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A midgut-specific lytic polysaccharide monooxygenase of Locusta migratoria is indispensable for the deconstruction of the peritrophic matrix

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Insect Science 2022年第5期29卷 1287-1298页

作者： Ming-bo Qu Xiao-Xi guo Lin Kong ling-Jie Hou Qing Yang School of Bioengineering Dalian University of TechnologyDalianLiaoning ProvinceChina State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong ProvinceChina

Lytic polysaccharide monooxygenases(LPMOs)are important enzymes that boost the hydrolysis of recalcitrant polysaccharides,such as *** are found extensively in different insect species and are classified as auxiliary activities family 15(AA15)LPMOs(LPMO15).Some of them were identified from the insect midgut and proven to act on ***,knowledge about their physiological roles during insect growth and development remains ***,we found that midgut-specific LPMO15s are widely distributed in different insect orders,such as the orthopteran Locusta migratoria and the lepidopteran bombyx *** *** as a model insect,the function of midgut-specific LmLPMO15-3 during development was ***-stranded RNA-mediated downregulation of LmLPMO15-3 expression at the 4th or 5th instar nymph stage severely decreased the survival rate and resulted in lethal *** and eosin staining results indicated that the deficient individuals exhibited incompletely digested peritrophic matrix(PM),which suggested that LmLPMO15-3 is essential for the deconstruction of the PM during *** study provides direct evidence of the physiological importance of a midgut-specific LPMO15 during insect *** *** is one of the most destructive agricultural pests,LmLPMO15-3 is a potential target for pest management.

关键词： chitin Locusta migratoria lytic polysaccharide monooxygenase midgut peritrophic matrix RNAi

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Real-Time Investigation of the Growth Kinetics of an Organometallic Complex Crystal ATMB

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Chinese Physics Letters 1996年第8期13卷 606-609页

作者： SUN Yi YU Xi-ling HOU Wen-bo ZHANG Shu-jun guo Shi-yi The State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100

This paper reports the growth kinetics of a new kind of organometallic complex crystal triallylthiourea mercury bromide(ATMB),investigated by in situ microscopic *** step trains formed by the layer growth mechanism have larger width(ranged from 2 to 15μm) and lower height(40-250nm).The relationship between the growth rate R and the relative supersaturationσwas obtained by directly measuring the movement of step trains of ATMB crystal in aqueous *** variation of growth mechanism with supersaturationσis also discussed.

关键词： solution crystal saturation

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A review on bath fluid flow stirring technologies in EAF steelmaking

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Journal of Iron and Steel Research International 2021年第11期28卷 1341-1351页

作者： ling-zhi Yang Hang Hu Ze-shi Yang bo-tao Xue Yu-feng guo Shuai Wang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore

In the contemporary electric arc furnace(EAF)steelmaking industry,increasing contents and temperature homogenization via fluid flow stirring is found to be an effective method of improving production quality and smelting *** is a trend for different factories with bowl-shaped furnaces to apply the bath fluidity enhancement *** has plenty of advantages in modern steelmaking industry,and the improvements on the EAF steelmaking process have come up with two major tasks,namely reduction in energy consumption and tap-to-tap *** latter task requires an essential understanding of every phase in EAF steelmaking *** flat bath phase with poor bath fluid flow was crucial to the product quality and metallurgical efficiency considering EAF’s bowl-shaped *** research of three stirring bath methods,oxygen jets injection,electromagnetic stirring,and bottom blowing,were introduced,and then the detailed parameters of each method with their influences on molten bath fluidity were presented.

关键词： Electric arc furnace steelmaking Bath fluid flow Stirring technology Oxygen jets injection Electromagnetic stirring bottom blowing

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Capacitated stochastic coloured Petri net-based approach for computing two-terminal reliability of multi-state network

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Journal of Systems Engineering and Electronics 2012年第2期23卷 304-313页

作者： Tao Zhang bo guo College of Information Systems and Management National University of Defense TechnologyChangsha 410073R R.China

Classical network reliability problems assume both net- works and components have only binary states, fully working or fully failed states. But many actual networks are multi-state, such as communication networks and transportation networks. The nodes and arcs in the networks may be in intermediate states which are not fully working either fully failed. A simulation ap- proach for computing the two-terminal reliability of a multi-state network is described. Two-terminal reliability is defined as the probability that d units of demand can be supplied from the source to sink nodes under the time threshold T. The capacities of arcs may be in a stochastic state following any discrete or continuous distribution. The transmission time of each arc is also not a fixed number but stochastic according to its current capacity and de- mand. To solve this problem, a capacitated stochastic coloured Petri net is proposed for modelling the system behaviour. Places and transitions respectively stand for the nodes and arcs of a net- work. Capacitated transition and self-modified token colour with route information are defined to describe the multi-state network. By the simulation, the two-terminal reliability and node importance can be estimated and the optimal route whose reliability is highest can also be given. Finally, two examples of different kinds of multi- state networks are given.

关键词： two-terminal reliability multi-state network Petri net (PN) simulation node importance.

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The 3D nanoimaging beamline at SSRF

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Nuclear Science and Techniques 2023年第12期34卷 242-250页

作者： ling Zhang Fen Tao Jun Wang Ruo‑Yang Gao bo Su guo‑Hao Du Ai‑guo Li Ti‑Qiao Xiao Biao Deng Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Full-field transmission X-ray microscopy(TXM)is a powerful non-destructive three-dimensional(3D)imaging method with a nanoscale spatial resolution that has been used in most synchrotron facilities *** in-house-designed TXM system was constructed at the BL18B 3D nanoimaging beamline at the Shanghai Synchrotron Radiation *** beamline operates from 5 to 14 keV and enables 20 nm spatial resolution *** characterization details of the beamline are described in this *** performances in terms of spatial resolution,nano-CT,and nano-spectral imaging of the TXM beamline are also presented in this article.

关键词： Transmission X-ray microscopy(TXM) Nano-CT Synchrotron radiation

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A Photosensitivity Insecticide, 5-Aminolevulinic Acid, Exerts EffectiveToxicity to Oxya chinensis (Orthoptera: Acridoidea)

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Agricultural Sciences in China 2011年第7期10卷 1056-1063页

作者： YANG Mei-ling YIN Kun guo Ya-ping MA En-bo ZHANG Jian-zhen Research Institute of Applied Biology Shanxi University Taiyuan 030006 P.R.China Environmental Monitoring of China Beijing 100012 P.R.China School of Life Science and Technology Shanxi University Taiyuan 030006 P.R.China

5-Aminolevulinic acid （ALA）, a major photosensitivity insecticide, has attracted increasing attention as a new type of highly efficient, environmental friendly pesticide to be used to control the pest. To examine whether or not ALA acts effectively to grasshopper, Oxya chinensis and elucidate the detoxification mechanism of ALA, the susceptibility to ALA was assessed in O. chinensis and two major metabolic detoxification enzymes including glutathione S-transferases （GSTs） and general esterases （ESTs）-specific activities were compared in different development stages and different body sections of O. chinensis treated by ALA and the control. The results showed that the ALA exhibited obvious toxicity to the grasshopper in different development stages. In the low-dose treatment （0.0597 mmol L-1）, the mortalities of O. chinensis reached a significant level （55.5% in the 1st instar nymphs, 61.4% in the 2nd instar nymphs, 71.4% in the 3rd instar nymphs, and 64.4% in the 4th instar nymphs. But, there was no dose-dependent toxic effect. Thereby, we proposed that ALA has the potential for acting as photosensitivity insecticide for controlling O. chinensis. GSTs activity assays using CDNB and DCNB as substrates indicated that the thorax and abdomen of the different instar nymphs treated by ALA showed 1.52-5.56 fold significantly increased GSTs activities compared with the control. However, for the ESTs-specific activity assay, there was no significant difference between O. chinensis treated by ALA and the control within different instar nymphs, when a-NA, a-NB and b-NA were used as substrates. Therefore, GSTs-mediated metabolic detoxification as evidenced by significantly increased GSTs activities might contribute to protect against oxidative damage and oxidative stress by ALA in O. chinensis.

关键词： 5-aminolevulinic acid toxicity glutathione S-transferases general esterases Oxya chinensis

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Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments

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Integrative Zoology 2016年第2期11卷 86-97页

作者： Xinyi guo ling XIE Xuze ZHANG Yinfa JI Juan CHEN bo PANG Yongtao XU Delin QI Songchang guo Key laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyCASXiningChina University of Chinese Academy of Sciences BeijingChina Qinghai University for Nationalities XiningChina Qinghai Normal University XiningChina Animal Science Department of Agriculture and Animal Husbandry College Qinghai UniversityXiningChina

Fishes harbor a huge resource of phenotypic diversity and are useful for understanding the genetic basis of morphological ***,it is difficult to transfer classical genetic mapping to most non-model *** this study,we performed a comparative sequence analysis of Fgfr1a to first interpret the evolution of this candidate scale-loss gene in 15 schizothoracine fishes with various scale *** considerable amino acid(AA)substitutions were observed,molecular evolution analysis indicates that the overall coding regions were subject to functional *** also identified extra copies of Fgfr1a in 4 scale-loss fishes and detected accelerated evolution in one AA substitution specific to these *** speculate that Fgfr1a had accumulated mutations in the ancestral lineage of scale-loss schizothoracine fishes before experiencing duplication events,which was further followed by the diversification of *** silico mutation analysis predicted deleterious effects of the mutations while no disruptive molecular mechanism was ***,our results highlight the important role of Fgfr1a gene in the adaptive evolution of schizothoracine fishes during their radiation in the Qinghai-Tibetan Plateau.

关键词： adaptive evolution Fgfr1a scale loss Schizothoracine

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Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia guo Hanghang Zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

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AN EXPANDED CHARACTERISTIC-MIXED FINITE ELEMENT METHOD FOR A CONVECTION-DOMINATED TRANSPORT PROBLEM

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Journal of Computational Mathematics 2005年第5期23卷 479-490页

作者： ling guo Huan-zhen Chen Department of Mathematics Shanghai Jiao Tong UniversityShanghai 200030China Department of Mathematics Shandong Normal UniversityJinan 250014China

In this paper, we propose an Expanded Characteristic-mixed Finite Element Method for approximating the solution to a convection dominated transport problem. The method is a combination of characteristic approximation to handle the convection part in time and an expanded mixed finite element spatial approximation to deal with the diffusion part. The scheme is stable since fluid is transported along the approximate characteristics on the discrete level. At the same time it expands the standard mixed finite element method in the sense that three variables are explicitly treated： the scalar unknown, its gradient, and its flux. Our analysis shows the method approximates the scalar unknown, its gradient, and its flux optimally and simultaneously. We also show this scheme has much smaller time-truncation errors than those of standard methods. A numerical example is presented to show that the scheme is of high performance.

关键词： Convection diffusion problems Expanded characteristic mixed finite elementmethod Optimal error estimates Numerical test

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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin Dong Dan Zou Zhijun Yang Lili guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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