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Carbon Energy 2024年第8期6卷 122-133页

作者： Jian‐Zhao Peng Yin‐Long Li Yao‐Ti Cheng Fu‐Zhi Li bo Cao Qing Wang Xian Yue Guo‐Tao lai Yang‐Gang Wang Jun Gu Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdongChina Institute for Catalysis Hokkaido UniversitySapporoJapan

Metal–N–C single‐atom catalysts,mostly prepared from pyrolysis of metalorganic precursors,are widely used in heterogeneous *** metal sites with diverse local structures coexist in this type of material and it is challenging to characterize the local structure,a reliable structure–property relationship is difficult to *** macrocyclic complexes adsorbed on carbon support are well‐defined models to mimic the singleatom ***–N_(4)site with four electroneutral pyridine‐type ligands embedded in a graphene layer is the most commonly proposed structure of the active site of single‐atom catalysts,but its molecular counterpart has not been *** this work,we synthesized the conjugated macrocyclic complexes with a metal center(Co,Fe,or Ni)coordinated with four electroneutral pyridinic ligands as model catalysts for CO_(2)*** comparison,the complexes with anionic quadri‐pyridine macrocyclic ligand were also *** Co complex with the electroneutral ligand expressed a turnover frequency of CO formation more than an order of magnitude higher than that of the Co complex with the anionic *** ab initio molecular dynamics simulations based on the well‐defined structures of the model catalysts indicate that the Co complex with the electroneutral ligand possesses a stronger ability to mediate electron transfer from carbon to CO_(2).

关键词： ab initio molecular dynamics CO_(2)reduction electrocatalysis model catalyst single‐atom catalyst

Inhibition of c-Jun N-terminal Kinase Signaling Pathway Alleviates Lipopolysaccharide-induced Acute Respiratory Distress Syndrome in Rats

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Chinese Medical Journal 2016年第14期129卷 1719-1724页

作者： Jian-bo lai Chun-Fang Qiu Chuan-Xi Chen Min-Ying Chen Juan Chen Xiang-Dong Guan Bin Ouyang Department of Critical Care Medicine First Affiliated Hospital of Sun Yat-Sen University Guangzhou Guangdong 510080 China

Background： An acute respiratory distress syndrome （ARDS） is still one of the major challenges in critically ill patients. This study aimed to investigate the effect of inhibiting c-Jun N-terminal kinase （JNK） on ARDS in a lipopolysaccharide （LPS）-induced ARDS rat model. Methods： Thirty-six rats were randomized into three groups： control, LPS, and LPS ＋ JNK inhibitor Rats were sacrificed 8 h alter LPS treatment. The lung edema was observed by measuring the wet-to-dry weight （W/D） ratio of the lung. The severity of ptdmonary inflammation was observed by measuring myeloperoxidase （MPO） activity of lung tissue. Moreover, the neutrophils in bronchoalveolar lavage fluid （BALF） were cotinted to observe the airway inflammation. In addition, lung collagen accumulation was quantified by Sircol Collagen Assay. At the same time, the pulmonary histologic examination was perlbrmed, and lung injury score was achieved in all three groups. Results： MPO activity in lung tissue was found increased in rats treated with LPS comparing with that in control （I.26 ＋ 0.15 U in LPS vs. 0.77 ± 0.27 U in control, P 〈 0.05）. Inhibiting ,INK attenuated LPS-induced MPO activity upregulation （0.52 ± 0. 12 U in LPS ＋ JNK inhibitor vs. 1.26 ± 0.15 U in LPS, P 〈 0.05）. Neutrophils in BALF were also found to be increased with LPS treatment, and inhibiting ,INK attenuated LPS-induced neutrophils increase in BALF （255.0 ± 164.4 in LPS vs. 53 （44.5-103） in control vs. 127.0 ± 44.3 in LPS JNK inhibitor, P 〈 0.05）. At the same time, the lung injury score showed a reduction in LPS ＋ JNK inhibitor group comparing with that in LPS group （ 13.42 ± 4.82 vs. 7.00 ± 1.83, P 0.001 ）. However, the lung W/D ratio and the collagen in BALF did not show any difl＇erences between LPS and LPS ＋ JNK inhibitor ***： Inhibiting JNK alleviated LPS-induced acute lung inflammation and had no effects on pulmonary edema and fibrosis..INK inhibitor might be a potential therapeutic medication in ARDS, in the context o

关键词： Acute Respiratory Distress Syndrome: c-Jun N-terminal Kinase Inhibitor Lung lnflalnmation C14HsN20

Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： Qing Tang Xiao-Yong Dai Qiang Lin Zhi-Peng Ling Yi-Kun Hao Tian-Xi Zhu Ji-Hui Zhang Yi-bo Hou Yao-Lan Li lai-Qiang Huang Jing-Hao Wang Guo-Cai Wang Yu-bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health Engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum *** 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring *** 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of *** 4 is the second example of c-22-nor yuzurimine-type *** structures and absolute configurations were elucidated by HRESIMS,NMR spectroscopic analyses,EcD calculations,and single-crystal X-ray ***,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma

Supercoiled DNA Minicircles under Double-strand Breaks

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Chinese Journal of Polymer Science 2024年第9期42卷 1353-1359,I0007页

作者： Ye-Peng Qiao Chun-lai Ren National Laboratory of Solid State Microstructures and Department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China

Understanding how supercoiled DNA releases intramolecular stress is essential for its functional ***,the molecular mechanism underlying the relaxation process remains insufficiently *** we employed MD simulations based on the oxDNA2 model to investigate the relaxation process of a 336-base pair supercoiled minicircular DNA under double-strand breaks with two fixed *** simulations show that the conformational changes in the DNA occur continuously,with intramolecular stress release happening abruptly only when the DNA chain traverses the breakage *** relaxation process is influenced not only by the separation distance between the fixed ends but also their ***,we observe an inhibitory effect on the relaxation characterized by small angles,where short terminal loops impede DNA conformational adjustments,preserving the supercoiled *** findings elucidate the intricate interplay between DNA conformational change,DNA motion and intramolecular stress release,shedding light on the mechanisms governing the relaxation of supercoiled DNA at the molecular level.

关键词： Supercoiled DNA DNA minicircle DNA relaxation oxDNA model MD simulation

Preparation of Fe-As alloys by mechanical alloying and vacuum hot-pressed sintering:microstructure evolution,mechanical properties,and mechanisms

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Rare Metals 2024年第8期43卷 3876-3892页

作者： Fei Chai Fei-Ping Zhao Zhan Hu Shi-Yi Wen Ben-Hammouda Samia Ze-Lin Fu Xin-Ting lai Yan-Jie Liang Xiao-bo Min Li-Yuan Chai School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control&Treatment of Heavy Metal Pollution Institute of Environmental EngineeringCentral South UniversityChangsha 410083HunanChin State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Department of Building Civiland Environmental EngineeringConcordia UniversityMontreal H3G 1M8Canada

Arsenic materials have attracted great attention due to their unique ***,research concerning iron-arsenic(Fe-As) alloys is very scarce due to the volatility of As at low temperature and the high melting point of ***,a new Fe-As alloy was obtained by mechanical alloying(MA) followed by vacuum hot-pressed sintering(VHPS).Moreover,a systematic study was carried out on the microstructural evolution,phase composition,leaching toxicity of As,and physical and mechanical properties of Fe-As alloys with varying weight fractions of As(20%,25%,30%,35%,45%,55%,65%,and 75%).The results showed that pre-alloyed metallic powders(PAMPs) have a fine grain size and specific supersaturated solid solution after MA,which could effectively improve the mechanical properties of Fe-As alloys by VHPS.A high density(> 7.350 g·cm^(-3)),low toxicity,and excellent mechanical properties could be obtained for FeAs alloys sintered via VHPS by adding an appropriate amount of As,which is more valuable than commercial Fe-As *** Fe-25% As alloy with low toxicity and a relatively high density(7.635 g·cm^(-3)) provides an ultra-high compressive strength(1989.19 MPa),while the Fe-65% As alloy owns the maximum Vickers hardness(HVo.5 899.41).After leaching by the toxicity characteristic leaching procedure(TCLP),these alloys could still maintain good mechanical performance,and the strengthening mechanisms of Fe-As alloys before and after leaching were *** in the grain size,micro structure,and phase distribution induced significant differences in the compressive strength and hardness.

关键词： Mechanical alloying Vacuum hot-pressed sintering High-pressure Arsenic-iron alloys Mechanical properties

基于判决反馈的 OFDM 载波频率同步环路

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电子与信息学报 2005年第11期27卷 1710-1713页

作者：郑来波胡健栋北京邮电大学电信工程学院

对OFDM 系统中一种基于接收时域信号重构的载波频率盲估计算法进行了进一步的研究,分析了在这种方法中影响估计精度的4个方面的因素。为了减少载波频率估计的剩余误差,通过在频率补偿时增加反馈因子,提出了一种基于判决反馈的载波频率... 详细信息

对OFDM 系统中一种基于接收时域信号重构的载波频率盲估计算法进行了进一步的研究,分析了在这种方法中影响估计精度的4个方面的因素。为了减少载波频率估计的剩余误差,通过在频率补偿时增加反馈因子,提出了一种基于判决反馈的载波频率同步环路结构。通过调整同步环路的环路增益,可以获得更好的频率跟踪性能。如果信噪比达到9dB,即使存在较大的频率漂移,剩余频偏也被限制在子载波间隔的1%以内。

关键词： OFDM系统载波频率偏移判决反馈跟踪多径信道

基于信号重构的OFDM频偏跟踪算法的跟踪范围

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北京邮电大学学报 2005年第2期28卷 80-83页

作者：郑来波胡健栋北京邮电大学电信工程学院

对多径信道下的一种基于时域接收信号重构的正交频分复用系统频偏跟踪算法的跟踪范围进行了进一步的研究,发现这种算法的跟踪范围不是固定不变的.分析表明,影响时域接收信号重构准确性和跟踪范围的主要因素是判决误差,而子载波调制方式... 详细信息

对多径信道下的一种基于时域接收信号重构的正交频分复用系统频偏跟踪算法的跟踪范围进行了进一步的研究,发现这种算法的跟踪范围不是固定不变的.分析表明,影响时域接收信号重构准确性和跟踪范围的主要因素是判决误差,而子载波调制方式、子载波数目以及加性高斯白噪声和信道估计误差都对判决误差有影响,因而也都影响到跟踪范围.通过仿真,得出了子载波的调制方式和子载波的数目是影响频偏跟踪范围的主要因素的结论,并确定了子载波使用二进制调相和16QAM调制的情况下对应于不同子载波数目的频偏跟踪范围.

关键词：正交频分复用系统载波频率偏移频偏跟踪

OFDM系统中基于导符号和判决数据的频率跟踪环路

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电子学报 2006年第1期34卷 127-130页

作者：郑来波胡健栋山东大学信息科学与工程学院山东济南250100 北京邮电大学电信工程学院北京100876

在相干正交频分复用(OFDM)系统中为跟踪多径信道的实时变化通常在时频网格上插入导符号来进行信道估计.对利用这些导符号结合判决数据进行频率跟踪的算法作了进一步的研究.在时域和频域都重新推导了频偏的估计结果,经过合理近似,得到了... 详细信息

在相干正交频分复用(OFDM)系统中为跟踪多径信道的实时变化通常在时频网格上插入导符号来进行信道估计.对利用这些导符号结合判决数据进行频率跟踪的算法作了进一步的研究.在时域和频域都重新推导了频偏的估计结果,经过合理近似,得到了时域最大似然估计的近似解;在频域推导了另一种形式的似然函数,得出了最大似然估计的解析表达式.新的频率跟踪算法降低了计算量,提高了频率同步的精确度.

关键词： OFDM系统载波频率偏移最大似然跟踪

Recent progress on fabrication, spectroscopy properties, and device applications in Sn-doped CdS micro-nano structures

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Journal of Semiconductors 2024年第9期45卷 7-27页

作者： bo Cao Ye Tian Huan Fei Wen Hao Guo Xiaoyu Wu Liangjie Li Zhenrong Zhang lai Liu Qiang Zhu Jun Tang Jun Liu State Key Laboratory of Dynamic Measurement Technology School of Semiconductors and PhysicsNorth University of ChinaTaiyuan 030051China Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement North University of ChinaTaiyuan 030051China School of Instrument Science and Technology Xi'an Jiaotong UniversityXi'an 710049China

One-dimensional semiconductor materials possess excellent photoelectric properties and potential for the construction of integrated nanodevices. Among them, Sn-doped CdS has different micro-nano structures, including nanoribbons,nanowires, comb-like structures, and superlattices, with rich optical microcavity modes, excellent optical properties, and a wide range of application fields. This article reviews the research progress of various micrometer structures of Sn-doped CdS, systematically elaborates the effects of different growth conditions on the preparation of Sn-doped CdS micro-nano structures, as well as the spectral characteristics of these structures and their potential applications in certain fields. With the continuous progress of nanotechnology, it is expected that Sn-doped CdS micro-nano structures will achieve more breakthroughs in the field of optoelectronics and form cross-integration with other fields, jointly promoting scientific, technological, and social development.

关键词： Sn-doped CdS micro-nano structure superlattices optical microcavity

陈博来基于“肾为生痰之本”辨治肾虚痰阻型腰痛

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广州中医药大学学报 2024年第6期41卷 1616-1620页

作者：孙文熙彭棋黄玉符叶江南李红梅林涌鹏王洪伸陈博来(指导) 广州中医药大学广东广州510405 广东省中医院广东广州510120 成都中医药大学针灸推拿学院四川成都610075 广州中医药大学第三附属医院广东广州1510378

肾主水,为先天之本,对于体内津液的运行输布具有重要作用,且肾与水腑膀胱互为表里,通过冲脉与“水谷之海”的胃有经络上的联系,故肾在痰的生成中起着关键作用。陈博来教授认为,肾虚痰阻型腰痛为本虚标实之证,“痰阻”为其标,“肾虚”为... 详细信息

肾主水,为先天之本,对于体内津液的运行输布具有重要作用,且肾与水腑膀胱互为表里,通过冲脉与“水谷之海”的胃有经络上的联系,故肾在痰的生成中起着关键作用。陈博来教授认为,肾虚痰阻型腰痛为本虚标实之证,“痰阻”为其标,“肾虚”为其本,临床以腰骶钝痛、痛处固定、腰部僵硬、肢体麻木或偏枯为主要特点,兼见腰膝酸软、喜按喜揉等表现。肾虚痰阻型腰痛的治疗可基于“肾为生痰之本”,以补肾祛痰为法,拟定理痰汤(主要组成药物为芡实、半夏、黑芝麻、柏子仁、白芍、陈皮、茯苓等)为基础方,针对不同兼症辅以健脾、宣肺等药进行加减治疗。其辨治思路可为临床中医治疗腰痛提供参考。

关键词：腰痛肾虚痰阻肾为生痰之本补肾祛痰理痰汤陈博来