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上海汽车 2005年第9期 7-11页

作者：倪波盖洛普咨询有限公司

近年来中国汽车市场起起落落,导致业界表现出一种审慎甚至悲观的情绪。文章用大量调查的数据表明,中国的车市前景依然乐观。指出未来数年农村地区有望成为私家车市场新的增长点,而性价比、品牌凝聚力将成为未来汽车市场领导者突出的核... 详细信息

近年来中国汽车市场起起落落,导致业界表现出一种审慎甚至悲观的情绪。文章用大量调查的数据表明,中国的车市前景依然乐观。指出未来数年农村地区有望成为私家车市场新的增长点,而性价比、品牌凝聚力将成为未来汽车市场领导者突出的核心竞争优势。

关键词：市场研究汽车展望市场发展前景汽车市场中国农村地区竞争优势数据表增长点

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基于流形的特定人体组织轮廓的医学图像分割

黄冈职业技术学院学报 2012年第1期14卷 90-92页

作者：倪波黄石理工学院计算机学院湖北黄石43500 武汉大学计算机学院湖北武汉430072

图像分割是医学图像分析中的重要问题。以前的基于模型的分割算法都是从不特定人群的统计出模型的先验知识。文章提出了一种新的全自动医学图像分割算法.这种方法旨在提出一种基于特定人先验轮廓模型。该模型通过基于流形的学习方法,从... 详细信息

图像分割是医学图像分析中的重要问题。以前的基于模型的分割算法都是从不特定人群的统计出模型的先验知识。文章提出了一种新的全自动医学图像分割算法.这种方法旨在提出一种基于特定人先验轮廓模型。该模型通过基于流形的学习方法,从而达到更加准确的分割效果。

关键词：图像分割轮廓模型流形学习

Thermal transport in composition graded silicene/germanene heterostructures

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Chinese Physics B 2024年第4期33卷 49-54页

作者：曹增强王超宇张宏岗游波倪宇翔 School of Physical Science and Technology Southwest Jiaotong UniversityChengdu 610031China Department of Materials Science and the Advanced Coatings Research Center of the China Educational Ministry Fudan UniversityShanghai 200433China Key Laboratory of High Performance Scientific Computation School of ScienceXihua UniversityChengdu 610039China

Through equilibrium and non-equilibrium molecular dynamics simulations,we have demonstrated the inhibitory effect of composition graded interface on thermal transport behavior in lateral ***,we investigated the influence of composition gradient length and heterogeneous particles at the silicene/germanene(SIL/GER)heterostructure interface on heat *** results indicate that composition graded interface at the interface diminishes the thermal conductivity of the heterostructure,with a further reduction observed as the length increases,while the effect of the heterogeneous particles can be considered *** unveil the influence of composition graded interface on thermal transport,we conducted phonon analysis and identified the presence of phonon localization within the interface composition graded *** these analyses,we have determined that the decrease in thermal conductivity is correlated with phonon localization within the heterostructure,where a stronger degree of phonon localization signifies poorer thermal conductivity in the *** research findings not only contribute to understanding the impact of interface gradient-induced phonon localization on thermal transport but also offer insights into the modulation of thermal conductivity in heterostructures.

关键词： composition graded interface thermal transport phonon localization molecular dynamics

可膨胀石墨/聚氨酯弹性体复合材料的制备及性能研究

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山东化工 2018年第14期47卷 14-15页

作者：倪波太原工业学院材料工程系山西太原030008

研究了可膨胀石墨(EG)添加量、粒径对聚氨酯弹性体(PUE)各项性能的影响,对其阻燃性能、力学性能、热稳定性进行了探讨。结果表明EG能够有效改善PUE的阻燃性能,随着EG含量增加或者粒径增大,其氧指数都随之提高。特别是当粒径为50目的可... 详细信息

研究了可膨胀石墨(EG)添加量、粒径对聚氨酯弹性体(PUE)各项性能的影响,对其阻燃性能、力学性能、热稳定性进行了探讨。结果表明EG能够有效改善PUE的阻燃性能,随着EG含量增加或者粒径增大,其氧指数都随之提高。特别是当粒径为50目的可膨胀石墨添加量为15%时,其极限氧指数可达27.0%;并且,EG的添加均可以提高复合材料的热稳定性。

关键词：聚氨酯弹性体可膨胀石墨阻燃性能热稳定性

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情报价值与情报增值分析

图书情报工作 1999年第6期43卷 3-8页

作者：朱庆华倪波南京大学信息管理系南京210093

从情报价值的概念出发 ,讨论情报价值的分类及特性 ,分析情报价值与价格的构成及关系 ,并对情报增值的概念、途径和条件进行系统探讨。

关键词：情报价值情报增值情报价格情报学

Enzalutamide and olaparib synergistically suppress castration-resistant prostate cancer progression by promoting apoptosis through inhibiting nonhomologous end joining pathway

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Asian Journal of Andrology 2023年第6期25卷 687-694页

作者： Hui-Yu Dong Pan Zang Mei-Ling Bao Tian-Ren Zhou Chen-bo ni Lei Ding Xu-Song Zhao Jie Li Chao Liang Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

Recent studies revealed the relationship among homologous recombination repair(HRR),androgen receptor(AR),and poly(adenosine diphosphate-ribose)polymerase(PARP);however,the synergy between anti-androgen enzalutamide(ENZ)and PARP inhibitor olaparib(OLA)remains ***,we showed that the synergistic effect of ENZ and OLA significantly reduced proliferation and induced apoptosis in AR-positive prostate cancer cell ***-generation sequencing followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed the significant effects of ENZ plus OLA on nonhomologous end joining(NHEJ)and apoptosis *** combined with OLA synergistically inhibited the NHEJ pathway by repressing DNA-dependent protein kinase catalytic subunit(DNA-PKcs)and X-ray repair cross complementing 4(XRCC4).Moreover,our data showed that ENZ could enhance the response of prostate cancer cells to the combination therapy by reversing the anti-apoptotic effect of OLA through the downregulation of anti-apoptotic gene insulin-like growth factor 1 receptor(IGF1R)and the upregulation of pro-apoptotic gene death-associated protein kinase 1(DAPK1).Collectively,our results suggested that ENZ combined with OLA can promote prostate cancer cell apoptosis by multiple pathways other than inducing HRR defects,providing evidence for the combined use of ENZ and OLA in prostate cancer regardless of HRR gene mutation status.

关键词： apoptosis enzalutamide nonhomologous end joining olaparib prostate cancer

Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-Yong Hou ni-Yuan Zhang Lu Wang Mei-Yu Lv Xiang-Peng Li Peng Zhang Yue-Ze Wang Lei Shen Xiu-Hai Wu bo Fu Peng-Yu Guo Zi-Qi Wang Dong-Bing Cheng Hao Wang Wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University Department of Urology Harbin Medical University Cancer Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like ***, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy

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面积管长比法划分汇水面积的探讨

中国给水排水 2006年第8期22卷 51-54页

作者：施建刚蔡波妮中交第三航务工程勘察设计院上海200032

提出了雨水系统设计计算中划分汇水面积的新方法——面积管长比法(亦称“树分法”),即将汇水面积按管长分配的方法。通过绘制汇流等时线图模拟了实际雨水的汇水情形并以此为参照,分析了面积管长比法与传统汇水面积划分法及“汇流等时线... 详细信息

提出了雨水系统设计计算中划分汇水面积的新方法——面积管长比法(亦称“树分法”),即将汇水面积按管长分配的方法。通过绘制汇流等时线图模拟了实际雨水的汇水情形并以此为参照,分析了面积管长比法与传统汇水面积划分法及“汇流等时线法”的异同和优缺点。

关键词：雨水系统设计面积管长比汇水面积

Modal Vibration Control of Cantilever Plates

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Modal Vibration Control of Cantilever Plates

基于稀疏特征竞争和形状相似性的超声图像序列分割方法

第二十九届中国控制会议

作者： HU Chao,ni bo,GUO Wang School of Aerospace Engineering and Applied Mechanics,Tongji University,Shanghai 200092,P.R.China

Applying theory of thin plates and Hamilton formulism,the mode vibration control of cantilever plates was investigated.a solution of cantilever plate vibration was *** equations of propagation mode of plates were deduced from eigenfunction expansion *** mode control was applied to study the active vibration control of the strip plates,and the control effect was compared to the Euler-Bernoulli *** last,the results were analyzed and discussed.

关键词： Cantilever plate Hamilton formulism Dispersion equations Vibration control Elastic wave

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中国科学：信息科学 2017年第6期47卷 752-770页

作者：倪波蔡贤涛邓丹君袁涌湖北理工学院计算机学院黄石435003 武汉大学计算机学院武汉430072

从超声图像序列中精确地分割出目标区域对于提高基于超声图像引导的计算机辅助治疗的效果具有重要的意义.活动轮廓模型被广泛地应用于医学图像的分割,但是超声图像固有的低信噪比、灰度分布不均匀等特点导致活动轮廓容易搜索到错误的区... 详细信息

从超声图像序列中精确地分割出目标区域对于提高基于超声图像引导的计算机辅助治疗的效果具有重要的意义.活动轮廓模型被广泛地应用于医学图像的分割,但是超声图像固有的低信噪比、灰度分布不均匀等特点导致活动轮廓容易搜索到错误的区域.为此,学者们提出了不同的目标特征或形状先验知识来约束活动轮廓的演化.目前,大多数目标图像特征的工作仅限于提取目标区域信息的特征,目标形状先验也需要通过对大量训练样本中的目标形状进行学习,而且训练样本中形状是否能足够描述分割目标的形状信息也是值得怀疑的.本文提出了一种基于稀疏特征竞争和形状相似性的超声图像序列分割方法.该方法首先利用稀疏表达理论分别构建目标和背景的特征字典,并根据目标和背景特征字典的重构误差构建一种基于稀疏特征竞争的目标搜索策略,从而提高活动轮廓搜索真实边缘的鲁棒性.然后,对图像序列中目标形状的相似性进行建模,并证明了目标形状的变化符合低秩属性,该属性可看作是对图像序列中目标形状的先验知识进行无监督学习.为了验证该方法的性能,本文采用临床的超声图像序列作为训练和测试集合,并与其他3种典型的分割方法在同一测试集合下进行比较.实验结果显示,针对超声图像中出现的边缘模糊、缺失等缺点,该方法提供了更准确和鲁棒的分割结果,从而提高了计算机辅助治疗的效率和效果.

关键词：超声图像序列分割活动轮廓模型稀疏特征竞争形状相似性