency）. However, the power patterns for both antennae are quite similar. To provide a more qualitative understanding regarding the generation of harmonics in the field of the plasma antenna, a bi-spectral analysis is performed to study the nonlinear interactions in the current fluctuations. Some specific features of the plasma antenna are investigated in our study, which may enhance the application prospect of the plasma antenna with respect to the conventional metallic antenna.

关键词： plasma column antenna parameters plasma antenna metallic copper antenna non-linear interactions

Solar photocatalytic pathogenic disinfection:Fundamentals to state-of-the-art

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Water Science and Engineering 2023年第2期16卷 132-142页

作者： Leena V.bora Department of Chemical Engineering Institute of TechnologyNirma UniversitySarkhej-Gandhinagar HighwayAhmedabad 382481India

It is necessary to treat pathogen-infected water before its *** conventionally used treatment methods,solar photocatalysis has gained considerable momentum owing to its operational simplicity and capacity to use freely and abundantly available solar *** article systematically reviewed the disinfection of water with *** addressed the concerns of microbial infection of water and the fundamentals behind its treatment with *** presented an in-depth description of pathogenic deactivation with powerful reactive oxygen *** emphasis was given to process intensification as it is an attractive technique that provides multifunctionality and/or equipment *** reactor design regarding mobilised/immobilised photocatalysts and compound parabolic concentrators were ***,key parameters governing photoperformance,corresponding trade-offs,and the need for their optimisation were ***,this article is a single point of reference for researchers,environmentalists,and industrialists who address the ever-severing challenge of providing clean water whilst also maintaining energy sustainability.

关键词： Water Solar light Photocatalysis Pathogen E.coli Intensification Photoreactor Disinfection

Development of yield forecast model using multiple regression analysis and impact of climatic parameters on spring wheat

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International Journal of Agricultural and Biological Engineering 2019年第4期12卷 110-115页

作者： Purbasha Mistry Ganesh bora Natural Resources Management North Dakota State UniversityFargoND 58102USA Agricultural and Biological Engineering Department Mississippi State UniversityStarkvilleMS 39762USA

Understanding the impacts of climate change in agriculture is important to ensure optimal and continuous crop *** agricultural sector plays a significant role in the economy of Upper Midwestern states in the USA,especially that of North Dakota(ND).Spring wheat contributes most of the wheat production in ND,which is a major producer of wheat in the *** study focuses on assessing possible impacts of three climate variables on spring wheat yield in ND by building a regression ***-five years of field data were collected and the trend of average minimum temperature along with average maximum temperature,average precipitation,and spring wheat yield was analyzed using Mann-Kendall *** study area was divided into 9 divisions based on physical *** minimum temperature plays an important role in the region as it impacts the physiological development of the *** trend was noticed for 6 divisions for average minimum temperature and average precipitation during growing *** and Southeast division showed the strongest increasing trend for average minimum temperature and average precipitation,***-central division had the most decreasing trend for average maximum temperature.A significant relationship was established between spring wheat yield and climatic parameters as the p-value is lower than 0.05 level which rejects the null *** regression model was tested for forecasting *** percentage deviation of error for the model is approximately±30%in most of the years.

关键词： yield forecast modelling multiple regression climatic parameters spring wheat

Massive MIMO system lower bound spectral efficiency analysis with precoding and perfect CSI

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Digital Communications and Networks 2021年第3期7卷 342-351页

作者： Tasher Ali Sheikh Joyatri bora Md Anwar Hussain Department of Electronics and Communication Engineering North Eastern Regional Institute of Science and TechnologyNirjuliArunachal Pradesh791109India

The analytical lower bound of Spectral Efficiency(SE)of downlink transmission of the Massive Multiple Input Multiple Output(Ma-MIMO)system is *** this paper,we derive some novel and approximate mathematical expressions for the lower bound of the SE of a Ma-MIMO with linear precoding schemes,i.e.,Minimum Mean Square Error(MMSE)and Zero-Forcing(ZF).For simulation analysis of the SE,we consider three joint users and antenna scheduling algorithms,namely,the semi-orthogonal,random,and distance-based user scheduling algorithms,whereas the antennas are selected based on Maximum Signal to Noise Ratio(MSNR)with scheduled *** channel between the user and the transmitter is assumed to have characteristics of Small Scale Fading(SSF)and Large Scale Fading(LSF)with the Rayleigh fading *** investigate the effect of the variation of transmitting SNR,the number of base station antennas(M),and the radius(R)of the cell area on the *** simulate the downlink transmission of Ma-MIMO and compare the simulation and analytical *** is observed that the trends of variation of both results are similar to the variation of identical factors,and the difference between the simulated and analytical lower bounds of the SE is approximately 1-1.5 *** analytical lower bound is smaller than the simulation result.

关键词： Fifth-generation Spectral efficiency Ma-MIMO LSF coefficient Precoding

Geostatistical seismic inversion and 3D modelling of metric flow units,porosity and permeability in Brazilian presalt reservoir

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Petroleum Science 2024年第3期21卷 1699-1718页

作者： Rodrigo Penna Wagner moreira Lupinacci Exploratory Interpretation and Reservoir Characterization Group(GIECAR) Department of Geology and GeophysicsUniversidade Federal FluminenseNiteroiRJ24210-346Brazil Petrobras Rio de JaneiroRJ20031-912Brazil

Flow units(FU)rock typing is a common technique for characterizing reservoir flow behavior,producing reliable porosity and permeability estimation even in complex geological ***,the lateral extrapolation of FU away from the well into the whole reservoir grid is commonly a difficult task and using the seismic data as constraints is rarely a subject of *** paper proposes a workflow to generate numerous possible 3D volumes of flow units,porosity and permeability below the seismic resolution limit,respecting the available seismic data at larger *** methodology is used in the Mero Field,a Brazilian presalt carbonate reservoir located in the Santos Basin,who presents a complex and heterogenic geological setting with different sedimentological processes and diagenetic *** generated metric flow units using the conventional core analysis and transposed to the well log ***,given a Markov chain Monte Carlo algorithm,the seismic data and the well log statistics,we simulated acoustic impedance,decametric flow units(DFU),metric flow units(MFU),porosity and permeability volumes in the metric *** aim is to estimate a minimum amount of MFU able to calculate realistic scenarios porosity and permeability scenarios,without losing the seismic lateral *** other words,every porosity and permeability volume simulated produces a synthetic seismic that match the real seismic of the area,even in the metric *** achieved 3D results represent a high-resolution fluid flow reservoir modelling considering the lateral control of the seismic during the process and can be directly incorporated in the dynamic characterization workflow.

关键词： Flowunits Geostatistical inversion Presalt reservoir 3D reservoir modelling Petrophysical modelling

Growth inhibitory effect of phenolic extracts of Ziziphus jujuba *** dengue vector Aedes aegypti(L)in parent and F1 generation

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Asian Pacific Journal of Tropical Medicine 2017年第8期10卷 850-854页

作者： Urbbi Devi Dipsikha bora Department of Life Sciences Dibrugarh UniversityDibrugarhAssamIndia

Objective: To evaluate the lethal and emergence inhibitory effect of alkaloid, phenolic and terpenoid extracts of Ziziphus jujuba(Z. jujuba; Rhamnaceae) against Aedes aegypti(Diptera: Culicidae), and to explore the effect of the most effective fraction on developmental and biochemical parameters of the dengue vector. Methods: The fourth instar larvae of Aedes aegypti were exposed to alkaloid, phenolic and terpenoid extracts from Z. jujuba leaves to test their toxicity and emergence inhibitory effects. Phenolic extract, being the most effective was further tested against the mosquitoes for their growth inhibitory effect supported by biochemical changes in the parent and F1 generation. Results: While the different secondary metabolite fractions i.e., alkaloid, phenolics and terpenoid caused mortality at larval and pupal stages, the LC_(50) value was the lowest for phenolic fraction. Further study carried out with the phenolic fraction revealed that it affected growth by decreasing adult life span, fertility and fecundity of the mosquitoes. The reduction in growth was also accompanied by decrease in carbohydrate and lipid levels. Conclusions: It is concluded that the phenolic extract of the leaves of Z. jujuba is a potential candidate for control of Aedes mosquitoes.

关键词： Ziziphus jujuba Toxicity Aedes mosquito