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Long-term follow-up after complete ablation of Barrett's esophagus with argon plasma coagulation

World Journal of Gastroenterology 2005年第8期11卷 1182-1186页

作者： Ahmed Madisch Stephan Miehike Ekkehard Bayerdoerffer birgit Wiedemann David Antos Anke Sievert Michael Vieth Manfred Stolte Heinrich Schulz Medical Department Ⅰ Department of Hematology and Oncology Institute of Medical Statistics and Biometry Clinic for Pediatric Diseases Gastroenterologist in private practice Institute of Pathology

AIM: To report the long-term outcome of patients after complete ablation of non-neoplastic Barrett's esophagus (BE) with respect to BE relapse and development of intraepithelial neoplasia or esophageal adenocarcinoma. METHODS: In 70 patients with historically proven non neoplastic BE, complete BE ablation was achieved by argon plasma coagulation (APC) and high-dose proton pump inhibitor therapy (120 mg omeprazole daily). Sixty-six patients (94.4%) underwent further surveillance endoscopy. At each surveillance endoscopy four-quadrant biopsies were taken from the neo-squamous epithelium at 2 cm intervals depending on the pre-treatment length of BE mucosa beginning at the neo-Z-line, and from any endoscopically suspicious lesion. RESULTS: The median follow-up of 66 patients was 51 mo (range 9-85 mo) giving a total of 280.5 patient years. A mean of 6 biopsies were taken during surveillance endoscopies. In 13 patients (19.7%) tongues or islands suspicious for BE were found during endoscopy. In 8 of these patients (12.1%) non-neoplastic BE relapse was confirmed histologically giving a histological relapse rate of 3% per year. In none of the patients, intraepithelial neoplasia nor an esophageal adenocarcinoma was detected. Logistic regression analysis identified endoscopic detection of islands or tongues as the only positive predictor of BE relapse (P= 0.0004). CONCLUSION: The long-term relapse rate of non neoplastic BE following complete ablation with high-power APC is low (3% per year).

关键词： Barrett's esophagus Argon plasma coagulation Esophageal adenocarcinoma

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A Combination of Wheat Bran and Vegetable Oils as Feedstuff in Laying Hens’Diet:Impact on Egg Quality Parameters

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Agricultural Sciences 2018年第6期9卷 676-691页

作者： Elisa Wanzenbock Matthias Schreiner Ulrike Zitz birgit Bleich Sophie Figl Wolfgang Kneifel Karl Schedle Institute of Food Science University of Natural Resources and Life Sciences ViennaViennaAustria Institute of Animal Nutrition Livestock Productsand Nutrition PhysiologyUniversity of Natural Resources and Life Sciences ViennaViennaAustria

Wheat bran (WB) is an important side product of the milling industry and plays an increasing role in animal feeding. Despite its nutritional value, its application is limited as a result of its pronounced fiber content. Taking into account the potential use of WB supplementation in feed for laying hens thereby replacing human edible foodstuffs, the influence of different WB levels (0 g·kg-1, 75 g·kg-1, and 150 g·kg-1) combined with sunflower or rapeseed oil on egg quality was studied. Among the egg-related quality parameters investigated, eggshell cleanliness, shell rigidity, egg weight, haugh units, yolk and albumen mass, color, pH value, dry matter, crude protein, crude ash, fatty acid spectrum, cholesterol and α-tocopherol of the yolk were monitored. No negative effect of WB supplementation was observed in terms of egg weight, shell weight, albumen weight, yolk weight, haugh unit, shell thickness and eggshell breaking strength. However, certain parameters (i.e. α-tocopherol content, Σn-3 PUFA) were enhanced by feeding 75 g·kg-1 and 150 g·kg-1 WB. The use of WB (75 g·kg-1 and 150 g·kg-1) had no negative effect on egg quality and can, therefore, be recommended for laying hen diets up to 150 g·kg-1. Additionally, the application of rapeseed oil high in Σn-3 PUFA resulted in yolks exhibiting a low Σn-6 PUFA/Σn-3 PUFA ratio.

关键词： Laying Hens Wheat Bran Vegetable Oils Egg Quality Fatty Acid Profile

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以光学为基础的量化诊断初期龋的方法应用

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实用口腔医学杂志 2007年第1期23卷 144-147页

作者：杨丽芳 birgit. Angmar-Mansson Xie Qi Shi 云南医学高等专科学校口腔系 650031 Department of Cariology and Endodontology Institute of OdontologyKarolinska Institutet Sweden Department

定量诊断初期龋的先进方法，近年来受到了高度重视。相对于传统的常规定性诊断方法来说，一些先进的定量诊断方法能检测到龋病的早期脱钙现象，这对于早期采取预防和控制措施都是非常重要的，一些技术现在已推向市场。

关键词：初期龋量化诊断光学定量诊断诊断方法控制措早期

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Stimulated Brillouin scattering in chiral photonic crystal fiber

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Photonics Research 2022年第3期10卷 711-718页

作者： Xinglin Zeng Wenbin He Michael HFrosz Andreas Geilen Paul Roth Gordon K.L.Wong Philip St.J.Russell birgit Stiller Max-Planck Institute for the Science of Light 91058 ErlangenGermany Department of Physics Friedrich-Alexander-Universität91058 ErlangenGermany

Stimulated Brillouin scattering(SBS)has many applications;for example,in sensing,microwave photonics,and signal ***,we report the first experimental study of SBS in chiral photonic crystal fiber(PCF),which displays optical activity and robustly maintains circular polarization states against external *** a result,circularly polarized pump light is cleanly backscattered into a Stokes signal with the orthogonal circular polarization state,as is required by angular momentum *** comparison,untwisted PCF generates a Stokes signal with an unpredictable polarization state,owing to its high sensitivity to external *** use chiral PCF to realize a circularly polarized continuous-wave Brillouin *** results pave the way for a new generation of stable circularly polarized SBS systems with applications in quantum manipulation,optical tweezers,optical gyroscopes,and fiber sensors.

关键词： polarization fiber scattering

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Impact of single annual treatment and four-monthly treatment for hookworm and Ascaris lumbricoides,and factors associated with residual infection among Kenyan school children

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Infectious Diseases of Poverty 2017年第1期6卷 249-260页

作者： Stella Kepha Charles S.Mwandawiro Roy M.Anderson Rachel L.Pullan Fred Nuwaha Jorge Cano Sammy M.Njenga Maurice R.Odiere Elizabeth Allen Simon J.Brooker birgit Nikolay School of Public Health Makerere University College of Health SciencesKampalaUganda Eastern and Southern Africa Centre of International Parasite Control Kenya Medical Research Institute(KEMRI)NairobiKenya London Centre for Neglected Tropical Disease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK London School of Hygiene and Tropical Medicine LondonUK Centre for Global Health Research KEMRIKisumuKenya KEMRI-Wellcome Trust Research Programme NairobiKenya

Background:School-based deworming is widely implemented in various countries to reduce the burden of soil-transmitted helminths(STHs),however,the frequency of drug administration varies in different *** this study,we compared the impact of a single annual treatment and 4-monthly treatment over a follow-up among Kenyan school children,and investigated the factors associated with residual ***:We performed a secondary analysis of data from a randomized trial investigating whether deworming for STHs alters risk of acquiring *** received either a single treatment or 4-monthly albendazole treatments were followed longitudinally from February 2014 to October *** relative impact of treatment and factors associated with residual infections were investigated using mixed-effects regression *** to infection was assessed based on Spearman’s rank and Kendall’s Tau correlation ***:In the 4-monthly treatment group,the proportion of children infected with hookworm decreased from 59.9 to 5.7%,while Ascaris lumbricoides infections dropped from 55.7 to 6.2%.In the single treatment group,hookworm infections decreased over the same time period from 58.7 to 18.3%(12.6%absolute difference in reduction,95%CI:8.9-16.3%),and *** from 56.7 to 23.3%(17.1%absolute difference in reduction,95%CI:13.1-21.1%).There was strong evidence for predisposition to both STH *** hookworm infection among children on 4-monthly treatment were associated with male sex and baseline nutritional status,whereas *** infection was associated with individual and school-level infection at baseline,latrine cleanliness at ***:This study found that 4-monthly treatment w more effective than single annual *** treatments led to dramatic reductions in the intensities of STHs,but did not completely clear infections among school children in Kenya,a presumed reflection of reinfection in a setti

关键词： School-based deworming Soil-transmitted helminths Albendazole School children Kenya

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Co-contaminants of microplastics in two seabird species from the Canadian Arctic

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Environmental Science and Ecotechnology 2022年第4期12卷 87-96页

作者： Roxana Sühring Julia E.Baak Robert J.Letcher birgit M.Braune Amila de Silva Cody Dey Kim Fernie Zhe Lu Mark L.Mallory Stephanie Avery-Gomm Jennifer F.Provencher Department of Chemistry and Biology Toronto Metropolitan University(formerly known as Ryerson University)350 Victoria StTorontoONM5B 2K3Canada Department of Natural Resource Science McGill UniversitySainte Anne de BellevueQuebecH9X 3V9Canada Environment and Climate Change Canada National Wildlife Research CentreCarleton UniversityRaven RoadOttawaOntarioK1A 0H3Canada Aquatic Contaminants Research Division Environment and Climate Change CanadaBurlingtonOntarioL7S 1A1Canada Ecotoxicology&Wildlife Health Division Environment and Climate Change CanadaBurlingtonOntarioL7S 1A1Canada Institut des Sciences de la Mer de Rimouski Université du Québec à RimouskiRimouskiQuébecG5L 3A1Canada Department of Biology Acadia UniversityWolfvilleNova ScotiaB4P 2R6Canada

Through ingestion and subsequent egestion,Arctic seabirds can bioaccumulate microplastics at and around their colony breeding *** microplastics in Arctic seabirds have been well documented,it is not yet understood to what extent these particles can act as transport vehicles for plastic-associated contaminants,including legacy persistent organic pollutants(POPs),trace metals,and organic *** investigated the occurrence and pattern of organic and inorganic co-contaminants of microplastics in two seabird species from the Canadian Arctic-northern fulmar(Fulmarus glacialis)and black-legged kittiwake(Rissa tridactyla).We found that fulmars had higher levels of plastic contamination and emerging organic compounds(known to be plastic additives)than kittiwakes,whereas higher concentrations of legacy POPs were found in kittiwakes than the ***,fulmars,the species with the much larger foraging range(~200 km),had higher plastic pollution and overall contaminant burdens,indicating that birds may be acting as long-range transport vectors for plasticassociated *** results suggest a potential connection between plastic additive contamination and plastic pollution burdens in the bird stomachs,highlighting the importance of treating plastic particles and plastic-associated organic additives as co-contaminants rather than separate pollution issues.

关键词： Plastic contaminants Contaminants of emerging arctic concern Arctic Seabirds PFAS OPEs PBDEs Trace metals

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From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1629-1647页

作者： Tran Thi Van Anh Alilou Mostafa Zhigang Rao Simona Pace Stefan Schwaiger Christian Kretzer Veronika Temml Carsten Giesel Paul M.Jordan Rossella Bilancia Christina Weinigel Silke Rummler birgit Waltenberger Tran Hung Antonietta Rossi Hermann Stuppner Oliver Werz Andreas Koeberle Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria Faculty of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City 700000Viet Nam Michael Popp Institute and Center for Molecular Biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria Department of Pharmaceutical/Medicinal Chemistry Institute of PharmacyFriedrich Schiller University JenaJena 07743Germany Institute of Pharmacy Department of Pharmaceutical and Medicinal ChemistryParacelsus Medical University SalzburgSalzburgSalzburg 5020Austria Department of Pharmacy School of MedicineUniversity of Naples FedericoⅡNaples'80131Italy Institute of Transfusion Medicine University Hospital JenaJena 07747Germany

Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory *** mediators orchestrate both the initiation and resolution of *** from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation,though drug candidates exhibiting such features are *** from a library of Vietnamese medical plant extracts,we identified isomers of the biflavanoid 8-methylsocotrin-4’-ol from Dracaena cambodiana,which limit inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile from leukotrienes to specialized pro-resolving mediators(SPM).Elucidation of the absolute configurations of 8-methylsocotrin-4’-ol revealed the 2 S,γSisomer being most active,and molecular docking studies suggest that the compound binds to an allosteric site between the 5-lipoxygenase *** identified additional subordinate targets within lipid mediator biosynthesis,including microsomal prostaglandin E2 *** production is efficiently suppressed in activated human neutrophils,macrophages,and blood,while the induction of SPM biosynthesis is restricted to M2 *** shift from leukotrienes to SPM was also evident in mouse peritonitis in vivo and accompanied by a substantial decrease in immune cell *** summary,we disclose a promising drug candidate that combines potent 5-lipoxygenase inhibition with the favorable reprogramming of lipid mediator profiles.

关键词： Lipoxygenase Inflammation Resolution Natural product Lipidomics Lipid mediator

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Liquid Scintillation Spectroscopy of ^(227)Ac and Daughters

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Journal of Analytical Sciences, Methods and Instrumentation 2012年第1期2卷 33-36页

作者： Dag Oistein Eriksen birgit Ryningen Bent Wilhelm Schoultz Gro Salberg Roy Hartvig Larsen Institute for Energy Technology KjellerNorway Algeta ASA OsloNorway

In order to find a fast and reliable method for measurements of organic and aqueous liquid phases containing a- and b-emitters in mixtures we developed a method based on Liquid Scintillation Counting (LSC) using Quantulus Low Level Spectrometer. The use of low level LSC instead of g-spectroscopy allows reduced sample activity, shorter count rates and use of sample changer. This is of great advantage when many samples have to be measured during a short time period. The main nuclides of interest were 227Ac and 223Ra. 227Ac does not have any appropriate g-radiation, therefore measurements of the nuclei of interest must be based on a- and b-spectroscopy. In this study, it is shown that analyses of the radionuclidic purity of the liquid phases could be determined by a- and b-spectroscopy with Quantulus.

关键词： Dipex LSC Ra-223 Ac-227 Spectroscopy Quantulus

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狼獾凶猛动物界的生化武器

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环球人文地理 2013年第13期 76-85页

作者：了尘 birgit Fostervold

比起老虎、狮子、熊等大型猛兽。狼灌的体型称得上娇刁。但是,这种体长不超过1米的小型食肉哺乳动物,却能够捕杀身材巨大的的驯鹿,甚至面对棕熊也毫不胆法,即使无法战胜,也能全身而退。狼灌的尿液十分神奇:捕猎时.只要狼灌用尿液围着猎... 详细信息

比起老虎、狮子、熊等大型猛兽。狼灌的体型称得上娇刁。但是,这种体长不超过1米的小型食肉哺乳动物,却能够捕杀身材巨大的的驯鹿,甚至面对棕熊也毫不胆法,即使无法战胜,也能全身而退。狼灌的尿液十分神奇:捕猎时.只要狼灌用尿液围着猎物画一个圈,猎物就如同中了魔法,不再抵抗或逃跑,很快束手就擒。如果狼罐遇到大型猛兽,它们转圈撒尿,将自己围在圈内,从而化险为夷……

关键词：大兴安岭受精卵生化武器

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From Awareness to Action Using the Survey Feedback Method

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Journal of Health Science 2014年第7期2卷 325-329页

作者： Ann Fridner birgit Pingel Lise Tevik Lovseth Marie Gustafsson Senden Karin Schenck-Gustafsson Department of Psychology Centre of Gender Medicine Karolinska Institutet Stockholm University Stockholm SE-10691Sweden Centre of Gender Medicine Karolinska lnstitutet and Cardiac Unit Department of Medicine Karolinska University HospitalStockholm SE-10691 Sweden Department of Research and Development Trondheim St. Olavs University Hospital Norway

Reports from European university hospitals show an increase in work-related mental strain. Four European university hospitals started a comprehensive research program called Health and Organisation among University hospitals Physicians in Europe--the HOUPE Study in the year 2003. Based on the results from the HOUPE study, the authors conducted an intervention project together with HR-consultants at one of the participating hospitals. A collected cross-sectional survey in 2005 among permanently employed academic physicians （N = 1800, response rate 60%） at Karolinska University Hospital in Sweden. Results from the study were used in survey feedback seminars （N = 250）. This method is a way of systematic collection of data to process and give feedback to the organisation＇s members in order to initiate organisational change. By providing results based on the total sample, on each division, and unpublished data from each clinic the authors aimed to improve physicians＇ health and work satisfaction and thereby enhance the health of the physicians. Feedback seminars can arouse many emotions and might make people defensive. The role of resistance in the process of change is a paradox in that resistance slows down change. However, without resistance there will be no change at all. The authors conducted 20 feedback seminars of three hours duration where results were discussed relating mainly to the psychosocial work environment, psychological distress, and career paths, i.e., job demands, control at work, social interactions, leadership, commitment to the organisation, harassment at work, burnout, depression and suicide ideation. Altogether, 250 physicians participated in these meetings. To achieve acceptance for organisational change, data about relevant conditions in the organisation have to be processed in a systematic way in collaboration with all those who will benefit from changes, in concrete work units as divisions and clinics.

关键词： Work interventions HR-consultants physician health.

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