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World Journal of Gastroenterology 2006年第2期12卷 214-221页

作者： Hyun-Ock Pae Gi-Su Oh Sun-On Jeong Gil-Saeng Jeong bok-soo lee Byung-Min Choi Ho-Sub lee Hun-Taeg Chung Medicinal Resources Research Institute Wonkwang UniversityIksan-ShiChunbug570-749Republic of Korea Department of Microbiology and Immunology Wonkwang University School of MedicineWonkwang UniversityIksan-ShiChunbug570-749Republic of Korea

AIM: To examine the potency of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) as a hepatic heme oxygen-ase-1(HO-1) inducer and its regulation in HepG2 cells. METHODS: Expression of HO-1 and NF-E2-related factor 2 (Nrf2) and activation of mitogen-activated protein (MAP) kinases were analyzed by Western blot, immuno-fluorescence assay, and flow cytometry. Transfections of HO-1 gene, small interfering RNAs for HO-1 and Nrf2, and dominant-negative gene for MAP/extracellular signal-regulated kinase (ERK) were carried out to dissect the signaling pathways leading to HO-1 expression in HepG 2 cells. RESULTS: PGG up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-butyl hydroperoxide. Moreover, PGG induced Nrf2 nuclear translocation, which was found to be an upstream step of PGG-induced HO-1 expression, and ERK activation, of which pathway was involved in PGG-induced Nrf2 nuclear translocation, HO-1 expression and cytoprotection. CONCLUSION: PGG up-regulates HO-1 expression by stimulating Nrf2 nuclear translocation in an ERK-depen-dent manner, and HO-1 expression by PGG may serve as one of the important mechanisms for its hepatoprotective effects.

关键词： 1,2,3,4,6-penta-O-galloyl-β-D-glucose Heme oxygenase-1 Oxidative stress Hepatoprotection

Anticipating the lifespan: Predicting the durability of an anode-supported solid oxide fuel cell short stack over 50,000 h

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Progress in Natural Science:Materials International 2024年第3期34卷 606-613页

作者： Muhammad Zubair Khan Amjad Hussain Seung-bok lee Tak-Hyoung Lim Rak-Hyun Song Department of Materials Science & Engineering Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology Hydrogen Energy Research Division Korea Institute of Energy Research Department of Advanced Energy and System Engineering Korea University of Science and Technology (UST)

In the present study, the operational lifetime of a solid oxide fuel(SOFC) short stack is predicted by investigating the performance degradation of both the short stack and its cells throughout 1000 h at 800°C. The short stack and integral cell voltages are continuously measured during the long-term test, with electrochemical impedance spectroscopy(EIS) conducted every 200 h. The short stack voltage decreased rapidly for the initial 200–300 h and afterwards, it decreased at a slow rate due to the increase in the Ohmic and polarization resistances in the same manner. Scanning electron microscopy results show that there is no delamination or cracking among constituent layers of the short-stack cells. The single degradation effects of the Ni coarsening in the anode, cation migration and surface segregation in cathode and oxide scale growth in metallic interconnect mesh are successfully integrated into a comprehensive lifetime prediction model. The experimentally measured voltage degradation data of the short stack fits well with the developed mathematical model and allows the successful prediction of the lifetime up to 50,000 h.

关键词： Degradation Impedance Lifetime SOFC Stack

Intelligent structured nanocomposite adhesive for bioelectronics and soft robots

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Nano Research 2024年第2期17卷 534-549页

作者： Yeon soo lee Min-Seok Kim Da Wan Kim Changhyun Pang School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Mechanical Metrology Group Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of Electronic Engineering Korea National University of TransportationChungbuk 27469Republic of Korea Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The remarkable functionality of biological systems in detecting and adapting to various environmental conditions has inspired the design of the latest electronics and robots with advanced *** review focuses on intelligent bio-inspired strategies for developing soft bioelectronics and robotics that can accommodate nanocomposite adhesives and integrate them into biological *** underlying principles of the material and structural design of nanocomposite adhesives were investigated for practical applications with excellent functionalities,such as soft skin-attachable health care sensors,highly stretchable adhesive electrodes,switchable adhesion,and untethered soft *** addition,we have discussed recent progress in the development of effective fabrication methods for micro/nanostructures for integration into devices,presenting the current challenges and prospects.

关键词： biomimetics bio-adhesive switchable adhesion bioelectronics nanocomposite soft robotics

Evolution of nonmetallic inclusions in 80-t 9CrMoCoB large-scale ingots during electroslag remelting process

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1525-1539页

作者： Shengchao Duan Min Joo lee Yao Su Wangzhong Mu Dong soo Kim Joo Hyun Park School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China Department of Materials Science and Chemical Engineering Hanyang UniversityAnsan 15588Rep.of Korea Department of Materials Science and Engineering KTH Royal Institute of TechnologyBrinellvägen 23Stockholm 10044Sweden Department of Engineering Science and Mathematics Division of Materials ScienceLuleåUniversity of Technology97187 LuleåSweden Casting&Forging Business Unit Nuclear Business GroupDoosan EnerbilityChangwon 51711Rep.of Korea

In combination with theoretical calculations,experiments were conducted to investigate the evolution behavior of nonmetallic inclusions(NMIs)during the manufacture of large-scale heat-resistant steel ingots using 9CrMoCoB heat-resistant steel and CaF_(2)–CaO–Al_(2)O_(3)–SiO_(2)–B_(2)O_(3)electroslag remelting(ESR)-type slag in an 80-t industrial ESR *** main types of NMI in the consumable electrode comprised pure alumina,a multiphase oxide consisting of an Al_(2)O_(3)core and liquid CaO–Al_(2)O_(3)–SiO_(2)–MnO shell,and M_(23)C_(6)carbides with an MnS *** Al_(2)O_(3)and MnS inclusions had higher precipitation temperatures than the M_(23)C_(6)-type carbide under equilibrium and nonequilibrium solidification ***,inclusions can act as nucleation sites for carbide layer *** ESR process completely removed the liquid CaO–Al_(2)O_(3)–SiO_(2)–MnO oxide and MnS inclusion with a carbide shell,and only the Al_(2)O_(3)inclusions and Al_(2)O_(3)core with a carbide shell occupied the remelted *** M_(23)C_(6)-type carbides in steel were determined as Cr_(23)C_(6)based on the analysis of transmission electron microscopy *** substitution of Cr with W,Fe,or/and Mo in the Cr_(23)C_(6)lattice caused slight changes in the lattice parameter of the Cr_(23)C_(6)***,Cr_(21.34)Fe_(1.66)C_(6),(Cr_(19)W_(4)C_(6),Cr_(18.4)Mo_(4.6)C_(6),and Cr_(16)Fe_(5)Mo_(2)C_(6)can match the fraction pattern of Cr_(23)C_(6)*** Al_(2)O_(3)inclusions in the remelted ingot formed due to the reduction of CaO,SiO_(2),and MnO components in the liquid *** increased Al content in liquid steel or the higher supersaturation degree of Al_(2)O_(3)precipitation in the remelted ingot than that in the electrode can be attributed to the evaporation of CaF_(2)and the increase in CaO content in the ESR-type slag.

关键词： nonmetallic inclusion heat-resistant steel electroslag remelting M_(23)C_(6) carbide MnS inclusion supersaturation degree

Utilization of biomarkers for the prognostic prediction of cardiac arrest survivors using a multi-modal approach

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World Journal of Emergency Medicine 2024年第2期15卷 131-134页

作者： Changshin Kang Yeonho You Jung soo Park Byeong Kwon Park Jae Kwang lee Byung Kook lee Department of Emergency Medicine College of MedicineChungnam National UniversityDaejeon 35015Republic of Korea Department of Emergency Medicine Chungnam National University HospitalDaejoen 35015Republic of Korea Department of Emergency Medicine Konyang University HospitalCollege of MedicineDaejeon 35015Republic of Korea Department of Emergency Medicine Chonnam National University Medical SchoolChonnam National University HospitalGwangju 61469Republic of Korea

International guidelines for post-cardiac arrest care recommend using multi-modal strategies to avoid the withdrawal of life-sustaining therapy(WLST)in patients with the potential for neurological recovery.[1]However,a clear methodology for multi-modal approaches has yet to be ***-specific enolase(NSE)is currently the only recommended biomarker,and the European Resuscitation Council(ERC)and the European SocietyofIntensiveCareMedicine(ESICM)have proposed a cutoff value of 60μg/L at 48 and/or 72 h after the return of spontaneous circulation(ROSC)as a multimodal prognostic tool for predicting poor neurological outcomes.

关键词： cardiac modal return

Room and cryogenic deformation behavior of AZ61 and AZ61-xCaO(x=0.5,1 wt.%)alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1996-2009页

作者： Umer Masood Chaudry Hafiz Muhammad Rehan Tariq Nooruddin Ansari soo Yeol lee Tea-Sung Jun Department of Mechanical Engineering Incheon National UniversityIncheon 22012Republic of Korea Research Institute for Engineering and Technology Incheon National UniversityIncheon 22012Republic of Korea Department of Materials Science&Engineering Chungnam National UniversityDaejeon 34134Republic of Korea

This study investigates the influence of CaO(0.5,1(wt.%))alloying on the microstructural evolution,texture development and deformation behavior of AZ61 magnesium *** uniaxial tension tests at room(RT)and cryogenic(CT,-150℃)temperature were performed to investigate the twinability and dislocation behavior and its consequent effect on flow stress,ductility and strain hardening *** results showed that the AZ61-1CaO exhibited superior strength/ductility synergy at RT with a yield strength(YS)of 223 MPa and a ductility of 23% as compared to AZ61(178 MPa,18.5%)and AZ61-0.5CaO(198 MPa,21%).Similar trend was witnessed for all the samples during CT deformation,where increase in the YS and decrease in ductility were *** Mtex tools based in-grain misorientation axis(IGMA)analysis of RT deformed samples revealed the higher activities of prismatic slip in AZ61-CaO,which led to superior ***,subsequent EBSD analysis of CT deformed samples showed the increased fraction of fine{10-12}tension twins and nucleation of multiple{10-12}twin variants caused by higher local stress concentration at the grain boundaries,which imposed the strengthening by twin-twin ***,the detailed investigations on strengthening contributors showed that the dislocation strengthening has the highest contribution towards strength in all samples.

关键词： Magnesium Twinning Twinning variant EBSD Cryogenic deformation

A Review of Rechargeable Zinc-Air Batteries:Recent Progress and Future Perspectives

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Nano-Micro Letters 2024年第7期16卷 358-401页

作者： Ghazanfar Nazir Adeela Rehman Jong-Hoon lee Choong-Hee Kim Jagadis Gautam Kwang Heo Sajjad Hussain Muhammad Ikram Abeer AAlObaid Seul-Yi lee soo-Jin Park Department of Nanotechnology and Advanced Materials Engineering Hybrid Materials Research Center(HMC)Sejong UniversitySeoul 05006Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea Department of Chemistry Inha UniversityIncheon 22212Republic of Korea Solar Cell Applications Research Lab Department of PhysicsGovernment College University LahoreLahore 54000 PunjabPakistan Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia

Zinc-air batteries(ZABs)are gaining attention as an ideal option for various applications requiring high-capacity batteries,such as portable electronics,electric vehicles,and renewable energy *** offer advantages such as low environmental impact,enhanced safety compared to Li-ion batteries,and cost-effectiveness due to the abundance of ***,early research faced challenges due to parasitic reactions at the zinc anode and slow oxygen redox *** advancements in restructuring the anode,utilizing alternative electrolytes,and developing bifunctional oxygen catalysts have significantly improved *** have achieved battery reversibility over thousands of cycles,introduced new electrolytes,and achieved energy efficiency records surpassing 70%.Despite these achievements,there are challenges related to lower power density,shorter lifespan,and air electrode corrosion leading to performance *** review paper discusses different battery configurations,and reaction mechanisms for electrically and mechanically rechargeable ZABs,and proposes remedies to enhance overall battery *** paper also explores recent advancements,applications,and the future prospects of electrically/mechanically rechargeable ZABs.

关键词： Zinc-air batteries Energy storage Affordability Reversibility

Mixed-dimensional stacked nanocomposite structures for a specific wavelength-selectable ambipolar photoresponse

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Nano Research 2024年第6期17卷 5549-5558页

作者： Young Jae Park Jaeho Shim Joo Song lee Kyu Seung lee Ji-Yeon Kim Kang bok Ko Sang-Youp Yim Seongjun Kim Hoon-Kyu Shin Donghee Park Yong Ju Yun Dong Ick Son Institute of Advanced Composite Materials Korea Institute of Science and TechnologyJeollabuk-do 55324Republic of Korea National Institute for Nanomaterials Technology Pohang University of Science and TechnologyGyeongsangbuk-do 37673Republic of Korea Department of Semiconductor Science and Technology Semiconductor Physics Research CenterJeonbuk National UniversityJeonju 54896Republic of Korea Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Center for Opto-Electronic Materials and Devices Post-Silicon Semiconductor InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Graduate School of Energy and Environment(KU-KIST Green School) Korea UniversitySeoul 02841Republic of Korea KIST School Department of Nanomaterials and Nano ScienceUniversity of Science and Technology(UST)Daejeon 34113Republic of Korea

Mixed-dimensional composite structures using zero-dimensional(0D)quantum dots(QDs)and two-dimensional(2D)transition metal dichalcogenides(TMDs)materials are expected to attract great interest in optoelectronics due to the potential to generate new optical ***,we report on the unique optical characteristics of a devices with mixed dimensional vertically stacked structures based on tungsten diselenide(WSe_(2))/CdSeS QDs monolayer/molybdenum disulfide(MoS_(2))(2D/0D/2D).Specifically,it exhibits an ambipolar photoresponse characteristic,with a negative photoresponse observed in the 400-600 nm wavelength range and a positive photoresponse appeared at 700 nm *** resulted in the high negative responsivity of up to 52.22 mA·W^(−1)under 400 nm,which is 163 times higher than that of the photodetector without CdSeS *** also demonstrated the negative photoresponse,which could be due to increased carrier collision probability and non-radiative *** modeling and simulation reveal that Auger recombination among the types of non-radiative recombination is the main cause of negative photocurrent ***,we discovered ambipolar photoresponse near a specific wavelength corresponding to the energy of quantum *** study revealed interesting phenomenon in the mixed low-dimensional stacked structure and paved the way to exploit it for the development of innovative photodetection materials as well as for optoelectronic applications.

关键词： mixed-dimension quantum dot heterostructure photodetector ambipolar photoresponse

TonEBP expression is essential in the IL-1β–induced migration and invasion of human A549 lung cancer cells

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Oncology Research 2024年第1期32卷 151-161页

作者： HEE JU SONG TAEHEE KIM HAN NA CHOI soo JIN KIM SANG DO lee Department of Physiology School of MedicineChungnam National UniversityDaejeon35015Korea

Lung cancer has the highest mortality rate among all cancers,in part because it readily *** tumor microenvironment,comprising blood vessels,fibroblasts,immune cells,and macrophages[including tumor-associated macrophages(TAMs)],is closely related to cancer cell growth,migration,and *** secrete several cytokines,including interleukin(IL)-1β,which participate in cancer migration and invasion.p21-activated kinase 1(PAK1),an important signaling molecule,induces cell migration and invasion in several ***responsive enhancer-binding protein(TonEBP)is also known to participate in cancer cell growth,migration,and ***,the mechanisms by which it increases lung cancer migration remain ***,in this study,we aimed to elucidate the mechanisms by which IL-1βand TonEBP affect lung cancer cell migration and *** found that A549 cocultured-MΦ-secreted IL-1βinduced A549 cell migration and invasion via the PAK1 *** deficiency reduced A549 cell migration and invasion and increased responsiveness to IL-1β–induced migration and ***1 phosphorylation,which was promoted by IL-1β,was reduced when TonEBP was *** results suggest that TonEBP plays an important role in IL-1βinduction and invasiveness of A549 cells via the PAK1 *** findings could be valuable in identifying potential targets for lung cancer treatment.

关键词： Lung cancer TonEBP Tumor microenvironment Tumor-associated macrophage IL-1β

Unraveling the Harmonious Coexistence of Ruthenium States on a Self-Standing Electrode for Enhanced Hydrogen Evolution Reaction

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ENERGY & ENVIRONMENTAL MATERIALS 2024年第6期7卷 303-311页

作者： Ma, Joonhee Cho, Jin Hyuk lee, Chaehyeon Kang, Moon Sung Choi, Sungkyun Jang, Ho Won Ahn, Sang Hyun Back, Seoin Kim, soo Young Korea Univ Dept Mat Sci & Engn Seoul 02841 South Korea Sogang Univ Inst Emergent Mat Dept Chem & Biomol Engn Seoul 04107 South Korea Pusan Natl Univ Coll Nanosci & Nanotechnol Dept Cogno Mechatron Engn Busan 46241 South Korea Seoul Natl Univ Res Inst Adv Mat Dept Mat Sci & Engn Seoul 08826 South Korea Chung Ang Univ Sch Chem Engn & Mat Sci Seoul 06974 South Korea

The development of cost-effective, highly efficient, and durable electrocatalysts has been a paramount pursuit for advancing the hydrogen evolution reaction (HER). Herein, a simplified synthesis protocol was designed to achieve a self-standing electrode, composed of activated carbon paper embedded with Ru single-atom catalysts and Ru nanoclusters (ACP/RuSAC+C) via acid activation, immersion, and high-temperature pyrolysis. Ab initio molecular dynamics (AIMD) calculations are employed to gain a more profound understanding of the impact of acid activation on carbon paper. Furthermore, the coexistence states of the Ru atoms are confirmed via aberration-corrected scanning transmission electron microscopy (AC-STEM), X-ray photoelectron spectroscopy (XPS), and X-ray absorption spectroscopy (XAS). Experimental measurements and theoretical calculations reveal that introducing a Ru single-atom site adjacent to the Ru nanoclusters induces a synergistic effect, tuning the electronic structure and thereby significantly enhancing their catalytic performance. Notably, the ACP/RuSAC+C exhibits a remarkable turnover frequency (TOF) of 18 s-1 and an exceptional mass activity (MA) of 2.2 A mg-1, surpassing the performance of conventional Pt electrodes. The self-standing electrode, featuring harmoniously coexisting Ru states, stands out as a prospective choice for advancing HER catalysts, enhancing energy efficiency, productivity, and selectivity. A self-standing electrode with the coexistence of Ru single atoms and Ru nanoclusters is designed for the hydrogen evolution reaction (HER). Additional acid activation process induces defects, anchoring more Ru ions on the substrate. Detailed experimental and computational investigations suggest that the electronic coupling effect between different Ru states significantly enhanced the overall HER performance. image

关键词： electrocatalysis electronic coupling effect hydrogen evolution reaction self-standing electrode CARBON ELECTROREDUCTION CATALYSTS PAPER