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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

Formulation of Moment Analysis on fJ(1710) for Incomplete Phase Space in J/ψ → γK^(+)K^(-)

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Chinese Physics Letters 2001年第3期18卷 358-360页

作者： CHEN Jie LI Xue-Qian LU Yong zou bing-song CCAST(World Laboratory) P.O.Box 8730Beijing 100080 Department of Physics Nankai UniversityTianjin 300071 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100039 Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080

We discuss the moment analysis method for the 0^(++)and 2^(++)coupling mode of fJ(1710)for incomplete phase space in the radiative decay J/ψ→γK^(+)K^(-),and give a new formulation of analyzing the fJ(1710)structure for the Beijing Spectrometer detector at the Beijing Electron-Positron *** incomplete detection phase space results in a significant effect on the moment analysis.

关键词： incomplete (1) moment

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi Qing Yifei Chen Jilian zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation

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Nano Research 2020年第3期13卷 795-801页

作者： Wentao song Yiming Wang bing Wang Yingfang Yao Wenguang Wang Jinhui Wu Qing Shen Wenjun Luo Zhigang zou Eco-materials and Renewable Energy Research Center(ERERC) College of Engneering and Applied SciencesNanjing UniversityNo.22 Hankou RoadNanjing210093China Jiangsu Key Laboratory for Nano Technology National Laboratory of Solid State MicrostructuresDepartment of PhysicsNanjing UniversityNo.22 Hankou RoadNanjing210093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNo.22 Hankou RoadNanjing210093China Faculty of Informatics and Engineering The University of Electro-CommunicationsTokyo182-8585Japan Macao Institute of Systems Engineering Macao University of Science and TechnologyMacao999078China

Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor ***,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical *** conquer this challenge,we herein introduce a nature inspired"stress-response"method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 *** further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low *** work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells.

关键词： CsPbBr3 nanocrystals stress response encapsulation cancer diagnose

Re-study of Nucleon Pole Contribution in J/ψ → NN^-π Decay

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Communications in Theoretical Physics 2006年第3X期46卷 507-513页

作者： ZONG Yuan-Yuan SHEN Peng-Nian zou bing-song LIU Ji-Feng LIANG Wei-Hong Institute of High Energy Physics the Chinese Academy of Sciences P.O. Box 918(4) Beijing 100049 China Department of Physics Guangxi Normal University Guilin 541004 China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator Lanzhou 730000 China Institute of Theoretical Physics the Chinese Academy of Sciences Beijing 100080 China

We re-study nucleon pole contribution in J/ψ → NN^-π decays by including the imaginary part for the propagator of the off-shell nucleon with energy above π N threshold. It is found that when including the imaginary part in the propagator, the branching ratio of the decay width will descend about 11% compared with the result without including the imaginary part, no matter whether including the off-shell form factors or not. It also leads to a phase of up to 25° for the off-shell nucleon propagator at invariant mass around 1400 MeV. This effect needs to be considered for detailed partial wave analysis of N^＊ resonances around this mass region.

关键词： J/ψ decay form factor

Porous Carbon Derived from Poplar Catkins and Its High-performance CO_(2)Capture

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Journal of Wuhan University of Technology(Materials Science) 2023年第4期38卷 789-795页

作者：李重阳 TIAN Shujian 宋小勇 zou bing 陈志权 ZHANG Zhen College of Energy and Power Engineering North China University of Water Resources and Electric PowerZhengzhou450045China Department of Oncology The Second Affiliated Hospital of Nanchang UniversityNanchang360000China School of Physical Science and Technology Wuhan UniversityWuhan430072China

In order to deal with the increasingly serious environmental problems,it is important and necessary to lower the concentration of greenhouse gases,especially the CO_(2)***_(2)capture and storage are the relative suitable options for the reduction of these harmful gas *** the variation of mass ratio of KOH to bio-char,the as prepared active carbon PC-4 exhibits a higher specific surface area of 2491.57 cm^(3)·g^(−1),with the ultra-micropores of 0.5 and 1.2 *** 298 K/1 bar,the CO_(2)adsorption capacity of PC-4 also represents the highest value of 5.81 mmol/*** work demonstrates that the both the pore size and the specific surface area are equally important to enhance the CO_(2)*** work provides a sustainable method to develop high efficiency waste-based adsorbents to deal with environmental issues of CO_(2)gas.

关键词： porous carbon biomass microporous CO_(2)adsorption

Regulation of T cell immunity by cellular metabolism

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Frontiers of Medicine 2018年第4期12卷 463-472页

作者： Zhilin Hu Qiang zou bing Su Shanghai Institute of Immunology Department of Immunology and Microbiology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

T cells are an important adaptive immune response arm that mediates cell-mediated immunity. T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effector function. Specific metabolic programs are tightly controlled to mediate T cell immune responses, and alterations in T cell metabolism may result in many immunological disorders. In this review, we will summarize the main T cell metabolic pathways and the important factors participating in T cell metabolic programming during T cell homeostasis, differentiation, and function.

关键词： T cell immunity metabolic pathways nutrient uptake metabolic checkpoints

Optical Properties of *** and Nanosaws Synthesized by Thermal Evaporation Method

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Chinese Journal of Chemical Physics 2012年第2期25卷 226-230,I0004页

作者： Zhi-wei Peng bing-suo zou School of Physics and Electronic Engineering Guangzhou UniversityGuangzhou 510006China Key Lab for Micro-Nano Optoeletronic Devices of MOE Hunan UniversityChangsha 410082China

By a simple one-step H2-assisted thermal evaporation method, high quality CdS nanos- tructures have been successfully fabricated on Au coated Si substrates in large scale. The as-synthesized CdS nanostructures consisted of sword-like nanobelts and toothed nanosaws with a single-crystal hexagonal wurtzite structure. The deposition temperature played an important role in determining the size and morphology of the CdS nanostruetures. A combination of vapor-liquid-solid and vapor-solid growth mechanisms were proposed to interpret the formation of CdS nanostructures. Photoluminescence measurement indicated that the nanobelts and nanosaws have a prominent green emission at about 512 nm, which is the band-to-band emission of CdS. The waveguide characteristics of both types of CdS nanos-truetures were observed and discussed.

关键词： CdS nanostructures Thermal evaporation Photoluminescence Optical waveguide

Labeled box-particle CPHD filter for multiple extended targets tracking

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Journal of Systems Engineering and Electronics 2019年第1期30卷 57-67页

作者： zou Zhibin song Liping CHENG Xuan School of Electronic Engineering Xidian University

In multiple extended targets tracking, replacing traditional multiple measurements with a rectangular region of the nonzero volume in the state space inspired by the box-particle idea is exactly suitable to deal with extended targets, without distinguishing the measurements originating from the true targets or *** on our recent work on extended box-particle probability hypothesis density(ET-BP-PHD) filter, we propose the extended labeled box-particle cardinalized probability hypothesis density(ET-LBP-CPHD) filter, which relaxes the Poisson assumptions of the extended target probability hypothesis density(PHD) filter in target numbers, and propagates not only the intensity function but also cardinality distribution. Moreover, it provides the identity of individual target by adding labels to box-particles. The proposed filter can improve the precision of estimating target number meanwhile achieve targets' tracks. The effectiveness and reliability of the proposed algorithm are verified by the simulation results.

关键词： extended target multiple targets tracking labled boxparticle cardinalized probability hypothesis density (CPHD).