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作者： bipin chaudhary 天津医科大学

学位级别：硕士

卵巢癌是妇科常见肿瘤,居世界恶性肿瘤的第七位,是女性患癌症死亡的第八位常见病因。卵巢癌被称为无声杀手,是最致命的妇科癌症。卵巢病变是所有年龄段妇女的巨大威胁,较年轻的女性病变可能性更大。女性卵巢癌的死亡率是5%,高于任何其... 详细信息

卵巢癌是妇科常见肿瘤,居世界恶性肿瘤的第七位,是女性患癌症死亡的第八位常见病因。卵巢癌被称为无声杀手,是最致命的妇科癌症。卵巢病变是所有年龄段妇女的巨大威胁,较年轻的女性病变可能性更大。女性卵巢癌的死亡率是5%,高于任何其他妇科疾病。当从影像不能鉴别肿瘤的良性、交界性和恶性时,卵巢肿瘤诊断也遇到瓶颈。由于临床症状不典型,癌症前期难以确诊,以致于疾病危及生命。早期诊断及治疗对患者的预后有重要价值,但是超过75%的卵巢癌患者症状出现在疾病晚期,其存活率很低。卵巢肿瘤病理组织学亚型可分为良性、交界性及恶性。良性卵巢肿瘤是一种在女性卵巢内外缓慢生长的异常组织块,约50%的卵巢肿瘤患者月经不规律,30%的患者月经正常。卵巢肿瘤通常是良性的,但如果不治疗,有些类型可能发展为恶性。15%的原发性卵巢肿瘤是交界性卵巢肿瘤,也称为低恶性肿瘤。术前区分卵巢良恶性肿瘤或交界性卵巢恶性肿瘤是手术设计的关键。与血清学诊断(CA-125)相比,有多种非侵入性的成像方法可以用于检测卵巢肿瘤的良恶性。目前,超声(Ultrasonography,US)、计算机断层扫描(Computed tomography,CT)和磁共振成像(magnetic resonance imaging,MRI)被广泛应用于卵巢肿瘤的诊断和研究。CT通常用于鉴别可疑的卵巢恶性肿瘤,但它有软组织分辨力低、放射性损害等缺点。MRI在特定问题上发挥作用,比如识别附件病变和在没有辐射危害的情况下提供有用手术策略建议。MRI能够识别骨盆区域的不同类型肿瘤,还有助于从恶性肿瘤中区分良性肿瘤和交界性肿瘤,MRI对畸胎瘤、子宫内膜癌、单纯性和出血性囊肿、纤维瘤的诊断具有较高的准确性和可信度。然而,形态标志的识别依赖于放射科医生的诊断经验。扩散加权成像(diffusion weighted imaging,DWI),它通过检测游离水分子的扩散程度来提供组织细胞和细胞膜完整性的信息。表观扩散系数(Apparent diffusion coefficient,ADC)具有定量水分子扩散的能力。ADC值与肿瘤细胞数量呈显著的负相关,这在以往肿瘤(乳腺癌、肾癌和前列腺癌)的研究中均有发现。目的本研究的目的是通过对卵巢肿瘤的实性成分进行DWI的ADC直方图分析,评价其在卵巢肿瘤鉴别诊断中的价值。材料与方法(1)受试者本研究为回顾性研究,收集并分析53例因可疑附件肿物在我院进行MR检查,并经手术病理证实的卵巢肿物患者。纳入标准:(1)行MR+DWI检查,图像完整清晰,无明显的运动伪影;(2)在我院行手术切除治疗,具有完整的病理诊断结果;(3)MR检查与手术间隔时间小于2周;(4)常规MR T2WI和T1WI显示囊实性卵巢肿物。排除标准:(1)经临床或影像确诊为卵巢肿瘤患者,在MR检查前接受放化疗治疗;(2)成熟囊性畸胎瘤;(3)子宫切除患者。53位患者的平均年龄为57.82?13.05岁,年龄范围为18-82岁。所有卵巢肿瘤患者均检测血清CA-125,并在MR检查后2周内进行手术且取得病理结果。(2)数据采集采用西门子磁共振扫描仪,对患者进行了盆腔MR平扫+DWI扫描,受试者取仰卧位,头先进,将线圈置于患者中下腹部,以子宫所在区域为中心。DWI检查取横轴位扫描,定位线同平扫,采用SE-EPI序列,b值分别为0和800s/mm2。将扩散敏感梯度分别施加于层面选择、相位编码和频率编码方向,分别得到三个方向上的信号平均后得到DWI影像并由此计算得到ADC图。(3)数据处理在飞利浦直方图分析软件工作站中,对卵巢囊实性-实性肿物的ADC值进行测量和评价。根据病理结果分为卵巢良性肿瘤、交界性肿瘤及恶性肿瘤(1组、2组、3组)三组。首先对三组数据进行正态分布检验,检验后数据满足正态分布,随即采用单因素方差分析(one way ANOVA)比较三组之间卵巢肿瘤实性成分的各参数值差异,若不满足正态分布,则采用非参数Kruskal-walllis检验比较参数值差异。三组间两两比较采用最小显著差值法(least significant difference,LSD)。p值<0.05为差异有统计学意义。同时,受试者操作特性曲线(receiver operating characteristic,ROC)用于评估卵巢肿瘤实性部分ADC值鉴别三种肿物性质的诊断能力,并确定截断值(cut-off value)、准确度、特异度、阳性预测值(PPV)、阴性预测值(NPV)。结果本研究共53例患者,病理结果为卵巢恶性肿瘤15例,平均年龄55.80±13.79(35-80)岁。交界性肿瘤18例,平均年龄54.29±14.28(32-82)岁。良性肿瘤20例,平均年龄60.06±9.72(18-82)岁。良性组CA-125为1.98±0.53U/ml,

关键词：磁共振成像扩散加权成像 ADC值卵巢肿物良性交界性恶性

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A cross-sectional study to assess medication safety,knowledge,attitude,and practices regarding nutrition and medication among pregnant women

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Asian pacific Journal of Reproduction 2024年第3期13卷 115-119页

作者： Gauthami R bipin Shaji Twinkle MJS Krishnapriya Radhakrishnan Reshma Kolar Juno Jerold Joel Nitte(Deemed to be University) NGSM Institute of Pharmaceutical Sciences(NGSMIPS)Department of Pharmacy PracticeDeralakatteMangaluruIndia Nitte(Deemed to be University) KS Hegde Medical Academy(KSHEMA)Department of Obstetrics and GynaecologyDeralakatteMangaluruIndia AJ Institute of Medical Sciences and Research Centre Department of Community MedicineMangaluruKarnatakaIndia

Objective:To assess pregnant women's knowledge,attitude,and practice regarding nutrition and medication usage,analyse the prescribing pattern,and categorize them based on the Food and Drug Administration(FDA)***:A cross-sectional study was conducted with 264 pregnant women in the obstetrics and gynaecology department of a tertiary care hospital from October 2022 to August 2023.A knowledge,attitude,and practice(KAP)questionnaire was prepared in English language by the researchers and validated by an expert panel consisting of 12 *** validated questionnaire was then translated into regional languages,Kannada and *** reliability of the questionnaire was assessed with test-retest method with a representative sample population of 30 subjects(10 subjects for each language).The subjects'knowledge,attitude,and practice were evaluated using the validated KAP *** safety of the medication was assessed using the FDA drug safety classification for ***:The mean scores for nutritional and medication usage knowledge,attitude,and practice were 4.14±1.15,4.50±1.09,and 3.00±1.47,*** 30 prescribed medications,3 belong to category A(no risk in human studies),8 belong to category B(no risk in animal studies),18 belong to category C(risk cannot be ruled out)and 1 drug is not classified.A significant association was observed between medication knowledge and practice(r=0.159,P=0.010).Conclusions:Most of the study population knows the need to maintain good dietary and medication practices during *** pregnant women regarding diet and medication usage is crucial in maternal care.

关键词： Pregnancy Nutrition Medication Knowledge Practice Safe medication

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Overview on pulse proteins for future foods:ingredient development and novel applications

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未来食品学报(英文) 2023年第4期3卷 340-356页

作者： bipin Rajpurohit Yonghui Li Department of Grain Science and Industry Kansas State UniversityManhattan 66506USA

We are facing the challenge of climate change and food insecurity for a growing *** current mode of animal protein production via animal agriculture is resource-intensive and ***,there is a need to find alternative sources of food protein that are environmentally ***-based proteins,specifically pulse-based proteins,provide a promising solution to the *** review aims to provide an overview and perspective on extraction,functionality,digestibility,sensory,and new food applications of pulse *** main methods,namely wet fractionation and dry fractionation are used to extract pulse-based *** compared to dry fractionation,wet fractionation yields high purity protein,but the process alters the structure and function of the *** biochemical and physical techniques can be used to assist wet extraction process to increase protein yield and/or reduce extraction *** main techno-functional properties of plant-based proteins determining their practical applicability are solubility,water/oil holding capacity(WHC/OHC),gelation,emulsification,foaming,and rheological ***,pulse proteins are deficient in one or more essential amino *** to overcome the deficiency are *** and non-volatile compounds inherent to pulses or developed during processing are mostly responsible for the off flavors in the extracted *** to improve the pulse protein flavor and remove or modify off-flavors are ***-based protein ingredients have applications in bakery products,pasta,meat analogues,dairy alternatives,and *** these applications,there is a need to explore novel applications of pulse proteins in infant and children’s formula,beverages,breakfast cereals,flavor development,and extruded snack products,develop new applications such as personalized and precision nutrition and bioactive peptides,and employ innovative technologies such as

关键词： Plant-based protein Off-flavors Pretreatment techniques Protein functionality Protein extraction

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Influence of quenching medium on the dendrite morphology,hardness,and tribological behaviour of cast Cu-Ni-Sn spinodal alloy for defence application

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Defence Technology（防务技术） 2023年第12期30卷 83-100页

作者： bipin Sankar Karthik V Shankar Vamu Sunil Hemanth Kashyap S Nikhil Nair Adarsh A.Nair Abhinav P M Department of Mechanical Engineering Amrita Vishwa VidyapeethamAmritapuriIndia

Cu-Ni-Sn spinodal alloys(Spinodal bronze)are potential materials with robust applications in components associated with defence applications like bearings,propellers,bushes,and shafts of heavily loaded aircraft,off-road vehicles,and *** paper presents a comparative study using water,Brine solution,and SAE 40 oil as the quenching media in regular bronze(Cu-6Sn)and spinodal bronze(Cu-9Ni-6Sn)*** analysis was conducted by optical microscopy,transmission electron microscopy(TEM),and X-ray diffraction technique(XRD)on bronze and spinodal bronze samples immersed in the three different quenching media to understand the grain size and hardness values *** analysis was performed to analyze the effect of quenching media on the wear aspects of bronze and spinodal bronze *** hardness value of the brine-aged spinodal bronze samples was as high as 320 Hv,and the grain size was very low in the range of 60μm.A quantitative comparison between brine-aged regular bronze and brine-aged spinodal bronze showed that the hardness(Hv)was almost 80%higher for brine-aged spinodal ***,the grain size was approximately 30%finer for spinodal bronze when compared with regular *** the load was increased in spinodal bronze samples,there was an initial dip in wear rate followed by a marginal *** was a steady increase in friction coefficient with a rise in load for brine-aged regular bronze and spinodal bronze *** results indicate that brine solution is the most effective quenching medium for cast Cu-Ni-Sn spinodal alloys.

关键词： Quenching Water Brine SAE 40 oil Grain size Hardness Wear rate Spinodal decomposition CuSn Spinodal alloy CuNiSn

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Identification and comparison of the local physicochemical structures of transition metal-based layered double hydroxides for high performance electrochemical oxygen evolution reactions

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Journal of Energy Chemistry 2023年第12期87卷 89-97,I0004页

作者： Min Sung Kim bipin Lamichhane Ju-Hyeon Lee Jin-Gyu Bae Jeong Yeon Heo Hyeon Jeong Lee Shyam Kattel Ji Hoon Lee School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea KNU Advanced Material Research Institute Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Department of Physics Florida A&M UniversityTallahasseeFlorida 32307United States

Layered double hydroxides(LDHs) have attracted considerable attention as a cost effective alternative to the precious iridium-and ruthenium-based electrocatalysts for an oxygen evolution reaction(OER),a bottleneck of water electrolysis for sustainable hydrogen *** their excellent OER performance,the structural and electronic properties of LDHs,particularly during the OER process,remain to be poorly *** this study,a series of LDH catalysts is investigated through in situ X-ray absorption fine structure analyses and density functional theory(DFT) *** experimental results reveal that the LDH catalyst with equal amounts of Ni and Fe(NF-LDH) exhibits the highest OER activity and catalytic life span when compared with its counterparts having equal amounts of Ni and Co(NC-LDH)and Ni only(Ni-LDH).The NF-LDH shows a markedly enhanced OER kinetics compared to the NC-LDH and the Ni-LDH,as proven by the lower overpotentials of 180,240,and 310 mV,respectively,and the Tafel slopes of 35.1,43.4,and 62.7 mV dec^(-1),*** DFT calculations demonstrate that the lowest overpotential of the NF-LDH is associated with the active sites located at the edge planes of NF-LDH in contrast to those located at the basal planes of Ni-LDH and *** current study pinpoints the active sites on various LDHs and presents strategies for optimizing the OER performance of the LDH catalysts.

关键词： Layered double hydroxides Oxygen evolution reaction In situ X-ray analyses Density functional theory Catalytic active sites

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3D-printed scaffolds with 2D hetero-nanostructures and immunomodulatory cytokines provide pro-healing microenvironment for enhanced bone regeneration

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Bioactive Materials 2023年第9期27卷 216-230页

作者： Xifeng Liu bipin Gaihre Sungjo Park Linli Li Babak Dashtdar Maria D.Astudillo Potes Andre Terzic Benjamin D.Elder Lichun Lu Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMN55905USA Department of Orthopedic Surgery Mayo ClinicRochesterMN55905USA Department of Cardiovascular Medicine and Center for Regenerative Medicine Mayo ClinicRochesterMN55905USA Department of Neurologic Surgery Mayo ClinicRochesterMN55905USA

Three-dimensional (3D) printing technology is driving forward the progresses of various engineering fields, including tissue engineering. However, the pristine 3D-printed scaffolds usually lack robust functions in stimulating desired activity for varied regeneration applications. In this study, we combined the two-dimensional (2D) hetero-nanostructures and immuno-regulative interleukin-4 (IL-4) cytokines for the functionalization of 3D-printed scaffolds to achieve a pro-healing immuno-microenvironment for optimized bone injury repair. The 2D hetero-nanostructure consists of graphene oxide (GO) layers, for improved cell adhesion, and black phosphorous (BP) nanosheets, for the continuous release of phosphate ions to stimulate cell growth and osteogenesis. In addition, the 2D hetero-nanolayers facilitated the adsorption of large content of immuno-regulative IL-4 cytokines, which modulated the polarization of macrophages into M2 phenotype. After in vivo implantation in rat, the immuno-functioned 3D-scaffolds achieved in vivo osteo-immunomodulation by building a pro-healing immunological microenvironment for better angiogenesis and osteogenesis in the defect area and thus facilitated bone regeneration. These results demonstrated that the immuno-functionalization of 3D-scaffolds with 2D hetero-nanostructures with secondary loading of immuno-regulative cytokines is an encouraging strategy for improving bone regeneration.

关键词： 3D-printing 2D materials Bone repair Osteo-immunomodulation Cytokines

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扭带式换热器水热关联的机器学习辅助建模

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Acta Mechanica Sinica 2023年第1期39卷 148-157页

作者： Jyoti Prakash Panda bipin Kumar Anil Kumar Patil Manoj Kumar Ravi Kumar Department of Mechanical Engineering DIT UniversityDehradunUttarakhandIndia

本文介绍了机器学习(ML)算法在带扭带插件的换热器传热关联(如努塞尔数和摩擦系数)建模中的应用.采用换热器在不同雷诺数(Re)、扭转比(t)、穿孔率(p)和不同扭带数(n)下的实验数据进行相关建模.在数据驱动的代理建模中使用了三种机器学... 详细信息

本文介绍了机器学习(ML)算法在带扭带插件的换热器传热关联(如努塞尔数和摩擦系数)建模中的应用.采用换热器在不同雷诺数(Re)、扭转比(t)、穿孔率(p)和不同扭带数(n)下的实验数据进行相关建模.在数据驱动的代理建模中使用了三种机器学习算法:多项式回归(PR)、随机森林(RF)和人工神经网络(ANN).为了保证模型的通用性,对ML模型的超参数进行了优化,分析了不同ML算法的性能参数(如R 2和MAE).结果表明,在不同的测试数据集上,人工神经网络对传热系数的预测优于PR和RF的预测.基于本文分析内容,对未来数据驱动的传热关联建模工作和类似研究提出了建议.

关键词：机器学习数据驱动测试数据集辅助建模多项式回归超参数穿孔率

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ON THE VOLUME OF FLUID METHOD FOR MULTIPHASE FLUID FLOW SIMULATION

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第2期4卷 74-100页

作者： bipin KUMAR MARTIN CRANE YAN DELAURE Institut fur Thermo-und Fluiddynamik Technische Universitat Ilmenau 98684 Ilmenau Germany School of Computing Dublin City University Dublin 9Ireland School of Mechanical and Manufacturing Engineering Dublin City University Dublin 9Ireland

Numerical study of multiphase fluid flows require mathematical methods for distinguishing interface between two *** volume of fluid(VOF)method is one of such method which takes care of fluid shape in a local domain and reconstructs the interface from volume fraction of one *** sharp interface during reconstruction is a challenging task and geometrical approach of VOF method better suits for incompressible *** paper provides a complete mathematical discussion of extended form of VOF method using a approach known as piecewise linear interface calculation(PLIC).An analytical relation between volume fraction and interface position has been explored with the help of primitive geometrical *** method with this analytical relation has been applied to multiphase fluid flow benchmark problems and found to be in good agreement.

关键词： Multiphase fluid flows VOF(PLIC)method analytic relation incompressible fluids interface reconstruction.

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Assigning conservation value and identifying hotspots of endemic rattan diversity in the Western Ghats, India

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Plant Diversity 2017年第5期39卷 263-272页

作者： Mukta Joshi bipin Charles G. Ravikanth N.A. Aravind Ashoka Trust for Research in Ecology and the Environment (ATREE) Royal Enclave Srirampura Jakkur PO Bangalore 560064 India Indian Institute of Sdence Education and Research Dr. Homi Bhabha Road Pashan Pune 411008 India

Rattans, or canes, are one of the most important non-timber forest products supporting the livelihood of many forest-dwelling communities in South and North-eastern India. Due to increased demand for rattan products, rattans have been extracted indiscriminately from the Western Ghats, a 1600-km mountain chain running parallel to the west coast of India. Extensive harvesting, loss of habitat and poor regeneration has resulted in dwindling rattan populations, necessitating an urgent attempt to conserve existing rattan resources. In this study, using niche-modelling tools, an attempt has been made to identify areas of high species richness of rattans in the Western Ghats, one of the mega-diversity regions of the world. We have also developed conservation values for 21 economically important and endemic rattans of the Western Ghats. We identified at least two to three sites of extremely high species richness outside the existing protected area network that should be prioritized for in situ *** study emphasizes the need to develop strategies for the long-term conservation of rattans in the Western Ghats, India.

关键词： Calamus NTFP Distribution Protected areas Gap analysis Species distribution models

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Ground bounce noise reduction aware combinational multi threshold CMOS circuits for nanoscale CMOS multiplier

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Frontiers of Optoelectronics 2013年第3期6卷 327-337页

作者： bipin Kumar VERMA Shyam Babu SINGH Shyam AKASHE Department of Electronics and Communication Engineering ITM University Gwalior (M.P.) 474001 India

Multi-threshold complementary metal-oxide- semiconductor （MTCMOS） is ofbn used to reduce the leakage current in idle circuit. Ground bounce noise produced during a transition mode （sleep-to-active） is an important challenge in MTCMOS. In this paper, various noise-aware combinational MTCMOS circuit was used to evaluate the ground bounce noise. An intermediate mode was applied in the sleep-to-active mode transition to reduce the charge stored on virtual lines to real ground. The dependence of ground bounce noise on voltage, transistor size and temperature was investigated with different MTCMOS circuit technique. The peak amplitude of ground bounce noise was reduced up to 78.82%. The leakage current of the circuit was decreased up to 99.73% and the active power of the circuit was reduced up to 62.32%. Simulation of multiplier with different MTCMOS circuit techniques was performed on 45nm CMOS technology.

关键词： multi-threshold complementary metal-oxide-semiconductor (MTCMOS) mode transition groundbounce noise sleep transistor

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