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Reading and Writing Practices： Case Studies at the Sergio Arboleda University of Colombia

Sino-US English Teaching 2012年第5期9卷 1113-1123页

作者： blanca yaneth gonzeilez Violeta Vega Pontificia Universidad Javeriana Bogota Colombia Sergio Arboleda University Bogota Colombia

This research project analyzes the reading and writing practices used in five first and second year undergraduate courses of different disciplines at a Colombian university. During one semester, we conducted polls, class observations, and interviews with teachers. The data collected contain information about the strategies that teachers use to guide, clarify, and evaluate the readings they assigned. It also informs about the ways in which teachers classify texts and participate in the process of composing, editing, and evaluating the students＇ writing. Finally, the data inform about the role that teachers assign to the practices of reading and writing in their courses. The results of the study prove that there is a misconception based on the idea that there is a unique way of understanding and practicing reading and writing in the academia, and that there is a set of unique strategies that are transferable to any discipline or field of study. The cases analyzed in this study suggest that it would be much more effective to incorporate intensive reading and writing strategies in disciplinary courses, than to concentrate on first year writing courses.

关键词： academic writing and reading practices allocation supervision academic dialogue evaluation

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IL-1β, TNF-α and Sambucus nigra Reactive Serum Proteins as Biomarkers of Mild Cognitive Impairment and Alzheimer Disease Progression

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Advances in Alzheimer's Disease 2015年第4期4卷 99-109页

作者： Luis Manuel Castillo Enrique Moreno yaneth Rodriguez-Agudelo MireyaChavez-Oliveros Zoila Trujillo blanca Espinosa Emma Rodriguez-Maldonado Luis Felipe Montano Jorge Guevara Departamento de Bioquimica Facultad de MedicinaUniversidad Nacional Autonoma de MexicoMexico CityMexico Departamento de Neuropsicologia Instituto Nacional de Neurologia y NeurocirugiaMexico CityMexico Geriatra Instituto Nacional de Neurologia y Neurocirugia Mexico CityMexico Laboratorio de Bioquimica Instituto Nacional de Enfermedades RespiratoriasMexico CityMexico Departamento de Fisiología Instituto Nacional de CardiologiaMexico CityMexico Departamento de Biologia Celular y Tisular Facultad de MedicinaUniversidad Nacional Autonoma de MexicoMexico CityMexico

Amyloid-β (Aβ) can induce a chronic inflammatory immune response that is associated, amongst many others, to abnormal glycosylation, inducible nitric oxide synthase (iNOS) and nitric oxide (NO). The relation between development of Mild Cognitive Impairment (MCI) and Alzheimer’s disease progression and these serum markers has not been evaluated. Serum levels of iNOs, NO, TNF-α, IL-1β, IL-6, IL-8, IL-10, and IL-12 are determined with commercially available kits. Sialylation of albumin-free serum patterns is determined by Western blot analysis with Sambucus nigra (specific for sialic acid attached to terminal galactose in α2,6 linkage) lectin. Apolipoprotein E (ApoE) haplotype is determined by Western blot using specific anti-ApoE 2, 3 or 4 antibodies. A mini-mental state examination (MMSE) test is also performed in the 10 MCI patients, 19 Alzheimer’s disease (AD) patients and 46 healthy age-matched controls evaluated. The results show an increase of iNOS in MCI and AD but significantly higher NO concentrations are only found in MCI patients. TNF-α and IL-1β concentrations are the only significantly increased cytokines in MCI patients;no differences between control and MCI or AD patients are found in regard to the other cytokines. An abnormal MMSE test result only correlates with a decrease in serum NO concentration in MCI patients. The terminal sialic acid linkage pattern of serum proteins also shows highly significant differences between MCI and AD patient. ApoE3/4 or 4/4 haplotypes are characteristic of MCI and AD patients. Our results imply that increased serum TNF-α, IL-1β, iNOS, NO and alterations of serum proteins glycosylation patterns in adult individuals with an abnormal MMSE test may serve as an early biomarker of MCI and AD development.

关键词： Alzheimer Disease Mild Cognitive Impairment Nitric Oxide Inflammatory Cytokines Glycosylation Apolipoprotein E4

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