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Does the use of double hormone replacement therapy for trauma patient organ donors improve organ recovery for transplant

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World Journal of Transplantation 2024年第2期14卷 119-125页

作者： Eden M Gallegos Tanner Reed Paige Deville blake Platt Claudia Leonardi Lillian Bellfi Jessica Dufrene Saad Chaudhary John Hunt Lance Stuke Patrick Greiffenstein Jonathan Schoen Alan Marr Anil Paramesh Alison A smith Department of Physiology Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70124United States Department of Medicine Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Surgery Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Trauma Surgery Tacoma General HospitalTacoma 98405United States Department of Public Health Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Donation Services Louisiana Organ Procurement AgencyCovingtonLA 70433United States Department of Surgery Tulane Transplant InstituteTulane University School of MedicineNew OrleansLA 70112United States

BACKGROUND With an ongoing demand for transplantable organs,optimization of donor management protocols,specifically in trauma populations,is important for obta-ining a high yield of viable organs per *** management of brain-dead potential organ donors(BPODs)is controversial,leading to heterogeneous clinical management *** studies have shown that when levo-thyroxine was combined with other treatments,including steroids,vasopressin,and insulin,BPODs had better organ recovery and survival outcomes were increased for transplant *** To determine if levothyroxine use in combination with steroids in BPODs increased the number of organs donated in trauma *** A retrospective review of adult BPODs from a single level 1 trauma center over ten years was *** criteria included patients who were not solid organ donors,patients who were not declared brain dead(donation after circulatory death),and patients who did not receive steroids in their hospital *** and steroid administration,the number of organs donated,the types of organs donated,and demographic information were *** analyses were performed with P0.05).In the ST/LT group,68.1%(n=47)donated a high yield(3-5)of organ types per donor compared to 42.1%(n=8)in the ST group(P=0.038).There was no difference in the total number of organ types donated between the groups(P=0.068).CONCLUSION This study suggests that combining levothyroxine and steroid administration increases high-yield organ donation per donor in BPODs in the trauma patient *** to this study include

关键词： Organ donation Trauma Brain death Levothyroxine Hormone replacement therapy Steroids Organ donor Retrospective

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Pulse-burst laser-based 10kHz Thomson scattering measurements

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Plasma Science and Technology 2019年第10期21卷 83-90页

作者： Zichen HE Cary smith Zhili ZHANG theodore M BIEWER Naibo JIANG Paul S HSU Sukesh ROY Mechanical Aerospace and Biomedical EngineeringUniversity of TennesseeKnoxville TN 37996 United States of America Fusion Energy Division Oak Ridge National LaboratoryOak Ridge TN 37931United States of America Spectral Energies LLC Dayton OH 45431United States of America

Thomson scattering (TS), as a popular and reliable diagnostic technique, has successfully measured electron temperatures and electron number densities of plasmas for many years. However, conventional TS techniques using Nd:YAG lasers operate only at tens of hertz. Here, we present the development of a high-repetition-rate TS instrument based on a high-speed, pulse-burst laser system to greatly increase the temporal resolution of measurements. Successful instrument prototype testing was carried out by collecting TS light from laboratory helium and argon plasmas at 10 kHz. Calibration of the instrument detection sensitivity using nitrogen/ oxygen rotational Raman scattering signal is also presented. Quantitative electron number densities and electron temperatures of the plasma were acquired at 10 kHz, for stable plasma discharges as, respectively,~0.9 eV and ~5.37×10^21 m^-3 for the argon plasma, and ~1 eV and ~6.5×10^21 m^-3 for the helium plasma.

关键词： Thomson scattering high-speed pulse-burst laser

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Retinal imaging and diagnostics

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Annals of Eye Science 2021年第3期 1-2页

作者： R.theodore smith Department of Ophthalmology Icahn School of Medicine at Mount SinaiNew YorkNYUSA.

This special series is devoted to a broad range of breakthroughs in multimodal retinal imaging that will be of interest to all specialists,and to those in the many other disciplines that increasingly rely on imaging for research,diagnosis and clinical ***,the topics themselves are not broad,but are developed in enough detail to bring a depth of understanding to the most enquiring mind,one that might consider further applications.

关键词： diagnosis clinical breakthrough

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温哥华公寓

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城市环境设计 2019年第2期118卷 210-219页

作者： Carl McDonald Melissa Bauld Aaron Mark Alan Tansey Alex Wu Alexandra Gustafsson Alina Tamosiunaite Amina Blacksher Aran Coakley Arash Adel Ahmadian Armen Menendian Barbora Srpkova Ben Zunkeler Benjamin Caldwell Benjamin Novacinski Bennett Gale Birk Daugaard blake theodore smith Brian Foster Brian Rome Carolien Schippers Christopher James Malcolm Jr. Christopher Junkin Christopher Tron David Brown David Dottelonde Deborah Campbell Doug Stechschulte Douglass Alligood Edward Yung Elena Bresciani Filip Milovanovic Francesca Portesine Gabriel Hernandez Solano Gabriel Jewell-Vitale Hector Garcia Ivy Hume Jan Leenknegt Janice Rim John Kim Josiah Poland Julian Liang Julianne Gola Julie Kaufman Karol Bogdan Borkowski Kurt Nieminen Lauren Turner Lorenz Krisai Lucio Santos Marcella Martinez Martin Voelkle Matthew Dlugosz Megan Ng Michael Robert Taylor Otilia Pupezeanu Paula Domka Phillip MacDougall Ryan Yang Sean Franklin Sebastian Grogaard Simon Scheller Spencer Hayden Taylor Fulton Terrence Chew Terry Lallak Thomas smith Tianqi Zhang Tobias Hjortdal Tran Le Valentina Mele Xinyu Wang Yaziel Juarbe Yoanna Shivarova Zach Walters Zhifei Xu Andrew Latreille Glotman Simpson Urban YVR 运小红

温哥华公寓的建成预示着这个年轻的城市正在打开城市政策制定的新局面。它将成为从Granville大桥进入温哥华市中心的城市大门。塔楼和群房的设计是对新城市主义地域类型中的"温哥华主义"建筑的全新解读,配合一座纤细的塔楼,试图保留城... 详细信息

温哥华公寓的建成预示着这个年轻的城市正在打开城市政策制定的新局面。它将成为从Granville大桥进入温哥华市中心的城市大门。塔楼和群房的设计是对新城市主义地域类型中的"温哥华主义"建筑的全新解读,配合一座纤细的塔楼,试图保留城市视觉通廊并激活步行通道。住宅塔楼借助高度和毗邻河流的地理位置,是唯一可以同时享受水景和山景的建筑,坐拥温哥华广袤的自然风光。

关键词：温哥华平面图 Dialog 立面图

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Sub-threshold nanosecond laser(SNL)treatment in intermediate AMD(IAMD)

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Annals of Eye Science 2019年第1期4卷 4-7页

作者： R.theodore smith New York Eye and Ear Infirmary of Mount Sinai New York CityNYUSA

Summary The Laser intervention in early stages of age-related macular degeneration(LEAD)study(1)is a 36-month,multicenter,randomized,sham-controlled trial conducted from 2012-2015 of 292 participants with bilateral soft drusen,aka intermediate AMD(iAMD),who underwent q 6-month treatment with sub-threshold nanosecond laser(SNL)or sham treatment to the study eye.

关键词： treatment AMD SNL

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The spatial dynamics of Ukraine air quality impacted by the war and pandemic

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International Journal of Digital Earth 2023年第1期16卷 3680-3705页

作者： vizhi Qian Liu theodore S.Trefonidesc Sina Hasheminassab Jennifer smith Thomas Huang Kevin M.Marlis Joe T.Roberts Zifu Wang Dexuan Sha Ana Beatriz Moura Pereira Heramb Podar Jacob Cain Chaowei Yang Department of Geography and GeoInformation Science George Mason UniversityFairfaxVAUSA Jet Propulsion Laboratory California Institute of TechnologyPasaden1CAUSA Dartmouth College HanoverNHUSA Bayer WashingtonDCUSA Northern Virginia Community College AnnandaleVAUSA Indian Institute of Technology RoorkeeIndia

In recent years,our world has experienced significant disruptions due to the COviD-19 pandemic,and Russia's 2022 invasion of Ukraine,impacting human activities and the global *** paper explored air quality changes in Ukraine due to COVID-19,and Russia's invasion of Ukraine using on-demand with a what-you-see-is-what-you-get *** the cOVID-19 pandemic,strict quarantine policies in Ukraine led to a 2%reduction in tropospheric NO_(2) concentration before the lockdown and 4%during the lockdown *** like Kyiv,Donetsk,and Dnipro exhibited reductions of 5%,11%,and 16%,*** SO_(2) column concentration decreased by 6%before the lockdown and 2.5%during the lockdown period,except in high population density *** showed the highest reduction of 17%in SO_(2) concentration,while Donetsk and Dnipro exhibited an 11%***,during the Russian invasion,there was a significant increase in tropospheric NO_(2) concentration in heavily destroyed Kharkiv while most eastern regions experienced a *** total SO_(2) column was 48%higher before the war but reduced throughout the country after the war,except for in Kyiv and a few central *** findings can contribute to analyzing air pollution and building digital twin simulations for future reconstruction scenarios.

关键词： ukraine war air pollution pandemic climate change environment spatiotemporal computing digital twins

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Immunoprotective antigens of Eimeria maxima:identification using genetics and the immune host

Immunoprotective antigens of Eimeria maxima:identification u...

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The 15th World Veterinary Poultry Congress

作者： Darner P blake Martin W Shirley Adrian L smith Institute for Animal Health ComptonBerkshireRG20 7NNUK Institute for Animal Health ComptonBerkshireRG20 7NNUK Institute for Animal Health ComptonBerkshireRG20 7NNUK

＜正＞Control of the Eimeria species,causative organisms of the disease coccidiosis,has largely been based up- on chemotherapy or vaccination with live wild-type or attenuated ***,the widespread oc- currence of drug r...

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Parasite Genetics, the Immune Host and DNA Fingerprinting in the Identification of Loci Encoding Protective Antigens of Eimeria Maxima

Parasite Genetics, the Immune Host and DNA Fingerprinting in...

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12th International Congress of Protozoology

作者： Damer P. blake Adrian L. smith Martin W. Shirley Institute for Animal Health Compton BerkshireRG20 7NNUK Institute for Animal Health Compton BerkshireRG20 7NNUK Institute for Animal Health Compton BerkshireRG20 7NNUK

＜正＞Many protozoan genomes are the subject of extensive sequencing projects but the identification of genes that encode antigens capable of stimulating a protective immune response remains a demanding task. The rational identification of genuinely immunoprotective gene products encoded by unsequenced genomes is even more daunting. The majority of screens for vaccine candidates protective against protozoan infection have been largely empirical, based upon the induction of an immune response rather than protection. However, consideration of the genetics of immune escape by different strains of Eimeria maxima has raised the possibility of the targeted identification of a gene （or genes） under immune

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先进封装技术提升系统散热性能

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电子产品世界 2006年第2X期13卷 98-100页

作者： Carl blake Carl smith International Rectifier

近年来,随着对功率的需求越来越高,PCB板的散热设计变得更为关键。本文以几个实例论述了MOSFET封装如何改善整个电路板的温度,使其在期望的范围之内。除了DC总线转换器(可达220W级别),本文还讨论了在控制和同步FET插座内带有不同MOSFET... 详细信息

近年来,随着对功率的需求越来越高,PCB板的散热设计变得更为关键。本文以几个实例论述了MOSFET封装如何改善整个电路板的温度,使其在期望的范围之内。除了DC总线转换器(可达220W级别),本文还讨论了在控制和同步FET插座内带有不同MOSFET的同步降压转换器。对不同设备的相关性能进行了比较。通过测试同步降压转换器和DC总线转换器,发现并联MOSFET并不像期望的那样会降低电路板的温度。优化DC总线转换器会得到比较好的效果,这说明每个插座中的单个设备只有具备良好的Rdson和散热性能,才能达到最佳的整体性能。

关键词：散热性能封装技术提升系统同步降压转换器 MOSFET 总线转换器散热设计 PCB板相关性能通过测试

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Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 374-382页

作者： Yasser Fouad Melissa Palmer Minjun Chen Arie Regev Rajarshi Banerjee Rob Myers Robert Riccio Richard Torstenson Ramy Younes Puneet SArora Henrik Landgren Morten A.Karsdal Martin blake David A.Shapiro Hans-Juergen Gruss Muhammad Y.Sheikh Dina Attia Steven Bollipo Alastair D.smith Bradley Freilich Robert G.Gish Detlef Schuppan Department of Gastroenterology Hepatologyand Endemic MedicineFaculty of MedicineMinia UniversityMiniaEgypt Gan-nex/Ascletis Pharma Co Ltd BeijingChina Liver Consulting LLC New YorkNYUSA Division of Bioinformatics and Biostatis-tics National Center for Toxicological ResearchUS Food and Drug AdministrationJeffersonARUSA Eli Lilly and Company IndianapolisINUSA Perspectum Diagnostics Ltd OxfordUK Gilead Sciences Inc Foster CityCAUSA Syneos Health LLC MorrisvilleNCUSA Allergan Marlow International BuckinghamshireUKAstraZenecaCambridgeUK Boehringer Ingel-heim International GmbHIngelheimGermany Genentech IncSouth San FranciscoCAUSA AbbVie MarlowBuck-inghamshireUK Nordic Bioscience A/S HerlevDenmark Resonance Health BurswoodWAAustralia Intercept Phar-maceuticals Inc San DiegoCAUSA Fresno Clinical Research Center FresnoCAUSA Gastroenterology and Hepatology Department Beni-Suef UniversityBeni SuefEgypt Department of Gastroenterology and Endoscopy John Hunter HospitalNewcastleNSWAustralia School of Medicine and Public Health University of NewcastleNewcastleNSWAustralia Kan-sas City Research Institute Kansas CityMOUSA Division of Gastroenterology and Hepatology Loma Linda UniversityLoma LindaCAUSA Institute of Translational Immunology and Research Center for Immune Therapy University Medical CenterMainzGermany Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Metabolic(dysfunction)-associated fatty liver disease(MAFLD)affects a third of the population and is a leading cause of liver-related *** no effective treatments exist,novel approaches to drug development are ***,outdated terminology and definitions of the disease are hampering efforts to develop new drugs and *** international consensus panel has put forth an influential proposal for the disease to be renamed from nonalcoholic fatty liver disease(NAFLD)to MAFLD,includ-ing a proposal for how the disease should be *** allies with the many stakeholders in MAFLD care―including patients,patients’advocates,clinicians,researchers,nurse and allied health groups,regional societies,and others―we are aware of the negative consequences of the NAFLD term and *** share the sense of urgency for change and will act in new ways to achieve our *** there is much work to be done to overcome clinical inertia and reverse worrisome recent trends,the MAFLD initiative provides a firm foundation to build *** provides a roadmap for moving for-ward toward more efficient care and affordable,sustainable drug and device innovation in MAFLD *** hope it will bring promising new opportunities for a brighter future for MAFLD care and improve care and outcomes for patients of one of the globe’s largest and costliest public health *** this viewpoint,we have revisited this initiative through the perspectives of drug development and regulatory science.

关键词： NAFLD MAFLD NASH Fatty liver disease Liver Fibrosis

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