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Advances in Enzyme research 2022年第4期10卷 83-100页

作者： Silvia Alejandra Meza-Ireta blanca Colin-Lozano Penélope Merino-Montiel José Luis Vega-Báez Sara Montiel-Smith Facultad de Ciencias Químicas Ciudad Universitaria Benemérita Universidad Autónoma de Puebla Puebla México

Hormone receptor positive (HR+) breast cancer is the most common malignancy in women. New strategies in the treatments have targeted the estrogen biosynthesis pathways including the inhibition of the aromatase and 17β-HSD1 enzymes. The present work, describes the study of a new family of 9 hybrid compounds derived from estrone attached to a coumarin fragment, linked through different lengths of hydrocarbon chains. The activity of these compounds was evaluated by molecular docking with two relevant enzymes in breast cancer (HR+). It has been proposed nine compounds as 17β-HSD1 inhibitors and six as aromatase inhibitors. We found important interactions with key amino acids at the orthosteric site of each enzyme and their score values compared to the crystallographic ligand. The in silico analysis showed good score values in the proposed compounds, where the steroidal portion presented important interactions with Met374 and Tyr155 in aromatase and in 17β-HSD1 respectively. Highlighting Compounds 2, 5 and 8 with an aromatic ring at the C4 position of the coumarin moiety, which favored arene-H type interactions essential for protein-ligand recognition. In addition, the results related to the 17β-HSD1 enzyme demonstrated how the length of the linker influences the interaction;the best score was found for derivative 8 with a chain of 8 methylenes.

关键词： Estrone Coumarins Aromatase Inhibitors 17β-HSD1 Inhibitors Molecular Docking

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高雪维尔的白色诱惑

现代装饰（家居） 2014年第4期 28-35页

作者： blanca Sanchez Polly Baldwin Roxanne Holland 肖俊英国Halo Design Interiors

英国室内设计事务所HaloDesignInteriors最近完成了依偎在高雪维尔滑雪场附近的滑雪小屋的改造设计。面对年久失修的建筑结构，业主希望借用温馨的木材和天然材料打造一个永恒的室内空间，

关键词：改造设计室内设计建筑结构室内空间天然材料滑雪场事务所业主

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牛裂体吸虫线粒体DNA序列和基因排序分析

中国寄生虫学与寄生虫病杂志 2010年第4期28卷 252-256页

作者：肖景莹蔡连顺長瀧充德弘慎治 Jarilla blanca R. 嶋田雅暁 David Blair 吾妻健日本高知大学医学部高知783-8505 佳木斯大学基础医学院佳木斯154007 日本长崎大学热带医学研究所长崎852-8523 澳大利亚詹姆斯库克大学热带生物学院汤斯维尔QLD 4811

目的为探讨牛裂体吸虫(Schistosoma bovis)在裂体属内的系统发生位置,测定牛裂体吸虫线粒体基因部分序列,并分析该编码区域的基因序列和基因排序。方法以GNT-K法抽提牛裂体吸虫成虫基因组DNA,用兼并和特异引物扩增目的基因。扩增产物经... 详细信息

目的为探讨牛裂体吸虫(Schistosoma bovis)在裂体属内的系统发生位置,测定牛裂体吸虫线粒体基因部分序列,并分析该编码区域的基因序列和基因排序。方法以GNT-K法抽提牛裂体吸虫成虫基因组DNA,用兼并和特异引物扩增目的基因。扩增产物经纯化后克隆于pGEM1T质粒载体,并转化大肠埃希菌。抽提和纯化阳性质粒DNA,并测序。以纯化后的阳性质粒DNA为模板,根据已获得的序列设计内部特异引物,采用引物步移法获得全长目的片段。在GenBank中查找曼氏血吸虫等相关血吸虫线粒体基因序列,作基因排序及比较分析后,以邻接法绘制系统发生树。结果测定了牛裂体吸虫线粒体烟酰胺腺嘌呤二核苷酸脱氢酶亚基Ⅳ～Ⅰ基因序列(nicotinamide adeninedinucleotide dehydrogenase subunit4-1gene,nad4-nad1),其长度为2214bp。分析该编码区基因排序为nad4-trnQ(Gln)-trnK(Lys)-nad3-trnD(Asp)-nad1。牛裂体吸虫在该区域的线粒体基因排序与非洲支系血吸虫相似,与亚洲支系血吸虫有很大的不同;根据牛裂体吸虫与其他8种吸虫部分nad4,nad3,部分nad1和部分nad4+nad3+nad1基因序列比对结果,分别构建系统发生树。结果表明,牛裂体吸虫与埃及血吸虫位于同一簇,归属于非洲血吸虫支系,这与由基因排序推测的牛裂体吸虫的系统发生位置结果相一致。结论牛裂体吸虫属于非洲支系而非亚洲支系血吸虫。

关键词：牛裂体吸虫 nad4 nad3 nad1 基因排序系统发生关系

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Normal values of heart rate variability at rest in a young, healthy and active Mexican population

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Health 2012年第7期4卷 377-385页

作者： Marina Medina Corrales blanca de la Cruz Torres Alberto Garrido Esquivel Marco Antonio Garrido Salazar José Naranjo Orellana Pablo de Olavide University Seville Spain Sports Organisation Faculty Autonomous University of Nuevo León Monterrey Mexico University of Seville Seville Spain

This study analyzed Heart Rate Variability in a large sample of active young subjects within a narrow age range (18 to 25), using time and frequency domain methods and a Poincaré plot. Heart rate was recorded (beat to beat) for 30 minutes at rest in 200 healthy subjects divided into 4 groups: 50 sportsmen (20.54 ± 1.52 years);50 active men (21.22 ± 1.31 years);50 sportswomen (20.10 ± 1.87 years) and 50 active women (20.92 ± 1.87 years). Significant differences were found for most parameters between athletes and active subjects (male and female) but not between genders. Percentile distributions were provided for all parameters (according to gender and physical activity level) to be used as references in future researches.

关键词： Heart Rate Variability Time Domain Frequency Domain Poincaré Plot

Qualification of nursing potential in maternal mortality in Mexico

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International Journal of Nursing Sciences 2020年第3期7卷 344-348页

作者： rey Arturo Salcedo-Alvarez blanca Consuelo González-Caamano Sara Huerta-González Andrea Del Prado-Vázquez Universidad Nacional Autónoma de México Escuela Nacional de Enfermería y ObstetriciaCamino viejo a Xochimilco S/N y Viaducro TlalpanColonia San Lorenzo Huipulco14370Mexico CityMexico Universidad Veracruzana Región Poza Rica-Tuxpan.Boulevard Lázaro Cárdenas#801Colonia Morelos93240Poza RicaVeracruzMexico

Objectives:To develop a method that measures nursing potential through the factor analysis of relevant nursing data and social context by taking maternal mortality as the study ***:A Cross-sectional and analytical study,a multivariate analysis was *** Nursing Coverage Index,the Human Development Index,population density and the proportion of nurses with a bachelor's degree or upper degree,are studied by federative entity,only data from government sources are *** Index of Nursing Qualification in Mexico(INQM)was constructed through principal component ***:The highest correlation was between the INQM and the Nursing Coverage Prioritization Index(NCPI),which was 0.849(Prelation with the INQM(0.716,Pree factors were extracted by principal component analysis and the INQM was generated with the three main components in a *** is very low correlation between INQM and maternal mortality rate(MMR)and no statistical significance was ***:This study shows that nursing qualification must include economic,geographic and social *** INQM is an indicator that summarises the potential of each federative *** these results,a contribution is provided for the application of these indices,which can help determine nursing potential in a specific geographical region.

关键词： Maternal mortality Mexico Nursing care Population density

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ESP及其他:寻求相关性

外语教学理论与实践 1992年第2期 23-26页

作者： blanca A.de Escorcia 刘运同华侨大学

引言尽管这篇文章主要涉及南美洲的ESP情况,但我并不打算把它写成一个现有水平的报告;相反地,我想提出几个近期ESP领城中的关键性问题,然后细致地考察南美洲国家是如何对待这些问题的。在南美洲已经形成了三个非常独特的发展模式,这可... 详细信息

引言尽管这篇文章主要涉及南美洲的ESP情况,但我并不打算把它写成一个现有水平的报告;相反地,我想提出几个近期ESP领城中的关键性问题,然后细致地考察南美洲国家是如何对待这些问题的。在南美洲已经形成了三个非常独特的发展模式,这可以举智利、巴西和哥伦比亚的ESP情况作为例子。尽管总的来说存在着一个明显的倾向,即追随该领域全球范围内的一般发展趋势,但每个国家处理问题的方式自然不同。我将把哥伦比亚的情况作为一个起点,试着把它放在其他国家更广的范围来考察。

关键词：南美洲国家语言教师学习策略语言教学 ESP 阅读策略学习技巧教材编写语言学习外语交际

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review of the biological and engineering aspects of algae to fuels approach

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International Journal of Agricultural and Biological Engineering 2009年第4期2卷 1-30页

作者： Paul Chen Min Min Yifeng Chen Liang Wang Yecong Li Qin Chen Chenguang Wang Yiqin Wan Xiaoquan Wang Yanling Cheng Shaobo Deng Kevin Hennessy Xiangyang Lin Yuhuan Liu Yingkuan Wang blanca Martinez Roger Ruan Center for Biorefining Department of Bioproducts and Biosystems EngineeringUniversity of Minnesota1390 Eckles Ave.St.PaulMN 55108USA State Key Laboratory of Food Science and Technology Engineering Research Center for Biomass ConversionMinistry of EducationNanchang UniversityNanchang 330047China Biochemical Engineering College Beijing Union UniversityBeijingChina College of Biological Science and Technology Fuzhou UniversityFuzhou 350108China Chinese Academy of Agricultural Engineering Beijing 100125China

Current biofuel production relies on limited arable lands on the earth,and is impossible to meet the biofuel *** producing algae are alternative biofuel feedstock with potential to meet the world’s ambitious goal to replace fossil *** review provides an overview of the biological and engineering aspects in the production and processing technologies and recent advances in research and development in the algae to fuels *** article covers biology,selection and genetic modification of algae species and strains,production systems design,culture media and light management,harvest and dewatering,downstream processing,and environment and economic *** the many advances made over several decades,commercialization of algal fuels remains challenging chiefly because of the techno-economic *** breakthroughs in all major aspects must take place before commercial production of algal fuels becomes economically viable.

关键词： algae microalgae open pond enclosed photobioreactor light harvest dewatearing extraction hydrothermal liquefaction gasification pyrolysis fermentation

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湖畔浅居

现代装饰（家居） 2015年第12期 32-41页

作者： blanca Sanchez Richard Gooding 范嘉苑英国Halo Design Interiors

这座度假别墅位于英格兰的科茨沃尔德,毗邻湖畔,被一片美丽的郊野景色所包围。业主是一对年轻的夫妇及其四个孩子,平常居住在萨里,为了释放工作和生活压力,他们选择在离萨里不远的地方购买了一套别墅,周末的时候可以一家人过来放松娱乐... 详细信息

这座度假别墅位于英格兰的科茨沃尔德,毗邻湖畔,被一片美丽的郊野景色所包围。业主是一对年轻的夫妇及其四个孩子,平常居住在萨里,为了释放工作和生活压力,他们选择在离萨里不远的地方购买了一套别墅,周末的时候可以一家人过来放松娱乐一下。首层是主要的起居空间,一排玻璃落地滑门在起居室一侧一字排开,优美的湖光景色自然而然地映入室内空间之中。

关键词：落地玻璃人过来萨里科茨暗色调儿童房往前走沃尔德地滑《星球大战》

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Low serum levels of ghrelin are associated with gallstone disease

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World Journal of Gastroenterology 2006年第19期12卷 3096-3100页

作者： Nahum Méndez-Sánchez Guadalupe Ponciano-Rodríguez Luisa Bermejo-Martínez Antonio R Villa Norberto C Chávez-Tapia Daniel Zamora-Valdés Raúl Pichardo-Bahena blanca Barredo-Prieto Martha H Uribe-Ramos Martha H Ramos Héctor A Baptista-González Misael Uribe Liver Unit Biomedical research Department Medica Sur Clinic and FoundationMexico CityMexico Faculty of Medicine National Autonomous University of Mexico (UNAM) Mexico CityMexico Clinical research Department National Institute of Perinatology Mexico CityMexico Clinical Epidemiology Unit National Institute of Medical Sciences and Nutrition Mexico CityMexico

AIM： To explore the role of ghrelin in gallstone disease. METHODS： We carried out a cross-sectional study in 150 subjects, 38 with gallstones （cases） and 112 controls. We also did a real-time PCR-RT study in twenty gallbladder samples each. Body mass index （BNI）, serum insulin, ghrelin, and serum lipids were measured. Logistic regression analyses （univariate and multivariate） were conducted to estimate the probability of gallstone disease associated with serum ghrelin concentrations. reSULTS： Cases were statistically different from controls in gender distribution （P = 0.01）, age （53 vs 44 yr, P = 0.002）, BNI （28 vs 25; P = 0.004）, and glucose （5.26 vs 4.98 mmol/L; P = 0.05）. The prevalence of ghrelin serum levels above the third tercile was lower in subjects without metabolic syndrome （P 〈 0.05）. In a multivariate model, we found a protective effect, when ghrelin values were higher than the median value （OR = 0.27, 95%CI 0.09-0.82, P = 0.02）. Twenty （20%） gallbladder specimens expressed ghrelin mRNA. CONCLUSION： Serum ghrelin concentrations are associated with a protective effect of GD.

关键词： Gallstones Obesity Ghrelin Gallbladder Gastrointestinal hormones

Evaluation of antimycobacterium activity of the essential oils of cumin (Cuminum cyminum), clove (Eugenia caryophyllata), cinnamon (Cinnamomum verum), laurel (Laurus nobilis) and anis (Pimpinella anisum) against Mycobacterium tuberculosis

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Advances in Biological Chemistry 2013年第5期3卷 480-484页

作者： Andrade-Ochoa Sergio Chacón-Vargas Fabiola Nevarez-Moorillon Guadalupe Rivera-Chavira blanca Hernández-Ochoa León Facultad de Ciencias Químicas Universidad Autónoma de Chihuahua Campus Universitario #2 Chihuahua México

In this study Essential oils were used with cumin, cloves, cinnamon, laurel and anis to determine Minimum Inhibitory Concentration (MIC) against Mycobacterium tuberculosis strains. The MICs were determined on M. tuberculosis H37Rv sensitive to all five firstline antituberculosis drugs (streptomycin, isoniazid, rifampicin, ethambutol and pirazinamide), two H37-Rv (CH-8 and CH-15) isoniazid-resistant, two H37Rv (CH-07 and CH-09) rifampicin-resistant, two H37Rv (CH-03 and CH-06) streptomycin-resistant, and two H37Rv (CH-09 and CH-10) ethambutol-resistant using the microplate alamar blue assay. The results obtained showed that the cumin and cinnamon essential oils showed a MIC of 12.5 μg/ml against reference strain H37Rv. The five essential oils used in this study were effective against the isoniazid-resistant variant of H37RV with MIC values in the range 12.5-100 μg/ml, the most potent being the cumin and cin-namon (MIC = 12.5). Similar results were obtained against rifampicin-resistant variant of H37RV with MIC values in the range 12.5-100 μg/ml;the most active ones?in this case were the essential oils of cumin and cloves. The essential oils of anis and laurel were active with MIC value to 100 μg/ml. Clove, cumin, and cinnamon essential oils were active against all strains utilized in this study, with MIC values in the range 6.25 μg/ml to 25 μg/ml.

关键词： Antimycobacterial Activity Essential Oils Monoterpenoids Mycobacterium tuberculosis