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Jour.al of Magnesium and Alloys 2021年第1期9卷 112-122页

作者： bjor. Wiese r.gine Willumeit-r.mer.Dietmar.Letzig Jan Bohlen Division Metallic Biomater.als Institute of Materials ResearchHelmholtz-Zentrum GeesthachtMax-Planck-Str.1Geesthacht 21502Germany Magnesium Innovation Center.MagIC) Institute of Materials ResearchHelmholtz-Zentrum GeesthachtMax-Planck-Str.1Geesthacht 21502Germany

The effect of Ag in solid solution on the micr.str.ctur.,textur. and the defor.ation behaviour.of indir.ctly extr.ded Mg was *** as a solid solution str.ngthener.affects the behaviour.dur.0} extr.sion,r.sulting in enhanced defor.ation r.lated heating and cor.esponding coar.er.gr.ined *** substantial effect on the textur. development is *** mechanical pr.per.ies simultaneously incr.ase in str.ss and str.in levels with incr.asing Ag content,especially in tension as a r.sult of the changing impact of the slip modes which can be associated with a decr.ase of the lattice par.meter. as well as the c/a r.tio of the hcp lattice *** compr.ssion tests with twin dominated flow,the impact is much smaller.on the compr.ssive yield str.ss but higher.with r.spect to the twinning r.lated str.in har.ening *** solution str.ngth functions for.Fleischer.and Labusch wer. deter.ined,also confir.ing the anisotr.pic behaviour.of the extr.ded Mg alloys.

关键词： Mg-Ag-alloys Lattice par.meter. Indir.ct extr.sion Micr.str.ctur. Mechanical pr.per.ies

Numer.cal modeling of zer.-offset labor.tor. data in a str.ng topogr.phic envir.nment: r.sults for.a spectr.l-element method and a discr.tized Kir.hhoff integr.l method

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Ear.hquake Science 2014年第4期27卷 391-399页

作者： Nathalie Favr.tto-Cr.stini Anastasiya Tantser.va Paul Cr.stini bjφr. Ur.in Dimitr. Komatitsch Ar.ady M.Aizenberg Labor.tor. of Mechanics and Acoustics (LMA) CNRS AixMarseille UniversityCentrale Marseille Depar.ment of Petr.leum Engineer.0} and Applied Geophysics Norwegian University of Science and Technology Institute of Petr.leum Geology and Geophysics SB r.S

Abstr.ct Accur.te simulation of seismic wave pr.paga- tion in complex geological str.ctur.s is of par.icular.inter.st nowadays. However.conventional methods may fail to simulate r.alistic wavefields in envir.nments with gr.at and r.pid str.ctur.l changes, due for.instance to the pr.sence of shadow zones, diffr.ctions and/or.edge effects. Differ.nt methods, developed to impr.ve seismic model- ing, ar. typically tested on synthetic configur.tions against analytical solutions for.simple canonical pr.blems or.r.f- er.nce methods, or.via dir.ct compar.son with r.al data acquir.d in situ. Such appr.aches have limitations,especially if the pr.pagation occur. in a complex envi- r.nment with str.ng-contr.st r.flector. and sur.ace ir.eg- ular.ties, as it can be difficult to deter.ine the method which gives the best appr.ximation of the ＂r.al＂ solution, or.to inter.r.t the r.sults obtained without an a pr.or. knowledge of the geologic envir.nment. An alter.ative appr.ach for.seismics consists in compar.0} the synthetic data with high-quality data collected in labor.tor. exper.- ments under.contr.lled conditions for.a known configur.tion. In contr.st with numer.cal exper.ments, labor.tor. data possess many of the char.cter.stics of field data, as r.al waves pr.pagate thr.ugh models with no numer.cal appr.ximations. We thus pr.sent a compar.son of labor.tor.-scaled measur.ments of 3D zer.-offset wave r.flection of br.adband pulses fr.m a str.ng topogr.phic envir.nment immer.ed in a water.tank with numer.cal data simulated by means of a spectr.l-element method and a discr.tized Kir.hhoff integr.l method. The r.sults indicate a good quantitative fit in ter.s of time ar.ivals and acceptable fit in amplitudes for.all datasets.

关键词： Numer.cal modeling . Zer.-offset r.flection Labor.tor. exper.ments Str.ng topogr.phy

爱立信IMSweShar.分享每一天（系列之二）如何提供出色的用户体验？

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通讯世界 2006年第10期12卷 88-89页

作者： Mikael E．bjō1ing Jennie Car.sten Piotr.Kessler.Er.k Kr.se MatsStille

爱立信IMS weShar.业务有20％的开发与用户视觉体验相关（用户界面、图标、标签以及进度条），其它的80％则主要致力于设备间的系统。与此相对比，用户的体验则完全（100％）有赖于其可接触的事物。移动业务内置于移动电话有限的空间里... 详细信息

爱立信IMS weShar.业务有20％的开发与用户视觉体验相关（用户界面、图标、标签以及进度条），其它的80％则主要致力于设备间的系统。与此相对比，用户的体验则完全（100％）有赖于其可接触的事物。移动业务内置于移动电话有限的空间里，而这里也是用户体验的诞生之处。然而，体验的质量则取决于同支持系统如何交互，及系统的性能如何？

关键词：用户界面爱立信支持系统移动业务移动电话 IMS 进度条

Str.ng pr.gnostic value of nodal and bone mar.ow micr.-involvement in patients with pancr.atic ductal car.inoma r.ceiving no adjuvant chemother.py

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Wor.d Jour.al of Gastr.enter.logy 2006年第40期12卷 6515-6521页

作者： Emr. F Yekebas Dean Bogoevski Michael Bubenheim bjr.-Chr.stian Link Jussuf T Kaifi r.bin Wachowiak Oliver.Mann Asad Kutup Guellue Cataldegir.en Lar. Wolfr.m Andr.as Er.1}sdobler.Chr.stoph Klein Klaus Pantel Jakob r.Izbicki Depar.ment of Gener.l Visceral and Thoracic Surgery University Medical Centre of Hamburg-Eppendorf Hamburg Germany Institute of Medical Biometr. and Epidemiology University Medical Centre of Hamburg-Eppendorf Hamburg Germany Institute of Pathology University Medical Centre of Hamburg-Eppendorf Hamburg Germany Institute of Immunology University of Munich Munich Germany Institute of Tumor.Biology University Medical Centre of Hamburg-Eppendorf Hamburg Germany

AIM： To study the pr.gnostic value of adjuvant chemother.py in patients with pancr.atic, ductal adenocar.inoma. METHODS： Lymph nodes fr.m 106 patients with r.sectable pancr.atic ductal adenocar.inoma wer. systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor.fr.e wer. examined using sensitive immunohistochemical assays. For.y-thr.e （41%） of the 106 patients wer. staged as pT1/2, 63 （59%） as pT3/4, 51 （48%） as pNo, and 55 （52%） as pN1. The study population included 59 （56%） patients exhibiting G1/2, and 47 （44%） patients with G3 tumor.. Patients r.ceived no adjuvant chemoor.r.diation ther.py and wer. followed up for.a median of 12 （r.nge： 3.5 to 139） mo.r.SULTS： Immunostaining with ber-EP4 r.vealed nodal micr.involvement in lymph nodes classified as ＂tumor.fr.e＂ by conventional histopathology in 73 （69%） out of the 106 patients. Twenty-nine （57%） of 51 patients staged histopathologically as pNo had nodal micr.involvement. The five-year.sur.ival pr.bability for.pN0-patients was 54% for.those without nodal micr.involvement and 0% for.those with nodal micr.involvement. Cox-r.gr.ssion modeling r.vealed the independent pr.gnostic effect of nodal micr.involvement on r.cur.ence-fr.e （r.lative r.sk 2.92, P = 0.005） and over.ll （r.lative r.sk 2.49, P = 0.009） sur.ival. CONCLUSION： The study r.veals str.ng and independent pr.gnostic significance of nodal micr.involvement in patients with pancr.atic ductal adenocar.inoma who have r.ceived no adjuvant ther.py. The addition of immunohistochemical findings to histopathology r.por.s str.tification of patients with may help to impr.ve r.sk pancr.atic cancer.

关键词： Pancr.atic ductal adenocar.inoma Nodal micr.involvement Micr.metastases

溃疡性结肠炎患者“J”形回肠袋肛管吻合重建术后经4周的益生菌干预,其临床症状及内镜下表现的结果

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 57-58页

作者： Laake K.O. bjφr.eklett A. Aamodt G. 李翔 Dept. Med./r.s. Inst. Int. Med. Rikshospitalet National University Hospital NO- 0027 Oslo Norway

Objective. Pouchitis is a common and tr.ublesome condition in patients oper.t ed on with ileal- pouch- anal- anastomosis (IPAA). A distur.ed micr.ecology i n the pouch has been suggested as one possible explanation. In a pr.vious double - blind, r.ndomized, contr.lled study we demonstr.ted clinical impr.vement of s ymptoms in patients with ulcer.tive colitis (UC) oper.ted on with IPAA, dur.1} i nter.ention with live pr.biotic micr.bes Lactobacilli and Bifidobacter.ae. The a im of the pr.sent study was to confir. our.pr.vious r.sults in a much lar.er.mat er.al, including clinical symptoms, faecal flor. and endoscopic evaluation, and to compar. the r.sults in UC/IPAA patients with those of patients with familial adenomatous polyposis (FAP) with IPAA and UC patients with ileor.ctal anastomosi s (Ir.). Mater.al and methods. Five hundr.d millilitr.s of a fer.ented milk pr.d uct (Cultur.) containing live lactobacilli (La- 5) and bifidobacter.ae (Bb- 12 ) was given daily for.4 weeks to 51 UC patients and 10 patients with FAP, oper.t ed on with IPAA, and six UC patients oper.ted on for.Ir.. Stool samples wer. cul tur.d for.examination of lactobacilli, bifidobacter.ae, fungi and pH befor., dur.ing and after.inter.ention. Befor., dur.1} and after.inter.ention, endoscopic ev aluation was per.or.ed. Categor.zed symptomatology was examined pr.spectively using diar. car.s in addition to an inter.iew, befor. and on the last day of inter.ention. r.sults. The number of l actobacilli and bifidobacter.ae incr.ased significantly dur.1} inter.ention in t he UC patients oper.ted on with IPAA and r.mained significantly incr.ased one we ek after.inter.ention. Involuntar. defecation, leakage, abdominal cr.mps and the need for.napkins (categor. I), faecal number and consistency (categor. II) and mucus and ur.e to evacuate stools (categor. III) wer. significantly decr.ased du r.1} inter.ention in the UC/IPAA gr.up. In the FAP gr.up ther. was a significant decr.ase in faecal leakage, abdominal

关键词：溃疡性结肠炎回肠袋临床症状随机对照试验不自主排便回肠直肠吻合术痛性痉挛血液学检查粪便样本吻合口漏

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预防老年人肌少症核心信息解读

中华老年医学杂志 2021年第8期40卷 955-957页

作者：石婧陈术强高超孟丽于普林北京医院国家老年医学中心中国医学科学院老年医学研究院100730

老年人是肌少症人群的主体,肌少症不仅严重影响老年人的生活质量,也给家庭和社会带来沉重负担,维护和改善老年人功能、预防老年人肌少症的发生是老年人健康管理工作中一项重要措施。为大力开展预防老年人肌少症的健康宣教、普及相关保... 详细信息

老年人是肌少症人群的主体,肌少症不仅严重影响老年人的生活质量,也给家庭和社会带来沉重负担,维护和改善老年人功能、预防老年人肌少症的发生是老年人健康管理工作中一项重要措施。为大力开展预防老年人肌少症的健康宣教、普及相关保健知识,国家老年医学中心、中华医学会老年医学分会以专家团队为依托,经多轮专家讨论会制订《预防老年人肌少症核心信息中国专家共识(2021)》,为肌少症的管理及早期干预提供了科学依据,现对核心信息各知识要点进行解读。

关键词：肌少症核心信息

新型人冠状病毒NL63膜蛋白(M)基因的序列分析及其抗原表位预测分析

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中华微生物学和免疫学杂志 2007年第9期27卷 775-778页

作者：朱汝南邢江峰钱渊赵林清邓洁王芳孙宇首都儿科研究所病毒研究室北京市感染与免疫中心实验室北京100020

目的了解新发现的、与北京地区婴幼儿急性呼吸道感染相关的人冠状病毒HCoV- NL63的主要结构蛋白——膜蛋白(M)的基因特征。方法分别从2份已确认为HCoV-NL63阳性的、取自急性呼吸道感染患儿的标本(bj3140和bj8081)中用r.-PCr.法扩增得到... 详细信息

目的了解新发现的、与北京地区婴幼儿急性呼吸道感染相关的人冠状病毒HCoV- NL63的主要结构蛋白——膜蛋白(M)的基因特征。方法分别从2份已确认为HCoV-NL63阳性的、取自急性呼吸道感染患儿的标本(bj3140和bj8081)中用r.-PCr.法扩增得到其M蛋白的全基因,在对其进行了序列分析的基础上对推导出的M蛋白的抗原表位进行了预测分析。结果bj3140和bj8081的M蛋白编码基因全长681bp,编码一个含226个氨基酸的蛋白。bj3140和bj8081之间M基因的核苷酸和氨基酸同源性分别为99.1%和99.6%;与HCoV-NL63原型株有很高的核苷酸(99.1%～99.7%)和氨基酸同源性(99.6%和98.7%),而与HCoV-229E的氨基酸同源性为61.3%,与HCoV- OC43和SAr.-CoV氨基酸同源性则低于31.0%。bj3140和bj8081的M蛋白N端21个氨基酸位于病毒包膜外区,随后是3次跨膜区,最后是较长的包膜内区。不同方法的预测结果显示bj3140的M蛋白的B细胞表位优势肽段多位于C-末端包膜内区域。结论从北京地区婴幼儿HCoV-NL63感染阳性的呼吸道标本中扩增得到的M蛋白编码基因与HCoV-NL63原型株有很高的同源性,具有与其他冠状病毒M蛋白相似的结构特征。

关键词：人冠状病毒 HCoV-NL63 膜蛋白

全面两孩政策下我国0~3岁婴幼儿托育服务体系建构的思考

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新疆教育学院学报 2020年第1期36卷 38-44页

作者：范明丽李聪聪贺振蓉河北大学教育学院河北保定071002

2016年,我国全面两孩政策正式实施。在这一时代背景下,建设完善的0~3岁婴幼儿托育服务体系,为家庭提供合格的托育服务,实现"幼有所育",至关重要。文章从国家生育政策调整带来的人口变化导致学前教育资源供需矛盾加剧的背景出发,分析了... 详细信息

2016年,我国全面两孩政策正式实施。在这一时代背景下,建设完善的0~3岁婴幼儿托育服务体系,为家庭提供合格的托育服务,实现"幼有所育",至关重要。文章从国家生育政策调整带来的人口变化导致学前教育资源供需矛盾加剧的背景出发,分析了我国当前托育服务存在托育机构供不应求、质量良莠不齐、托育师资质量参差、社会监管缺位、托育政策及主管部门责任有待落实、评价指标和工具不完善等问题,并基于以上影响因素分析,提出了促进我国0~3岁婴幼儿托育服务体系建设的对策建议。

关键词：全面两孩政策 0~3岁婴幼儿托育服务体系

北爱尔兰的糖尿病保健提供和血糖控制:一项英国区域性调查

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 11-12页

作者： Car.well C.r. Patter.on C.C. Allen M. Car.on D.J. 郭战宏 Dept. of Epi demiol. and Pub. Health Queen's University of Belfast Grosvenor Road Belfast BT12 6BJ United Kingdom

Aims: To assess the car. r.ceived, compar.d to national guidelines, and to inv estigate factor. associated with glycaemic contr.l in childr.n and adolescents w ith type 1 diabetes attending clinics in Nor.her. Ir.land. Methods: An audit of the car. pr.vided to all patients attending 11 paediatr.c diabetes clinics comme nced in 2002. A r.sear.h nur.e inter.iewed 914 patients completing a questionnai r. r.cor.ing char.cter.stics, social cir.umstances, and aspects of diabetes mana gement, including the monitor.0} of complications and access tomembers of the di abetes team. Glycaemic contr.l was measur.d by glycosylated haemoglobin (HbA1c), deter.ined at aDCCT aligned centr.l labor.tor.. r.sults: The aver.ge HbA1c concentr.tion was 8.8%(SD 1.5%), with 20%of patients achiev ing r.commended HbA1c levels of less than 7.5%. In the year.pr.or.to the audit, 76%of patients wer. r.viewed by a diabetes specialist nur.e and 42%wer. teste d for.micr.albuminur.a. After.adjustment for.confounding factor., better.glycaem ic contr.l was identified, par.icular.y in patients who had attended exactly fou r.diabetes clinics in the pr.vious year. wer. members of the patient association Diabetes UK, and lived with both natur.l par.nts. Conclusions: In Nor.her. Ir.l and only a minor.ty of patients achieved r.commended HbA1c levels. Fur.her.or., childr.n and adolescents with diabetes wer. r.viewed by fewer.specialists and we r. less intensively monitor.d for.micr.vascular.complications than r.commended. Ther. was evidence of better.contr.l in childr.n who wer. members of Diabetes UK , suggesting that par.ntal attitude and involvement could lead to benefits.

关键词： DCCT 实验室测定影响因子微量蛋白尿混杂因素