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Open Journal of Blood Diseases 2020年第2期10卷 41-47页

作者： Lydie Ocini Ngolet Vulliez Renucci Nkounkou blaise atipo ibara Alexis Elira Dokekias Department of Medical Hematology University Hospital of Brazzaville Brazzaville The Republic of the Congo Department of Internal Medicine and Gastroenterology Unit University Hospital of Brazzaville Brazzaville The Republic of the Congo

Background: There are no consensual diagnosis criteria to make diagnosis of sickle cell intrahepatic cholestasis and identify its 2 variants. Here we delineate the frequency of the complication in its severe form and describe its clinical features. Methods: We included in the study all the patients with sickle cell disease who were presenting fever, jaundice, pain in the upper right quadrant and filling up the biological criteria of the severe sickle cell intrahepatic cholestasis (serum direct bilirubin ≥ 78.5 mg/dL). Patients with evidence of viral hepatitis or gallstones were not included in the study. Results: Sixty-two patients with an average age of 21.5 years (range 18 and 25 years) meet the inclusion criteria, minimum serum direct bilirubin: 82 versus 528 for the maximum. The liver cytolysis was major and ranged from 310 to 1550 UI/L. Forty-nine patients (83.9%) did not develop any organ failure. The symptoms and biological abnormalities resolved with supportive treatment within 7 days. The global lethality was 16.1% associated with liver failure. Conclusion: Severe sickle cell intrahepatic cholestasis is more frequent than we thought and was mainly represented by borderline clinical feature. Early intervention may reduce the progression to organ failure stage and ultimate death.

关键词： Sickle Cell Disease Serum Direct Bilirubin Borderline Clinical Feature

Helicobacter Pylori Infection: Epidemiological, Clinical and Endoscopic Aspects in Brazzaville

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Open Journal of Gastroenterology 2023年第4期13卷 131-139页

作者： Bienvenu H. atipo-ibara Anicet Boumba Lucie C. atipo ibara Ollandzobo Ikobo Arnaud Mongo-Onkouo Jile F. Mimiesse Monamou Ngala A. Itoua-Ngaporo Donatien Moukassa blaise I. atipo ibara Jean-Rosaire ibara Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo Hugues Dieudonné Loemba Molecular Biology Laboratory Pointe-Noire Republic of the Congo Pointe-Noire Research Zone National Institute for Research in Health Sciences (IRSSA) Pointe-Noire Republic of the Congo Department of Gastroenterology and Internal Medicine CHU Brazzaville Brazzaville Republic of the Congo Department of Anatomical Pathology Edith Lucie Bongo Odimba General Hospital Oyo Republic of the Congo

Introduction: Helicobacter pylori infection is a real health problem worldwide. It is the most common chronic bacterial infection in the world, and is particularly prevalent in developing countries. Objective: To determine the frequency of Helicobacter pylori infection and to study the epidemiological, clinical and endoscopic characteristics associated with this infection in Brazzaville. Patients and Methods: This was a descriptive cross-sectional study conducted from January to November 2020, i.e. 11 months. This work focused on 100 symptomatic patients over 18 years old referred for upper GI endoscopy. Gastric biopsies for biological study by urease test and molecular study by real time PCR technique were taken. Results: With a mean age of 46.32 ± 15.20 years, the frequency of Hp infection was 91%, with a female predominance of 53%. The sex ratio was 0.92. The average age was 46.32 ± 15.20 years. Carriage of the infection was more important in households with more than 3 persons, in patients consuming public tap water and in those using both types of sanitary facilities. Endoscopy was indicated for epigastralgia in 93.1% of cases. About 56.14% of the infected patients had normal mucosa versus 12.28% with ulcerated lesions and 22.81% with gastritis. Conclusion: The prevalence of Helicobacter pylori infection is significant in Congo, justifying early detection in order to improve management.

关键词： Helicobacter pylori Carriage Chronic Gastritis Gastric Ulcer Brazzaville

Prevalence of Hepatitis C Virus Infection and Risk Factors among Pregnant Women in Pointe Noire, Republic of Congo

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Journal of Biosciences and Medicines 2019年第8期7卷 84-93页

作者： Brunel M. Angounda Serge O. Mokono Ngala Itoua-Ngaporo Jourdain B. Nziengue M’vouala Jile F. Mimiesse Clausina M. Ahoui Apendi Gabriel Ahombo blaise I. atipo ibara Jean Rosaire ibara Faculty of Science and Technology Marien NGOUABI University Brazzaville Congo National Center of Blood Transfusion Brazzaville Congo Faculty of Health Sciences Marien NGOUABI University Brazzaville Congo Hospital and University Center of Brazzaville Brazzaville Congo

Background: Hepatitis C virus (HCV) is a public health problem and is highly endemic in Sub-Saharan Africa. This study was carried out to determine the prevalence and potential risk factors of hepatitis C virus in pregnant women. Methods: This was a cross-sectional study involving pregnant women who attended at seven antenatal clinics in Pointe Noire, from June to November 2018. Structured questionnaires were used to obtain participants data. Samples were screened for HCV infection by using 4th ELISA methods and data analysis was done by Epi-info version 7.0 statistical software. Results: A total of 150 pregnant women were included, out of which 11 (7.3%) were positive for HCV. The high proportion of HCV was found in age group 25 - 34 years (45.4%), educated (81.1%), professional (36.4%) and 54.6% were in second trimester gestational stage. Moreover, 54.6% of HCV positive patients had scarification and 45.5% had a history of surgery. There was not a statistically significant association between demographics characteristics, risks factors and HCV seropositivity (p > 0.05). Conclusion: This study showed a high prevalence of HCV infection and confirmed that this infection is a public health problem in pregnant women in Pointe Noire.

关键词： Pregnancy HCV Risk Factors

Quality of Life of Chronic Kidney Disease Patients in the Republic of the Congo

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Open Journal of Nephrology 2021年第4期11卷 495-505页

作者： Gael Honal Mahoungou Daniel Tony Eyeni Sinomono Yannick Dimi Nyanga Tanee Fomum Steve Ondziel Opara Helena Botokoto Bothard Jean Lucien Mobengo Richard Loumingou blaise Iréné atipo ibara Department of Nephrology University Hospital of Brazzaville Brazzaville Republic of the Congo Faculty of Heath Sciences University Marien Ngouabi Brazzaville Republic of the Congo Department of Urology University Hospital of Brazzaville Brazzaville Republic of the Congo Department of Gastroenterology University Hospital of Brazzaville Brazzaville Republic of the Congo

Background: Chronic kidney disease could impair the quality of life of patients regardless of the stage of the disease. So far, there is no data on this subject in the Congolese population. The objective of this study was to assess the quality of life of patients with chronic kidney disease in Congo. Patients and methods: We conducted a cross-sectional, descriptive study of 91 patients followed in the department of nephrology and in dialysis centers in Brazzaville, Pointe-Noire and Oyo from July 1st to November 30th, 2020, i.e. five months. We used the Kidney disease quality of life short form health survey score (KDQOL-SF 36) to assess the quality of life of patients and a questionnaire was used to determine socio-demographic, clinical and therapeutic features. Data analysis was done on SPSS 2.2 software. Result: The average age was 51.9 ± 15 years. The sex ratio M/F was 2.03. The average time of patient follow-up was 15 months;90% of them had hypertension. The overall average score of specific dimensions was 52 ± 18;disease burden was the dimension most affected;that of the generic dimensions was 34 ± 25 with the limitation of physical activity dimension being the most affected. No patient had received psychological follow-up. Conclusion: This study indicates the value of a systematic assessment of the quality of life of patients with chronic kidney disease as well as the need for assistance for these patients in different areas of their life.

关键词： Chronic Kidney Disease Quality of Life KDQOL

Helicobacter Pylori Infection in Brazzaville: Comparative Study of Two Identification Tests

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Open Journal of Gastroenterology 2019年第11期9卷 223-227页

作者： Ngala Akoa Itoua-Ngaporo Lucie C. A. I. O. Ikobo Arnaud Mongo-Onkouo Jile Florent Mimiesse Monamou Clausina Philestine Ahoui Apendi Rody Stéphane Ngami Marlyse Ngalessami Mouakosso Deby Gassaye blaise Irenée atipo ibara Jean-Rosaire ibara Department of Hepatogastroenterology and Internal Medicine of Brazzaville University Hospital Center Brazzaville Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Department of Infant Pediatrics of Brazzaville University Hospital Center Brazzaville Congo

Objective: To determine the place of two identification tests for Helicobacter pylori infection available in Congo. Materials and Methods: This was a comparative study carried out in two digestive endoscopy centers in Brazzaville from 1 January to 31 May 2018. Symptomatic patients referred for upper gastrointestinal endoscopy were included systematically. The frequency of infection was determined from two identification tests, namely the rapid urease test in gastric biopsies and the detection of antigen (Ag) for the germ in the stool. The criterion for judging the presence of the germ in each patient was the positivity of at least one of the two tests. The McNEMAR X2 test (p < 0.05) was used for the comparison of averages. Results: During the study period, 137 consenting patients were included, including 62 men and 75 women. The overall incidence of Helicobacter pylori (Hp) infection was 79.6% (109/28). Of the 137 patients, 18 were urease positive only;6 were looking for Hp Ag in the stool, and 85 were in the two tests. The frequency of infection was 75.2% (103/137) with the rapid urease test and 66.4% (91/137) with the Hp Ag test in stool. The rapid urease test proved more reliable in the diagnosis of Helicobacter pylori infection than the stool antigen test.

关键词： Helicobacter Pylori Identification Tests Brazzaville

Knowledge, Attitudes and Perceptions of Colorectal Cancer Screening in Brazzaville

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Open Journal of Gastroenterology 2024年第11期14卷 414-430页

作者： Clausina Mikolélé Ahoui Apendi Jhonsial Joseph Bovane Molami Aranud Mongo-Onkouo Jile Florient Mimiesse Monamou Rody Stéphane Ngami Mardochée Motoula Latou Ngala Akoa Itoua-Ngaporo Marlyse Ngalessami Mouakosso Céline Sandra Adoua Deby Gassaye blaise Irenée atipo ibara Department of Gastroenterology and Internal Medicine Brazzaville University Hospital Brazzaville Republic of the Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo

Objective: assess the knowledge, attitudes, and perceptions of Brazzaville residents on colorectal cancer and its screening. Population and Methods: a CAP-type cross-sectional study was conducted from June 1 to October 31, 2022, with 803 workers approached at their place of service. Information was collected using a questionnaire administered to participants. The variables studied concerned knowledge, attitudes, and perceptions about colorectal cancer. SPSS software, along with Chi-square and Fisher tests, was used for data entry and analysis. Odds ratios were calculated to determine the strength of the association between variables. Results: The average age of the participants was 33.5 ± 10 years, with a sex ratio of 0.9. There were 231 health workers. The main sources of information were health personnel (78.2%) and the internet (52.6%). The site of the pathology was known to 87% of participants. About 40% identified age, genetic predispositions, and a diet rich in animal fats as risk factors. No signs of the disease were known by 50% of the participants. Colonoscopy was known as a screening method by 40% of participants. Seventy-five percent were willing to participate in a CRC awareness campaign, but only 5% agreed to a screening colonoscopy, although 96% recognized its usefulness. Overall, the level of knowledge was insufficient in 70.4% of cases;attitudes were adapted in 55.7% of cases, and perceptions were adapted in 97.3% of cases. Factors influencing knowledge included young age (p = 0.006), a good level of education, being a healthcare worker, and high socio-economic level. Conclusion: colorectal cancer and its screening are poorly understood by the population. Awareness activities must be organized to improve knowledge and promote screening and early diagnosis of CRC.

关键词： Colorectal Cancer Screening Knowledge Attitudes Perceptions Brazzaville

Charactistics of Anemia in Cirrhotics in the Gastroenterology Department at Brazzaville University Hospital

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Open Journal of Gastroenterology 2024年第11期14卷 402-413页

作者： Clausina Mikolélé Ahoui Apendi Daulores Sylavnie Abena Ebembe Ngala Akoa Itoua-Ngaporo Jenny Carmela Angala Andzi Arnaud Mongo-Onkouo Jile Florient Mimiesse Monamou Rody Stéphane Ngami Mardochée Motoula Latou Marlyse Ngalessami Mouakosso Céline Sandra Adoua Deby Gassaye blaise Irenée atipo ibara Department of Gastroenterology and Internal Medicine Brazzaville University Hospital Brazzaville Republic of the Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo

Objective: Study of the frequency of anemia, its characteristics and its relationship with different epidemiological, diagnostic and prognostic parameters of cirrhosis. Patients and methods: This was a retrospective descriptive study from January 2016 to December 2019 in the Gastroenterology and Internal Medicine department at the Brazzaville University Hospital. It concerned all cirrhotics hospitalized during the study period and presenting anemia. The epidemiological, diagnostic, and prognostic data studied were collected from medical records. The characteristics of anemia on the blood count were defined based on WHO values. The information collected was entered and processed with Excel 8.0 and EPI data 3.1 software. The Pearson chi2 test at the significance level ≤ 5% was used to compare the results. Results: We collected 102 files of cirrhotic patients during the study period. There were 63 men and 39 women, a sex ratio of 1.6. Among these patients, 77 presented anemia, i.e., a frequency of 75.5% with a male predominance (57.2%). Anemia increased without a significant relationship with age and was more severe in young female subjects (42.8%). The normochromic normocytic character was the most observed (52%). Anemia was more frequent in post-hepatitic cirrhosis, representing 67.5% of cases of anemia. It worsened during digestive bleeding, with the abundance of ascites and the severity of hepatic encephalopathy (p > 0.05). It was significantly associated with the drop in prothrombin level (63.6%), hypoalbuminemia (64.9%), and the Child-Pugh score (p < 0.05).

关键词： Anemia Cirrhosis CHU Brazzaville

Ingestion of Caustics by Children in Brazzaville (CONGO)

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Open Journal of Pediatrics 2018年第3期8卷 283-291页

作者： Lucie Charlotte atipo-ibara Ikobo Ollandzobo Clausina Ahoui-Apendi Jile Florient Mimiesse-Monamou Jean Robert Mabiala Babela Deby-Gassaye blaise Irénée atipo ibara Jean-Rosaire ibara Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Infant Pediatric Service University Hospital of Brazzaville Brazzaville Congo Gastroenterology and Internal Medicine Service University Hospital of Brazzaville Brazzaville Congo

Ingestion of caustics by children is serious because of the increase in their frequency and the difficulties due to their management. Objective: To improve the management of caustic lesions in Pediatric Department at the University Hospital of Brazzaville. Patients and Methods: Prospective study was conducted from January 2014 to December 2015 in the Pediatric Departments of the UHB and centers of digestive endoscopy in Brazzaville. All children who ingested a caustic product and hospitalized were included after obtaining parental’s consent. The studied parameters were: Age, sex, nature and quantity of the caustic, the family’s attitude, clinical signs, endoscopic results according to Zagar’s classification, therapeutic modalities and evolution. Results: 8292 children were hospitalized and 68 because of the ingestion of caustic, a frequency of 0.8%. The average age was 23.6 months [2 months - 16 years]. The male sex was predominant (57.4%). Ingestion was accidental in 88.2% and voluntary in 11.8%. Factors favoring ingestion were storage methods (81.5%) and parental’s inattention or negligence (10.8%). Bleach was the most incriminated caustic (54.4%) followed by caustic soda (29.4%). The estimated quantity ingested was assumed to be minimal in 61.7%. Unsuitable acts were practiced by the family before the medical consultation in 66.1%. The dominant symptoms were digestive (47%) and neurological (25%). The average time to perform endoscopy was 48 hours in 88.2%. Endoscopy revealed lesions in 51.7%, the different stages were I (12 cases), II (16 cases) and III (3 cases). The mains factors of gravity were inappropriate gestures (85%) and the non-respect of the fasting (9%). Proton pump inhibitors were used in 50%. The evolution was favorable for in 73.5%. Conclusion: Ingestion of caustics by children is most often accidental favored by the inadequate packaging and storage. Prevention is about educating people in order to reduce their frequency.

关键词： Caustic Lesions Child Brazzaville

Prevalence of Children Vaccinated against Viral Hepatitis B in Brazzaville

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Open Journal of Pediatrics 2024年第2期14卷 426-434页

作者： Lucie Charlotte Ollandzobo Ikobo Farrèche Colombe Missidi Hostaud Bienvenu atipo-ibara Arnaud Mongo Onkouo Clausina Philestine Ahoui Apendi Jile Florent Mimiesse blaise Irénée atipo ibara Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo Infant Paediatrics Department Brazzaville University Hospital Brazzaville Republic of the Congo Gastroenterology and Internal Medicine Department Brazzaville University Hospital Brazzaville Republic of the Congo

Introduction: Viral hepatitis B (VHL) is a public health problem, particularly in sub-Sahara Africa. The aim of this study was to assess vaccination coverage against HBV in children in Brazzaville. Patients and Methods: This was a cross-sectional analytical study conducted in Brazzaville health centres from January to September 2019. It involved children aged between six months and six years who received a vaccination against HBV. Sampling was exhaustive and based on stratified sampling. Results: The overall prevalence of children vaccinated against HBV in Brazzaville was 96.2%. It was insufficient in the Talangai health district (79%). The pentavalent vaccine was administered to 97.7% of children, 85% of whom had received all three doses. The reasons for incomplete vaccination were parents’ ignorance of HVB (85.6%) and of vaccination (14.3%). Conclusion: Although the prevalence of vaccinated children is high in Brazzaville, it is still insufficient in some health districts, particularly Talangai, because parents are unaware of the disease and of vaccination. Pentavalent is the only vaccine available in the national vaccination programme, which is why an effective national vaccination policy needs to be put in place. .

关键词： Prevalence Vaccination Viral Hepatitis B Child Brazzaville

Varioliform Gastritis after Ibuprofen Poisoning

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Open Journal of Gastroenterology 2018年第3期8卷 103-106页

作者： atipo ibara blaise Irénée Mongo Onkouo Arnaud Ahoui Apendi Clausina atipo ibara Ollandzobo Lucie Charlotte Mimiesse Monamou Jile Florient Itoua-Ngaporo Akoa Ngala Deby Gassaye Bossali Firmin ibara Jean-Rosaire Faculty of Medical Sciences Marien Ngouabi University Brazzaville Congo Department of Gastroenterology and Internal Medicine Brazzaville University Hospital Centre Brazzaville Congo Paediatric Service Brazzaville University Hospital Centre Brazzaville Congo

Diffuse varioliform gastritis is a rare attack of the gastric mucosa occurring mostly on atopic ground. This report is based on the observation of a 16-year-old girl with diffuse varioliform gastritis discovered after an internal medical examination via endoscope after attempting a suicidal act by overdosing herself with Ibuprofen. After the medical examination of the patient. Despite the quantity of ingested ibuprofen and presence of Helicobacter pylori on the biopsie, the particularity of this study is that there is no exudative lesion of the gastric mucosa. With hélicobacter pylori eradication evolution was favorable.

关键词： Varioliform Gastritis Ibuprofen Teenager