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A near-zero quiescent power breeze wake-up anemometer based on a rolling-bearing triboelectric nanogenerator

Microsystems & Nanoengineering 2024年第2期10卷 241-249页

作者： Xianpeng Fu Zhichao Jiang Jie Cao Zefang Dong Guoxu Liu Meiling Zhu Chi zhang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing100049China Center on Nanoenergy Research Guangxi Colleges and Universities Key Laboratory of Blue Energy and Systems IntegrationSchool of Physical Science&TechnologyGuangxi UniversityNanning530004China Institute of Intelligent Flexible Mechatronics Jiangsu UniversityZhenjiang212013China College of Engineering Mathematics and Physical ScienceUniversity of ExeterExeterEX44QFUK

Wind sensors have always played an irreplaceable role in environmental information monitoring and are expected to operate with lower power consumption to extend service ***,we propose a breeze wake-up anemometer(B-WA)based on a rolling-bearing triboelectric nanogenerator(RB-TENG)with extremely low static *** B-WA consists of two RB-TENGs,a self-waking-up module(SWM),a signal processing module(SPM),and a wireless transmission *** two RB-TENGs are employed for system activation and wind-speed *** the ambient wind-speed exceeds 2 m/s,the wake TENG(W-TENG)and the SWM can wake up the system within 0.96 *** the same time,the SPM starts to calculate the signal frequency from the measured TENG(M-TENG)to monitor the wind speed with a sensitivity of 9.45 Hz/(m/s).After the wind stops,the SWM can switch off the B-WA within 0.52 s to decrease the system energy *** quiescent on-duty mode,the operating power of the B-WA is less than 30 nW,which can greatly extend the service lifetime of the *** integrating triboelectric devices and rolling bearings,this work has realized an ultralow quiescent power and self-waked-up wireless wind-speed monitoring system,which has foreseeable applications in remote weather monitoring,IoT nodes,and so on.

关键词： generator power service

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Joint Biomedical Entity and Relation Extraction Based on Multi-Granularity Convolutional Tokens Pairs of Labeling

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Computers, Materials & Continua 2024年第9期80卷 4325-4340页

作者： Zhaojie Sun Linlin Xing Longbo zhang Hongzhen Cai Maozu Guo Department of Computer Science and Technology Shandong University of TechnologyZibo255000China Department of Agricultural Engineering and Food Science Shandong University of TechnologyZibo255000China Department of Electrical and Information Engineering Beijing University of Civil Engineering and ArchitectureBeijing100044China

Extracting valuable information frombiomedical texts is one of the current research hotspots of concern to a wide range of *** biomedical corpus contains numerous complex long sentences and overlapping relational triples,making most generalized domain joint modeling methods difficult to apply effectively in this *** a complex semantic environment in biomedical texts,in this paper,we propose a novel perspective to perform joint entity and relation extraction;existing studies divide the relation triples into several steps or ***,the three elements in the relation triples are interdependent and inseparable,so we regard joint extraction as a tripartite classification *** the same time,fromthe perspective of triple classification,we design amulti-granularity 2D convolution to refine the word pair table and better utilize the dependencies between biomedical word ***,we use a biaffine predictor to assist in predicting the labels of word pairs for relation *** model(MCTPL)Multi-granularity Convolutional Tokens Pairs of Labeling better utilizes the elements of triples and improves the ability to extract overlapping triples compared to previous ***,we evaluated our model on two publicly accessible *** experimental results show that our model’s ability to extract relation triples on the CPI dataset improves the F1 score by 2.34%compared to the current optimal *** the DDI dataset,the F1 value improves the F1 value by 1.68%compared to the current optimal *** model achieved state-of-the-art performance compared to other baseline models in biomedical text entity relation extraction.

关键词： Deep learning biomedical joint extraction triple classification multi-granularity 2D convolution

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Lipid-derived radical-trapping antioxidants suppress ferroptosis

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Life Metabolism 2024年第2期3卷 6-8页

作者： Ruoxi zhang Guido Kroemer Daolin Tang Department of Surgery UT Southwestern Medical CenterDallasTX 75390United States Centre de Recherche des Cordeliers INSERM U1138Equipe labellisée-Ligue contre le cancerUniversitéParis CitéSorbonne UniversitéInstitut Universitaire de FranceParis 75006France Metabolomics and Cell Biology Platforms Gustave Roussy Cancer CampusVillejuif 94800France Institut du Cancer Paris CARPEM Department of BiologyHôpital Européen Georges PompidouAssistance Publique-Hôpitaux de ParisParis 75015France

Ferroptosis,characterized by lipid peroxidation-mediated cell demise,is governed by a nuanced interplay of lipid species influencing its *** recent publications in Nature discovered 7-dehydrocholesterol,a cholesterol precursor,as a radical-trapping antioxidant that can suppress ferroptosis,thereby presenting a novel metabolic target to improve ferroptosis-related cancer therapy.

关键词： Lipid peroxidation cholesterol

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Field testing of shear strength of granite residual soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3718-3732页

作者： Song Yin Pengfei Liu Xianwei zhang Wenyuan He Pan Yan Yuzhou Sun School of Civil Engineering and Architecture Zhongyuan University of TechnologyZhengzhou450007China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

The characteristics of residual soils are very different from those of sedimentary *** the strength characteristics of sedimentary soils have been studied extensively,the shear strength characteristics of granitic residual soils(GRS)subjected to the weathering of parent rocks have rarely been *** this study,the shear strength characteristics of GRS in the Taishan area of southeast China(TSGRS)were studied by field and laboratory *** field tests consisted of a cone penetration test(CPT),borehole shear test(BST),self-boring pressuremeter test(SBPT),and seismic dilatometer Marchetti test(SDMT).The shortcomings of laboratory testing are obvious,with potential disturbances arising through the sampling,transportation,and preparation of soil *** to the special structure of GRS samples and the ease of disturbance,the results obtained from laboratory tests were generally lower than those obtained from situ *** CPT and scanning electron microscopy(SEM)results indicated significant weathering and crustal hardening in the shallow *** resulted in significant differences in the strength and strength parameters of shallow soil obtained by the *** on the SDMT and SBPT results,a comprehensive evaluation method of shear strength for TSGRS was *** SBPT was suitable for evaluating the strength of shallow *** material index(ID)and horizontal stress index(KD)values obtained by the SDMT satisfied the empirical relationship proposed by Marchetti based on the ID index,and were therefore considered suitable for the evaluation of the shear strength of deep GRS.

关键词： Granite residual soils Shear strength Field tests Self-boring pressuremeter Seismic dilatometer Borehole shear test

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Potential Adverse Outcome Pathways of Chlorinated Organophosphate Flame Retardants

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China CDC weekly 2024年第23期6卷 542-546,I0008-I0011页

作者： Meiyu Zhou Huilin zhang Qi Xiao Kexin Li Xiaoting Li Haiyan Chu Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineSchool of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Genetic Toxicology The Key Laboratory of Modern Toxicology of Ministry of EducationCenter of Global HealthSchool of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Nutrition and Food Safety School of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina

What is already known about this topic?Chlorinated organophosphate flame retardants(Cl-OPFRs)are frequently detected chemicals in the environment and biological samples,yet there is a lack of systematic evaluation regarding the adverse effects and toxicological mechanisms of *** is added by this report?This study utilizes the adverse outcome pathway(AOP)framework to assess the health implications and mechanisms of Cl-OPFRs,identifying multi-system toxicity,with a particular emphasis on reproductive issues and the possible toxic *** are the implications for public health practice?These results enhance knowledge of the health hazards linked to Cl-OPFRs,supporting the creation of focused risk evaluations and suitable regulatory actions.

关键词： utilize supporting Chlorin

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An artificial systems,computational experiments and parallel execution-based surface electromyogram-driven anti-disturbance zeroing neurodynamic strategy for upper limb human-robot interaction control

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 511-525页

作者： Yongbai Liu Keping Liu Gang Wang Jiliang zhang Yao Chou Zhongbo Sun Department of Mechanical Engineering Changchun University of TechnologyChangchunChina Department of Control Engineering Changchun University of TechnologyChangchunChina School of Electrical and Information Engineering Jilin Engineering Normal UniversityChangchunChina College of Information Science and Engineering Northeastern UniversityShenyangChina Department of Electrical and Computer Engineering Brigham Young UniversityProvoUtahUSA

In recent years,intelligent robots are extensively applied in the field of the industry and intelligent rehabilitation,wherein the human-robot interaction(HRI)control strategy is a momentous part that needs to be ***,the efficacy and robustness of the HRI control algorithm in the presence of unknown external disturbances deserve to be *** deal with these urgent issues,in this study,artificial systems,computational experiments and a parallel execution intelligent control framework are constructed for the HRI *** upper limb-robotic exoskeleton system is re-modelled as an artificial *** on surface electromyogram-based subject's active motion intention in the practical system,a non-convex function activated anti-disturbance zeroing neurodynamic(NC-ADZND)controller is devised in the artificial system for parallel interaction and HRI control with the practical ***,the linear activation function-based zeroing neurodynamic(LAF-ZND)controller and proportionalderivative(posterior deltoid(PD))controller are presented and *** results substantiate the global convergence and robustness of the proposed controller in the presence of different external *** addition,the simulation results verify that the NC-ADZND controller is better than the LAF-ZND and the PD controllers in respect of convergence order and anti-disturbance characteristics.

关键词： neural network pattern recognition robotics signal processing

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Descriptor-augmented machine learning for enzyme-chemical interaction predictions

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Synthetic and Systems Biotechnology 2024年第2期9卷 259-268页

作者： Yilei Han Haoye zhang Zheni Zeng Zhiyuan Liu Diannan Lu Zheng Liu Department of Chemical Engineering Tsinghua UniversityBeijing100084China Department of Computer Science and Technology Tsinghua UniversityBeijing100084China

Descriptors play a pivotal role in enzyme design for the greener synthesis of biochemicals,as they could characterize enzymes and chemicals from the physicochemical and evolutionary *** study examined the effects of various descriptors on the performance of Random Forest model used for enzyme-chemical relationships *** curated activity data of seven specific enzyme families from the literature and developed the pipeline for evaluation the machine learning model performance using 10-fold *** influence of protein and chemical descriptors was assessed in three scenarios,which were predicting the activity of unknown relations between known enzymes and known chemicals(new relationship evaluation),predicting the activity of novel enzymes on known chemicals(new enzyme evaluation),and predicting the activity of new chemicals on known enzymes(new chemical evaluation).The results showed that protein descriptors significantly enhanced the classification performance of model on new enzyme evaluation in three out of the seven datasets with the greatest number of enzymes,whereas chemical descriptors appear no effect.A variety of sequence-based and structure-based protein descriptors were constructed,among which the esm-2 descriptor achieved the best *** enzyme families as labels showed that descriptors could cluster proteins well,which could explain the contributions of descriptors to the machine learning *** a counterpart,in the new chemical evaluation,chemical descriptors made significant improvement in four out of the seven datasets,while protein descriptors appear no *** attempted to evaluate the generalization ability of the model by correlating the statistics of the datasets with the performance of the *** results showed that datasets with higher sequence similarity were more likely to get better results in the new enzyme evaluation and datasets with more enzymes were more likely beneficial from the protein

关键词： Enzyme-substrate interaction Enzyme design Machine learning Descriptor

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Self-adjuvant Astragalus polysaccharide-based nanovaccines for enhanced tumor immunotherapy:a novel delivery system candidate for tumor vaccines

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Science China(Life Sciences) 2024年第4期67卷 680-697页

作者： Nan Li Yun zhang Miaomiao Han Tian Liu Jinjia Wu Yingxia Xiong Yikai Fan Fan Ye Bing Jin Yinghua zhang Guibo Sun Xiaobo Sun Zhengqi Dong State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Chinese Academy of Medical Sciences&Peking Union Medical College(CAMS)Institute of Medicinal Plant Development(IMPLAD)Beijing 100193China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine from Ministry of Education Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine(Natural Medicine)and Translational MedicineKey Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription from Chinese Academy of Medical SciencesCAMSIMPLADBeijing 100193China Department of Pharmaceutics School of Pharmaceutical SciencesHeilongjiang University of Chinese MedicineHarbin 150036China Jilin Academy of Chinese Medicine Sciences Changchun 130012China Joint Research Center for Chinese Medicinal Herbs IMPLADABRC&ACCLBeijing 100193China

The study of tumor nanovaccines(NVs)has gained interest because they specifically recognize and eliminate tumor ***,the poor recognition and internalization by dendritic cells(DCs)and insufficient immunogenicity restricted the vaccine ***,we extracted two molecular-weight Astragalus polysaccharides(APS,12.19 k D;APSHMw,135.67 k D)from Radix Astragali and made them self-assemble with OVA257–264directly forming OVA/APS integrated nanocomplexes through the microfluidic *** nanocomplexes were wrapped with a sheddable calcium phosphate layer to improve *** in the formed nanocomplexes served as drug carriers and immune adjuvants for potent tumor *** optimal APS-NVs were approximately 160 nm with uniform size distribution and could remain stable in physiological saline *** FITC-OVA in APS-NVs could be effectively taken up by DCs,and APS-NVs could stimulate the maturation of DCs,improving the antigen cross-presentation efficiency in *** possible mechanism was that APS can induce DC activation via multiple receptors such as dectin-1 and Toll-like receptors 2 and *** accumulation of APS-NVs both in draining and distal lymph nodes were observed following *** APS-NVs could easily access the lymph ***,APS-NVs could markedly promote antigen delivery efficiency to DCs and activate cytotoxic T *** addition,APS-NVs achieve a better antitumor effect in established B16-OVA melanoma tumors compared with the OVA+Alum treatment *** antitumor mechanism correlated with the increase in cytotoxic T cells in the tumor ***,the poor tumor inhibitory effect of APS-NVs on the nude mouse model of melanoma also confirmed the participation of antitumor adaptive immune response induced by ***,this study developed a promising APS-based tumor NV that is an efficient tumor immunotherapy without systemic side effects.

关键词： Astragalus polysaccharides nanovaccines OVA immunotherapy self-adjuvant

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Study on the Impact of Massive Refracturing on the Fracture Network in Tight Oil Reservoir Horizontal Wells

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Fluid Dynamics & Materials Processing 2024年第5期20卷 1147-1163页

作者： Jianchao Shi Yanan zhang Wantao Liu Yuliang Su Jian Shi Exploration and Development Research Institute Changqing Oilfield CompanyXi’an710018China National Engineering Laboratory for Exploration and Development of Low Permeability Oil and Gas Fields Xi’an710018China Key Laboratory of Unconventional Oil and Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580China

Class III tight oil reservoirs have low porosity and permeability,which are often responsible for low production rates and limited *** repeated fracturing is a well-known technique to fix some of these *** such methods,existing fractures are refractured,and/or new fractures are created to facilitate communication with natural *** study explored how different refracturing methods affect horizontal well fracture networks,with a special focus on morphology and related fluid flow *** particular,the study relied on the unconventional fracture model(UFM).The evolution of fracture morphology and flow field after the initial fracturing were analyzed *** simulation results indicated that increased formation energy and reduced reservoir stress differences can promote fracture *** was shown that the length of the fracture network,the width of the fracture network,and the complexity of the fracture can be improved,the oil drainage area can be increased,the distance of oil and gas seepage can be reduced,and the production of a single well can be significantly increased.

关键词： Type III tight oil reservoirs refracturing methods horizontal wells fracture network study fracture network evolution

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Simulation model optimization for bonnet polishing considering consistent contact area response

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Frontiers of Mechanical Engineering 2024年第4期19卷 87-105页

作者： Yanjun HAN Haiyang zhang Menghuan YU Jinzhou YANG Linmao QIAN School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China Institute of Data Science Maastricht UniversityMaastricht 6229ENthe Netherlands

Simulation model optimization plays a crucial role in the accurate prediction of material removal function in bonnet polishing processes,but model complexity often poses challenges to the practical implementation and efficiency of these *** paper presents an innovative method for optimizing simulation model parameters,focusing on achieving consistent contact area and the accurate prediction of the material removal function while preventing increase in model ***,controllable and uncontrollable factors in bonnet simulations are analyzed,and then a simplified contact model is developed and applied under constant force *** characterize the bonnet's contact performance,a contact area response curve is introduced,which can be obtained through a series of single spot contact ***,a rubber hyperelastic parameter optimization model based on a neural network is proposed to achieve optimal matching of the contact area between simulation and *** average deviation of the contact area under different conditions was reduced from 22.78%before optimization to 3.43%after optimization,preliminarily proving the effectiveness of the proposed simulation optimization ***,orthogonal experiments are further conducted to validate the proposed *** comparison between the experimental and predicted material removal functions reveals a high consistency,validating the accuracy and effectiveness of the proposed optimization method based on consistent contact *** research provides valuable insights into enhancing the reliability and effectiveness of bonnet polishing simulations with a simple and practical approach while mitigating the complexity of the model.

关键词： bonnet polishing simulation contact area tool influence function optimization

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