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Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng liu Changyu Zhang Zipeng li Wanying Ma Jia liu Xiang Xia Ning Xu wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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Unraveling the impacts of intermolecular interaction on morphology evolution for highly efficient organic solar cells and modules

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Science China Chemistry 2025年第01期 264-272页

作者： Xueqing Ma Yingying Cheng Yuqiang liu Xinming Zheng Guangliu Ran Hongxiang li Xinyue Cui Andong Zhang wenkai Zhang Pei Cheng wenchao Huang Zhishan bo Beijing Key Laboratory of Energy Conversion and Storage Materials College of Chemistry Beijing Normal University College of Textiles and Clothing State Key Laboratory of Bio-fibers and Eco-textiles Qingdao University Key State Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of Technology Department of Physics and Applied Optics Beijing Area Major Laboratory Center for Advanced Quantum Studies Beijing Normal University State Key Laboratory of Polymer Materials Engineering College of Polymer Science and Engineering Sichuan University

Understanding the effect of intermolecular interaction on the growth dynamic of active layers is critical for advancing organic solar cells(OSCs). However, the diverse structure of donors and acceptors makes the research challenging. Additives with customizable structures and properties could simplify this complexity. Herein, we meticulously tailor two additives of 3,4-ethylenedioxythiophene(EDOT) and 2,5-dibromo-3,4-ethylenedioxythiophene(DBEDOT), possessing distinct intermolecular interaction features to elaborate the inherent relationship. It is found that varied interaction strengths can alter film formation processes. The enhanced intermolecular interaction between the DBEDOT and non-fullerene acceptor BTP-e C9-4F results in pre-aggregation and longer crystallization duration of BTP-e C9-4F, facilitating the formation of films with compact molecular packing and decent phase separation. Thus, exciton dissociation and charge transport become more efficient. Finally, devices processed with DBEDOT exhibit a remarkable power conversion efficiency of 19.35% in small-area OSCs and 14.11% in bladecoated 5 cm × 5 cm organic solar mini-modules. Especially, OSCs can maintain 80% of their initial efficiency after continuous annealing at 85 °C for over 2,100 h.

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Scyphiphin D,a new iridoid glucoside dimer from-Scyphiphora hydrophyllacea

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Scyphiphin D,a new iridoid glucoside dimer from-Scyphiphora ...

Enhancement on the ammonia oxidation capacity of ammonia-oxidizing archaeon originated from wastewater:Utilizing low-density static magnetic field

第九届全国药用植物及植物药学术研讨会

作者： Yan-bo Zeng,wen-li Mei,Hui Wang,Xiao-Na li,and Hao-Fu Dai~* (a Key Laboratory of Tropical Crop Biotechnology,Ministry of Agriculture,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou, 571101,China b Hainan Key Laboratory for Research and Development of Natural Product from li Folk Medicine,Haikou 571101,Hainan,P.R.China)

From the aerial parts of Scyphiphora hydrophyllacea Gaertn.F.A new iridoid glucoside dimer scyphiphin D(1) and a known iridoid glucoside geniposidic acid(2) were *** structure of this new compound was determined on th... 详细信息

关键词： Scyphiphin D iridoid glucoside iridoid glucoside dimer Scyphiphora hydrophyllacea mangrove plant

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Frontiers of Environmental Science & Engineering 2021年第5期15卷 67-74页

作者： Zeshen Tian bo Wang Yuyang li bo Shen Fengjuan li Xianghua wen State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China

Ammonia-oxidizing archaeon(AOA)could play important roles for nitrogen removal in the bioreactors under conditions such as low pH and low dissolved ***,enhancing ammonia oxidation capability of AOA has great significance for water and wastewater treatment,especially under conditions like low dissolved oxygen *** a novel AOA strain SAT1,which was enriched from a wastewater treatment plant by our group,the effect of magnetic field on AOA’s ammonia oxidation capability,its magnetotaxis and heredity were investigated in this *** with control experiment,AOA’s maximum nitrite-N formation rate during the cultivation increased by 56.8%(0.65 mgN/(L·d))with 20 mT magnetic ***,it was testified that AOA possessed a certain ***,results manifested that the enhancement of AOA’s ammonia oxidation capability was not heritable,that is,lost once the magnetic field was ***,the possible mechanism of improving AOA’s ammonia oxidation capability by magnetic field was owing to the promotion of AOA single cells’growth and fission,rather than the enhancement of their ammonia oxidation *** results shed light on the application of AOA and methods to enhance AOA’s ammonia oxidation capability,especially in wastewater treatment processes under certain conditions.

关键词： Ammonia-oxidizing archaeon Ammonia oxidation Magnetic field Magnetotaxis Heredity

Precipitation behavior of 14H-LPSO structure in Mg–12Gd–2Er–1Zn–0.6Zr Alloy

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Rare Metals 2016年第5期35卷 367-373页

作者： Kai wen wen-bo Du Ke liu Zhao-Hui Wang Shu-bo li College of Materials Science and Engineering Beijing University of Technology

The microstructures of as-cast and as-solution Mg–12Gd–2Er–1Zn–0.6Zr alloys were investigated by optical microscopy（OM）, scanning electron microscopy（SEM）, transmission electron microscopy（TEM）, highresolution transmission electron microscopy（HRTEM）X-ray diffraction（XRD） and selected-area electron diffraction（SAED） in the present investigation. The results show that the primary eutectic phase Mg5（Gd, Er, Zn） and some flocculent features are found in the as-cast alloy; the SAED pattern indicates that these flocculent features are the dense areas of stacking faults. The 14H-LPSO structure precipitates in the temperature range of 673–793 K, and the volume fraction of 14H-LPSO structure increases with the extension of heating time; however, there is no precipitation of 14H-LPSO structure when the temperature reaches up to 803 K. In addition, the Mg5（Gd, Er, Zn） phase dissolves gradually along with the precipitation of 14H-LPSO structure.

关键词： Mg–Gd–Er–Zn–Zr alloy Dense stacking faults area Heat treatment Microstructure

Microstructures and mechanical properties of homogenization and isothermal aging Mg–Gd–Er–Zn–Zr alloy

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Rare Metals 2016年第6期35卷 443-449页

作者： Kai wen wen-bo Du Ke liu Zhao-Hui Wang Shu-bo li College of Materials Science and Engineering Beijing University of Technology

The effects of homogenization and isothermal aging treatment on the mechanical properties of Mg-12Gd- 2Er-1Zn-0.6Zr （wt%） alloy were investigated. The precipitated long-period stacking order （LPSO） structure and the aging precipitation sequence of the conditioned alloys were observed and analyzed, respectively. The results indicate that the 14H-LPSO structure occurs after the homogenization treatment and the 131 phase forms after the isothermal aging process. These two independent processes could be controlled by the precipitation temperature range. The significant increase in the elongation of the as-cast alloy after homogenization treatment is attributed to the disappearance of the coarse primary Mgs（Gd, Er, Zn） phase and the presence of the 14H-LPSO structure. The precipitation sequence of the investigated alloy is α-Mg（SSS）/β″（D019）/β′（cbco）/β. Furthermore, the yield tensile strength （YTS） and ultimate tensile strength （UTS） values of the isothermal aging alloy have a great improvement, which could be attributed to the high density of the precipitated β′ phase.

关键词： Magnesium alloys Isothermal aging Mechanical properties Mg-Gd-Er-Zn(Zr) Microstructures

东北老工业基地国企工人组织认同特征及影响因素分析——基于哈尔滨原三大动力企业的调查

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哈尔滨工业大学学报（社会科学版） 2017年第1期19卷 60-67页

作者：尹海洁侯博文秦国丽哈尔滨工业大学人文社科与法学学院哈尔滨150001

选取哈尔滨电机厂(东北老工业基地哈尔滨原三大动力企业)工人作为研究对象,并对其组织认同作量化分析。电机厂工人对本企业组织认同程度较高,但也出现了"对企业情感疏离,奉献精神弱化"的特征。企业中岗位价值感知越强、收入满意度越高以... 详细信息

选取哈尔滨电机厂(东北老工业基地哈尔滨原三大动力企业)工人作为研究对象,并对其组织认同作量化分析。电机厂工人对本企业组织认同程度较高,但也出现了"对企业情感疏离,奉献精神弱化"的特征。企业中岗位价值感知越强、收入满意度越高以及"人际关系"越好的工人,则越呈现出较高的组织认同。建立清晰的工资制度、保障畅通的职业晋升机制以及提供切实有效的"技能培训"等措施,应该成为建构工人对国企归属感和认同感的重要途径。此外,国有企业管理者不仅应对工人生产活动进行精准管理,同时还应树立基于现代"雇佣关系"和中国传统"熟人社会"的管理理念,进而提升国有企业工人的组织认同。

关键词：组织认同东北老工业基地国有企业国企工人

Stochastic Variational Inference-Based Parallel and Online Supervised Topic Model for Large-Scale Text Processing

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Journal of Computer Science & Technology 2018年第5期33卷 1007-1022页

作者： Yang li wen-Zhuo Song bo Yang College of Computer Science and Technology Jilin University Changchun 130012 China Key Laboratory of Symbolic Computation and Knowledge Engineering Ministry of Education Jilin University Changchun 130012 China Aviation University of Air Force Changchun 130062 China

Topic modeling is a mainstream and effective technology to deal with text data, with wide applications in text analysis, natural language, personalized recommendation, computer vision, etc. Among all the known topic models, supervised Latent Dirichlet Allocation （sLDA） is acknowledged as a popular and competitive supervised topic model. How- ever, the gradual increase of the scale of datasets makes sLDA more and more inefficient and time-consuming, and limits its applications in a very narrow range. To solve it, a parallel online sLDA, named PO-sLDA （Parallel and Online sLDA）, is proposed in this study. It uses the stochastic variational inference as the learning method to make the training procedure more rapid and efficient, and a parallel computing mechanism implemented via the MapReduce framework is proposed to promote the capacity of cloud computing and big data processing. The online training capacity supported by PO-sLDA expands the application scope of this approach, making it instrumental for real-life applications with high real-time demand. The validation using two datasets with different sizes shows that the proposed approach has the comparative accuracy as the sLDA and can efficiently accelerate the training procedure. Moreover, its good convergence and online training capacity make it lucrative for the large-scale text data analyzing and processing.

关键词： topic modeling, large-scale text classification, stochastic variational inference, cloud computing online learning

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花键过度磨损原因分析

失效分析与预防 2020年第6期15卷 388-392页

作者：朱孝录胡炜薄文丽李东武北京科技大学北京100083 沃德传动(天津)股份有限公司天津300409

以内外花键磨损为实例,根据磨损断口形貌观察,判定花键齿的磨损主要是由于内外花键轴线不同轴引起。给出花键齿的滑动速率和摩擦功的计算式,分析偏心量、法向力、摩擦因数、齿数等参数对花键磨损的影响。结果表明:内、外花键轴的轴线不... 详细信息

以内外花键磨损为实例,根据磨损断口形貌观察,判定花键齿的磨损主要是由于内外花键轴线不同轴引起。给出花键齿的滑动速率和摩擦功的计算式,分析偏心量、法向力、摩擦因数、齿数等参数对花键磨损的影响。结果表明:内、外花键轴的轴线不同轴是造成花键磨损的主要原因之一;内、外花键轴的轴线不同轴(轴线偏心)使键齿齿面产生滑动;轴线偏心使各键齿齿面的载荷分配不均匀,加速齿面的磨损;防止花键齿的磨损最有效的措施是提高与轴线偏心量有关零件的加工精度和安装精度,尽量减少内外花键的偏心量;提高花键硬度,可以增加花键的磨损寿命。

关键词：失效分析花键微动磨损滑动速率摩擦功