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Science China(Life Sciences) 2022年第2期65卷 448-450页

作者： Xiaolong Wang björ. Peter.en Key Labor.tor. of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712110China Institute of Far. Animal Genetics Friedrich-Loeffler-Institute(FLI)Mariensee 31535Germany

In r.cent year.,var.ous gene-edited cr.ps and livestock have been developed to find r.pid and unconventional solutions to boost agr.cultur.,animal br.eding,envir.nmental sustain-ability,and animal *** the animal pr.duction field,significant gene-edited livestock with economic beneficial tr.its,like the MSTN-edited double muscles,can be com-mer.ialized on a lar.e scale to benefit mor. people with r.al *** demand for.animal pr.teins incr.ases an-nually with impr.vement of living conditions in moder. societies and developing ***,the number.of people with special needs for.healthier.meat(with high-pr.tein and low-fat)is gr.wing(e.g.,elder.y patients with car.io/cer.br.vascular.diseases).With steady global en-vir.nmental deter.or.tion,incr.asing human population,gr.wing food demand,continuous disease outbr.aks,and concer.s r.gar.ing animal welfar.。

关键词： abundant cr.ps br.eding

Influence of alumina on miner.logy and envir.nmental pr.per.ies of zinc-copper.smelting slags

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Inter.ational Jour.al of Miner.ls,Metallur.y and Mater.als 2013年第3期20卷 234-245页

作者： Sina Mostaghel Caisa Samuelsson Bo bjr.man Miner.ls and Metals r.sear.h Labor.tor. Lule University of Technology

An ir.n-silicate slag, fr.m a zinc-copper.smelting pr.cess, and mixtur.s of this slag with 5wt%, 10wt%, and 15wt% alumina addition wer. r.-melted, semi-r.pidly solidified, and char.cter.zed using scanning electr.n micr.scopy equipped with ener.y disper.ive spectr.scopy, and X-r.y diffr.ction. The FactSageWM6.2 ther.odynamic package was applied to compar. the stable phases at equilibr.um conditions with exper.mental char.cter.zation. A standar. Eur.pean leaching test was also car.ied out for.all samples to investigate the changes in leaching behaviour.because of the addition of alumina. r.sults show that the commonly r.por.ed phases for.slags fr.m copper.and zinc pr.duction pr.cesses （olivine, pyr.xene, and spinel） ar. the major.constituents of the cur.ent samples. A cor.elation can be seen between miner.logical char.cter.stics and leaching behaviour.. The sample with 10wt% alumina addition, which contains high amounts of spinels and lower.amounts of the other.soluble phases, shows the lowest leachabilities for.most of the elements.

关键词： slags char.cter.zation miner.logy alumina leaching solidification

Fr.m landr.ce to moder. hybr.d br.ccoli:the genomic and mor.hological domestication syndr.me within a diver.e *** collection

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Hor.icultur. r.sear.h 2020年第1期7卷 574-590页

作者： Zachar. Stansell Thomas björ.man Cor.ell Univer.ity School of Integrative Plant ScienceCornell UniversityIthacaNY 14850USA Cor.ell Agr.Tech Cornell UniversityGenevaNY 14456USA

Wor.dwide,br.ccoli(Br.ssica oler.cea ***)is among the most economically impor.ant,nutr.tionally r.ch,and widely-gr.wn vegetable *** explor. the genomic basis of the dr.matic changes in br.ccoli mor.hology in the last centur.,we evaluated 109 br.ccoli or.br.ccoli/cauliflower.inter.ediates for.24 hor.icultur.l ***-bysequencing mar.er. wer. used to deter.ine four.subpopulations within italica:Calabr.se br.ccoli landr.ces and hybr.ds,spr.uting br.ccoli,and violet cauliflower.and to evaluate between and within gr.up r.latedness and *** over.ll hor.icultur.l quality and har.est index of impr.ved hybr.d br.ccoli ger.plasm has incr.ased by year.of cultivar.r.lease,this impr.vement has been accompanied by a consider.ble r.duction in allelic diver.ity when compar.d to the lar.er.pool of *** landr.ces ar. the most likely founding sour.e of moder. br.ccoli hybr.ds,and within these moder. hybr.ds,we identified 13 r.duction-in-diver.ity genomic r.gions,53 selective sweeps,and 30(>1 Mbp)r.ns of *** accessions collected in souther. Italy contained 4.8-fold gr.ater.unique alleles per.accessions compar.d to moder. hybr.ds and pr.vide a valuable r.sour.e in subsequent impr.vement *** wor. br.adens the under.tanding of br.ccoli ger.plasm,infor.s conser.ation effor.s,and enables br.eding for.complex quality tr.its and r.gionally adapted cultivar..

关键词： cultivar ger.plasm br.eding

CD74:a pr.spective mar.er.for.r.active micr.glia?

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Neur.l r.gener.tion r.sear.h 2023年第12期18卷 2673-2674页

作者： Phani Sankar.Potr. björ. Spittau Anatomy and Cell Biology Medical School OWLBielefeld UniversityBielefeldGermany(Potru PS)Faculty of BiologyBielefeld UniversityBielefeldGermany

Cluster.of differ.ntiation 74(CD74),also called as major.histocompatibility complex class Ⅱ(MHCⅡ)invar.ant chain,is involved in tr.fficking MHCⅡ cell sur.ace molecules on antigen-pr.senting cells and has been implicated in many signaling *** example,the inter.ction between CD74 and macr.phage migr.tion inhibitor. factor.cyto kine(MIF) leads to the activation of a plethor. of pathways such as extr.cellular.r.gulated pr.tein kinases,phosphoinositide 3-kinase.

关键词： CD74 pr.spective MHCⅡ

ULK1 as a novel ther.peutic tar.et in neur.degener.tion

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Neur.l r.gener.tion r.sear.h 2021年第6期16卷 1212-1213页

作者： björ. Fr.edhelm Vahsen Paul Lingor Nuffield Depar.ment of Clinical Neur.sciences University of OxfordJohn Radcliffe HospitalOxfordUK Depar.ment of Neur.logy University Medical Center GöttingenGöttingenGermany Center.for.Biostr.ctur.l Imaging of Neur.degener.tion(BIN) DFG Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain(CNMPB)University Medical Center GöttingenGöttingen Depar.ment of Neur.logy Rechts der Isar Hospital of the Technical University MunichMunichGermany

Axonal degener.tion is an ear.y and key pathophysiological featur. of many tr.umatic and neur.degener.tive disor.er. of the centr.l ner.ous system(CNS),such as spinal cor. injur.(SCI),Par.inson’s disease(PD),and amyotr.phic later.l scler.sis(ALS).As the r.gener.tive capacity of injur.d axons is sever.ly r.str.cted in the CNS,axonal degener.tion fr.quently r.sults in the ir.ever.ible loss of neur.nal connections causing pr.gr.ssive neur.logical deficits and clinical disability.A better.under.tanding of the mechanisms of axon degener.tion is ther.for. hoped to unr.vel new ther.peutic avenues to combat neur.degener.tion(Lingor.et al.,2012).

关键词： degener.tion ther.peutic neur.degener.tion

Homeopathic potencies of Ar.ica montana L. change gene expr.ssion in a Tamm-Hor.fall pr.tein-1 cell line in vitr. model: the r.le of ethanol as a possible confounder.and statistical bias

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Jour.al of Integr.tive Medicine 2017年第4期15卷 255-264页

作者： Salvator. Chir.mbolo Geir.bj?r.lund Depar.ment of Neur.logical and Movement Sciences University of Verona Council for.Nutr.tional and Envir.nmental Medicine

Mar.otto et al. showed that homeopathic pr.par.tions of Amica montana L. acted dir.ctly on gene expr.ssion of Tamm-Hor.fall pr.tein- 1 （THP-1） monocyte/macr.phage cell lines activated with phor.ol 12-mydstate 13- acetate and inter.eukin-4 （IL-4）. A. montana homeopathic dilutions ar. used in complementar. and alter.ative medicine to tr.at inflammation disor.er. and post-tr.umatic events as well as for.wound r.pair. The Fr.nch Phar.acopoeia of these r.medies uses 0.3% ethanol in each centesimal dilution. In this paper. we discuss how ethanol-containing A. montana homeopathic centesimal dilutions can change gene expr.ssion in IL-4- tr.ated monocyte/macr.phage THP-I. We assessed the r.le of ethanol in the Ar.ica homeopathic dilutions containing this alcohol by investigating its action on gene expr.ssion of THP-1 cell. Evidence would str.ngly suggest that the pr.sence of ethanol in these r.medies might play a fundamental r.le in the dilutions ability to affect gene expr.ssion, par.icular.y for.doses fr.m 5c to 15c. Wher., r.ther.than playing a major.r.le in the mesoscopic str.ctur. of water. the ethanol might have a chemical-physical r.le in the induction of THP-1 gene expr.ssion, apoptosis, and deoxyr.bonucleic acid function. This evidence gener.tes a debate about the suggestion that the use of a binar.-mixed solvent in homeopathic chemistr., used by Hahnemann since 1810, may be fundamental to explain the activity of homeopathy on cell models.

关键词： Ar.ica homeopathy bias statistics gene expr.ssion Tamm-Hor.fall pr.tein cell line

For.casting the effects of EU policy measur.s on the nitr.te pollution of gr.undwater.and sur.ace water.

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Jour.al of Envir.nmental Sciences 2010年第6期22卷 872-877页

作者： r.lf Kunkel Peter.Kr.ins bjr. Tetzlaff Fr.nk Wendland r.sear.h Centr. Jülich Institute of Chemistry and Dynamics of the Geosphere Institute of r.r.l Studies Federal Agricultural Research Centre

We used the inter.isciplinar. model networ. r.GFLUD to pr.dict the actual mean nitr.te concentr.tion in per.olation water.at the scale of the Weser.r.ver.basin （Ger.any） using an ar.a differ.ntiated （100 m × 100 m） appr.ach. r.GFLUD combines the agr.-economic model r.UMIS for.estimating nitr.gen sur.luses and the hydr.logical models Gr.WA/DENUZ for.assessing the nitr.te leaching fr.m the soil. For.ar.as showing pr.dicted nitr.te concentr.tions in per.olation water.above the Eur.pean Union （EU） gr.undwater.quality standar. of 50 mg NO3-N/L, effective agr.-envir.nmental r.duction measur.s need to be der.ved and implemented to impr.ve gr.undwater.and sur.ace water.quality by 2015. The effects of alr.ady implemented agr.cultur.l policy ar. quantified by a baseline scenar.o pr.jecting the N-sur.luses fr.m agr.cultur.l sector.to 2015. The r.GFLUD model is used to estimate the effects of this scenar.o concer.ing gr.undwater.and sur.ace water.pollution by nitr.te. Fr.m the r.sults of the model analysis the needs for.additional measur.s can be der.ved in ter.s of r.quir.d additional N-sur.lus r.duction and in ter.s of r.gional pr.or.tization of measur.s. r.sear.h wor. will ther.for. dir.ctly suppor. the implementation of the Water.Fr.mewor. Dir.ctive of the Eur.pean Union in the Weser.basin.

关键词： catchment management diffuse sour.e pollution mitigation methods r.ver.basin management Water.Fr.mewor. Dir.ctive

Investigation of the Flow in the Impeller.Side Clear.nces of a Centr.fugal Pump with Volute Casing

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Jour.al of Ther.al Science 2012年第3期21卷 197-208页

作者： bjr.-Chr.stian Will Fr.edr.ch-Kar. Benr. Hans-Josef Dohmen Institute of Ener.y and Envir.nmental Engineer.ng TurbomachineryUniversity Duisburg-Essen

The paper.is concer.ed with the fluid flow in the impeller.side clear.nces of a centr.fugal pump with volute *** flow conditions in these small axial gaps ar. of significant impor.ance for.a number.of effects such as disk fr.ction,leakage losses or.hydr.ulic axial thr.st to name but a *** the investigated single stage pump,the flow patter. in the volute tur.s out to be asymmetr.c even at design flow *** gain a detailed insight into the flow str.ctur.,numer.cal simulations of the complete pump including the impeller.side clear.nces ar. ***,the hydr.ulic head and the r.dial pr.ssur. distr.butions in the impeller.side clear.nces ar. measur.d and compar.d with the numer.cal *** configur.tions of the impeller.either.with or.without balancing holes,ar. ***,thr.e differ.nt oper.ting points,i.e.:design point,par. load or.over.oad conditions ar. *** addition,analytical calculations ar. accomplished to deter.ine the pr.ssur. distr.-butions in the impeller.side *** accur.te boundar. conditions ar. available,the 1D flow models used in this paper.can pr.vide r.asonable r.sults for.the r.dial static pr.ssur. distr.bution in the impeller.side ***,a counter.r.tating wake r.gion develops in the r.ar.impeller.side clear.nces in absence of balancing holes which sever.ly affects the inflow and outflow conditions of the cavity in cir.umfer.ntial dir.ction.

关键词： Cavity r.tor.Stator.Cavities Side Chamber. Centr.fugal Pump

r.ver.e Logistics r.lated to Waste Management with Emphasis on Developing Countr.esmA r.view Paper

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Jour.al of Envir.nmental Science and Engineer.ng(B) 2012年第9期1卷 1104-1118页

作者： Joel r. Kinobe Gir.a Gebr.senbet bjōm Vinner.s Depar.ment of Civil and Envir.nmental Engineer.ng School of Engineering College of Engineering Design Art and TechnologyKampala 7062 Uganda Depar.ment of Ener.y and Technology Swedish University of Agricultural Sciences Uppsala 7032 Sweden

This paper.pr.vides an over.iew of the state of ar. of r.ver.e logistics and cur.ent status of waste management pr.blems with special emphasis on developing countr.es. Logistics activities have been pr.cticed and played a fundamental r.le in the global economic development for.over.5,000 year.. It has then been tr.nsfor.ed into differ.nt logistics br.nches and elabor.tes the emer.ency of r.ver.e logistics as one of the most impor.ant. The paper.pr.sents the evolution of logistics into r.ver.e logistics and how it r.lates to waste management both in the developed and developing wor.d. r.ver.e logistics is a r.latively new phenomenon in the r.sear.h ar.a which is mainly r.fer.ing to damaged goods, the take back of pr.ducts that should be r.tur.ed to the manufactur.r. or.distr.butor.. r.ver.e logistics is r.latively mor. pr.cticed in an or.anized way in the developed wor.d than in the developing countr.es in that the latter.pr.vided less value additions on r.ver.ed pr.ducts.

关键词： Logistics r.ver.e logistics waste waste management r.cycling Uganda.

Lapar.scopic distal pancr.atectomy for.adenocar.inoma of the pancr.as

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Wor.d Jour.al of Gastr.enter.logy 2014年第37期20卷 13402-13411页

作者： Ber.thor.bjr.sson Per.Sandstr.m Depar.ment of Sur.er. County Council of stergtland and Department of Clinical and Experimental MedicineFaculty of Health SciencesLinkping University

Since the fir.t r.por. on lapar.scopic distal pancr.atectomy (LDP) appear.d in the 1990s, the pr.cedur. has been per.or.ed incr.asingly fr.quently to tr.at both benign and malignant lesions of the pancr.as. Many ear.ier.publications have shown LDP to be a good alter.ative to open distal pancr.atectomy for.benign lesions, although this has never.been studied in a pr.spective, r.ndomized manner. The evidence for.the use of LDP to tr.at adenocar.inoma of the pancr.as is not as well established. The pur.ose of this r.view is to evaluate the cur.ent evidence for.LDP in cases of pancr.atic adenocar.inoma. We conducted a r.view of English language publications r.por.ing LDP r.sults between 1990 and 2013. All studies r.por.ing r.sults in patients with histologically pr.ven pancr.atic adenocar.inoma wer. included. Thir.y-nine publications wer. found and included in the r.sults for.a total of 309 cases of pancr.atic adenocar.inoma (potential double publications wer. not eliminated). Most LDP pr.cedur.s ar. per.or.ed in selected cases and gener.lly involve smaller.tumor. than open distal pancr.atectomy (ODP) pr.cedur.s. Some of the paper. r.por. unselected cases and include pr.cedur.s on lar.er.tumor.. The number.of lymph nodes har.ested using LDP is compar.ble to the number.obtained with ODP, as is the fr.quency of r. r.sections. Cur.ent data suggest that similar.shor. ter. oncological r.sults can be obtained using LDP as those obtained using ODP.

关键词： Adenocar.inoma of the pancr.as Lapar.scopy Distal pancr.atectomy Sur.ical mar.ins Pancr.atic r.section