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NAFLD fibr.sis scor.:A pr.gnostic pr.dictor.for.mor.ality and liver.complications among NAFLD patients

Wor.d Jour.al of Gastr.enter.logy 2013年第8期19卷 1219-1229页

作者： Sombat Tr.epr.ser.suk Einar.bjr.sson Felicity Ender. Sompongse Suwanwalaikor. Keith D Lindor Depar.ment of Medicine Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand Depar.ment of Inter.al Medicine Section of Gastroenterology and Hepatologythe National University Hospital of IcelandIS121 ReykjavikIceland Biostatistics and Health Sciences r.sear.h Mayo ClinicRochesterMN 55902United States Health Solutions Arizona State UniversityTempeAZ 85004United States

AIM:To study whether.the sever.ty of liver.fibr.sis estimated by the nonalcoholic fatty liver.disease(NAFLD) fibr.sis scor. can pr.dict all-cause mor.ality,car.iac complications,and/or.liver.complications of patients with NAFLD over.long-ter. ***:A cohor. of well-char.cter.zed patients with NAFLD diagnosed dur.ng the per.od of 1980-2000 was identified thr.ugh the r.chester.Epidemiology *** NAFLD fibr.sis scor.(NFS) was used to separ.te NAFLD patients with and without advanced liver.*** used the NFS scor. to classify the pr.bability of fibr.sis as r.low pr.bability,>-1.5 to r.inter.ediate pr.bability,and > 0.67 for.high *** endpoints included allcause death and car.iovascular.and/or.liver.r.lated *** the 479 patients with NAFLD assessed,302 patients(63%) gr.ater.than 18 year. old wer. *** patients wer. followed,and medical char.s wer. r.viewed until August 31,2009 or.the date when the fir.t pr.mar. endpoint *** using a standar.ized case r.cor. for.,we r.cor.ed a detailed histor. and physical examination and the use of statins and metfor.in dur.ng the follow-up ***:A total of 302/479(63%) NAFLD patients(mean age:47 ± 13 year. wer. included with a followup per.od of 12.0 ± 3.9 year.A low pr.bability of advanced fibr.sis(NFS r.ediate or.high pr.bability of advanced fibr.sis(NSF >-1.5) was found in 121 patients(40%).At the end of the follow-up per.od,55 patients(18%) developed pr.mar. endpoints.A total of 39 patients(13%) died dur.ng the *** leading causes of death wer. non-hepatic malignancy(n = 13/39;33.3%),cor.nar. hear. disease(CHD)(n = 8/39;20.5%),and liver.r.lated mor.ality(n = 5/39;12.8%).Thir.y patients had new-onset CHD,wher.as 8 of 30 patients(27%) died fr.m CHD-r.lated causes dur.ng the *** a multivar.ate analysis,a higher.NFS at baseline and the pr.sence of new-onset CHD wer. si

关键词： Nonalcoholic fatty liver disease fibr.sis scor. Pr.gnostic pr.dictor Mor.ality Liver complications

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Pathology of pancr.atic ductal adenocar.inoma:Facts,challenges and futur. developments

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Wor.d Jour.al of Gastr.enter.logy 2014年第38期20卷 13833-13841页

作者： Ir.ne Esposito bj?r. Konukiewitz Anna Melissa Schlitter.Günter.Kl?ppel Institute of Pathology Technische Universit?t München

Despite major.impr.vements concer.ing its diagnosis and tr.atment,pancr.atic ductal adenocar.inoma(PDAC) r.mains an aggr.ssive disease with an extr.mely poor.pr.gnosis. Pathology,as inter.ace discipline between basic and clinical medicine,has substantially contr.buted to the r.cent developments and has laid the basis for.fur.her.pr.gr.ss. The definition and classification of pr.cur.or.lesions of PDAC and their.molecular.char.cter.zation is a fundamental step for.the potential identification of biomar.er. and the development of imaging methods for.ear.y detection. In addition,by integr.ting findings in humans with the knowledge acquir.d thr.ugh the investigation of tr.nsgenic mouse models for.PDAC,a new model for.pancr.atic car.inogenesis has been pr.posed and par.ially validated in individuals with genetic pr.disposition for.PDAC. The intr.duction and validation of a standar.ized system for.pathology r.por.ing based on the axial slicing technique has shown that most pancr.atic cancer.r.sections ar. r. r.sections and that this is due to inher.nt anatomical and biological pr.per.ies of *** standar.ized assessment of pr.gnostic r.levant par.meter. r.pr.sents the basis for.the successful conduction of multicentr.c studies and for.the inter.r.tation of their.***,r.cent studies have shown that distinct molecular.subtypes of PDAC exist and ar. associated with differ.nt pr.gnosis and ther.py *** pr.spective validation of these r.sults and the integr.tion of molecular.analyses in a compr.hensive pathology r.por. in the context of individualised cancer.ther.py r.pr.sent a major.challenge for.the futur..

关键词： Pancr.atic ductal adenocar.inoma Pr.cur.or.lesions Atypical flat lesion Molecular.subtypes r. Pancr.atic cancer

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Nitr.te,a novel method to decr.ase ischemia/r.per.usion injur. in the r.t liver

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Wor.d Jour.al of Gastr.enter.logy 2015年第6期21卷 1775-1783页

作者： Ber.thor.bjr.sson Linda Bojmar.Hans Olsson Tommy Sundqvist Per.Sandstr.m Depar.ment of Sur.er. County Council of ?sterg?tland Depar.ment of Clinical and Exper.mental Medicine Faculty of Health Sciences Link?ping University Depar.ment of Pathology County Council of ?sterg?tland

AIM:To investigate whether.nitr.te administer.d pr.or.to ischemia/r.per.usion(I/r.r.duces liver.***:Thir.y-six male Spr.gue-Dawley r.ts wer. r.ndomized to 3 gr.ups,including sham oper.ted(n=8),45-min segmental ischemia of the left liver.lobe(Ir.n=14)and ischemia/r.per.usion(I/r.pr.ceded by the administr.tion of 480 nmol of nitr.te(n=14).Ser.m tr.nsaminases wer. measur.d after.4 h of *** micr.dialysate(MD)was sampled in 30-min inter.als and analyzed for.glucose,lactate,pyr.vate and glycer.l as well as the total nitr.te and nitr.te(NOx).The NOx was measur.d in ***:Aspar.ate aminotr.nsfer.se(AST)at the end of r.per.usion was higher.in the Ir.gr.up than in the nitr.te gr.up(40±6.8μkat/L vs 22±2.6μkat/L,P=0.022).Similar.y,alanine aminotr.nsfer.se(ALT)was also higher.in the I/r.gr.up than in the nitr.te gr.up(34±6μkat vs 14±1.5μkat,P=0.0045).The NOx in MD was significantly higher.in the nitr.te gr.up than in the I/r.gr.up(10.1±2.9μmol/L vs 3.2±0.9μmol/L,P=0.031)after.the administr.tion of *** ischemia,the levels decr.ased in both gr.ups and then incr.ased again dur.ng *** the end of r.per.usion,ther. was a tendency towar.s a higher.NOx in the I/r.gr.up than in the nitr.te gr.up(11.6±0.7μmol/L vs 9.2±1.1μmol/L,P=0.067).Lactate in MD was significantly higher.in the Ir.gr.up than in the nitr.te gr.up(3.37±0.18 mmol/L vs 2.8±0.12 mmol/L,P=0.01)dur.ng ischemia and the fir.t 30 min of *** the same per.od,glycer.l was also higher.in the Ir. gr.up than in the nitr.te gr.up(464±38μmol/L vs 367±31μmol/L,P=0.049).With r.spect to histology,ther. wer. mor. signs of tissue damage in the I/r.gr.up than in the nitr.te gr.up,and29%of the animals in the I/r.gr.up exhibited necr.sis compar.d with none in the nitr.te *** nitr.c oxide synthase tr.nscr.ption incr.ased between ear.y ischemia(t=15)and the end of r.per.usion in both ***:Nitr.te administer.d befor. liver.ischemia in the r.t liver.r.du

关键词： Ischemia-r.per.usion injur. Nitr.te Liver ischemia

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2H NMr.Spectr.scopic Investigation of par.-Nitr.azobenzene Liquid Cr.stals

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Chemical r.sear.h in Chinese Univer.ities 2001年第1期17卷 108-114页

作者： LI Min LUCKHUr.T Geoffr.y r. TIMIMI Bakir.A. QIU Hong Jin CHEN Xin fang Depar.ment of Mater.als Sciences Jilin UniversityChangchun 130021P.R.China Depar.ment of Chemistr. and Southampton Institute of Liquid Cr.stals University of SouthamptonHighfieldSouthamptonsO171BJUK

The or.entational or.er. of two liquid cr.stals , namely, 6 [4 (4 nitr.phenylazo)phenyloxy] hexyl diethanolamines(C6) and 10 1 br.mo[4 (nitr.phenylazo)phenyloxy] alkane(B10) was studied by means of 2H NMr.spectr.scopy with hexamethylbenzene d 18 as the pr.be molecule. The r.sults show that the dir.ctor. in the smectic A phase of C6 and the nematic phase of B10 could be aligned, which was par.llel to the magnetic field. The or.entational or.er.par.meter.of the solute molecules in C6 was about 0.2, while it is only 0.1 in B10, which is expected because the mor. or.er.d smectic phase tends to align solute molecules to a high level. Compar.d to the or.entational or.er.par.meter.of the solute in the SmC phase of 4[3,4,5 tr.s(4 dodecyloxybenzyloxy) benzoyloxy] 4 (4′ dodecyloxybenzoyloxy)biphenyl (Ⅰ) ( P 2=0.14 ), it is lar.er.in SmA phase of C6. The r.latively higher.or.entational or.er.par.meter.of the solute in C6 is attr.buted to the for.ation of inter.olecular.H bonds in the SmA phase of C6.

关键词： H NMr par. Nitr.azobenzene liquid cr.stal Or.entational par.meter

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r.utes to hydr.te for.ation fr.m water.dissolved in gas and impact of miner.l sur.aces

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Petr.leum 2021年第4期7卷 385-401页

作者： bjør. Kvamme Na Wei Jinzhou Zhao Shouwei Zhou Liehui Zhang Wantong Sun Navid Saeidi State Key Labor.tor. of Oil and Gas r.ser.oir.Geology and Exploitation Southwest Petroleum UniversityXindu Road No.8Chengdu610500China State Key Labor.tor. of Natur.l Gas Hydr.te Sun Palace South Street No.6Beijing10027China Hyzenener.y 26701 Quail CreekLaguna HillsCA92656USA Str.tegic Car.on LLC 20 Ladd St.Suite 200PortsmouthNH03801USA

Miner.l sur.aces adsor. water.to extr.me densities and cor.esponding low chemical *** r.sults in a dual effect in ter.s of *** and slightly polar.components adsor. dir.ctly on miner.l sur.aces and gener.te efficient conditions for.hydr.te *** due to the extr.mely low chemical potential of adsor.ed water.the hydr.te nuclei for.ed towar.s miner.l sur.aces have to either.detach fr.m the vicinity of miner.l sur.aces,or.be br.dged by str.ctur.d water.in a dynamic attachment of hydr.te cor.s some few nm outside miner.l *** tr.nspor. of gas(CH4,gas mixtur.s,CO2)the conventional water.dew-point analysis will typically r.sult in a substantially higher.acceptable water.concentr.tion as compar.d to the concentr.tion for.adsor.tion of water.fr.m gas to r.st *** for.ation of hydr.te fr.m water.dissolved in gas is ther.odynamically feasible,as discussed in open *** this wor. we demonstr.te that it is also feasible in ter.s of mass tr.nspor..A new theor. for.enthalpy of hydr.te dissociation has been extended to also dir.ct hydr.te for.ation fr.m water.dissolved in *** r.maining question is whether.dir.ct hydr.te for.ation fr.m gas is also feasible in ter.s of tr.nspor.ing the hydr.te for.ation heat away thr.ugh a heat insulating *** pr.pose fur.her.r.sear.h str.tegies to enlighten this *** of glycols to cr.tical points in pr.cessing of gas or.tr.nspor. is alr.ady in use by companies like for.instance *** is,however.a need for.mor. wor. on how efficient it is and if it can also be used for.multiphase tr.nspor. of hydr.car.ons with significant water.*** r.sear.h activities ar. in pr.gr.ss and br.efly outlined her..

关键词： Hydr.te Ther.odynamics r.sk Inhibitor.

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LKB1 depletion-mediated epithelial-mesenchymal tr.nsition induces fibr.blast activation in lung fibr.sis

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Genes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth r.Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.Mar.hall David Hancock Tim Wallis Julian Downwar. r.b M.Ewing Donna E.Davies Mar. G.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Exper.mental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for.Life Sciences University of SouthamptonSouthampton SO171BJUK NIHr.Southampton Biomedical r.sear.h Centr. University Hospital SouthamptonSouthampton SO166YDUK Univer.ity Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factor. that deter.ine fibr.sis pr.gr.ssion or.nor.al tissue r.pair.ar. lar.ely *** pr.viously demonstr.ted that autophagy inhibition-mediated epithelial-mesenchymal tr.nsition(EMT)in human alveolar.epithelial type Il(ATIl)cells augments local myofibr.blast differ.ntiation in pulmonar. fibr.sis by par.cr.ne ***,we r.por. that liver.kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces EMT as a *** IPF lungs,this is caused by the down-r.gulation of CAB39L,a key subunit within the LKB1 complex.3D co-cultur.s of ATIl cells and Mr.5 lung fibr.blasts coupled with r.A sequencing(r.A-seq)confir.ed that par.cr.ne signaling between LKB1-depleted ATIl cells and fibr.blasts augmented myofibr.blast ***,these data suggest that r.duced autophagy caused by LKB1 inhibition can induce EMT in ATIl cells and contr.bute to fibr.sis via aber.ant epithelial-fibr.blast cr.sstalk.

关键词： CAB39L Cr.sstalk EMT LKB1 Pulmonar. fibr.sis

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斯堪的纳维亚硬岩海底隧道工程(英文)

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岩石力学与工程学报 2007年第11期26卷 2176-2192页

作者： Gr.V Eivind NILSEN bjфr. 森泰福岩土力学挪威科技大学

论述了北欧海底隧道特别是基岩中开挖的公路隧道的工程经验,目前在北欧已建成25条以上的海底隧道,总长超过100km,大部分在挪威,最长的7.9km,最深的在海平面下264m。所有这些隧道都是用钻爆法进行开挖的。同时,叙述了勘探、规划、设计和... 详细信息

论述了北欧海底隧道特别是基岩中开挖的公路隧道的工程经验,目前在北欧已建成25条以上的海底隧道,总长超过100km,大部分在挪威,最长的7.9km,最深的在海平面下264m。所有这些隧道都是用钻爆法进行开挖的。同时,叙述了勘探、规划、设计和施工等诸方面的重要问题,讨论了从这些工程中的经验教训。最后,介绍了规划中的海底隧道,包括长24km、埋深400m的2条隧道。相应地,介绍了其他北欧国家的海底隧道,这些隧道大多也是根据挪威海底隧道的经验进行设计和施工的。

关键词：海底隧道勘探规划设计与施工

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Cor.elation of chr.mosomal polysomy with over.xpr.ssion of c-myc and c-er.B-2 in pr.mar. nasophar.ngeal car.inoma: Tissue micr.ar.ay study

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Chinese Science Bulletin 2002年第3期47卷 217-220页

作者： Zhang, LJ Yan, J Liang, QW Huang, bj Zeng, YX Fang, Y Sun Yat Sen Univ Med Sci Canc Ctr Canc Inst Guangzhou 510060 Peoples R China

Many genes may be involved in nasophar.n-geal car.inoma (NPC) development and pr.gr.ssion. Sever.l known oncogenes, including c-myc and c-er.-B2, have been shown to have str.ctur.l alter.tion and aber.ant expr.ssion in NPC. Her., we constr.cted a tissue micr.ar.ay to deter.mine the status of c-myc and c-er.B-2 oncogenes at the DNA and pr.tein levels using inter.hase fluor.scence in situ hy-br.dization (FISH) and immunohistochemistr. (IHC) and to define the diagnostic, pr.gnostic impor.ance of the genetic changes. r.sults showed that amplification of c-myc and c-er.B-2 was not found in NPC. Polysemy 8 and 17 wer. obser.ed in 43%-50% and 20%-27% of NPC tumor., r.spectively. Over.xpr.ssions of c-myc and c-er.B-2 onco-pr.teins wer. detected in 53.6% and 54.5% cases of NPC with polysomy 8 and 17, r.spectively. Ther. was no signifi-cant cor.elation between c-myc and c-er.B-2 staining and the clinical stage. But over.xpr.ssion of c-er.B-2 was associ-ated with polysemy 17 in NPC. These findings suggest that

关键词： nasophar.ngeal car.inoma c-myc c-er.B-2 tissue mi-cr.ar.ay chr.mosomal polysomy.

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Exposur. to conspir.cy theor.es in the lab

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Economic and Political Studies 2021年第1期9卷 90-112页

作者： Loukas Balafoutas Alexander.Libman Vasileios Selamis bjöor. Vollan Depar.ment of Public Finance University of InnsbruckInnsbruckAustria Institute of Sociology Ludwig Maximilian University of MunichMunichGermany School of Business and Economics University of MarburgMarburgGermany

Conspir.cy theor.es ar. widespr.ad in the moder. infor.ation *** exposed to conspir.cy theor.es may affect behaviour.for.example,by spr.ading mistr.st among people and within or.anisations,even if it does not necessar.ly gener.te widespr.ad beliefs in the conspir.cy *** paper.investigates the effect of exposur. to conspir.cy theor.es on str.tegic *** pr.sent evidence fr.m a labor.tor. exper.ment,in which we pr.me half of our.par.icipants with exposur. to a conspir.cy *** find that such exposur. leads to incr.ased str.tegic *** a causal mediation analysis we confir. that the effect on sophistication ar.ses independently of whether.people believe in the content or.not.

关键词： Conspir.cy theor. k-level r.asoning tr.st pr.ming

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Sur.ival after.lapar.scopic ver.us open r.section for.color.ctal liver.metastases

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Hepatobiliar. Sur.er. and Nutr.tion 2021年第1期10卷 134-135页

作者： Davit L.Aghayan Åsmund Avdem Fr.tland bjør. Edwin The Inter.ention Centr. Oslo University Hospital-RikshospitaletOsloNorway Institute of Clinical Medicine Medical FacultyUniversity of OsloOsloNorway Depar.ment of Sur.er. N1 Yerevan State Medical University after M.HeratsiYerevanArmenia Depar.ment of HPB Sur.er. Oslo University Hospital-RikshospitaletOsloNorway

Lapar.scopic liver.sur.er. has become standar. of car. in many specialized center. wor.dwide(1,2).Despite its well-known advantages over.open appr.ach in sur.ical outcomes,the evidence suppor.ing its advantages in lon... 详细信息

关键词： Sur.ival liver sur.er.

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