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Correlation of vascular endothelial growth factor to permeability of blood-brain barrier and brain edema during high-altitude exposure

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Neural Regeneration Research 2009年第10期4卷 775-779页

作者： Qiquan zhou Chang'e Liu Jing Wang Yunli Wang bo zhou Department of High Altitude Disease College of High Altitude Military Medicine Third Military Medical University of Chinese PLA Chongqing 400038 China Key Laboratory of High Altitude Medicine Ministry of Education and Key Laboratory of High Altitude Physiology and High Altitude Disease of Chinese PLA Chongqing 400038 China Department of Animal Science College of Basic Medicine Third Military Medical University of Chinese PLA Chongqing 400038 China Department of Pathology and Pathophysiology Chengdu Medical College Chengdu 610083 Sichuan Province China Clinical Laboratory the25 Hospital of Chinese PLA Jiuquan 735000 Gansu Province China

BACKGROUND： Many studies have evaluated the role of vascular endothelial growth factor （VEGF） in traumatic brain edema and hemorrhagic brain edema. OBJECTIVE： To observe the effects of VEGF expression on permeability of the blood-brain barrier （BBB） during high-altitude and hypoxia exposure, and to investigate the correlation between VEGF expression and BBB permeability with regard to Evans blue staining and brain edema during high-altitude exposure. DESIGN, TIME AND SETTING： The randomized, controlled, animal study was performed at the Tanggula Etape, Central Laboratory of Chengdu Medical College, and Central Laboratory of General Hospital of Chengdu Military Area Command of Chinese PLA, China, from July 2003 to November 2004. MATERIALS： Quantitative RT-PCR kit （Sigma, USA）, VEGF ELISA kit （Biosource, USA）, and Evans blue （Jingchun, China） were acquired for this study. METHODS： A total of 180 Wistar rats were equally and randomly assigned to 15 groups： low-altitude （500 m）, middle-altitude （2 880 m）, high-altitude （4 200 m）, super-high-altitude （5 000 m）, 1,3, 5, 7, 9, 11, 13, 15, 17, 19, and 21 days of super high-altitude exposure. Wistar rats were exposed to various altitude gradients to establish a hypoxia model. MAIN OUTCOME MEASURES： Brain water content was calculated according to the wet-to-dry weight ratio. BBB permeability to Evans blue was determined by colorimetric method. VEGF mRNA and protein levels in brain tissues were detected using RT-PCR and double-antibody sandwich ELISA. RESULTS： Brain water content, BBB permeability to Evans blue, and VEGF mRNA and protein levels in brain tissues increased with increasing altitude and prolonged exposure to altitude. The greatest increase was determined on day 9 upon ascending 5 000 m. Simultaneously, VEGF expression positively correlated to BBB permeability of Evans blue and brain water content （r = 0.975, 0.917, P〈 0.01）. CONCLUSION： Increased VEGF protein and mRNA expression was responsible for increased BBB p

关键词： high-altitude blood-brain barrier permeability vascular endothelial growth factor

An adaptive physics-informed deep learning method for pore pressure prediction using seismic data

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Petroleum Science 2024年第2期21卷 885-902页

作者： Xin Zhang Yun-Hu Lu Yan Jin Mian Chen bo zhou State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China College of Artificial Intelligence China University of Petroleum(Beijing)Beijing102249China PetroChina Tarim Oilfield Company KorlaXinjiang841000China

Accurate prediction of formation pore pressure is essential to predict fluid flow and manage hydrocarbon production in petroleum *** deep learning technique has been receiving more interest due to the great potential to deal with pore pressure ***,most of the traditional deep learning models are less efficient to address generalization *** fill this technical gap,in this work,we developed a new adaptive physics-informed deep learning model with high generalization capability to predict pore pressure values directly from seismic ***,the new model,named CGP-NN,consists of a novel parametric features extraction approach(1DCPP),a stacked multilayer gated recurrent model(multilayer GRU),and an adaptive physics-informed loss *** machine training,the developed model can automatically select the optimal physical model to constrain the results for each pore pressure *** CGP-NN model has the best generalization when the physicsrelated metricλ=0.5.A hybrid approach combining Eaton and bowers methods is also proposed to build machine-learnable labels for solving the problem of few *** validate the developed model and methodology,a case study on a complex reservoir in Tarim Basin was further performed to demonstrate the high accuracy on the pore pressure prediction of new wells along with the strong generalization *** adaptive physics-informed deep learning approach presented here has potential application in the prediction of pore pressures coupled with multiple genesis mechanisms using seismic data.

关键词： Pore pressure prediction Seismic data 1D convolution pyramid pooling Adaptive physics-informed loss function High generalization capability

DiastereoselectiveandEnantioselectiveSynthesisof(1S,2S)-2-Ethyl-1-aminocyclopropaneCarboxylicAcid

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Chinese Chemical Letters 2002年第10期13卷 939-941页

作者： Yi bo zhou Jun An MA Li Xin WANG Qi Lin zhou State Key Laboratoratory and Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071

Pd(0) Complex prepared from Pd(dba)(2) and chiral quinolinyl-oxazoline ligand can catalyze alkylation and cyclization reaction of 1, 4-dichlorobut-2-ene 1 with anion of N-(diphenylmethylene)amino acetonitrile 2 to provide (E)-2-ethenyl-1-N-(diphenylmethylene) amino cyclopropane carbonitrile 3 with 100% de and 20% cc. Reduction of (E)-3 by diimide followed by acidic hydrolysis afforded (1S, 2S)-2-ethyl-1-aminocyclopropanecarboxylic acid 9, a natural product coronamic acid.

关键词： Chiral Pd catalyst quinolinyl-oxazoline cyclopropanecarboxylic acid.

Case Report:Recurrent severe vomiting due to hyperthyroidism

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第3期11卷 218-220页

作者： Li-ying CHEN bo zhou zhou-wen CHEN Li-zheng FANG Department of Family Medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China Department of Family Medicine Community Health Services Center in Pengbu Town Hangzhou 310017 China

Thyrotoxicosis may present in many ways;severe vomiting as a prominent symptom of thyrotoxicosis is *** this paper,we report a 24-year-old Chinese male with hyperthyroidism who presented with recurrent severe *** patient had had intermittent vomiting for seven years and had lost approximately 15 kg of *** examinations revealed chronic gastritis and one occasion peptic *** was treated with antacid and proton pump inhibitors,but his symptoms had no *** presenting symptoms suggested hyperthyroidism and were confirmed by laboratory *** a month of propylthiouracil therapy,his symptoms were *** should be noted that hyperthyroidism patients can have unexplained vomiting,and that hyperthyroidism may coexist with peptic ulcer in rare *** of such atypical presentations of hyperthyroidism may help to make a correct diagnosis.

关键词： Vomiting Hyperthyroidism Peptic ulcer

Transformations of N-arylpropiolamides to indoline-2,3-diones and acids via C≡C triple bond oxidative cleavage and C(sp^2)–H functionalization

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Science China Chemistry 2020年第2期63卷 222-227页

作者： Ming-bo zhou Yang Li Xuan-Hui Ouyang Jin-Heng Li Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China Key Laboratory of Chemical Biology&Traditional Chinese Medicine Research(Ministry of Education) Hunan Normal UniversityChangsha 410081China State Key Laboratory of Applied Organic Chemistry Lanzhou University'Lanzhou 730000China

A new palladium-catalyzed oxidative conversion of N-arylpropiolamides and H2O to various indoline-2,3-diones and acids through the C≡C triple bond cleavage and C(sp2)–H functionalization is described,which is promoted by a cooperative action of catalytic CuBr2,2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)and *** method provides a practical tool for transformations of alkynes by means of a C–H functionalization strategy,which enables the formation of one C–C bond and multiple C–O bonds in a single reaction with high substrates compatibility and excellent functional group tolerance.

关键词： alkynes indoline-2,3-diones acids C≡C bond oxidative cleavage C–H functionalization

CMIP5 analysis of the interannual variability of the Pacific SST and its association with the Asian-Pacific oscillation

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Atmospheric and Oceanic Science Letters 2017年第2期10卷 138-145页

作者： zhou bo-Tao XU Ying National Climate Center China Meteorological Administration Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science & Technology

This study analyzed the interannual variability of sea surface temperature （SST） over the Pacific in the historical simulation and under the Representative Concentration Pathways （RCPs, including RCP4.5 and RCPS.5） from 27 models archived in the Coupled Model Intercomparison Project Phase 5 （CMIPS）. Its association with the Asian-Pacific oscillation （APO） was also *** evaluation results showed that the multi-model ensemble mean （MME） and most of the individual models perform well in reproducing the relatively stronger interannual variability of SST over the North Pacific and tropical eastern Pacific. They can also capture reasonably well the observed in-phase and out-of-phase relationships of the APO with the SST in the above two regions, respectively. Under the RCP4.5 and RCPS.5 scenarios, the interannual variability of the SST over the North Pacific and the tropical eastern Pacific is projected by the MME to be weakened during 2050-99 compared to 1950-99. The majority of the CMIP5 models show the same projection as the MME. Besides, the MME projection indicates that the present relationship between the APO and the SST over those two regions would still be dominant under both RCPs. However, considerable discrepancies exist in the changes of the relationships among the individual models.

关键词： Interannual variability Pacific SST CMIPS evaluation projection

Unravelling a solution-based formation of single- crystalline kinked wurtzite nanowires： The case of MnSe

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Nano Research 2017年第7期10卷 2311-2320页

作者： Xinyi Yang bo zhou Chuang Liu Yongming Sui Guanjun Xiao Yingjin wei Xin Wang bo Zou State Key Laboratory of Superhard Materials Jilin University Changchun 130012 China Laboratory of Physics and Technology for Advanced Barteries (Ministry of Education) Jilin University Changchun 130012 China College of Physics Jilin University Changchun 130012 China

The search for a novel strategy to sculpt semiconductor nanowires （NWs） at the atomistic scale is crucial for the development of new paradigms in optics, electronics, and spintronics. Thus far, the fabrication of single-crystalline kinked semiconductor NWs has been achieved mainly through the vapor-liquid-solid growth technique. In this study, we developed a new strategy for sculpting single-crystalline kinked wurtzite （WZ） MnSe NWs by triggering the nonpolar axial-oriented growth, thereby switching--at the atomistic scale---the NW growth orientation along the nonpolar axes in a facile solution-based procedure. This presents substantial challenges owing to the dominant polar c axis growth in the solution-based synthesis of one-dimensional WZ nanocrystals. More significantly, the ability to continuously switch the nonpolar axial-growth orientation allowed us to craft the kinking landscape of types 150°, 120°, 90°, and 60°. A probabilistic analysis of kinked MnSe NWs reveals the correlations of the synergy and interplay between these two sets of nonpolar axial growth-orientation switching, which determine the actual kinked motifs. Furthermore, discriminating the side-facet structures of the kinked NWs significantly strengthened the spatially selected interaction of Au nanoparticles. We envisage that such a facile solution-based strategy can be useful for synthesizing other single-crystalline kinked WZ-type transition-metal dichalcogenide NWs to develop novel functional materials with finely tuned properties.

关键词： kinked nanowires single-crystalline nonpolar axial growth wurtzite MnSe

Promoting effect of ethanol on dewetting transition in the confined region of melittin tetramer

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Nuclear Science and Techniques 2012年第4期23卷 252-256页

作者： REN Xiuping zhou bo WANG Chunlei Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Graduate School of the Chinese Academy of Sciences Beijing 100080 China

To study the influence of ethanol molecules on the melittin tetramer folding,we investigated the dewetting transition of the melittin tetramer immersed in pure water and 8%aqueous ethanol solution(mass fraction) by the molecular dynamics *** found that the marked dewetting transitions occurred inside a nanoscale channel of the melittin tetramer both in pure water and in aqueous ethanol ***,ethanol molecules promoted this dewetting *** attributed this promoting effect to ethanol molecules which prefer to locate at the liquidvapor interface and decrease the liquid-vapor surface *** results provide insight into the effect of ethanol on the water dewetting phenomena.

关键词：乙醇水溶液四聚体蜂毒肽去湿分子动力学模拟密闭质量分数促进效果

Synthesis of (S)-2-(3-Arylacrylamido)-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)ethoxy]phenyl}propanoic Acids

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Chinese Chemical Letters 2005年第10期16卷 1301-1304页

作者： Xin bo zhou Cui Fang LIN Song LI School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Beijing 100850

The synthesis of （S）-2-（3-arylacrylamido）-3-{4-[2-（5-methyl-2-phenyloxazol-4-yl）etho- xy]phenyl}propanoic acids is described. Their structures were confirmed by ^1H-NMR.

关键词： (S)-2-(3-Arylacrylamido)-3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenylpropanoic acids synthesis.