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Oxygen Radical Generation as an Index of Neurotoxic Damage

作者： (1969-)bondy Christopher

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Biomedical and Environmental Sciences 1991年第1期4卷 217-223页

作者： STEPHEN C.bondy CARL P.LEBEL Department of Community and Environmental Medicine University of California Irvine CA Arthur D. Little Inc. Chemical and Life Sciences Acorn Park Cambridge 92717 Massachusetts 02140

Biochemical, anatomical, and physiological characteristics of the brain make it especially vulnerable to insult. Specifically, some of these characteristics such as myelin and a high energy requirement provide for the introduction of free radical-induced insult. Recently, the biochemistry of free radicals has received considerable attention. It also has become increasingly suggestive that many drug and chemical-induced toxicities may be evoked via free radicals and oxidative stress. Major points addressed in this work are the regulation of neural-free radical generation by antioxidants and protective enzymes, xenobiotic-induced disruption of cerebral redox status, and specific examples of neurotoxic agent-induced alterations in free radicals as measured by the fluorescent probe dichlorofluorescein. This article considers that free radical mechanisms may contribute significantly to the properties of several diverse neurotoxic agents and proposes that free radicals may be common phenomena of neurotoxicity.

关键词： Oxygen Radical Generation as an Index of Neurotoxic Damage

Oxygen Radical Generation as an Index of Neurotoxic Damage

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Biomedical and Environmental Sciences 1991年第Z1期 217-223页

作者： STEPHEN C.bondy,CARL P.LEBEL Department of Community and Environmental Medicine University of California Irvine CA Arthur D. Little Inc. Chemical and Life Sciences Acorn Park Cambridge 92717 Massachusetts 02140

Biochemical, anatomical, and physiological characteristics of the brain make it especially vulnerable to insult. Specifically, some of these characteristics such as myelin and a high energy requirement provide for the introduction of free radical-induced insult. Recently, the biochemistry of free radicals has received considerable attention. It also has become increasingly suggestive that many drug and chemical-induced toxicities may be evoked via free radicals and oxidative stress. Major points addressed in this work are the regulation of neuralfree radical generation by antioxidants and protective enzymes, xenobiotic-induced disruption of cerebral redox status, and specific examples of neurotoxic agent-induced alterations in free radicals as measured by the fluorescent probe dichlorofiuorescein. This article considers that free radical mechanisms may contribute significantly to the properties of several diverse neurotoxic agents and proposes that free radicals may be common phenomena of neurotoxicity.

关键词： Oxygen Radical Generation as an Index of Neurotoxic Damage

Hormone replacement therapy and menopause

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北京大学学报（医学版） 2002年第4期34卷 309-315页

作者： Constantine DIMITRAKAKIS Jose A. ARRAZTOA Carolyn A. bondy Developmental Endocrinology Branch National Institute of Child Health and Human Development National Institutes of Health 美国 Bethesda

Hormone replacement therapy (HRT) was initiated almost half a century ago to treat menopausal symptoms. Initially, its use remained limited even among symptomatic women and the move toward postmenopausal hormone use for disease prevention came later. Improved treatment schedules and delivery systems expanded the use of HRT worldwide. However, large trials of postmenopausal hormones with disease outcomes were even later in coming and today HRT has become a specialized, multidisciplinary area of research. As the population continues to grow older, there has been an increased focus on the effects of ageing. HRT may affect length and quality of life through disease prevention. It may have possible beneficial effects on cognition, on the incidence of hip fracture, myocardial infarction and stroke, and adverse effects on the incidence of breast cancer, endometrial cancer, and venous ***’s attitudes about the hormonal treatments for the menopausal transition have moved from expansive optimism to contracting disappointment amidst safety concerns and equivocal results and faces greater skepticism and scrutiny. The health and well being of large numbers of women are at stake, and researchers, clinicians and the general public are watching and weighing the options.

关键词：绝经期激素替代疗法综述

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特纳综合征患者血清转化生长因子β的变化

北京大学学报（医学版） 2012年第5期44卷 720-724页

作者：周键 Sruthi AREPALLI Clara M.CHENG Vladimir K.BAKALOV Carolyn A.bondy Section on Epigenetics&Development Program on Developmental Endocrinology and GeneticsNational Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesda

目的:观察转化生长因子β(transforming growth factor-beta,TGFβ)在特纳综合征(Turner syndrome,TS)患者血清中的变化及其与内分泌和心血管参数的关系。方法:选择TS患者和健康志愿者妇女(对照组)各40例,采用酶联免疫方法测定血清中的... 详细信息

目的:观察转化生长因子β(transforming growth factor-beta,TGFβ)在特纳综合征(Turner syndrome,TS)患者血清中的变化及其与内分泌和心血管参数的关系。方法:选择TS患者和健康志愿者妇女(对照组)各40例,采用酶联免疫方法测定血清中的TGFβ1、TGFβ2及转化生长因子受体(endoglin)。所有TS患者均行心血管系统磁共振和超声检查。结果:TS患者血清中TGFβ1和endoglin水平均高于对照组(P<0.000 1),而TGFβ2的水平则低于对照组(P<0.000 1)。TGFβ的改变与年龄、血压、血小板、甲状腺功能、体重指数或心血管疾病的分型无关。结论:TS患者血清中TGFβ显著性改变对疾病的研究具有重要意义。

关键词：特纳综合征转化生长因子β 心血管疾病 X染色体主动脉

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图形论及其应用

图形论及其应用

Turner综合征胎儿淋巴水肿与先天性心血管缺陷之间的相关性

丛书名：大专用书

1982年

作者：（美）邦迪（bondy J.A.）默蒂（Murty U.S.R.）吴森原译

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世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 40-41页

作者： Loscalzo M.L. Van P.L. Ho V.B. C.A. bondy 韩浩 Building 10/10N262 National Institutes of Health 10 Center Dr BethesdaMD20892 United States Dr.

Objectives. Turner syndrome (TS) is associated with congenital cardiovascular defects (CCVD), most commonly bicuspid aortic valve (BAV) and aortic coarctation (COARC), congenital renal anomalies, and fetal lymphedema. It has been theorized that compressive or obstructive effects of fetal lymphedema may actually cause cardiovascular and renal dysmorphogenesis in TS. The objective of this study was to determine whether there is a specific association between a history of fetal lymphedema and CCVD in monosomy X, or TS, independent of karyotype or general severity of the phenotype. Methods. This was a prospective study of 134 girls and women who have TS (mean age: 30 years) and were clinically evaluated for evidence of fetal lymphedema, classified as central (signified by the presence of neck webbing) or peripheral (current or perinatal, or dysplastic fingernails). The presence of BAV and/or COARC was detected by magnetic resonance imaging combined with echocardiography, and renal anomalies were determined by ultrasound. Results. There is a strong association between developmental central lymphedema, signified by neck webbing, and the presence of BAV (χ2=10) and COARC (χ2=8). The association between webbed neck and CCVD was independent of karyotype. There was, in contrast, no significant association between renal anomalies and webbed neck or CCVD. Conclusions. The strong, statistically significant association between neck webbing and the presence of BAV and COARC in TS suggests a pathogenetic connection between fetal lymphatic obstruction and defective aortic development. The presence of neck webbing in TS should alert the clinician to the possibility of congenital cardiovascular defects.

关键词： Turner综合征淋巴水肿畸形发生先天性肾脏畸形中枢型超声心动图染色体组型围生期二叶

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LIVESPORT办公空间

现代装饰 2024年第3期 42-49页

作者： Jakub Heidler(设计) Jan Kacer(设计) Marek Svoboda(设计) Lukas Baksi(设计) Jachym bondy(设计) Jurij Lyzhanov(设计) Barbora Lickova(设计) Tomas PlocLukas Kral(设计) Studio Flusse(摄影) 舒禹(编译) 不详

Livesport的新办公室建在以前的楼层上,一个将体育与现代技术融为一体的空间。设计灵感来自于训练中的艰苦努力,准备过程中的自我提升。健身房空间由方块地毯表示,无缝天花板上分布规则的聚光灯网格。三个主要元素进一步增强空间,分别... 详细信息

Livesport的新办公室建在以前的楼层上,一个将体育与现代技术融为一体的空间。设计灵感来自于训练中的艰苦努力,准备过程中的自我提升。健身房空间由方块地毯表示,无缝天花板上分布规则的聚光灯网格。三个主要元素进一步增强空间,分别是地板线条、运动器材和电子笔,它们是从设计元素中抽象出来的,线条划分办公室不同区域,运动器材增强使用体验,电子笔则是导航系统,帮助新来的运动员快速融入团队与比赛。

关键词：运动器材办公空间自我提升健身房聚光灯设计元素电子笔导航系统

Comparative study of breast cancer in Mexican and Mexican-American women

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Health 2010年第9期2卷 1040-1048页

作者： Maria Elena Martinez Luis Enrique Gutierrez-Millan Melissa bondy Adrian Daneri-Navarro Maria Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz Maria Adriana Balderas-Pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes Mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary EEdgerton Maria Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-Perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray Jesse NNodora Antonio Oceguera-Villanueva Miguel Angel Ortiz Martinez Laura Perez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de Sonora Ciudad ObregónMexico Instituto Mexicano del Seguro Social HermosilloMexico Instituto Mexicano del Seguro Social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del Seguro Social Ciudad ObregonMexico OPD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de Salud Publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational Study Breast Cancer Hispanics Mexico United States