检索结果-南通市图书馆

Therapeutic advances of targeting receptor tyrosine kinases in cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第9期9卷 3765-3815页

作者： Ciprian Tomuleasa Adrian-bogdan Tigu Raluca Munteanu Cristian-Silviu Moldovan David Kegyes Anca Onaciu Diana Gulei Gabriel Ghiaur Hermann Einsele Carlo MCroce Medfuture Research Center for Advanced Medicine Iuliu Hatieganu University of Medicine and PharmacyCluj-NapocaRomania Department of Hematology Iuliu Hatieganu University of Medicine and PharmacyCluj NapocaRomania Department of Hematology Ion Chiricuta Clinical Cancer CenterCluj NapocaRomania Academy of Romanian Scientists Ilfov 3050044 BucharestRomania Department of Leukemia Sidney Kimmel Cancer Center at Johns HopkinsJohns Hopkins University School of MedicineBaltimoreMDUSA Universitätsklinikum Würzburg Medizinische Klinik IIWürzburgGermany Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State UniversityColumbusOHUSA

Receptor tyrosine kinases(RTKs),a category of transmembrane receptors,have gained significant clinical attention in oncology due to their central role in cancer *** alterations,including mutations,amplifications,and overexpression of certain RTKs,are critical in creating environments conducive to tumor *** their discovery,extensive research has revealed how RTK dysregulation contributes to oncogenesis,with many cancer subtypes showing dependency on aberrant RTK signaling for their proliferation,survival and *** findings paved the way for targeted therapies that aim to inhibit crucial biological pathways in *** a result,RTKs have emerged as primary targets in anticancer therapeutic *** the past two decades,this has led to the synthesis and clinical validation of numerous small molecule tyrosine kinase inhibitors(TKIs),now effectively utilized in treating various cancer *** this manuscript we aim to provide a comprehensive understanding of the RTKs in the context of *** explored the various alterations and overexpression of specific receptors across different malignancies,with special attention dedicated to the examination of current RTK inhibitors,highlighting their role as potential targeted *** integrating the latest research findings and clinical evidence,we seek to elucidate the pivotal role of RTKs in cancer biology and the therapeutic efficacy of RTK inhibition with promising treatment outcomes.

关键词： alterations finding gained

Extrapancreatic necrosis volume:A new tool in acute pancreatitis severity assessment?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第31期9卷 9395-9405页

作者： bogdan Cucuteanu DragoşNegru Otilia Gavrilescu Iolanda Valentina Popa Mariana Floria Cătălina Mihai Cristina Cijevschi Prelipcean Mihaela Dranga Department of Radiology “Grigore T.Popa”University of Medicine and Pharmacy“Saint Spiridon”HospitalIaşi City 700115Romania Department of Gastroenterology “Grigore T.Popa”University of Medicine and Pharmacy“Saint Spiridon”HospitalIaşi City 700115Romania Department of Gastroenterology “Grigore T.Popa”University of Medicine and PharmacyIaşi City 700115Romania Department of Internal Medicine “Grigore T.Popa”University of Medicine and PharmacyIaşi City 700115Romania

BACKGROUND Many scores have been suggested to assess the severity of acute pancreatitis upon *** extrapancreatic necrosis volume is a novel,promising score that appears to be superior to other scores investigated so *** To evaluate the discriminatory power of extrapancreatic necrosis volume to identify severe cases of acute *** A total of 123 patients diagnosed with acute pancreatitis at Institute of Gastroenterology and Hepatology,St Spiridon Hospital between January 1,2017 and December 31,2019 were analyzed *** was classified according to the revised Atlanta classification(rAC)as mild,moderate,or *** was also evaluated by computed tomography and classified according to the computed tomography severity index(CTSI)and the modified CTSI(mCTSI).The results were compared with the extrapancreatic volume necrosis to establish the sensitivity and specificity of each *** The CTSI and mCTSI imaging scores and the extrapancreatic necrosis volume were highly correlated with the severity of pancreatitis estimated by the rAC(r=0.926,P<0.001 and r=0.950,P<0.001;r=0.784,P<0.001,respectively).The correlation of C-reactive protein with severity was positive but not as strong,and was not significant(r=0.133,P=0.154).The best predictor for the assessment of severe pancreatitis was the extrapancreatic necrosis volume[area under the curve(AUC)=0.993;95%confidence interval(CI):0.981-1.005],with a 99.5%sensitivity and 99.0%specificity at a cutoff value of 167 mL,followed by the mCTSI 2007 score(AUC=0.972;95%CI:0.946-0.999),with a 98.0%sensitivity and 96.5%specificity,and the CTSI 1990 score(AUC=0.969;95%CI:0.941-0.998),with a 97.0%sensitivity and 95.0%*** Radiological severity scores correlate strongly and positively with disease *** necrosis volume shows the best diagnostic accuracy for severe cases.

关键词： Acute pancreatitis Extrapancreatic necrosis volume Computed tomography index Modified computed tomography index C-reactive protein Severity score

Big data and machine learning: A roadmap towards smart plants

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Engineering Management 2022年第4期9卷 623-639页

作者： bogdan DORNEANU Sushen ZHANG Hang RUAN Mohamed HESHMAT Ruijuan CHEN Vassilios SVASSILIADIS Harvey ARELLANO-GARCIA LS-Prozess und Anlagentechnik Brandenburgische Technische Universität Cottbus-Senftenberg03044 CottbusGermany Department of Chemical Engineering and Biotechnology University of CambridgeCambridgeCB21TNUnited Kingdom School of Mathematics University of EdinburghEdinburghEH93FDUnited Kingdom Department of Architecture and Building Environment University of the West of EnglandBristolBS161QYUnited Kingdom School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074China Cambridge Simulation Solutions LTD. Larnaca 7550Cyprus

Industry 4.0 aims to transform chemical and biochemical processes into intelligent systems via the integration of digital components with the actual physical units *** process can be thought of as addition of a central nervous system with a sensing and control monitoring of components and regulating the performance of the individual physical assets(processes,units,etc.)*** technologies central to the digital integrating components are smart sensing,mobile communication,Internet of Things,modelling and simulation,advanced data processing,storage and analysis,advanced process control,artificial intelligence and machine learning,cloud computing,and virtual and augmented *** essential element to this transformation is the exploitation of large amounts of historical process data and large volumes of data generated in real-time by smart sensors widely used in *** of the information contained in these data requires the use of advanced machine learning and artificial intelligence technologies integrated with more traditional modelling *** purpose of this paper is twofold:a)to present the state-of-the-art of the aforementioned technologies,and b)to present a strategic plan for their integration toward the goal of an autonomous smart plant capable of self-adaption and self-regulation for short-and long-term production management.

关键词： big data machine learning artificial intelligence smart sensor cyber–physical system Industry 4.0 intelligent system digitalization

Copper Release Kinetics and Ageing of Insulation Paper in Oil-Immersed Transformers

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Engineering（科研） 2015年第8期7卷 514-529页

作者： Olena Sevastyanova bogdan Pasalskiy Boris Zhmud Departmentof Fibre and Polymer Technology KTH—The Royal Institute of Technology Stockholm Sweden Wallenberg Wood Science Centre KTH—The Royal Institute of Technology Stockholm Sweden Kyiv National University of Trade and Economics Kyiv Ukraine Sveacon Consulting Stockholm Sweden

The paper provides a general overview of chemical processes leading to the degradation of oil-paper insulation in oil-immersed electrical current transformers. Previous knowledge available in literature is complemented by new results placing a specific emphasis on the physicochemical factors which affect the copper release in the insulation oil and the oil oxidation kinetics. It is demonstrated that various ageing processes interact with each other, with one or another process dominating under specific conditions. Comprehensive but disjoint studies focusing on separate sub-processes may produce rather misleading results, and occasionally, lie behind rather irrelevant quality demands imposed on the insulating liquids.

关键词： Transformer Oil Insulating Oil Copper Corrosion Paper Degradation Ageing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

涡扇发动机高压涡轮叶片新型冷却结构研究

涡扇发动机高压涡轮叶片新型冷却结构研究

作者： bogdan Seredinov 上海交通大学

学位级别：硕士

在燃气涡轮发动机中,涡轮入口温度是至关重要的参数之一。在现代涡轮设计中,入口温度不断提升,高效冷却结构的设计是确保涡轮叶片乃至整个发动机寿命至关重要的因素。针对上述问题,本文以高压涡轮转子叶片为研究对象,采用数值模拟方法... 详细信息

在燃气涡轮发动机中,涡轮入口温度是至关重要的参数之一。在现代涡轮设计中,入口温度不断提升,高效冷却结构的设计是确保涡轮叶片乃至整个发动机寿命至关重要的因素。针对上述问题,本文以高压涡轮转子叶片为研究对象,采用数值模拟方法对叶片的气膜冷却结构形式及流动机理进行了研究,以寻求降低涡轮叶片表面温度的更为有效的冷却方案。首先本文介绍了扇形气膜冷却孔相较与传统气膜冷却孔的冷却机理的不同,在此基础上对采用传统圆柱气膜孔型的高压涡轮转子进行了气热耦合条件下的数值模拟工作。进一步的将叶片压力侧的双排圆柱孔进行了优化设计,采用扇形孔取代初始圆柱气膜孔结构,为保证流量特性,降低了扇形孔的冷却通道的数量,并进行了气热耦合条件下的数值模拟工作。研究结果显示,与初始模型相比,采用扇形气膜冷却孔的方案,在保持冷却量不变的情况下,在冷却孔后方叶片表面的温度显著降低,但是叶片表面整体温度相差不大。因此相较于圆柱形气膜冷却方案,扇形孔气膜孔结构是解决叶片表面局部过热问题的有效手段。从流动机理上看,与传统圆柱形气膜孔相比,扇形孔最大的作用是阻止了冷却射流产生的肾形涡将冷气卷吸至主流区域,因此提升了气膜冷却效率。

关键词：扇形孔涡轮叶片气膜冷却数值模拟

Interstitial cells of Cajal in the gut-A gastroenterologist’s point of view

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第41期14卷 6285-6288页

作者： Lucian M Negreanu Philippe Assor bogdan Mateescu Catalin Cirstoiu Department of Hepato-Gastroenterology Trousseau University Hospital Center Gastroenterology Department University Hospital Gastroenterology Department Colentina HospitalBucharest 020125 Romania Orthopedics and Surgery Department University Hospital

Alterations of normal function of interstitial cells of Cajal (ICC) are reported in many intestinal disorders. Diagnosis of their involvement is rare (infrequent), but necessary to propose a specifi c treatment. This article reviews the place of ICC in the pathogenesis of achalasia, gastroesophageal reflux disease, infantile hypertrophic pyloric stenosis, chronic intestinal pseudoobstruction and slow transit constipation. Moreover we discuss the role of the Cajal cells in the development of stromal tumors of the gastrointestinal tract.

关键词： Cajal cells c-kit Intestinal motility Achalasia Gastrointestinal stromal tumor

Cancer stem cells: Involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第31期20卷 10790-10801页

作者： Cristiana Pistol Tanase Ana Iulia Neagu Laura Georgiana Necula Cristina Mambet Ana-Maria Enciu bogdan Calenic Maria Linda Cruceru Radu Albulescu Department of Biochemistry-Proteomics Victor Babes National Institute of Pathology Stefan S Nicolau Institute of Virology Carol Davila University of Medicine and Pharmacy National Institute for Chemical Pharmaceutical Research and Development

Pancreatic cancer is one of the most aggressive and lethal malignancies. Despite remarkable progress in understanding pancreatic carcinogenesis at the molecular level, as well as progress in new therapeutic approaches, pancreatic cancer remains a disease with a dismal prognosis. Among the mechanisms responsible for drug resistance, the most relevant are changes in individual genes or signaling pathways and the presence of highly resistant cancer stem cells(CSCs). In pancreatic cancer, CSCs represent 0.2%-0.8% of pancreatic cancer cells and are considered to be responsible for tumor growth, invasion, metastasis and recurrence. CSCs have been extensively studied as of late to identify specific surface markers to ensure reliable sorting and for signaling pathways identified to play a pivotal role in CSC self-renewal. Involvement of CSCs in pancreatic cancer pathogenesis has also highlighted these cells as the preferential targets for therapy. The present review is an update of the results in two main fields of research in pancreatic cancer, pathogenesis and therapy, focused on the narrow perspective of CSCs.

关键词： Cancer stem cells Pancreatic cancer Cancer stem cells signaling pathways Targeted therapy miRNA

On the Mechanism of Nucleon-Nucleon Attraction by Pion Exchange

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Physics 2018年第8期9卷 1459-1468页

作者： Nicolae bogdan Mandache Dragos Iustin Palade Plasma Physics and Nuclear Fusion Laboratory National Institute for Laser Plasma and Radiation Physics Bucharest-Magurele Romania

A formula is derived for the central nucleon-nucleon potential, based on an analysis of the physical origin of the nucleon-nucleon attraction by pion exchange. The decrease of the dynamical mass of the interaction field, exchanged pion in this case, is the principal mechanism responsible for the nuclear attraction in a similar way that the decrease of the kinetic energy of the exchange electron in the diatomic molecule is directly responsible for the covalent molecular attraction. The minimum value of this central nucleon-nucleon potential and the position of the minimum are similar with the values reported in literature for a potential calculated by lattice QCD, which shares the features of the phenomenological nucleon-nucleon potentials. The Schrodinger equation with this central nucleon-nucleon potential was solved numerically for different values of the pion mass. The binding energy increases with the decrease of the pion mass. For masses higher than the real pion mass the nucleon-nucleon system is unbound. We discuss on the two pion exchange and hard core repulsion. The minimum value of the potential for two pion exchange is comparable with the minimum value of the CD Bonn potential. For a hard core radius of 0.5 fm the binding energy is equal to the deuteron binding energy.

关键词： Pion Exchange Dynamical Mass Central Nucleon-Nucleon Potential Bound State

Role of immunotherapy in gastric cancer with liver metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第11期15卷 1383-1389页

作者： bogdan Gafton Stefan Morarasu Gabriel Dimofte Department of Oncology Regional Institute of OncologyIasi 700483Romania Department of Oncology Grigore T.Popa University of Medicine and PharmacyIasi 700115Romania Second Department of Surgical Oncology Regional Institute of OncologyFaculty of MedicineGrigore T.Popa University of Medicine and PharmacyIasi 700115Romania Department of Surgery University of Medicine and Pharmacy Grigore T.Popa IaşiRegional Institute of Oncology IasiIasi 700483Romania

Gastric cancer continues to be a significant issue for public health,marked by its widespread occurrence and high mortality rates,even as the incidence of the disease shows a declining *** liver is the primary site for metastatic spread,with the peritoneum,lungs,and bones also being common *** the advent of biologic treatments and the introduction of immunotherapy for patients with metastatic conditions,the options to treat metastatic gastric cancer have *** diversified therapeutic approach is designed to enhance patient quality of life and prolong survival,showcasing the progress in treatment modalities for individuals with gastric cancer and liver metastases.

关键词： Gastric cancer Immunotherapy Liver metastases Metastatic gastric cancer Oncology Surgical oncology