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Prognostic Value of NT-proBNP in Stable Coronary Artery Disease in Chinese Patients after Percutaneous Coronary Intervention in the Drug-eluting Stent Era

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Biomedical and Environmental Sciences 2018年第12期31卷 859-866页

作者： zhao Xue Yan LI Jian Xin TANG Xiao Fang XU Jing Jing SONG Ying JIANG Lin CHEN Jue SONG Lei gao Li Jian gao Zhan QIAO Shu Bin YANG Yue Jin gao Run Lin XU bo yuan Jin Qing State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College

Objective The predictive value of N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with stable coronary artery disease(SCAD) in the drug-eluting stent era is not yet clear. We aimed to evaluate the prognostic value of NT-proBNP in SCAD patients after percutaneous coronary intervention(PCI). Methods We examined 4,293 consecutive SCAD patients who underwent PCI between January 2013 and December 2013 in Fuwai Hospital, China. The primary endpoint was all-cause death. NT-proBNP levels were measured before PCI using Elisa kits(Biomedica, Austria). The indication for PCI was based on the degree of coronary stenosis and evidence of ischemia. Results Among 3,187 SCAD patients with NT-proBNP data, after a 2-year follow-up, NT-proBNP levels were predictive for all-cause death in the SCAD population [area under the receiver operating characteristic curve, 0.768; 95% confidence interval(CI), 0.687-0.849; P < 0.001]. At the optimum cutoff point of 732 pg/mL, the sensitivity and specificity of death was 75.0% and 72.3%, respectively. In a multivariable Cox regression model, the death hazard ratio was 6.43(95% CI, 2.99-13.82; P < 0.001) for patients with NT-proBNP levels ≥ 732 pg/mL, compared with < 732 pg/mL. Conclusion NT-proBNP is a strong predictor of 2-year death with SCAD after PCI in the drug-eluting stent era.

关键词： NT-proBNP Stable coronary disease Death Prognosis Percutaneous coronary intervention

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Biomaterials and regulatory science

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Journal of Materials Science & Technology 2022年第33期128卷 221-227页

作者： Xu Song Zhonglan Tang Wenbo Liu Kuan Chen Jie Liang bo yuan Hai Lin Xiangdong Zhu Yujiang Fan Xinli shi Peng zhao Lei Yang Kai Zhang Antonios G.Mikos Xingdong Zhang Institute of Regulatory Science for Medical Devices Sichuan UniversityChengdu 610064China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China School of Biomedical Engineering Sichuan UniversityChengdu 610064China Center for Medical Device Evaluation National Medical Products AdministrationBeijing 100081China Sichuan Testing Center for Biomaterials and Medical Devices Chengdu 610064China Center for Health Sciences and Engineering School of Health Sciences and Biomedical EngineeringHebei University of TechnologyTianjin 300130China Departments of Bioengineering Chemical and Biomolecular EngineeringRice UniversityHoustonTX 77251USA

The fast development of both biomaterials and regulatory science calls for a convergence,which is addressed in this article via their link through medical products of biomaterials and related safety and efficacy *** updated definition of biomaterials,and concepts of biomaterials-related medical products and so-called medical-grade and implantable materials are firstly *** a brief overview of the concept and history of regulatory science and its assessment of safety and efficacy of medical products,as well as the currently ongoing biomaterials-related regulatory science programs are ***,the opportunities provided by regulatory science for biomaterials as well as challenges on how to develop a biomaterials-based regulatory science system are *** the first article in the field to elucidate the relationship between biomaterials and regulatory science,key take-home messages include(1)biomaterials alone are not medical products;(2)regulatory authorities approve/clear final medical products,not biomaterials;(3)there is no definition/regulation on the so-called medical-grade or implantable materials;and(4)safety and efficacy refer to final medical products,not biomaterials alone.

关键词： Biomaterials Medical products Regulatory science Safety Efficacy

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Property evolution and service life prediction of novel metallic materials for future lunar bases

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Rare Metals 2024年第10期43卷 5318-5331页

作者： Sen-Kuan Meng Rui-Song Zhu Hong-Liang Zheng Tong gao shi-Hao Jiang Wen-Hao Wang Shu-Hao Zhang Zi-yuan zhao Xuan Ge Wei-Min Wang Li-Na Hu Zheng Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China Department of Chemistry and Bioscience Aalborg University9220AalborgDenmark

While lunar bases have been a focus of development in recent years,the complex and extreme environment of the lunar surface remains a considerable challenge for lunar *** those on Earth,lunar day and night temperature variations cause the properties of materials,especially metallic materials,to evolve in completely different *** this study,we investigated the property evolution of nine typical highperformance metallic materials using laboratory simulations of the extremely long-period lunar temperature *** lunation treatment improves the properties of all metallic materials,the microscopic mechanisms vary for amorphous and crystalline alloys with different *** treatment reduces both the loosely packed regions and heterogeneity in amorphous alloys while causing significant phase changes in crystalline ***,a conservative prediction of the service life of metallic materials on lunar bases is provided based on analyzing microplastic events,followed by the practical material selection recommendations in various lunar application scenarios.

关键词： Metallic glass Property evolution Lunar exploration Metallic material

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2021年5月21日云南漾濞M_(S)6.4地震序列重新定位、震源机制及应力场反演

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地球物理学报 2022年第3期65卷 1006-1020页

作者：赵博高原马延路中国地震台网中心北京100045 中国地震局地震预测研究所(地震预测重点实验室) 北京100036

2021年5月21日云南省大理州漾濞县发生了M_(S)6.4地震,引起了社会的极大关注.本研究利用双差定位法对云南漾濞M_(S)6.4地震序列(2021年5月18—24日)进行了重新定位,获得331个地震重新定位结果,主震震源位置为(99.869°E,25.689°N,8.8 k... 详细信息

2021年5月21日云南省大理州漾濞县发生了M_(S)6.4地震,引起了社会的极大关注.本研究利用双差定位法对云南漾濞M_(S)6.4地震序列(2021年5月18—24日)进行了重新定位,获得331个地震重新定位结果,主震震源位置为(99.869°E,25.689°N,8.8 km).利用远场Rayleigh面波振幅的频谱陷波相,通过理论地震图的波形拟合,测定了主震震源深度为7.5 km.由于使用了远场数据,基本避免了区域速度模型对深度定位产生的影响,确定的震源深度准确度优于传统的走时定位.本文使用云南省区域地震台网波形数据,对主震及29个M_(L)3.5以上余震进行震源机制反演.反演结果表明,主震为一次走滑型地震,震源机制为节面I走向143°/倾角80°/滑动角-165°,节面II走向50°/倾角75°/滑动角-10°,矩震级为M_(W)6.0.根据余震序列分布情况,推断节面I为发震断层面.利用地震序列震源机制解的力轴数据,反演得到震源区的主压应力方向为近NS向(7°).本文研究表明,震源机制反演得到的主压应力方向与上地壳各向异性揭示的主压应力方向有高度的一致性.

关键词：漾濞地震双差定位发震断裂震源机制震源深度面波振幅谱应力

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Survey of design and security evaluation of authenticated encryption algorithms in the CAESAR competition

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Frontiers of Information Technology & Electronic Engineering 2018年第12期19卷 1475-1499页

作者： Fan ZHANG Zi-yuan LIANG bo-lin YANG Xin-jie zhao shi-ze GUO Kui REN College of Information Science and Electronic Engineering Zhejiang University Institute of Cyberspace Research Zhejiang University State Key Laboratory of Cryptology Alibaba-Zhejiang University Joint Institute of Frontier Technologies Institute of North Electronic Equipment

The Competition for Authenticated Encryption: Security, Applicability, and Robustness(CAESAR)supported by the National Institute of Standards and Technology(NIST) is an ongoing project calling for submissions of authenticated encryption(AE) schemes. The competition itself aims at enhancing both the design of AE schemes and related analysis. The design goal is to pursue new AE schemes that are more secure than advanced encryption standard with Galois/counter mode(AES-GCM) and can simultaneously achieve three design aspects: security,applicability, and robustness. The competition has a total of three rounds and the last round is approaching the end in 2018. In this survey paper, we first introduce the requirements of the proposed design and the progress of candidate screening in the CAESAR competition. Second, the candidate AE schemes in the final round are classified according to their design structures and encryption modes. Third, comprehensive performance and security evaluations are conducted on these candidates. Finally, the research trends of design and analysis of AE for the future are discussed.

关键词： CAESAR competition Authenticated cipher Block cipher Stream cipher Hash function Security evaluation

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Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis

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Engineering 2024年第7期38卷 144-154页

作者： Jun-Su Zhou Long Cheng yuan gao Zhan-Peng Ge Bin Zhou Jing-Ya Li Jin-Xin zhao Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

Four new norditerpenoid heterodimers with different dimerization patterns-namely,trigofragiloids A-C(denoted as compounds 1-3)and(+)-and(-)-trigofragiloid D(compound 4)-and three new phenanthrenone norditerpenoids-namely,trigofragiloids E-G(compounds 5-7)-were isolated from Trigonostemon *** 1 and 2 feature a novel heterodimeric carbon skeleton formed by the conjugation of a tetra-norditerpenoid and an ennea-norditerpenoid;they have been identified as class 2 atropisomers by means of quantum chemical *** 3 is an unprecedented phenylpropanoid-norditerpenoid adduct with a new dimerization ***(+)-and(-)-4 are the first example of S-shaped 1,4-dioxane-fused norditerpenoid *** by the structure elucidation of compound 4,two co-occurring analogues,actephilol A and epiactephilol A,were structurally revised as a pair of geometrical isomers and were identified as two pairs of enantiomers,(+)-and(-)-8 and(+)-and(-)-9,*** structures were characterized using a combined ***,compound 7 exhibits remarkable adenosine triphosphate-citrate lyase(ACLY)inhibition with a halfmaximal inhibition concentration(IC50)value of(0.46±0.11)lmol·L^(-1),as active as the positive control BMS-303141,and a molecular docking study offers deep insight into the interaction between compound 7 and ACLY.

关键词： Norditerpenoid heterodimer Trigonostemon fragilis Euphorbiaceae Trigofragiloid Structural revision Adenosine triphosphate-citrate lyase(ACLY) inhibitory activity

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Precise calibration of cavity forward and reflected signals using low-level radio-frequency system

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Nuclear Science and Techniques 2022年第1期33卷 35-43页

作者： Jin-Ying Ma Feng Qiu Long-bo shi Zheng-Long Zhu Tian-Cai Jiang Zong-Heng Xue Ke-An Jin Qi Chen Cheng-Ye Xu Xing-Hao Ding Zheng gao Lie-Peng Sun Gui-Rong Huang yuan He Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Precise measurements of the cavity forward(Vf)and reflected signals(Vr)are essential for characterizing other key parameters such as the cavity detuning and forward *** practice,it is challenging to measure V_(f) and V_(r) precisely because of cross talk between the forward and reflected channels(e.g.,coupling between the cavity reflected and forward signals in a directional coupler with limited directivity).For DESY,a method based on the cavity differential equation was proposed to precisely calibrate the actual V_(f) and V_(r).In this study,we verified the validity and practicability of this approach for the Chinese ADS front-end demo superconducting linac(CAFe)facility at the Institute of Modern Physics and a compact energy recovery linac(cERL)test machine at *** the CAFe facility,we successfully calibrated the actual V_(f) signal using this *** result demonstrated that the directivity of directional couplers might seriously affect the accuracy of V_(f) *** the cERL facility,we calibrated the Lorentz force detuning(LFD)using the actual *** study confirmed that the precise calibration of V_(f) significantly improves the accuracy of the cavity LFD measurement.

关键词： Forward and reflected signals Measurement Calibration

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汶川M_S8.0地震及余震序列重新定位

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地震 2011年第2期31卷 1-10页

作者：赵博石玉涛高原中国地震局地震预测研究所北京100036

从2008年5月12日汶川8.0级地震发震时刻起到2008年12月31日,四川省及其周边省区布设的区域台网、水库台网以及流动台共记录到10 000余次余震序列（M≥2.0）。我们采用双差定位法对主震及余震序列进行重新定位,得到7 000多个地震的重新... 详细信息

从2008年5月12日汶川8.0级地震发震时刻起到2008年12月31日,四川省及其周边省区布设的区域台网、水库台网以及流动台共记录到10 000余次余震序列（M≥2.0）。我们采用双差定位法对主震及余震序列进行重新定位,得到7 000多个地震的重新定位结果。结果表明,余震分布带长约350 km。在西南部,余震沿龙门山后山、中央以及前山断裂分布;在中段,余震主要沿龙门山中央断裂分布;在北段,余震横穿青川—平武断裂分布。余震震源深度主要分布在10~20 km,重新定位后的平均震源深度为13 km。

关键词：双差定位法汶川地震余震序列龙门山断裂带

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用双差定位结果分析华北地区的地震活动

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地震 2013年第1期33卷 12-21页

作者：赵博高原石玉涛中国地震台网中心北京100045 中国地震局地震预测研究所北京100036

华北地区北部是阴山—燕山隆起区、华北平原和太行山隆起的交界处,区域内地震活跃,北部有张家口—渤海地震活动带(张渤带),西邻山西地震活动带。本研究采用双差定位法对华北地区2006—2009年发生的地震进行重新定位,结果显示,近年来华... 详细信息

华北地区北部是阴山—燕山隆起区、华北平原和太行山隆起的交界处,区域内地震活跃,北部有张家口—渤海地震活动带(张渤带),西邻山西地震活动带。本研究采用双差定位法对华北地区2006—2009年发生的地震进行重新定位,结果显示,近年来华北地区的地震主要集中在北部的张渤带上,总体呈WNW向分布。震源深度主要集中在0～20km的中上地壳,占地震总数的96.3%,有大约57.5%的地震分布在10km以上的地壳内。张渤带东部的唐山地区是该地震带上地震最密集的地区,地震分布与区域内的断层有密切关系。华北平原中南部的邢台地区也是地震相对较密集的区域,定位结果显示,邢台地区的新河断裂可能深达Moho面,在该断裂的下方可能存在速度异常体,把邢台地区西南部的地震活动从空间上隔离成上下两部分。沿新河断裂的地震分布出现异常,在深度10km处,地震分布由北东向西南逐渐与上部的地震分离,震源深度逐渐加深,最深可达30km左右。

关键词：地震活动双差定位法断裂张家口渤海地震带华北地区

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Petrogenesis of Early Cretaceous Pandian high-Mg diorites from the eastern North China Craton within an intracontinental setting:Implications for the skarn Fe mineralization

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Journal of Earth Science 2024年

作者： Si-yuan Li Chao Fu Qi-Wei Feng Xiao-bo zhao Zhi-Cai Dang Kang-Kang Xu Ming-bo gao Ji-Lei gao Zhuang Duan Ming Ma Tianjin Center China Geological Survey (North China Center for Geoscience Innovation) Shandong Engineering Research Center of High-Grade Iron Deposits Exploration and Exploitation China University of Geosciences (Beijing) No.1 Institute of Geology and Mineral Resources of Shandong Province Geological Exploration Institute of Shandong Zhengyuan China Metallurgical Geology Bureau Shandong Provincial Bureau of Geology & Mineral Resources Institute of Geophysical and Geochemical Exploration Chinese Academy of Geological Sciences

High-magnesium andesitic rocks （HMAs） were initially interpreted to have formed via interaction of slab melt with mantle in arc ***,high-magnesium diorites （HMDs,analogs of HMAs）have been recognized can be formed in intracontinental *** of the HMDs producedsignificant Fe skarn *** genesis of HMDs and how they earn high Fe mineralization fertilities remain *** Pandian HMDs,located in Luxi Block,eastern North China Craton（NCC）,formed in continental interior and show a close spatiotemporal and genetic relationship to Fe skarn *** contribution carried out a comprehensive geochemical study on the Pandian HMDs to constrain the genesis of HMDs and further shed light on the key factors leading to their high Feskarn mineralization *** rocks show high Mg#values （55–80）,andesitic compositions （SiO2:55.3–66.2 wt%）,and arc-like *** Pandian HMDs possess (87Sr/86Sr)iof0.70720–0.70737,εNd（t） values of-11.8–-12.6,(206Pb/204Pb)iof 17.3706–17.4575,(207Pb/204Pb)iof15.3945–15.4440,and (208Pb/204Pb)iof 36.6606–*** notably distinct geochemicalcharacteristics between the Pandian HMDs and ancient lower crust in the NCC make it unlikely that the Pandian HMDs were sourced from the ***,The chemical characteristics of Pandian HMDs are akin to the proximal and contemporaneous mantle-derived Ji’nan *** presentresults,combined with geological analysis,reveal that Pandian HMDs were most likely primarily derived from an ancient sub-continental lithospheric mantle （SCLM） experienced metasomatism related to the subducted Paleo-Pacific slab-released *** higher La/Sm and Hf/Sm ratios and more enriched radiogenic Sr-Pb isotopes of Pandian HMDs relative to Ji’nan gabbro indicate crustalmaterial involvement during magma *** of crustal material assimilation,based on Sr-Nd isotopes,suggests parental melts of the Pandian HMDs assimilated about 20%Archean TTG gneisses and 60%Ordovicia

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