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Temperature-dependent synergistic evolution mechanism of rhenium and irradiation defects in tungsten-rhenium alloys

Journal of Materials Science & Technology 2023年第14期145卷 221-234页

作者： Yu-Hao Li Fang-Ya Yue Zhong-zhu Li Peng-Wei Hou Yu-Ze Niu Hui-Zhi Ma Ying Zhang Xun-Xiang Hu Hui-Qiu Deng Hong-bo Zhou Fei Gao Guang-Hong Lu Department of Physics Beihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China College of Physics Sichuan UniversityChengdu 610065China School of Physics and Electronics Hunan UniversityChangsha 410082China Department of Nuclear Engineering and Radiological Science University of MichiganAnn ArborMI 48109USA

We have systemically investigated the synergistic evolution of rhenium(Re)and irradiation defects in tungsten(W)-Re alloys under different temperatures and irradiation doses using object Kinetic Monte Carlo *** results revealed the underlying mechanism for the transition of Re effect on W from beneficial to harmful during the Re-defects evolution with the increase of irradiation dose,in which tem-perature always plays a critical *** the one hand,Re will significantly promote the defect annihila-tion at low irradiation doses and high temperatures,thereby effectively reducing their sizes and number *** is due to the formation of stable Re-SIAs complexes that can be eliminated by the mobile vacancy-type defects,whereas the transition of the migration pattern of SIAs only plays a weak role in the defect recombination in W-Re *** the other hand,with the increase of irradiation dose,Re will aggregate to form Re-rich clusters or even ***,the formation mechanism of Re-rich clusters is also dependent on *** low temperatures,the interstitial-mediated mech-anism plays a crucial role in the Re-rich cluster formation,while at high temperatures,both SIA-type and vacancy-type defects will act as the transport carriers of Re to promote their ***,the critical conditions for the transition of Re from beneficial to harmful and the formation of Re-rich clusters at different tem peratures and irradiation doses are given with the help of the phase *** work presents the temperature dependence of the synergy of Re and irradiation defects in W-Re in fusion-relevant environment,which provides a good reference for the development of radiation-resistant materials and the prediction of W performance in fusion reactors.

关键词： Synergistic evolution Irradiation defects Defects recombination Rhenium-rich clusters Tungsten-rhenium alloys

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Matching-based two-color X-ray free-electron laser generation utilizing laser-plasma accelerated electron beam

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High Power Laser Science and Engineering 2022年第1期10卷 1-9页

作者： Tao Liu Kaiqing Zhang Zheng Qi Si Chen Chao feng Haixiao Deng bo Liu Dong Wang Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

Laser-plasma accelerators(LPAs)have great potential to realize a compact X-ray free-electron laser(FEL),which is limited by the beam properties ***-color high-intensity X-ray FEL provides a powerful tool for probing ultrafast dynamic *** this paper,we present a simple and feasible method to generate a two-color X-ray FEL pulse based on an LPA *** this scheme,time-dependent mismatch along the bunch is generated and manipulated by the designed lattice system,enabling FEL lasing at different wavelength within two undulator *** time separation between the two pulses can be precisely adjusted by varying the time-delay *** simulations show that two-color soft X-ray FELs with gigawatt-level peak power and femtosecond duration can be generated,which confirm the validity and feasibility of the scheme.

关键词： free-electron lasers laser-plasma accelerator two-color X-ray

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Pattern analysis of schistosomiasis prevalence by exploring predictive modeling in Jiangling County,Hubei Province,***

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Infectious Diseases of Poverty 2017年第1期6卷 791-800页

作者： Shang Xia Jing-bo Xue Xia Zhang He-Hua Hu Eniola Michael Abe David Rollinson Robert Bergquist Yibiao Zhou Shi-zhu Li Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMinistry of HealthWHO Collaborating Center for Tropical DiseasesShanghai 200025People’s Republic of China Jiangling Institute of Schistosomiasis Control and Prevention Jiangling 434100People’s Republic of China Department of Zoology Natural History MuseumWolfson Wellcome Biomedical LaboratoriesCromwell RoadLondon SW75BDUK Ingerod BrastadSweden Department of Epidemiology School of Public HealthFudan UniversityShanghai 200032People’s Republic of China.

Background:The prevalence of schistosomiasis remains a key public health issue in *** County in Hubei Province is a typical lake and marshland endemic *** pattern analysis of schistosomiasis prevalence in Jiangling County is of significant importance for promoting schistosomiasis surveillance and control in the similar endemic ***:The dataset was constructed based on the annual schistosomiasis surveillance as well the socio-economic data in Jiangling County covering the years from 2009 to 2013.A village clustering method modified from the K-mean algorithm was used to identify different types of endemic *** these identified village clusters,a matrix-based predictive model was developed by means of exploring the one-step backward temporal correlation inference algorithm aiming to estimate the predicative correlations of schistosomiasis prevalence among different *** sampling of faeces from domestic animals,as an indicator of potential schistosomiasis prevalence,was carried out and the results were used to validate the results of proposed models and ***:The prevalence of schistosomiasis in Jiangling County declined year by *** total of 198 endemic villages in Jiangling County can be divided into four clusters with reference to the 5 years’occurrences of schistosomiasis in human,cattle and snail *** each identified village cluster,a predictive matrix was generated to characterize the relationships of schistosomiasis prevalence with the historic infection level as well as their associated impact ***,the results of sampling faeces from the front field agreed with the results of the identified clusters of endemic ***:The results of village clusters and the predictive matrix can be regard as the basis to conduct targeted measures for schistosomiasis surveillance and ***,the proposed models and methods can be modified to investigate the schistosomiasis pre

关键词： Schistosomiasis Clustering Predictive modelling

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DS-BPSK方案下的UWB非相干接收方法

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数据采集与处理 2008年第B09期23卷 96-100页

作者：孙博朱轶王刚江苏大学计算机科学与通信工程学院镇江212013

分析了采用DS-BPSK调制方式的UWB通信系统非相干接收方案,并研究了一种以差分能量检测非相干接收方式为基础的非相干接收处理算法,在此基础上进行了非相干接收方式下DS-BPSK UWB系统的性能分析,并利用Matlab进行了仿真。仿真结果表明:... 详细信息

分析了采用DS-BPSK调制方式的UWB通信系统非相干接收方案,并研究了一种以差分能量检测非相干接收方式为基础的非相干接收处理算法,在此基础上进行了非相干接收方式下DS-BPSK UWB系统的性能分析,并利用Matlab进行了仿真。仿真结果表明:本文所讨论的非相干接收算法对同步误差不敏感,可以很好地适用于不能精确同步的通信场合。

关键词：超宽带通信非相干信号处理误码率

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Effect of Jinfeng Pill on ovarian function of Tripterygium wilfordii polyglycoside tablets induced poor ovarian response rats

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生殖与发育医学(英文) 2024年第4期8卷 206-212页

作者： Li Yi Wang Jian-Fang Yan Xiao-Hong Ji Xiao-Lei Zhang Heng-Yuan Wu Rong-feng Li You-zhu Clinical Medical Research Center for Obstetrics and Gynecology Diseases of Fujian Province Laboratory of Research and Diagnosis of Gynecological Diseases of Xiamen City Department of Reproductive Medicine the First Affiliated Hospital of Xiamen University School of Medicine Xiamen University Xiamen China Internal Medicine Siming Branch The First Affiliated Hospital of Xiamen University School of Medicine Xiamen University Xiamen China Xiamen Assisted Reproductive Technology Quality Control Center Xiamen China School of Public Health Xiamen University Xiamen China School of Medicine Huaqiao University Quanzhou China

Objective: This study aimed to assess the effects of the Jinfeng pill on ovarian volume and endocrine function in rats with poor ovarian response and to elucidate the gene expression changes that contribute to the Jinfeng pill’s role in improving ovarian ***: Thirty 8-week-old specific pathogen-free (SPF) female rats were randomly assigned to five groups: control, model, estradiol, Jinfeng pill, and Jinfeng pill + estradiol, with six rats in each group. All groups, except the control were administered Tripterygium glycoside tablets. After establishing the poor ovarian response model, the three intervention groups (estradiol, Jinfeng pill, and Jinfeng pill + estradiol) received their respective drug interventions. Hematoxylin-eosin staining was employed to assess follicle distribution, and immunohistochemistry was used to evaluate the expression of vascular endothelial growth factor and endostatin in rat ovaries. Hormone levels were measured using ***: The uterine and total ovarian masses in the three intervention groups were higher than those in the model group; however, the differences were not statistically significant. The ovaries of the Jinfeng pill and Jinfeng pill + estradiol groups contained more follicles at various developmental stages. The three intervention groups showed significantly increased vascular endothelial growth factor expression and decreased endostatin expression compared with the model group, with the Jinfeng pill + estradiol group exhibiting the most pronounced differences. Anti-Müllerian hormone levels were slightly elevated in the Jinfeng pill group compared to the model group. However, only the Jinfeng pill + estradiol group showed a statistically significant decrease in follicle-stimulating hormone levels compared to the model group (P = 0.01).Conclusions: Jinfeng pill modulates ovarian protein expression, increases ovarian volume, and improves blood circulation. Additionally, it may elevate hormone levels and enha

关键词： Poor ovarian response Jinfeng Pill Sex hormone Vascular endothelial growth factor Endostatin

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NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts

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bone Research 2018年第4期6卷 368-382页

作者： Ling Ye feng Lou Fanyuan Yu Demao Zhang Chenglin Wang Fanzi Wu Xin Li Yilin Ping Xiao Yang Jing Yang Dian Chen bo Gao Dingming Huang Peng Liu State Key Laboratory of Oral Disease West China Hospital of Stomatology Sichuan University The Mount Sinai bone Program Department of MedicineMount Sinai School of Medicine

The adaptor protein NUMB is involved in asymmetric division and cell fate determination and recognized as an antagonist of *** studies have proved that Notch activation in osteoblasts contributes to a high bone mass. In this study, however, an osteopenic phenotype was found in 9-week-old mice using osteoblastic specific Col1a1–2.3-Cre to ablate both Numb and its homologue Numbl. The trabecular bone mass decreased dramatically while the cortical bone mass was unaffected. Here, the Notch signal was not activated,while the tensin homologue deleted on human chromosome 10(PTEN), which dephosphorylates phosphatidylinositide 3-kinases, was elevated, attenuating protein kinase B(Akt). The ubiquitination assay revealed that NUMB may physiologically promote PTEN ubiquitination in the presence of neural precursor cell-expressed developmentally downregulated protein 4–1. In addition, the deficiency of Numb/Numbl also activated the Hedgehog pathway through GLI1. This process was found to improve the ratio of the receptor activator of nuclear factor-k B ligand to osteoprotegerin, which enhanced the differentiation of osteoclasts and bone resorption. In conclusion, this study provides an insight into new functons of NUMB and NUMBL on bone homeostasis.

关键词： NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts GLI RANKL

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Finite-temperature ductility-brittleness and electronic structures of Al_(n)Sc(n=1,2 and 3)

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Rare Metals 2024年第8期43卷 3974-3989页

作者： Xue-Qian Wang Ying Zhao Hao-Xuan Liu Shu-Chen Sun Hong-bo Yang Jia-Min Zhong Gan-feng Tu Song Li Yu-Dong Zhang Claude Esling Hai-Le Yan Liang Zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Rare Earth Functional Materials(Xiong'an)Innovation Center Co. Ltd.Xiong'an 071700China Laboratoire d'étude des Microstructures et de Mécanique des Matériaux(LEM3) Unikersitéde Lorraine57045MetzFrance

Finite-temperature ductility-brittleness and electronic structures of Al_(3)Sc,Al_(2)Sc and AlSc are studied comparatively by first-principles calculations and ab initio molecular *** show that Al_(3)Sc and Al_(2)Sc are brittle at both ground state and finite temperatures,while AlSc possesses a significantly superior *** ground state,AlSc is ductile from Pugh's and Poisson's criteria,while it is brittle in Pettifor's *** ductility of all Al_(3)Sc,Al_(2)Sc and AISc improves greatly with the elevated ***,the Cauchy pressure of AlSc undergoes a transition from negative to *** T>600 K,AlSc is unequivocally classified as ductile from all criteria *** all compounds,the Al-Al bond originated from s-p and p-p orbital hybridizations,and the Al-Sc bond dominated by p-d covalent hybridization,are the first and second strongest chemical bonds,*** explain the difference in mechanical properties,the mean bond strength(MBS)is introduced in this *** weaker Al-Al bond in AlSc,leading to a smaller MBS,could be the origin of the softer elastic stiffness and superior intrinsic *** longer length of the Al-Al bond in AlSc is responsible for its weaker bond ***,the enhanced metallicity of the Al-Al bond in AlSc would also contribute to its exceptional *** longer length of the Al-Al bond in AISc is responsible for its weaker bond ***,the enhanced metallicity of the Al-Al bond in AlSc would also contribute to its exceptional ductility.

关键词： Al-Sc Target materials Intrinsic ductility Finite-temperature elastic constant First-principles calculation

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Liver infiltration of multiple immune cells during the process of acute liver injury and repair

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World Journal of Gastroenterology 2022年第46期28卷 6537-6550页

作者： Yuan Xie Ke-bo Zhong Yang Hu Yong-Lun Xi Shi-Xing Guan Meng Xu Yuan Lin feng-Yong Liu Wei-Jie Zhou Yi Gao General Surgery Center Department of Hepatobiliary Surgery ⅡGuangdong Provincial Research Center for Artificial Organ and Tissue EngineeringGuangzhou Clinical Research and Transformation Center for Artificial LiverInstitute of Regenerative MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280Guangdong ProvinceChina State Key Laboratory of Organ Failure Research Department of PathologyCancer Research InstituteSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of General Surgery&Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor Nanfang HospitalFirst Clinical Medical SchoolSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Interventional Radiology Senior Department of OncologyFifth Medical Center of PLA General HospitalBeijing 100853China State Key Laboratory of Organ Failure Research Southern Medical UniversityGuangzhou 510280Guangdong ProvinceChina

BACKGROUND Immune cells,including neutrophils,natural killer(NK)cells,T cells,NKT cells and macrophages,participate in the progression of acute liver injury and hepatic *** date,there has been no systematic study on the quantitative changes in these different immune cells from initial injury to subsequent *** To investigate the infiltration changes of various immune cells in acute liver injury models over time,and to study the relationship between the changes in leukocyte cellderived chemotaxin 2(LECT2)and the infiltration of several immune *** Carbon tetrachloride-and concanavalin A-induced acute liver injury models were employed to mimic toxin-induced and autoimmune-mediated liver injury *** quantitative changes in various immune cells were monitored at different time *** samples were collected,and liver tissues were ***6G,CD161,CD4,CD8 and F4/80 staining were used to indicate neutrophils,NK/NKT cells,CD4^(+)T cells,CD8^(+)T cells and macrophages,***2-KO mice were used to detect the function of *** During the injury and repair process,different types of immune cells began to increase,reached their peaks and fell into decline at different time ***,when the serum alanine transaminase(ALT)and aspartate transaminase(AST)indices reverted to normal levels 7 d after the injury,the infiltration of immune cells still existed even 14 d after the injury,showing an obvious lag *** found that the expression of LECT2 was upregulated in acute liver injury mouse models,and the liver injuries of Lect2-KO mice were less severe than those of wild-type *** with wild-type mice,Lect2-KO mice had different immune cell *** The recovery time of immune cells was far behind that of serum ALT and AST during the process of liver ***2 could regulate monocyte/macrophage chemotaxis and might be used as a therapeutic target for acute liver injury.

关键词： Immune cells Liver injury Liver repair Leukocyte cell-derived chemotaxin 2

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采用超声波电机的空间飞网自适应收口机构设计

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宇航学报 2013年第3期34卷 308-313页

作者：王波郭吉丰浙江大学电气工程学院杭州310027

介绍了一种采用超声波电机作为驱动源的空间飞网自适应收口机构(质量块)的设计及实现方法。通过分析捕获过程中质量块运动情况,研究超声波电机电流与负载的关系,确定以加速度信号和电流信号作为电机启动和停止的触发信号,在此基础上设... 详细信息

介绍了一种采用超声波电机作为驱动源的空间飞网自适应收口机构(质量块)的设计及实现方法。通过分析捕获过程中质量块运动情况,研究超声波电机电流与负载的关系,确定以加速度信号和电流信号作为电机启动和停止的触发信号,在此基础上设计并实现了质量块的驱动控制系统。通过在电机输出轴与卷筒间加入差动轮系构成双卷筒机构,力学分析证实了该机构在负载不均衡情况下的自适应性。分析证明该机构使飞网的捕获操作对捕获平台的精度要求降低,有容错能力。同时使收口机构在部分质量块故障时也能完成捕获任务。

关键词：空间飞网收口机构超声波电机差动轮系自适应

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时频二维逼近及在故障分量提取中的应用

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振动与冲击 2011年第4期30卷 173-177,193页

作者：刘小峰柏林赵玲重庆大学机械传动国家重点实验室重庆400044

机械故障信号通常是具有非线性时频关系多分量信号,其频谱占有较宽的频带,且各分量的频谱常常相互交叠,给故障诊断带来了很大的障碍。在传统信号分解的基函数线性逼近方法和时频重排的基础上,提出了基于时频二维逼近的信号分量提取方法... 详细信息

机械故障信号通常是具有非线性时频关系多分量信号,其频谱占有较宽的频带,且各分量的频谱常常相互交叠,给故障诊断带来了很大的障碍。在传统信号分解的基函数线性逼近方法和时频重排的基础上,提出了基于时频二维逼近的信号分量提取方法。该方法对所要提取的特征分量进行参数建模,并计算出分量模型的时频函数以及多分量信号的重排时频分布;然后采用模型的时频函数拟合逼近原始信号的时频分布,并采用非线性最小二乘法确定出模型的各个参数值;最后设置能量下降梯度阈值控制迭代次数,用拟合得出的参数模型重构出信号分量。仿真实例验证了,上述方法对比基于时频滤波的信号提取方法,只需要少数几次拟合就能提取出所需要的信号分量,分量的重构精度较高。这种方法在轴承故障冲击分量提取中的应用表明,其不仅可以较精确地对轴承故障进行定位,而且能为故障原因及故障程度提供准确的判断依据。

关键词：时频重排分量提取参数建模二维逼近故障诊断

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