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Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer:A systematic review

Journal of Integrative Medicine 2024年第2期22卷 137-162页

作者： bizhar ahmed tayeb Ikhwan Yuda Kusuma Alaa A.M.Osman Renáta Minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharmacy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Department of Clinical Pharmacy and Pharmacy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharmacy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized medicine has gained increasing attention in cancer care,with the aim of tailoring treatment strategies to individual patients for improved *** medicine,with its long-standing historical use and extensive bioactive compounds,offers a rich source of potential treatments for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A comprehensive literature search was conducted from multiple online databases,including Pub Med,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer medicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,employing natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessments of methodological *** quality assessment and biases of the studies were evaluated based on modified Jadad scales.A detailed quantitative summary of the included studies is presented,providing a comprehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them were considered as comprehensive experimental investigations both in vitro and in *** majority(n=85)of the studies included in this review were conducted in vitro,with 44 of them specifically investigating the effects of herbal medicine on animal ***,7 articles with a combined sample size of 31,271 patients,examined the impact of herbal medicine in clinical ***:Personal

关键词： Cancer Herbal medicine Personalized medication Active phytochemicals Natural compound

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Beyond boundaries:Neuroprotective effects of steroids and ecdysteroids in SH-SY5Y cells-A systematic review

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Neuroprotection 2024年第2期2卷 151-166页

作者： bizhar ahmed tayeb Isaac Kinyua Njangiru Renata Minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of SzegedSzegedHungary

Steroids and ecdysteroids have been shown to exhibit a range of biological effects,including anti-inflammatory,anticancer,and *** systematic review aims to highlight the evidence-based neuroprotective and antioxidant effects of steroids and ecdysteroids in SH-SY5Y neuroblastoma cells.A comprehensive literature search was conducted on May 11,2023,without publication source restrictions,using various electronic databases,including PubMed,Web of Science(WoS),Scopus,and Cumulative Index toNursing and Allied Health *** 103articles,only20 studies were included for investigating the neuroprotective effects of steroids and ecdysteroids in SH-SY5Y cells exposed to oxidative stress or neurotoxic *** risk of bias and quality assessment of the included studies were evaluated in accordance with the Nature Publication Quality Improvement Project specific *** selected studies reported the antioxidant effects of the tested compounds on SH-SY5Y cells and demonstrated their ability to scavenge free radicals and prevent lipid *** findings suggest that neurosteroids have potential therapeutic applications for the prevention and treatment of neurodegenerative diseases characterized by oxidative stress and neuronal *** studies have investigated the molecular mechanisms underlying the neuroprotective and antioxidant effects of steroids and ecdysteroids in SH-SY5Y *** mechanisms include the activation of antioxidant enzymes,such as superoxide dismutase and glutathione peroxidase,and the modulation of various signaling pathways,including the phosphoinositide 3-kinase/protein kinase B and mitogen-activated protein kinase/extracellular signal-regulated kinase *** review provides evidence that the tested compounds have remarkable neuroprotective and antioxidant effects in human neuroblastoma SH-SY5Y cells.

关键词： antiapoptotic cytoprotective neuroblastoma neurosteroids oxidative stress SH-SY5Y cells

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Enhancing photovoltaic energy forecasting: a progressive approach using wavelet packet decomposition

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CLEAN ENERGY 2024年第3期8卷 95-108页

作者： Ferkous, Khaled Guermoui, Mawloud Bellaour, Abderahmane Boulmaiz, tayeb Bailek, Nadjem Univ Ghardaia LMTESE Lab Mat Technol Energy Syst & Environm Ghardaia 47000 Algeria Renewable Energy Appl Res Unit URAER Ghardaia 47000 Algeria ahmed Draia Adrar Univ Fac Sci & Technol Dept Math & Comp Sci Lab Math Modeling & Applicat Adrar 01000 Algeria

Accurate photovoltaic (PV) energy forecasting plays a crucial role in the efficient operation of PV power stations. This study presents a novel hybrid machine-learning (ML) model that combines Gaussian process regression with wavelet packet decomposition to forecast PV power half an hour ahead. The proposed technique was applied to the PV energy database of a station located in Algeria and its performance was compared to that of traditional forecasting models. Performance evaluations demonstrate the superiority of the proposed approach over conventional ML methods, including Gaussian process regression, extreme learning machines, artificial neural networks and support vector machines, across all seasons. The proposed model exhibits lower normalized root mean square error (nRMSE) (2.116%) and root mean square error (RMSE) (208.233 kW) values, along with a higher coefficient of determination (R2) of 99.881%. Furthermore, the exceptional performance of the model is maintained even when tested with various prediction horizons. However, as the forecast horizon extends from 1.5 to 5.5 hours, the prediction accuracy decreases, evident by the increase in the RMSE (710.839 kW) and nRMSE (7.276%), and a decrease in R2 (98.462%). Comparative analysis with recent studies reveals that our approach consistently delivers competitive or superior results. This study provides empirical evidence supporting the effectiveness of the proposed hybrid ML model, suggesting its potential as a reliable tool for enhancing PV power forecasting accuracy, thereby contributing to more efficient grid management. This study proposes a new method for forecasting solar power generation 30 minutes ahead. It combines Gaussian process regression with wavelet packet decomposition to capture complex patterns in historical data. This approach outperforms other forecasting models across different seasons and forecast horizons. Graphical Abstract

关键词： short photovoltaic power forecasting wavelet packet decomposition sub-series reconstruction machine learning in energy forecasting sustainable power stations renewable energy DATA-DRIVEN MACHINE

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Line Shapes in the Magnetized Plasmas

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Journal of Modern Physics 2012年第9期3卷 943-946页

作者： Kamel Touati-ahmed Touati Mohammed-tayeb Meftah Department of Physics Laboratory of Research in Plasma and Surface University of Ouargla Ouargla Algeria Lycée Professionnel Léonard de Vinci Marseille France

Till now, the most studies of Lyman alpha line are concerned only by the Stark effect. In our knowledge few investigations are developed for the plasmas subjected to a magnetic field. In this paper we present the combined effect, Stark-Zeeman, on the spectral line shape. The dynamic effects due to the time fluctuation of the electric microfield and the radiation polarization are also taken into account.

关键词： Line Profiles Radiation Polarization Stark Effect Zeeman Effect

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A Rare Retroperitoneal Mass:Leiomyosarcoma of the Inferior Vena Cava

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World Journal of Cardiovascular Surgery 2014年第4期4卷 51-55页

作者： Aram Baram Zirak Anwar tayeb Delan ahmed Bakir Department of Thoracic and Cardiovascular Surgery Faculty of Medical SciencesSchool of MedicineUniversity of SulaimaniFrancois Mitterrand StreetSulaymaniyah46001Iraq

Leiomyosarcoma of the inferior vena cava (IVC) is a rare soft tissue tumor, mesenchymal in origin that arises from smooth muscles of tunica media;it accounts for about 0.5% of all soft tissue sarcomas, and it is the commonest vascular leiomyosarcoma. The tumor progression is slow, and it is asymptomatic until advanced stage in which involvement of surrounding structures even when the symptoms present are nonspecific. Presentation of Case: A 60 years old lady presented with upper abdominal pain for 3 months duration. Past surgical history was significant for Hysterectomy 15 years ago. On examination: soft abdomen, palpable non pulsating right hypochondrial mass. Ultrasound of the abdomen showed tumor of the head of pancreas. CT scan showed large retroperitoneal tumor extending from the head of pancreas to IVC. Trans abdominal CT guided FNAC showed retroperitoneal sarcoma while Immunohistochemistry (IHC) was proved to be Leiomyosarcoma of the IVC. Discussion: Leiomyosarcoma of inferior vena cava (IVC) is a rare soft tissue tumor, mesenchymal in origin that arises from smooth muscles of tunica media;it accounts for about 0.5% of all soft tissue sarcomas, and it is the commonest vascular leiomyosarcoma. The type of surgical management is a matter of debate and includes resection alone, primary repair/cavoplasty, or replacement with a graft. Reconstruction of the IVC is not always required especially in chronic occlusions. Conclusion: Despite all the advanced modalities, surgery remains the most effective method for treatment of Leiomyosarcoma.

关键词： Ivc Leiomyosarcoma Retroperitoneal Tumor Resection

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The Use of Sputum Dashboard and Dispatch Riders in Mitigating Delay in Sputum Samples’ Processing—Evidence from an Intervention in Lagos State, Nigeria

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Journal of Tuberculosis Research 2021年第3期9卷 146-159页

作者： Muse Olatunbosun Fadeyi Akinwumi Akindele Adebayo Bakare Bolaji ahmed Osman El-tayeb Taofeekat Ali Yasir Othman Obioha Udunze Gbolahan Dairo Aderonke Agbaje Damien Foundation Belgium (Nigeria Project) Ibadan Oyo State Nigeria Institute of Human Virology Nigeria (IHVN) Abuja Nigeria Hull University Teaching Hospitals NHS Trust Hull United Kingdom

The act of referring TB presumptive individuals after verbal screening to another health facility/diagnostic centres for testing often results in large loss to follow-up, owing to the many barriers people face in accessing care. The transportation of sputum samples is an efficient method of increasing access to tuberculosis (TB) diagnostics in areas where testing is not currently available. One of the major reasons for the low yield of TB cases in the field was delay in sputum sample transportation to diagnostic laboratories among other factors. Damien Foundation Belgium, carried out a unique sputum riders initiatives in 20 LGAs of Lagos state between Q3-2019 and Q4-2020. A total of 25 sputum dispatch riders across the 20 LGAs in the State who are monitored routinely on an electronic dashboard were engaged for sputum logistics. Therefore, this report highlights how the initiatives have contributed to increased TB case notification in a densely populated metropolitan city in Nigeria. Overall, 48,265 units of sputum samples were transported to the laboratory from the facilities 99.9% of results which were received from the laboratory by the dispatch riders. The contribution of sputum riders to the overall TB case detection by the project progressively increased from 9% when the intervention began to 57% as at Q4 2020. The transportation of sputum samples by motorcycle dispatch riders is an efficient method of increasing access to TB diagnostic services in communities where testing is not currently available.

关键词： Sputum Samples Dispatch Rider Electronic Dashboard Sputum Logistics Tuberculosis

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Assessment of the Contributions of Private Provider Engagement in Tuberculosis Case Finding and Notification in South West Nigeria

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Journal of Tuberculosis Research 2021年第3期9卷 160-171页

作者： Muse O. Fadeyi Bolaji ahmed Akinwumi Akindele Adebayo Bakare Modupe Ariyo Olalekan Onitiju Osman El-tayeb Taofeekat Ali Yasir Othman Aderonke Agbaje Damien Foundation Belgium (Nigeria Project) Ibadan Oyo State Nigeria Institute of Human Virology Nigeria (IHVN) Abuja Nigeria Hull University Teaching Hospitals NHS Trust Hull United Kingdom

Introduction: Tuberculosis is one of the leading causes of mortalities attributable to an infectious disease. In a private sector-driven health system such as Nigeria, the private health providers are very important stakeholders in tuberculosis diagnosis and management. Unfortunately, there are few data on the level of contribution of these private health providers to the case finding and notification of tuberculosis in Nigeria. Consequently, this study assessed the contribution of the private providers to the diagnosis and treatment of tuberculosis under the Global Fund Private Public Mix New Funding Model (2nd phase) grant (GF PPM NFM2) in the four implementing states of south west Nigeria. Materials and Methods: This is a retrospective, cross-sectional analysis of the NFM2 programme implementation data collected between January 1, 2019 and December 31, 2020. Data was extracted from the routine registers such as the presumptive TB registers;treatment register of the private health facilities engaged for PPM activities between 2019 and 2020. The data was entered and analyzed using Microsoft excel package. The variables were summarized using appropriate charts and table. Results: Concerning the percentage contribution of the Global Fund Private Public Mix (GF PPM) grant to the total sta

关键词： Private Provider Tuberculosis Diagnosis Notification

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Line Shapes in the Magnetized Plasmas

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Journal of Modern Physics（现代物理） 2012年第9期

作者： Kamel Touati-ahmed Touati Mohammed-tayeb Meftah

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A New Design of Compact Slot-Line Six-Port Circuit for Wireless Communication

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通讯和计算机（中英文版） 2010年第12期7卷 48-56页

作者： Mourad Nedil Azzeddine Djaiz Adnane Mohamed Habib tayeb ahmed Denidni UQAT-LRCS University of Quebec at Abitibi-Temiseaminque 450 3e avenue Val d＇or QC J9P 1S2 Canada INRS-EMT University of Quebec 800 de la Gaucheti~re 0. Montreal Qc. H5A I K6 Canada

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