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晶圆微凸点技术在先进封装中的应用研究进展

微纳电子与智能制造 2024年第1期6卷 1-11页

作者：刘冰夏良贺京峰孔云陈平贵州振华风光半导体股份有限公司

先进封装技术持续朝着连接密集化、堆叠多样化和功能系统化的方向发展，探索了扇出型封装、2.5D/3D封装、系统级封装等多种封装工艺。晶圆微凸点技术已被广泛应用于各种先进封装工艺中，是最重要的基础技术之一。本文介绍了微凸点制备... 详细信息

先进封装技术持续朝着连接密集化、堆叠多样化和功能系统化的方向发展，探索了扇出型封装、2.5D/3D封装、系统级封装等多种封装工艺。晶圆微凸点技术已被广泛应用于各种先进封装工艺中，是最重要的基础技术之一。本文介绍了微凸点制备的主要技术并进行优劣势比较，同时详述了锡球凸点和铜柱凸点两种不同的微凸点结构，为微凸点技术的更深入研究提供参考。最后，本文整理了微凸点技术在先进封装中的应用，并展望了未来的发展趋势。

关键词：先进封装微凸点制备技术凸点结构

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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

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Military Medical Research 2024年第1期11卷 115-147页

作者： Yuan-Peng Zhang Xin-Yun Zhang Yu-Ting Cheng bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam Ta Zhou Zong-Rui Ma Jia-Bao Sheng Victor CWTam Shara WYLee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 314-330页

作者： Lei Zheng Jia Lu Da-Lu kong Department of Colorectal Cancer Surgery National Clinical Research Center for CancerKey Laboratory of Cancer Immunology and Biotherapy of TianjinTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Infection Management National Clinical Research Center for CancerKey Laboratory of Cancer Immunology and Biotherapy of TianjinTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300060China

BACKGROUND Cyclin-dependent kinase 9(CDK9)expression and autophagy in colorectal cancer(CRC)tissues has not been widely ***9,a key regulator of transcription,may influence the occurrence and progression of *** expression of auto-phagy-related genes BECN1 and drug resistance factor ABCG2 may also play a role in *** normal physiological conditions,autophagy can inhibit tumorigenesis,but once a tumor forms,autophagy may promote tumor ***,understanding the relationship between autophagy and cancer,partic-ularly how autophagy promotes tumor growth after its formation,is a key motivation for this *** To investigate the relationship between CDK9 expression and autophagy in CRC,assess differences in autophagy between left and right colon cancer,and analyze the associations of autophagy-related genes with clinical features and *** We collected tumor tissues and paracarcinoma tissues from colon cancer patients with liver metastasis to observe the level of autophagy in tissues with high levels of CDK9 and low levels of *** also collected primary tissue from left and right colon cancer patients with liver metastasis to compare the autophagy levels and the expression of BECN1 and ABCG2 in the tumor and paracarcinoma *** The incidence of autophagy and the expression of BECN1 and ABCG2 were different in left and right colon cancer,and autophagy might be involved in the occurrence of chemotherapy *** analysis of the rela-tionship between the expression of autophagy-related genes CDK9,ABCG2,and BECN1 and the clinical features and prognosis of colorectal cancer showed that the high expression of CDK9 indicated a poor prognosis in colorectal *** This study laid the foundation for further research on the combination of CDK9 inhibitors and autophagy inhibitors in the treatment of patients with CRC.

关键词： Autophagy Tumorigenesis Tumor tissue Paracarcinoma tissue Expression Left/right colon cancer

巴拿赫空间上的Drazin可逆算子的反序律

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数学的实践与认识 2024年第5期54卷 198-206页

作者：曾芳莲孔瑶兵严锴福州大学数学与统计学院福建福州350108

在某些算子等式成立的前提下,研究了巴拿赫空间中的Drazin可逆算子的反序律及交换关系,利用Drazin可逆算子的矩阵表示,得到了两个Drazin可逆算子的反序律成立的充分必要条件.

关键词： Drazin可逆算子反序律巴拿赫空间

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Exploring differentiated improvement strategies of cultivated land quality in China

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Frontiers of Agricultural Science and Engineering 2024年第2期11卷 282-291页

作者： Wenguang CHEN Xiangbin kong Yubo LIAO College of Land Science and Technology China Agricultural UniversityBeijing 100193China

Quality is the core feature of cultivated land. In the face of deteriorating cultivated land quality and growing food demand, improving cultivated land quality is a top priority for guaranteeing the sustainable use of resources and national food security. Cultivated land quality in the new era can be considered in four dimensions: suitability, contiguity, resistance and ecological stress. Cultivated land suitability in China shows a decreasing trend from east to west, cultivated land contiguity is high in the north-east and low in the south-west. In terms of cultivated land resistance, the number of strongly and weakly resistant cropping fields is small and spatially clustered. Cultivated land with ecological stress is mainly located in the northern region. Based on the current situation of cultivated land quality and the strategic needs of national high-quality development, China's future goals for improving cultivated land quality include four aspects: promoting the sustainable use of resources,improving the economic benefits of farming, coping with extreme meteorological disasters and meeting the transition of the food *** the backdrop of a volatile international environment and high domestic demand for food, China should guarantee a safe supply of staples, a stable supply of animal feed and a moderate supply of high-nutrient food. In the future, China should create three major food production spaces: highstandard, low-to medium-yield, and marginal cultivated land. China urgently needs to construct three paths to implement the goal of improving cultivated land quality, namely the development of high-standard cultivated land with the core of spatial optimization, resilience enhancement and scale coupling,the transformation of low-to medium-yield cultivated land with the core of obstacle elimination, tenure adjustment, ecological sustainable, and the conservation development of marginal cultivated land with a focus on sustainable use.

关键词： China cultivated land quality differentiated improvement food security

Dealuminated Hβ zeolite for selective conversion of fructose to furfural and formic acid

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Green Energy & Environment 2024年第2期9卷 311-320页

作者： Rui Li Qixuan Lin Junli Ren Xiaobao Yang Yingxiong Wang Lingzhao kong State Key Laboratory of Pulp and Paper Engineering School of Light Industry and EngineeringSouth China University of TechnologyGuangzhou510640China Institute of Coal Chemistry Chinese Academy of Sciences27 South Taoyuan RoadTaiyuan030001China CAS Key Laboratory of Low-Carbon Conversion Science and Engineering Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai201210China School of Environmental Science and Technology Suzhou University of Science and Technology Suzhou Jiangsu215009China

The fructose-to-furfural transformation is facing major challenges in the selectivity and high efficiency. Herein, we have developed a simple and effective approach for the selective conversion of fructose to furfural using Hβ zeolite modified by organic acids for dealuminization to regulate its textural and acidic properties. It was found that citric acid-dealuminized Hβ zeolite possessed high specific surface areas, wide channels and high Brønsted acid amount, which facilitated the selective conversion of fructose to furfural with a maximum yield of 76.2% at433 K for 1 h in the γ-butyrolactone(GBL)-H_(2)O system, as well as the concomitant formation of 83.0% formic acid. The^(13)C-isotope labelling experiments and the mechanism revealed that the selective cleavage of C1–C2 or C5–C6 bond on fructose was firstly occurred to form pentose or C5 intermediate by weak Brønsted acid, which was then dehydrated to furfural by strong Brønsted acid. Also this dealuminized Hβ catalyst showed the great recycling performance and was active for the conversion of glucose and mannose.

关键词： Fructose Dealuminated-Hb zeolite Selective conversion Furfural

Impact of H_(2)S on Hg^(0)capture performance over nitrogen-doped carbon microsphere sorbent:experimental and theoretical insights

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 89-100页

作者： Guopei Zhang Xiaoyang Zhang Xiangwen Xing Xiangru kong Lin Cui Dong Yong National Engineering Laboratory for Reducing Emissions from Coal Combustion Shandong UniversityJinan250061China bingtuan Energy Development Institute Shihezi UniversityShihezi832000China

A nitrogen-doped carbon microsphere sorbent with a hierarchical porous structure was synthesized via aggregation-hydrothermal *** Hg^(0)adsorption performance of the nitrogen-doped carbon microsphere sorbent was tested and compared with that of the coconut shell activated carbon prepared in the *** effect of H_(2)S on Hg^(0)adsorption was also *** nitrogen-doped carbon microsphere sorbent exhibited superior mercury removal performance compared with that of coconut shell activated *** the absence of H_(2)S at a low temperature(≤100℃),the Hg^(0)removal efficiency of the nitrogen-doped carbon microsphere sorbent exceeded 90%.This value is significantly higher than that of coconut shell activated carbon,which is approximately 45%.H_(2)S significantly enhanced the Hg^(0)removal performance of the nitrogen-doped carbon microsphere sorbent at higher temperatures(100–180℃).The hierarchical porous structure facilitated the diffusion and adsorption of H_(2)S and Hg^(0),while the nitrogen-containing active sites significantly improved the adsorption and dissociation capabilities of H_(2)S,contributing to the generation of more active sulfur species on the surface of the nitrogen-doped carbon microsphere *** formation of active sulfur species and HgS on the sorbent surface was further confirmed using X-ray photoelectron spectroscopy and Hg^(0)temperature-programmed desorption *** functional theory was employed to elucidate the adsorption and transformation of Hg^(0)on the sorbent surface.H_(2)S adsorbed and dissociated on the sorbent surface,generating active sulfur species that reacted with gaseous Hg^(0)to form HgS.

关键词： nitrogen-doped carbon microsphere H_(2)S Hg^(0)removal adsorption mechanism

Achieving High Strength and Tensile Ductility in Pure Nickel by Cryorolling with Subsequent Low-Temperature Short-Time Annealing

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Engineering 2024年第2期33卷 190-203页

作者： Zhide Li Hao Gu Kaiguang Luo Charlie kong Hailiang Yu Light Alloys Research Institute Central South UniversityChangsha 410083China State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha 410083China College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Electron Microscope Unit University of New South WalesSydneyNSW 2052Australia

Ultra fine-grained pure metals and their alloys have high strength and low *** this study,cryorolling under different strains followed by low-temperature short-time annealing was used to fabricate pure nickel sheets combining high strength with good *** results show that,for different cryorolling strains,the uniform elongation was greatly increased without sacrificing the strength after annealing.A yield strength of 607 MPa and a uniform elongation of 11.7%were obtained after annealing at a small cryorolling strain(ε=0.22),while annealing at a large cryorolling strain(ε=1.6)resulted in a yield strength of 990 MPa and a uniform elongation of 6.4%.X-ray diffraction(XRD),transmission electron microscopy(TEM),scanning electron microscopy(SEM),and electron backscattered diffraction(EBSD)were used to characterize the microstructure of the specimens and showed that the high strength could be attributed to strain hardening during cryorolling,with an additional contribution from grain refinement and the formation of dislocation *** high ductility could be attributed to annealing twins and micro-shear bands during stretching,which improved the strain hardening *** results show that the synergistic effect of strength and ductility can be regulated through low-temperature short-time annealing with different cryorolling strains,which provides a new reference for the design of future thermo-mechanical processes.

关键词： Cryorolling Annealing Nickel Strain hardening Ductility

Impacts of agri-food e-commerce on traditional wholesale industry:Evidence from China

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Journal of Integrative Agriculture 2024年第4期23卷 1409-1428页

作者： Ruyi Yang Jifang Liu Shanshan Cao Wei Sun Fantao kong Institute of Agricultural Information Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Special Animal and Plant Sciences Chinese Academy of Agricultural SciencesChangchun 130112China

Rapidly expanding studies investigate the effects of e-commerce on company operations in the retail ***,the interaction between agri-food e-commerce(AEC)and the traditional agri-food wholesale industry(AWI)has not received enough attention in the existing *** on the provincial panel data from 2013 to 2020 in China,this paper examines the effect of AEC on AWI,comprising three dimensions:digitalization(DIGITAL),agrifood e-commerce infrastructure and supporting services(AECI),and agri-food e-commerce economy(AECE).First,AWI and AEC are measured using an entropy-based combination of *** results indicate that for China as a whole,AWI has remained practically unchanged,whereas AEC exhibits a significant rising ***,the findings of the fixed-effect regression reveal that DIGITAL and AECE tend to raise AWI,whereas AECI negatively affects ***,threshold regression results indicate that AECI tends to diminish AWI with three-stage inhibitory intensity,which manifests as a first increase and then a drop in the inhibition *** results suggest that with the introduction of e-commerce for agricultural product circulation,digital development will have catfish effects that tend to stimulate the vitality of the conventional wholesale industry and promote technical ***,the traditional wholesale industry benefits financially from e-commerce even while it diverts part of the traditional wholesale circulation for agricultural products.

关键词： agri-food e-commerce traditional wholesale industry panel threshold model dual-channel circulation