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Genomic organization and transcriptional modulation in response to endocrine disrupting chemicals of three vitellogenin genes in the self-fertilizing fish Kryptolebias marmoratus

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Journal of Environmental Sciences 2016年第4期28卷 187-195页

作者： bo-mi Kim min Chul lee Hye-min Kang Jae-Sung Rhee Jae-Seong lee Department of Biological Science College of ScienceSungkyunkwan University Department of Marine Science College of Natural SciencesIncheon National University

Vitellogenin（Vtg）is the precursor of egg yolk proteins,and its expression has been used as a reliable biomarker for estrogenic contamination in the aquatic *** examine the biomarker potential of the self-fertilizing killifish Kryptolebias marmoratus Vtgs（Km-Vtgs）,full genomic DNAs of Km-Vtgs-Aa,Km-Vtgs-Ab,and Km-Vtgs-C were cloned,sequenced,and *** Vtg genes in *** are tandemly placed in a550 kb section of the same *** silico analysis of promoter regions revealed that both the Km-Vtgs-Aa and Km-Vtgs-Ab genes had an estrogen response element（ERE）,but the Km-Vtgs-C gene did ***,all three Km-Vtgs genes had several ERE-half sites in their promoter *** analysis demonstrated that the three deduced amino acid residues were highly conserved with conventional Vtgs protein,forming distinctive clades within teleost *** tissue showed the highest expression of Km-Vtg transcripts in all tested tissues（brain/pituitary,eye,gonad,intestine,skin,and muscle）in response to endocrine disrupting chemical（EDC）-exposed ***-Vtg transcripts were significantly increased in response to 17β-estradiol（E2）,tamoxifen（TMX）,4-n-nonylphenol（NP）,bisphenol A（BPA）,and octylphenol（OP）over 24 hr *** Km-Vtg-A gene was highly expressed compared to the control in response to NP and ***-induced modulatory patterns of Km-Vtg gene expression were different depending on tissue,gender,and isoforms.

关键词： Kryptolebias marmoratus Vitellogenin Endocrine disrupting chemical

FTO Polymorphisms Are Associated with Obesity But Not with Diabetes in East Asian Populations:A Meta-analysis

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Biomedical and Environmental Sciences 2009年第6期22卷 449-457页

作者： bo XI JIE mi Graduate School Peking Union Medical College Beijing 100730 China Department of Epidemiology Capital Institute of Pediatrics Beijing 100020 China

Objective To clarify the contradictory findings in patients with obesity and type 2 diabetes by meta-analysis. Methods PubMed and Embase were searched for articles published up to March 2009. All studies on the association of FTO polymorphisms with obesity and type 2 diabetes were included. Pooled odds ratio was calculated using the model of fixed or random effects. Sensitivity analysis was performed to evaluate the stability of meta-analytic results. Results Meta-analysis suggested that rs9939609 A allele was more significantly associated with obesity risk than T allele （3 studies / 2 004 cases and 4 544 control subjects）： random effect odds ratio （OR）-1.28, 95%CI=1.05 and 1.55, P heterogeneity =0.05, I^2=66.6%. Similar results were observed in rs8050136 polymorphism （3 studies/2 404 cases and 5 713 control subjects）： fixed effect OR =1.25, 95%CI-1.13, 1.37, Pheterogeneity =0.12, 12=51.9%. However, no significant association was found between genetics and risk of type 2 diabetes after control of potential confounders （at least for Bmi） either for rs9939609 （fixed effect OR=1.05, 95% CI 0.97,1.13） or for rs8050136 polymorphism （fixed effect OR -1.07, 95%CI： 0.99, 1.16）. Furthermore, the sensitivity analysis strengthened our confidence in validity of the association. Conclusion FTO polymorphisms are associated with obesity but not with type 2 diabetes in East Asian populations. Further large-scale studies are required to conclusively establish the association.

关键词： FTO: Polymorphism Obesity Type 2 diabetes Meta-analysis

Genome-wide Association Studies of Common Obesity: Now and Future

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Biomedical and Environmental Sciences 2013年第10期26卷 787-791页

作者： XI bo mi Jie Department of Maternal and Child Health Care School of Public HealthShandong University Department of Epidemiology Capital Institute of Pediatrics

Obesity has become a major public health concern worldwide. Obesity is a complex disease influenced by both genetic and environmental factors. Epidemiological studies have indicated that environmental factors, such as excessive energy intake and lack of physical activity, might contribute to the development of obesity. Genetic factors also play an important role in the pathogenesis of obesity Indeed, approximately 40%-70% of the variation in body mass index （Bmi） can be attributed to genetic factors.

关键词： FTO gene Now and Future Genome-wide Association Studies of Common Obesity

Spontaneous ferroelectricity in strained low-temperature monoclinic Fe3O4： A first-principles study

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Frontiers of physics 2018年第2期13卷 77-83页

作者： Xiang Liu Wen-bo mi Tianjin Key Laboratory of Low Dimensional Materials Physics and Processing Technology School of Science Tianjin University Tianjin 300354 China

As a single-phase multiferroic material, Fe3O4 exhibits spontaneous ferroelectric polarization below 38 K. However, the nature of the ferroelectricity in Fe3O4and effect of external disturbances such as strain on it remains ambiguous. Here, the spontaneous ferroelectric polarization of low-temperature mon- oclinic Fe3O4 was investigated by first-principles calculations. The pseudo-centrosymmetric FeB42- FEB43 pair has a different valence state. The noncentrosymmetric charge distribution results in fer- roelectric polarization. The initial ferroelectric polarization direction is in the -x and -z directions. The ferroelectricity along the y axis is limited owing to the symmetry of the Cc space group. both the ionic displacement and charge separation at the FeB42-FeB43 pair are affected by strain, which further influences the spontaneous ferroelectric polarization of monoclinic Fe3O4. The ferroelectric polarization along the z axis exhibits an increase of 45.3% as the strain changes from 6% to -6%.

关键词： spontaneous ferroelectric polarization charge ordering biaxial strain Berry phase,modern theory of polarization

Reduced Arterial Compliance Associated with Metabolic Syndrome in Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2010年第2期23卷 102-107页

作者： bo XI LI ZHANG JIE mi Department of Epidemiology Capital Institute of Paediatrics Beijing 100020 China Graduate School Peking Union Medical College Beijing 100730 China

Objective To explore the metabolic syndrome and its association with arterial compliance in Chinese children and adolescents. Methods 337 participants aged 6 to 18 years with males accounted for 55.8% were grouped according to their traits of metablic syndrome. Anthropometry, blood pressure, fasting plasma glucose, insulin and serum lipid profile were measured. Homeostasis model was assessed and insulin resistance （HOMA-IR） index was measured and calculated for estimating individual insulin resistance. Arterial compliance was also measured using digital pulse wave analyzing method （micro medical, London）, and stiffness index was calculated. Results The stiffness index in participants with metablic syndrome was significant higher than that in participants with no riskof metablic syndrome [（7.69±1.63） vs （6.25±0.86） m/s, P〈0.01] and stiffness index and HOMA-IR were progressively increased with the increase of traits of metablic syndrom （P for linear trend 〈0.001）. After gender, age, and pubertal development were adjusted, both traits of metablic syndrome and HOMA-IR were correlated positively with stiffness index （both P〈0.05）. Conclusion The clustering of metablic syndrome was closely associated with risk at increased arterial stiffness in Chinese children and adolescents. It was suggested that arterial compliance assessment of children and adolescents might be an important measure for prevention of cardiovascular diseases.

关键词： Metabolic syndrome Arterial compliance Children and adolescents

Catalysts for electrochemical ammonia oxidation:Trend,challenge,and promise

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Science China Materials 2022年第12期65卷 3334-3352页

作者： Sol A lee mi Gyoung lee Ho Won Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Electrical and Computer Engineering University of TorontoToronto M5S 3G4OntarioCanada Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea

Developing sustainable and clean energy technology is critial to address the current energy and environmental *** an energy carrier,hydrogen has been getting attention due to its abundance,high energy density,and zero carbon *** to the difficulty of hydrogen storage and transport,the electro-oxidation of ammonia shows great potential for renewable energy since it satisfies both energy supply and environmental protection as a carbon-free fuel with high hydrogen ***,ammonia electro-oxidation is a sluggish reaction and shows low *** the complicated mechanism and intermediates is conducive to developing efficient electrocatalysts with high catalytic activity and *** review begins with the ammonia oxidation technologies and their *** two typical mechanisms for ammonia electro-oxidation,Oswin-Salomon mechanism and Gerischer-Mauerer mechanism,are discussed,and attention to the poisoning species is ***,the electrocatalysts for ammonia reaction are classified into Pt-based catalysts and non-noble metal-based catalysts,and their performances are reviewed with various *** on the progress on the electrochemical ammonia oxidation catalysts,the challenges and future insight on ammonia oxidation reaction are discussed and proposed.

关键词： NH3 oxidation reaction electrocatalysts green hydrogen

Reoxidation process and corrosion behavior of TA15 alloy by laser ablation

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Rare Metals 2021年第4期40卷 865-876页

作者： bo-Wen Liu Gao-Yang mi Chun-ming Wang School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

The thermal oxide layer formed of TA15 alloy has poor corrosion *** this paper,the changes of the elements and components on the surface after laser ablation with different energy densities(E) were *** formation process and corrosion behavior of laser-generated oxide layer were *** E increases,the oxygen content decreases from 8.52% to 5.43% and then increases to 11.89%.The surface oxide layer changes from TiO_(2)(R)(i.e.,rutile) to Ti_(2) O_(3)+TiO_(2)(R) and finally becomes TiO_(2)(R)+TiO_(2)(A)(i.e.,anatase).The TiO_(2)(R) gasification was confirmed by calculating the surface temperature *** surface reoxidation process was illustrated by a thermodynamically calculated ΔGT(i.e.,the Gibbs free energy changes with temperature).When E≥17.5 J·cm^(-2),the oxide layer exhibits an agitated morphology,and oxide falls off at the *** E increases,the corrosion rate decreases first and then *** energy density of 8.75 J·cm^(-2),the surface corrosion rate was 20.43 times slower than that of the untreated *** impedance spectrum and equivalent resistance results also prove the best corrosion resistance at 8.75 J·cm^(-2).The corrosion behavior of the oxide layer is analyzed from the properties of the oxide layer components and the reaction products with the electrolyte.

关键词： Laser ablation TA15 alloy Reoxidation process Corrosion behavior Elemental analysis

Lightweight,self-cleaning and refractory FeCo@MoS_(2)PVA aerogels:from electromagnetic wave-assisted synthesis to flexible electromagnetic wave absorption

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Rare Metals 2023年第4期42卷 1294-1305页

作者： Sai-bo Qian Guang Liu mi Yan Chen Wu School of Materials Science and Engineering State Key Laboratory of Silicon MaterialsZhejiang UniversityHangzhou310027China

The emergence of wearable and foldable electronic devices urges advanced electromagnetic(EM)wave absorbers with maintained performance under *** FeCo@MoS_(2)poly vinyl alcohol(PVA)aerogels have been fabricated with the assistance of EM waves for simultaneous splitting of the MoS_(2)flakes and dispersive growth of FeCo *** resultants in-return have been used for EM wave absorption with excellent performance,providing minimum reflection loss(RL_(min))of-40.7 dB and a broad effective absorption bandwidth(EAB)of 6.4 GHz at a thickness of 2.5 ***-time compression has been introduced to reveal the evolution of EM *** aerogels maintain satisfactory performance even under 50%compression due to the balance of impedance matching and *** the deterioration of impedance matching,the attenuation is significantly enhanced due to both strengthened conductive loss and magnetic *** addition,features such as lightweight,self-cleaning and refractory can be achieved for the aerogels for applications in complex *** such this work not only provides a versatile synthetic route assisted by EM wave energy,but also insights on the evolution of absorption performance under deformation together with the design strategy of multifunctional flexible wave absorbers.

关键词： Electromagnetic(EM)wave assistance Multifunctional aerogels Deformative wave absorption Impedance matching Conductive loss Magnetic loss

Inter-observer Reliability of Indicators and Decision of Pattern Identification Using Diagnostic Flowchart with Traditional Korean Medicine

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Chinese Journal of Integrative Medicine 2017年第5期23卷 338-344页

作者： Ju Ah lee Jeeyoun Jung mi mi Ko Myeong Soo lee Korean Medicine Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 305-811 Republic of Korea Clinical Research Division Korea Institute of Oriental Medicine Daejeon 305-811 Republic of Korea

Objective： To evaluate the consistency of patterns and pattern identification（PI）, and the improvement in the diagnosis of blood stasis after the standard operating procedures（SOPs） were enhanced by using a diagnostic flowchart. Methods： A total of 358 subjects who were admitted by the Jaseng Hospital of Korean Medicine between June 2013 and December 2014 were included in the study. Each patient was independently diagnosed by two experts from the same department. In 2014, the SOPs included the use of a diagnostic flowchart for each indicator. Inter-observer consistency was assessed by simple percent agreement and by the kappa and AC1 statistics. Results： The improvements in inter-observer agreement for the indicators（for al patients） and PI were greater in 2014 than in 2013. In 2013, the j-value measure of agreement between the two experts ranged from ＂poor＂（κ=–0.051） to ＂good＂（κ=0.968）. The AC1 measure of agreement between the experts was generally high for the indicators and ranged from –0.010 to 0.978. In most cases, agreement was considerably lower when it was assessed by the j-values compared with the AC1 values. In 2014, the j-value measure of agreement on the indicators（for the subjects） general y ranged from poor to good, with the values ranging from –0.007 to 0.994. Moreover, the AC1 measure of agreement between the experts was general y high for al of the indicators and ranged from ＂moderate＂（AC1=0.408） to ＂excel ent＂（AC1=0.996）. Conclusions： In four examinations, there was moderate agreement between the clinicians on the PI indicators of blood stasis. To improve clinician consistency（e.g., in the diagnostic criteria used）, it is necessary to analyse the reasons for inconsistency and to improve clinician training.（Trial registration No. KCT0000916）

关键词： blood stasis inter-observer reliability pattern identification traditional Chinese medicine traditional Korean medicine