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Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1344-1362页

作者： Zi-Ling Hu Yu-Xuan Wang Zi-Yue Lin wen-Shuo Ren bo Liu Hui zhao Qiong Qin Five Year Program of Ophthalmology and Optometry 2019 Beijing Tong Ren HospitalCapital Medical UniversityBeijing 100054China Four Year Program of Traditional Chinese Pharmacy 2020 School of Traditional Chinese MedicineCapital Medical UniversityBeijing 100069China School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Beijing Key Laboratory of TCM Collateral Disease Theory Research Beijing 100069China Five Year Program of Ophthalmology and Optometry 2021 School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Biochemistry&Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Age-related macular degeneration(AMD)is a complicated disease that causes irreversible visual *** evidences pointed retinal pigment epithelia(RPE)cells as the decisive cell involved in the progress of AMD,and the function of anti-oxidant capacity of PRE plays a fundamental physiological *** factor erythroid 2 related factor 2(Nrf2)is a significant transcription factor in the cellular anti-oxidant system as it regulates the expression of multiple anti-oxidative *** functions of protecting RPE cells against oxidative stress(OS)and ensuing physiological changes,including inflammation,mitochondrial damage and autophagy dysregulation,have already been *** the roles of upstream regulators of Nrf2 could provide further insight to the OS-mediated AMD *** the first time,this review summarized the reported upstream regulators of Nrf2 in AMD pathogenesis,including proteins and miRNAs,and their underlying molecular mechanisms,which may help to find potential targets via regulating the Nrf2 pathway in the future research and further discuss the existing Nrf2 regulators proved to be beneficial in preventing AMD.

关键词： Nrf2 upstream regulators retinal pigment epithelia age-related macular degeneration oxidative stress

λ/20-Thick cavity for mimicking electromagnetically induced transparency at telecommunication wavelengths

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Advanced Photonics 2024年第3期6卷 42-50页

作者： Hua Lu Shouhao Shi Dikun Li Shuwen bo Jianxu zhao Dong Mao Jianlin zhao Northwestern Polytechnical University School of Physical Science and TechnologyMOE Key Laboratory of Material Physics and Chemistry under Extraordinary ConditionsKey Laboratory of Light-Field Manipulation and Information AcquisitionMinistry of Industry and Information TechnologyShaanxi Key Laboratory of Optical Information TechnologyXi’anChina

Optical cavities play crucial roles in enhanced light-matter interaction,light control,and optical communications,but their dimensions are limited by the material property and operating *** planar cavities are urgently in demand for large-area and integrated optical ***,extremely reducing the planar cavity dimension is a critical challenge,especially at telecommunication ***,we demonstrate a type of ultrathin cavities based on large-area grown Bi_(2)Te_(3)topological insulator(TI)nanofilms,which present distinct optical resonance in the near-infrared *** result shows that the Bi_(2)Te_(3)TI material presents ultrahigh refractive indices of>6 at telecommunication *** cavity thickness can approach 1/20 of the resonance wavelength,superior to those of planar cavities based on conventional Si and Ge high refractive index ***,we observed an analog of the electromagnetically induced transparency(EIT)effect at telecommunication wavelengths by depositing the cavity on a photonic *** EIT-like behavior is derived from the destructive interference coupling between the nanocavity resonance and Tamm *** spectral response depends on the nanocavity thickness,whose adjustment enables the generation of obvious Fano *** experiments agree well with the *** work will open a new door for ultrathin cavities and applications of TI materials in light control and devices.

关键词： topological insulator optical nanocavity photonic crystal electromagnetically induced transparency-like effect

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Thermal and hydrological processes in permafrost slope wetlands affect thermosyphon embankment stability

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Advances in Climate Change Research 2024年第4期15卷 680-694页

作者： bo-wen TAI Qing-Bai WU Xiao-Ming XU State Key Laboratory of Frozen Soil Engineering Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

To ensure the long-term service performance of infrastructure such as railways,highways,airports and oil pipelines built on permafrost slope wetland sites,it is imperative to systematically uncover the long-term heat-water changes of soil in slope wetlands environment under climate *** specifically,considering valuable field data from 2001 to 2019,the long-term heat and water changes in active layers of the slope wetland site along the Qinghai-Xizang Railway(QXR)are illustrated,the effect of thermosyphon measures in protecting the permafrost environment is evaluated,and the influences of climate warming and hydrological effects on the stability of slope wetland embankments are systematically *** permafrost at the slope wetland site is rapidly degrading,demonstrating a reduction in active layer thickness of>3.7 cm per year and a permafrost temperature warming of>0.006℃ per *** thermosiphon embankment developed by QXR has a specific cooling period;thus,to mitigate the long-term impacts of climate warming on the thermal stability of permafrost foundation,it is essential to implement strengthening measures for the thermosiphon embankment,such as adding a crushed-rock layer or sunshade board on the slope of thermosiphon embankment to creating a composite cooling ***-term seasonal groundwater seepage intensifies frost damage to the slope wetland embankment,while long-term seasonal supra-permafrost water and groundwater seepage exacerbates uneven transverse deformation of slope wetland ***-term climate warming and slope effects have altered the surface water and groundwater hydrological processes of slope wetlands,potentially leading to an increased occurrence of slope embankment *** results are crucial for improving our understanding of heat and water variation processes in the active layer of slope wetland sites located in permafrost regions and ensuring long-term service safety for the QXR.

关键词： Heat and water process Active layer Slope wetland Permafrost environment Thermosyphon embankment

Sensing of membrane tensions:the pleiotropic functions of OSCA/TMEM63 mechanosensitive ion channels

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Journal of Genetics and Genomics 2024年第6期51卷 579-582页

作者： bo Yu Alex Costa Yang zhao Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China Key Laboratory of Plant Carbon Capture Chinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China Department of Biosciences University of MilanVia Celoria 26Milan 20133Italy

Organisms sense and respond to environmental and developmental signals to drive adaptive responses(Kefauver et al.,2020;Yu et al.,2024).These stimuli can be mainly divided into physical and chemical stimuli,and the physical stimuli include light,temperature,sound,vibration,pressure,stretch,shear stress,osmotic stress,and substrate *** of these physical stimuli trigger physical forces and alter membrane tension,which in turn activates mechanosensitive channels(MsCs)and converts the mechanical cues into biochemical signals.

关键词： deformation. convert mec

Determinants of saturation magnetic flux density in Fe-based metallic glasses: insights from machine-learning models

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Rare Metals 2024年第10期43卷 5256-5267页

作者： Jie Xiong bo-wen Bai Hao-Ran Jiang Angeles Faus-Golfe Materials Genome Institute Shanghai University Institute of Special Environments Physical Sciences Harbin Institute of Technology Laboratoire de Physique des 2 Infinis Irene Joliot-Curie (IJCLab) CNRS-IN2P3Universite′Paris-Saclay

Fe-based metallic glasses have garnered significant attention due to their low coercivity force and core loss. Enhancing the saturation magnetic flux density(Bs) of Fe-based metallic glasses is crucial for their industry applications. This work constructed a dataset comprising330 training data and 157 test data. The support vector regression model surpassed the tree-based ensemble models in the test set and demonstrated comparable accuracy to the tree-based ensemble models in the training set. Additionally, we proposed an indicator for Bsbased on symbolic regression. This newly proposed indicator exhibits a Pearson correlation coefficient exceeding 0.92 with Bs. The present work provides a simple and accurate formula for predicting the Bsof Fe-based amorphous alloys, demonstrating the effectiveness of machine learning approaches in discovering novel soft magnetic materials.

关键词： Fe-based metallic glasses Machine learning Saturation magnetic flux density Symbolic regression

Macrocyclic peptides:up-and-coming weapons to combat antimicrobial resistance

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1786-1787页

作者： wen-Jing Wang Xiang-Min Dong Guo-bo L Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuanChina Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education Department of Medicinal ChemistryWest China School of PharmacySichuan UniversityChengduSichuanChina

Recently,two companion papers published in Nature reported a first-in-class tethered macrocyclic peptide antibiotic targeting carbapenem-resistant ***(CRAB)and unveiled their unique antibacterial mechanism,which invol... 详细信息

关键词： outer macrocyclic Macrocyclic

Self-exothermic reaction driven large-scale synthesis ofphosphorescent carbon nanodots

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Nano Research 2021年第7期14卷 2231-2240页

作者： Shi-Yu Song Lai-Zhi Sui Kai-Kai Liu Qing Cao wen-bo zhao Ya-Chuan Liang Chao-Fan Lv Jin-Hao Zang Yuan Shang Qing Lou Xi-Gui Yang Lin Dong Kai-Jun Yuan Chong-Xin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023China Super Computer Center Smart City InstituteZhengzhou UniversityZhengzhou 450001China

Phosphorescent carbon nanodots(CNDs)have various attractive properties and potential applications,but it remains a formidable challenge to achieve large-scale phosphorescent CNDs limited by current ***,a large-scale synthesis method for phosphorescent CNDs has been demonstrated via precursors’self-exothermic reaction at room *** as-prepared CNDs show fluorescence and phosphorescence property,which are comparable with that synthesized by solvothermal and microwave *** and computational studies indicate that exotic atom doped sp^(2) hybridized carbon core works as an emissive center,which facilities the intersystem crossing from singlet state to triplet *** CNDs show phosphorescence with tunable lifetimes from 193 ms to 1.13 s at different *** demonstration of large-scale synthesis of phosphorescent CNDs at room temperature opens up a new window for room temperature fabrication phosphorescent CNDs.

关键词： carbon nanodots phosphorescence large scale self-exothermic reaction

Rapidly growing primordial black holes as seeds of the massive high-redshift JWST Galaxies

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 139-146页

作者： Guan-wen Yuan Lei Lei Yuan-Zhu Wang bo Wang Yi-Ying Wang Chao Chen zhao-Qiang Shen Yi-Fu Cai Yi-Zhong Fan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Deep Space Exploration Laboratory/Department of Astronomy School of Physical SciencesUniversity of Science and Technology of ChinaHefei 230026China Jockey Club Institute for Advanced Study The Hong Kong University of Science and TechnologyHong KongChina

A group of massive galaxies at redshifts of z■7 have been recently detected by the James Webb Space Telescope(JWST),which were unexpected to form at such an early time within the standard Big Bang *** this work,we propose that this puzzle can be explained by the presence of some primordial black holes(PBHs)with a mass of~1000M_(⊙).These PBHs act as seeds for early galaxy formation with masses of~10^(8)-10^(10)M_(⊙)at high redshift,hence accounting for the JWST *** use a hierarchical Bayesian inference framework to constrain the PBH mass distribution models,and find that the Lognormal model with the M_(c)~750M_(⊙)is preferred over other *** rapidly growing BHs are expected to have strong radiation and may appear as high-redshift compact objects,similar to those recently discovered by *** we focused on PBHs in this work,the bound on the initial mass of the seed black holes remains robust even if they were formed through astrophysical channels.

关键词： primordial black hole dark matter halo black hole accretion primordial galaxies

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Lowering Sodium-Storage Lattice Strains of Layered Oxide Cathodes by Pushing Charge Transfer on Anions

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Energy & Environmental Materials 2024年第4期7卷 99-106页

作者： Na Li wen Yin Baotian Wang Fangwei Wang Xiaoling Xiao Jinkui zhao Enyue zhao Songshan Lake Materials Laboratory Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Spallation Neutron Source Science Center Institute of High Energy Physics Chinese Academy of Sciences College of Materials Science and Opto-electronic Technology Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Due to a high energy density,layered transition-metal oxides have gained much attention as the promising sodium-ion batteries ***,they readily suffer from multiple phase transitions during the Na extraction process,re... 详细信息

关键词： anionic redox reaction lattice strains layered oxide cathodes phase transitions sodium-ion battery