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Unraveling links between aging,circadian rhythm and cancer:Insights from evidence-based analysis

Chinese Journal of Cancer Research 2024年第3期36卷 341-350页

作者： Dechao Feng Yuhan Xiao Jie Wang Ruicheng Wu Zhouting Tuo koo Han Yoo Wuran Wei Dilinaer Wusiman Zhipeng Wang Dengxiong Li Yubo Yang William C.Cho Mang Ke Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Division of Surgery&Interventional Science University College LondonLondon W1W 7TSUK Department of Urology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityTaizhou 317000China Department of Urology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China Department of Urology Kyung Hee UniversitySeoul 130-701South Korea Department of Comparative Pathobiology College of Veterinary MedicinePurdue UniversityWest LafayetteIN47907USA Purdue Institute for Cancer Research Purdue UniversityWest LafayetteIN 47907USA Department of Urology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Urology Three Gorges HospitalChongqing UniversityChongqing 404000China Department of Clinical Oncology Queen Elizabeth HospitalHong Kong SARChina

Aging and circadian rhythms have been connected for decades,but their molecular interaction has remained unknown,especially for *** this situation,we summarized the current research actuality and problems in this field using the bibliometric *** in the PubMed and Web of Science databases were ***,there is a rising trend in the publication volume regarding aging and circadian rhythms in the field of *** from USA,Germany,Italy,China and England have greater studies than *** three publication institutions are University of California System,UDICE-French Research Universities and University of Texas *** research hotspots include oxidative stress,breast cancer,melatonin,cell cycle,calorie restriction,prostate cancer and NF-κ*** conclusion,results generated by bibliometric analysis indicate that many approaches involve in the complex interactions between aging and circadian rhythm in *** established and emerging research directions guide our exploration of the regulatory mechanisms of aging and circadian rhythms in cancer and provide a reference for developing new research avenues.

关键词： Aging circadian rhythm human cancer bibliometric analysis oxidative stress

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Multifunctional MXene/Carbon Nanotube Janus Film for Electromagnetic Shielding and Infrared Shielding/Detection in Harsh Environments

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Nano-Micro Letters 2024年第10期16卷 543-560页

作者： Tufail Hassan Aamir Iqbal Byungkwon Yoo Jun Young Jo Nilufer Cakmakci Shabbir Madad Naqvi Hyerim Kim Sungmin Jung Noushad Hussain Ujala Zafar Soo Yeong Cho Seunghwan Jeong Jaewoo Kim Jung Min Oh Sangwoon Park Youngjin Jeong Chong Min koo School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Materials Science and Engineering Soongsil UniversitySeoul 06978Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and Technology92 Chudong-roBongdong-eupWanju-gunJeollabuk-do 55324Republic of Korea R&D Center INNOMXENE Co. Ltd.Daejeon 34365Republic of Korea School of Chemical Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea

Multifunctional,flexible,and robust thin films capable of operating in demanding harsh temperature environments are crucial for various cutting-edge *** study presents a multifunctional Janus film integrating highly-crystalline Ti_(3)C_(2)T_(x) MXene and mechanically-robust carbon nanotube(CNT)film through strong hydrogen *** hybrid film not only exhibits high electrical conductivity(4250 S cm^(-1)),but also demonstrates robust mechanical strength and durability in both extremely low and high temperature environments,showing exceptional resistance to thermal *** hybrid Janus film of 15μm thickness reveals remarkable multifunctionality,including efficient electromagnetic shielding effectiveness of 72 dB in X band frequency range,excellent infrared(IR)shielding capability with an average emissivity of 0.09(a minimal value of 0.02),superior thermal camouflage performance over a wide temperature range(−1 to 300℃)achieving a notable reduction in the radiated temperature by 243℃ against a background temperature of 300℃,and outstanding IR detection capability characterized by a 44%increase in resistance when exposed to 250 W IR *** multifunctional MXene/CNT Janus film offers a feasible solution for electromagnetic shielding and IR shielding/detection under challenging conditions.

关键词： MXene/carbon nanotube Janus film Electromagnetic interference shielding Infrared shielding Thermal camouflage Infrared detection

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Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun Kim Jun-koo Yi Jae-Jung Ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae Son Soo-Young Yum Won-Wu Lee Goo Jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7E1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP

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黑胶复兴与EMT JPA66 Mk3一场高品质黑胶重放的深度之旅(下)

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视听前线 2024年第7期 35-38页

作者： Ken koo 不详

上期的文章我们介绍了JPA66 Mk3唱放的输入部分、增益电路和阻抗匹配调节等功能,接下来我们将继续深挖EMT JPA66 Mk3的其它重要功能。唱放内拥有一件秘密式器——等化还原曲线电路。另一个直接决定唱放表现好坏、而且必须要有的电路就... 详细信息

上期的文章我们介绍了JPA66 Mk3唱放的输入部分、增益电路和阻抗匹配调节等功能,接下来我们将继续深挖EMT JPA66 Mk3的其它重要功能。唱放内拥有一件秘密式器——等化还原曲线电路。另一个直接决定唱放表现好坏、而且必须要有的电路就是等化曲线。

关键词： EMT 阻抗匹配 JPA 黑胶高品质功能

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黑胶复兴与EMT JPA66 Mk3 一场高品质黑胶重放的深度之旅(上)

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视听前线 2024年第6期 36-39页

作者： Ken koo 不详

黑胶唱片,可说是近年复兴最快的音乐重播载体,而且市场需求已不单只是纯发烧友及音乐爱好者,甚至已成为了一种时尚的“潮物”来欣赏和收藏。谈到黑胶唱片的发展,其实是一个长达超过半个世纪的悠长历史。在这段时间里,无论是唱片本身,还... 详细信息

黑胶唱片,可说是近年复兴最快的音乐重播载体,而且市场需求已不单只是纯发烧友及音乐爱好者,甚至已成为了一种时尚的“潮物”来欣赏和收藏。谈到黑胶唱片的发展,其实是一个长达超过半个世纪的悠长历史。在这段时间里,无论是唱片本身,还是所用的音响重播硬件.

关键词：音乐爱好者黑胶唱片重播市场需求重放音响高品质

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(EDTA)^(4-) supplements as superior modifier of the in-vitro-degradation properties of the magnesium alloy coated through discharge-assisted process

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Journal of Magnesium and Alloys 2023年第3期11卷 945-957页

作者： Zeeshan Ur Rahman Maqsood Ali Ye-Tang Pan David G.Churchill bon Heun koo College of Mechatronic Engineering Changwon National UniversityChangwonGyeongsangnam-doRepublic of Korea Department of Regenerative Medicines College of MedicinesSoonChunhyang UniversityCheonanRepublic of Korea National Engineering Technology Research Center of Flame Retardant Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijingPR China Department of Chemistry Molecular Logic Gate LaboratoryKorea Advanced Institute of Science and Technology(KAIST)Republic of Korea

The(EDTA)^(4-)organic substituents were supplemented with alkaline silicates electrolyte,however in varying concentration to explore the microstructure,chemical composition and subsequent effects on the biodegradation of the PEO coated Mg AZ91 *** surface analysis-,carried out through SEM,samples with zero-(EDTA)^(4-)were found-,lacking pancake structural features;however,supplementing electrolyte with(EDTA)^(4-),bulky and layered pancakes were obtained with minimum cracks and minimum porosity for *** the phase and inner layer analysis,it was found that EDTA can significantly alter the surface layers composition and could act as a passivation agent-;however,individual polycrystalline phases were not found to *** hardness value obtained for EDT-1 was~909.69 HV,the highest value found here which occurs with the shallowest indents found in this ***-vitro degradation analysis was carried out using potentiodynamic polarization at room temperature,cyclic polarization at RT and high fever conditions(HFT~40°C).The corrosion potential for coated AZ91 was obtained as a positive value of~0.1 V,for the first time in the PEO research;however,the results were not supported by the cyclic polarization tests at room temperature and at *** post corrosion microstructural analysis confirmed the effective role of EDTA up to 1.0 g·L^(-1)and revealed the formation of thin films during the forward polarization at HFT.

关键词： EDTA Soft plasma Magnesium Biodegradation Corrosion SBF

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Effects of Hybrid Voltages on Oxide Formation on 6061 Al-alloys During Plasma Electrolytic Oxidation

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Chinese Journal of Aeronautics 2009年第5期22卷 564-568页

作者： Kai Wang bon Heun koo Chan Gyu Lee Young Joo Kim Sunghun Lee Eungsun Byon School of Nano & Advanced Materials Engineering Changwon National University Changwon 641-773 Korea Surface Technology Research Center Korea Institute of Materials Science Changwon 641-010 Korea

Plasma electrolytic oxidation （PEO） is carried out on 6061 Al-alloys in a weak alkaline electrolyte containing NaOH, Na2SiO3 and NaCl. Centered on the correlation of composition and structure, analyses by means of X-ray diffration （XRD）, scanning electron microscope （SEM） and energy dispersive spectrometry （EDS） are conducted on the specimens, which have been PEO-treated under hybrid voltages of different direct current （DC） values （140-280 V） with constant alternate current （AC） amplitude （200 V）. Attention is paid to the composition, properties and growth mechanism of oxide layers formed with hybrid voltages. Moreover, the main effects of DC value are discussed. Ceramic layers with a double-layer structure which combines hard outer and soft inner layers are found to be consist of α-Al2O3,γ-Al2O3 and mullite. With the DC values increasing, the growth of the ceramic layers tends to have increasingly obvious three-stage feature.

关键词： plasma electrolytic oxidation oxide layer aluminum alloys alkaline electrolyte hybrid voltages

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Effects of electrolytes variation on formation of oxide layers of 6061 Al alloys by plasma electrolytic oxidation

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中国有色金属学会会刊：英文版 2009年第4期19卷 866-870页

作者： Kai WANG bon-Heun koo Chan-Gyu LEE Young-Joo KIM Sung-Hun LEE Eungsun BYON School ofNano ＆ Advanced Materials Engineering Changwon National University Changwon 641-773 Korea Surface Technology Research Center Korea Institute of Materials Science Changwon 641-010 Korea

Plasma electrolytic oxidation(PEO) processes were carried out to produce ceramic layers on 6061 aluminum substrates in four kinds of electrolytes such as silicate and aluminate solution with and without sodium *** PEO processes were carried out under a hybrid voltage(260 V DC combined with 200 V,60 Hz AC amplitude) at room temperature for 5 *** composition,microstructure and element distribution analyses of the PEO-treated layers were carried out by XRD and SEM & *** effect of the electrolyte contents on the growth mechanism,element distribution and properties of oxide layers were *** is obvious that the layers generated in aluminate solutions show smoother surfaces than those in silicate ***,an addition of fluorine ion can effectively control the layer porosity;therefore,it can enhance the properties of the layers.

关键词：等离子电解氧化 6061合金氧化层对格质变等离子体电解氟硅酸钠铝酸钠溶液

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Effect of Cu seed on the synthesis and characterization of FeCo alloy nano-particles by using polyol method

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Science China(Technological Sciences) 2009年第1期52卷 19-22页

作者： Uk Rae CHO Young Min LEE Shalendra KUMAR Chan Gyu LEE bon Heun koo School of Nano-Advanced Materials Engineering Changwon National University Changwon

Fine metal particles with uniform shape, narrow size distribution and high purity are increasingly needed for specific uses in high tech industrial application. We report the direct chemical synthesis of FeCo alloy particles using the mixture of FeCl2·4H2O, Co (Ac)2·4H2O (Ac: acetate) and NaOH in ethylene glycol, and then obtained FeCo alloy particles better dispersed by adding the polyvinylpyrrolidone (PVP) and also the size could be controlled by adding copper. The prepared nano-particles were characterized using FESEM, XRD and VSM. The mean diameter of these particles was varied in the range of sub- mi- crometer to nanometer with metal-ion concentration. FeCo particles showed the typical soft magnetic properties.

关键词： polyol method FeCo alloy nanoparticle Cu seed soft magnetic

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Chemically inducing room temperature spin-crossover in double layered magnetic refrigerants Pr1.4+xSr1.6-xMn2O7(0.0≤x≤0.5)

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Journal of Materials Science & Technology 2022年第29期124卷 232-242页

作者： Akshay Kumar Kavita Kumari Mohit K.Sharma Ankush Vij Shalendra Kumar Seok-Hwan Huh bon Heun koo Department of Materials Convergence and System Engineering Changwon National UniversityChangwonGyeongnam51140South Korea School of Material Science and Engineering Changwon National UniversityChangwonGyeongnam51140South Korea Department of Physics University of Petroleum&Energy StudiesDehradun248007India Department of Physics College of ScienceKing Faisal UniversityHofufAl-Ahsa31982Saudi Arabia

The height of total entropy(S)for a magnetic refrigerant material is essentially concerned with the magnetic and structural ***,the participation of such transitions in layered materials is not well ***,the purpose of this work is to investigate the interplay between double layer lattice with their single perovskite counterpart,to achieve optimal magnetocaloric performance.A series of self-doped Pr_(1.4+x)Sr_(1.6-x)Mn_(2)O_(7)(0.0≤x≤0.5)Ruddlesden-Popper(R-P)perovskite have been prepared through the solid-state sintering *** increasing the Pr-stoichiometry,the lattice faults have increased and the double layer lattice dramatically disintegrates into single perovskite *** to the reduction of bilayer R-P phase into single perovskite the spin crossover occurs from weak bilayer(T=304 K)interactions towards the strong three-dimensional(T=308 K)interactions *** series consistently develops thermomagnetic irreversibility in zero-field cooled(ZFC)-field cooled(FC)magnetization,which is indicative of a spin-glass *** glassy nature has been ascribed collectively to the lattice strain produced because of dislocations and to an antiferromagnetic phase segregated at the *** maximum value of temperature average entropy change(TEC)and adiabatic temperature(ΔT)has enhanced nearly by 4 folds from 0.53 J kg^(-1)K^(-1),0.59 K(for x=0.0)up to 1.85 J kg^(-1)K^(-1),10 K(for x=0.5)at 2.5 T,***,the room temperature relative cooling power has improved from 26.94 J/kg up to 77.84 J/kg with an applied field of 2.5 *** findings in this work suggest that the controlled reduction of double layer lattice into single perovskite and/or existence of both phases simultaneously in bilayer R-P manganites may be very effective in obtaining the desirable characteristics of magnetocaloric effects.

关键词： Magnetic refrigerant Bilayer manganites Magnetocaloric effect Ruddlesden-popper perovskite Relative cooling power

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