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An Objective Penalty Method for Optimistic Bilevel Programming Problems

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Journal of the Operations Research Society of China 2020年第1期8卷 177-187页

作者： june Liu Tao zhang Yu-Xin Fan Bing Han Yue Zheng School of Management Huaibei Normal UniversityHuaibei 235000AnhuiChina School of Information and Mathematics Yangtze UniversityJingzhou 434023HubeiChina Huazhong University of Science and Technology Wuhan 430074China

In this paper,we consider an optimistic nonlinear bilevel programming *** some conditions,we first show that the sequence of solutions to penalty problems converges to the optimal solution of the original bilevel programming *** then present an objective penalty method to solve such a ***,some numerical experiments are performed to illustrate its feasibility.

关键词： Bilevel programming Optimistic formulation Penalty method Objective penalty method

Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation

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Protein & Cell 2017年第7期8卷 514-526页

作者： Xiaojun Liu Shuguang Jiang Chongyun Fang Hua Li Xuhua zhang Fuqin zhang Carl H. june Yangbing Zhao Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology School of Basic Medical Sciences Shandong University Jinan 250012 China Center for Cellular Immunotherapies University of Pennsylvania Cancer Center Philadelphia PA 19104 USA Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104-5156 USA

The generation of T cells with maximal anti-tumor activities will significantly impact the field of T-cell- based adoptive immunotherapy. In this report, we found that OKT3/IL-2-stimulated T cells were phenotypically more heterogeneous, with enhanced anti-tumor activity in vitro and when locally administered in a solid tumor mouse model. To further improve the OKT3/IL-2-based T cell manufacturing procedure, we developed a novel T cell stimulation and expansion method in which peripheral blood mononuclear cells were electroporated with mRNA encoding a chimeric membrane protein consisting of a single-chain variable fragment against CD3 and the intracellular domains of CD28 and 4-1BB （OKT3-28BB）. The expanded T cells were phenotypically and functionally similar to T cells expanded by OKT3/IL-2. Moreover, co-electroporation of CD86 and 4-1BBL could further change the phenotype and enhance the in vivo anti-tumor activity. Although T cells expanded by the co- electroporation of OKT3-28BB with CD86 and 4-1BBL showed an increased central memory phenotype, the T cells still maintained tumor lytic activities as potent as those of OKT3/IL-2 or OKT3-28BB-stimulated T cells. In different tumor mouse models, T cells expanded by OKT3-28BB RNA electroporation showed anti-tumor activities superior to those of OKT3/IL-2 T cells. Hence, T cells with both a less differentiated phenotype and potent tumor killing ability can be generated by RNA electroporation, and this T cell manufacturing procedure can be further optimized by simply co-delivering other splices of RNA, thus providing a simple and cost-effec- tive method for generating high-quality T cells for adop- tive immunotherapy.

关键词： T lymphocytes CAR manufacture genetransfer RNA electroporation

Fortifying Smart Grids: A Holistic Assessment Strategy against Cyber Attacks and Physical Threats for Intelligent Electronic Devices

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Computers, Materials & Continua 2024年第8期80卷 2579-2609页

作者： Yangrong Chen june Li Yu Xia Ruiwen zhang Lingling Li Xiaoyu Li Lin Ge School of Computer Science Zhengzhou University of AeronauticsZhengzhou450046China Henan Xin’an Century Technology Co. Ltd.Henan Data Security Engineering Technology Research CenterZhengzhou450046China Key Laboratory of Aerospace Information Security and Trusted Computing Ministry of EducationSchool of Cyber Science and EngineeringWuhan UniversityWuhan430072China

Intelligent electronic devices(IEDs)are interconnected via communication networks and play pivotal roles in transmitting grid-related operational data and executing control *** the context of the heightened security challenges within smart grids,IEDs pose significant risks due to inherent hardware and software vulner-abilities,as well as the openness and vulnerability of communication *** grid security,distinct from traditional internet security,mainly relies on monitoring network security events at the platform layer,lacking an effective assessment mechanism for ***,we incorporate considerations for both cyber-attacks and physical faults,presenting security assessment indicators and methods specifically tailored for ***,we outline the security monitoring technology for IEDs,considering the necessary data sources for their security ***,we classify IEDs and establish a comprehensive security monitoring index system,incorporating factors such as running states,network traffic,and abnormal *** index system contains 18 indicators in 3 ***,we elucidate quantitative methods for various indicators and propose a hybrid security assessment method known as GRCW-hybrid,combining grey relational analysis(GRA),analytic hierarchy process(AHP),and entropy weight method(EWM).According to the proposed assessment method,the security risk level of IEDs can be graded into 6 levels,namely 0,1,2,3,4,and *** higher the level,the greater the security ***,we assess and simulate 15 scenarios in 3 categories,which are based on monitoring indicators and real-world situations encountered by *** results show that calculated security risk level based on the proposed assessment method are consistent with actual ***,the reasonableness and effectiveness of the proposed index system and assessment method are validated.

关键词： Smart grid intelligent electronic device security assessment abnormal behaviors network traffic running states

StudyoffinestructureoftemperatureintheequatorialwesternPacificOceanwithwavelettransform

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Acta Oceanologica Sinica 1998年第3期17卷 293-304页

作者： Jiang Mingshun and zhang Aijun(Received june 14, 1997 accepted November 10, 1997) Institute of Atmospheic Physics Chinese Academy of Sciences Beijing 100029 China National Oceanic Information Center Tianjing 300171 China

By using the wavelet transform (WT), we analysed part of the CTD data collected from the equatorialwestern Pacific Ocean, the results show that the temperature fine structure has selfsimilarity and may be describedwith fractal. The singularity exponents of temperature series and their probability distributions are also calculated. Theprobability distribution functions (pdfs) have nearly a universal form. The nonzero probability at negative exponentsimplies the possible existence of sigular points in the temperature profiles. When computing the averaged period of theWT,we find that the mean period of the WT of the temperature series has a power dependence on the transformscale a, i. e. , with ￣ 1 . This suggests that a simple dichomotous cascading mechanism may govern thefine-structure dynamics. In addtion, since the amplitudes of the wavelet transform is related with the strength of thetemperature fluctuations, the vertical distribution of fluctuation energy can be calculated by wavelet ***-pared to the FFT spectrum, the WT spectrum is more smooth and is capable of giving more accurate spectral slopes.

关键词： Temperature finestructure wavelet transform multifractal

Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

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Research 2024年第3期2023卷 35-50页

作者： june Li Danielle Karakas Feng Xue Yingyu Chen Guangheng Zhu Yeni H.Yucel Sonya A.MacParland Haibo zhang John W.Semple John Freedman Qizhen Shi Heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Keenan Research Centre for Biomedical Science of St.Michael's Hospital TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada Departments of Pediatrics Medical College of WisconsinMilwaukeeWIUSA Blood Research Institute Versiti WisconsinMilwaukeeWIUSA Departments of Ophthalmology and Vision Sciences Medicine University of TorontoTorontoONCanada Faculty of Engineering and Architectural Science Ryerson UniversityTorontoONCanada Multi-Organ Transplant Program Toronto General Hospital Research InstituteTorontoONCanada Department of Immunology University of TorontoTorontoONCanada Critical Care Medicine Department ofAnesthesiology and PainUniversity of TorontoTorontoONCanada Department of Physiology University of TorontoTorontoONCanada Department of Pharmacology University of TorontoTorontoONCanada. Division of Hematology and Transfusion Medicine Lund UniversityLundSweden clinical Immunology and Transfusion Medicine Ofice of Medical ServicesRegion SkaneLundSweden Department of Medicine University of TorontoTorontoONCanada Children's Research Institute Children's WisconsinWauwatosaWIUSA Midwest Athletes Against Childhood Cancer Fund Research Center MilwaukeeWIUSA.

Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platelet-associated and -independent antigen challenges. Utilizing multispectral photoacoustic tomography, we tracked dPLT trafficking to gut vasculature and an exclusive Kupffer cell-mediated dPLT clearance in the liver, a process that we identified to be synergistically dependent on platelet glycoprotein Ibα and hepatic Ashwell–Morell receptor. Mechanistically, Kupffer cell clearance of dPLT potentiated a systemic immunosuppressive state with increased anti-inflammatory cytokines and circulating CD4+ regulatory T cells, abolishable by Kupffer cell depletion. Last, in a clinically relevant model of hemophilia A, presensitization with dPLT attenuated anti-factor VIII antibody production after factor VIII ( infusion. As platelet desialylation commonly occurs in daily-aged and activated platelets, these findings open new avenues toward understanding immune homeostasis and potentiate the therapeutic potential of dPLT and engineered dPLT transfusions in controlling autoimmune and alloimmune diseases.

关键词： Platelet transfusion homeostasis

Study on the isozymes in two species of prawns

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Acta Oceanologica Sinica 1998年第3期17卷 343-348页

作者： Li Taiwu Su Xiurong zhang Jian Yin Hongying Xie Mingjie Ning Shuxiang(Received june 25, 1997 accepted August 30, 1997) Institute of Maring Biotechnology Liaoning Normal University Dalian 116029 China Department of Biology Liaoning Normal University Dalian 116029 China

This paper studies the activity and absolute content of six kinds of isozymes, such as lactate dehydrogenase,malate dehydrogenase, glucose-6-phosphate dehydrogenase, glutamate dehydrogenase, isocitrate dehydrogenase, alcoholdehydrogenase in Penaeus chinensis and P. japonicus. And by comparing, this study approaches the mechanism of high-er bought-endurance in P. japonicus.

关键词： P. chinensis. P.japonicus isozyme.

核心期刊评价的分学科方法解析——以《中文核心期刊要目总览》为例

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大学图书馆学报 2021年第3期39卷 67-75页

作者：张俊娥北京大学图书馆北京100871

大多数期刊评价体系都是分学科进行评价,但是不同的评价体系在进行期刊分学科评价时,对于期刊分类归属的方法都不相同。文章针对北京大学图书馆主持的《中文核心期刊要目总览》的分学科方法进行详细解读,分析了按学科论文入手进行指标... 详细信息

大多数期刊评价体系都是分学科进行评价,但是不同的评价体系在进行期刊分学科评价时,对于期刊分类归属的方法都不相同。文章针对北京大学图书馆主持的《中文核心期刊要目总览》的分学科方法进行详细解读,分析了按学科论文入手进行指标值统计,然后根据期刊所载论文和施引论文的分类进行综合计算给期刊自然归类的方法,并提出进一步研究的设想。

关键词：核心期刊期刊评价学科分类期刊分类

书目数据的跨行业共享实践与研究——以“高校文科图书引进专款”图书的书目数据共享为例

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大学图书馆学报 2017年第1期35卷 98-104页

作者：张俊娥北京大学图书馆北京100871

图书从出版、发行到图书馆订购并提供读者服务,需经过三个不同的行业。出版社、书商、图书馆在不同的环节都会对图书进行本行业所需要的编目,这样的重复工作,不仅造成人力和物力的浪费,而且也影响到图书的流通服务环节。通过"高校文科... 详细信息

图书从出版、发行到图书馆订购并提供读者服务,需经过三个不同的行业。出版社、书商、图书馆在不同的环节都会对图书进行本行业所需要的编目,这样的重复工作,不仅造成人力和物力的浪费,而且也影响到图书的流通服务环节。通过"高校文科图书引进专款"所购外文图书的跨行业书目数据共享实践,探讨了CALIS与书商进行编目合作的应用优势,阐明了把编目前置到出版社,形成出版社、书商、图书馆三者跨行业的书目数据共享联盟,将大大提高各行业的工作效率,使图书馆能将图书尽快服务于读者。

关键词：书目数据共享编目前置集中编目文科专款 CALIS CASHL

Experiments on Specific Energy and Pulping Quality of Extrusion Mechanical Pulping

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Experiments on Specific Energy and Pulping Quality of Extrus...