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Evaluating combined bevacizumab and XELOX in advanced colorectal cancer: Serum markers carcinoembryonic antigen, carbohydrate antigen 125, carbohydrate antigen 199 analysis

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World Journal of Clinical Cases 2024年第1期12卷 15-23页

作者： dong-bing Zhou Jun Cheng Xiong-Hui Zhang Department of Gastroenterology The Second People's Hospital of Jingzhou HubeiJingzhou 434000Hubei ProvinceChina Department of Gastrointestinal Surgery Qianjiang Central HospitalQianjing 433100Hubei ProvinceChina Department of Gastroenterology Xiantao First People's Hosepital Affiliated to Yangtze UniversityXiantao 433000Hubei ProvinceChina

BACKGROUND Colorectal cancer ranks third and second among common and fatal *** treatment of metastatic colorectal cancer(mCRC)is generally based on XELOX in clinical practice,which includes capecitabine(CAP)and *** tumor markers carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125 and CA199 are prognostic factors for various *** To investigate evaluating combined bevacizumab(BEV)and XELOX in advanced colorectal cancer:Serum markers CEA,CA125,CA199 *** In this retrospective study,a total of 94 elderly patients diagnosed with mCRC were recruited and subsequently categorized into two groups based on the distinct treatment modalities they *** control group was treated with XELOX plus CAP(n=47),while the observation group was treated with XELOX plus CAP and BEV(n=47).Several indexes were assessed in both groups,including disease control rate(DCR),incidence of adverse effects,serum marker levels(CEA,CA125,and CA19)and progression-free survival(PFS).RESULTS After 9 wk of treatment,the serum levels of CEA,CA199 and CA125 in the observation group were significantly lower than those in the control group(P0.05).CONCLUSION On the basis of XELOX treatment,the combination of BEV and CAP can reduce serum tumor marker levels and prolong PFS in patients with mCRC.

关键词： Metastatic colorectal cancer Bevacizumab Capecitabine XELOX Tumor markers

General radical difluoromethylation using difluoroacetic anhydride via photoredox catalysis

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Science China Chemistry 2024年第8期67卷 2637-2646页

作者： Meng He Yankai Yang Heng Zhang Zhipeng Guan Zhi-bing dong Hong Yi Aiwen Lei School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430205China College of Chemistry and Molecular Sciences and Institute for Advanced Studies(IAS) Wuhan UniversityWuhan 430072China

CF_(2)H-containing molecules play pivotal roles in diverse fields from medicinal chemistry to materials science. However, the application of existing CF_(2)H reagents as a source of CF_(2)H radical is limited by their reactivity and preparation. Herein, we develop a simple and general visible-light-catalyzed radical difluoromethylation reaction of alkenes, dienes, and heteroaromatics using commercially available, easy-to-handle, and low-cost difluoroacetic anhydride as the CF_(2)H reagent. This scalable protocol enables the convenient synthesis of a range of CF_(2)H-containing compounds under mild conditions, exhibiting a broad substrate scope and functional group tolerance. Potential applications are further demonstrated by gram-scale synthesis, sunlight experiments, derivatization experiments as well as the synthesis of bioactive molecules.

关键词： radical difluoromethylation alkenes/dienes/heteroaromatics difluoroacetic anhydride photoredox

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Fabrication of Superhydrophobic–Hydrophilic Patterned Cu@Ag Composite SERS Substrate via Femtosecond Laser

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Nanomanufacturing and Metrology 2024年第1期7卷 1-14页

作者： Yuheng Zhang Zongwei Xu Kun Zhang Ying Song bing dong Jianshi Wang Mengzhi Yan Qingqing Sun State Key Laboratory of Precision Measuring Technology and Instruments Laboratory of Micro/Nano Manufacturing TechnologyTianjin UniversityTianjin 300072China Shandong Agricultural Equipment Intelligent Engineering Laboratory Shandong Provincial Key Laboratory of Horticultural Machinery and EquipmentCollege of Mechanical and Electronic EngineeringShandong Agricultural UniversityTai’an 827101China

Ultralow concentration molecular detection is critical in various fields,e.g.,food safety,environmental monitoring,and dis-ease *** sensitive surface-enhanced Raman scattering(SERS)based on ultra-wettable surfaces has attracted attention due to its unique ability to detect trace ***,the complexity and cost associated with the preparation of traditional SERS substrates restrict their practical ***,an efficient SERS substrate preparation with high sensitivity,a simplified process,and controllable cost is *** this study,a superhydrophobic–hydrophilic patterned Cu@Ag composite SERS substrate was fabricated using femtosecond laser processing technology combined with silver plating and surface modification *** inducing periodic stripe structures through femtosecond laser processing,the developed substrate achieves uniform distribution *** the surface wettability difference,the object to be measured can be confined in the hydrophilic region and the edge of the hydrophilic region,where the analyte is enriched by the coffee ring effect,can be quickly located by surface morphology difference of micro-nanostructures;thus,greatly improving detec-tion *** fabricated SERS substrate can detect Rhodamine 6G(R6G)at an extraordinarily low concentration of 10^(−15)mol/L,corresponding to an enhancement factor of 1.53×10^(8).This substrate has an ultralow detection limit,incurs low processing costs and is simple to prepare;thus,the substrate has significant application potential in the trace analysis field.

关键词： Femtosecond laser Surface-enhanced Raman scattering Coffee ring effect Superhydrophobic–hydrophilic surface

Boosted photocatalytic removal of NO using direct Z-scheme UiO-66-NH2/Bi2MoO6 nanoflowers heterojunction:mechanism insight and humidity effect

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Rare Metals 2024年第8期43卷 3758-3770页

作者： Jiang-Yu-Shan Liang Hai-Tao Ren Abdelkader Labidi Qiu-Hui Zhu Qi-bing dong Ahmed A.Allam Ahmed Rady Chuan-Yi Wang School of Environmental Science and Engineering Shaanxi University of Science and Technology Zoology Department Faculty of ScienceBeni-Suef University Department of Zoology College of ScienceKing Saud University

In practical applications,relative humidity in the air is a key factor affecting the photocatalytic removal of NO,which is often overlooked in previous ***,we developed a direct Z-scheme UiO-66-NH2/Bi2MoO6heterojunction with a nanoflower-like structure to systematically investigate the effect of relative humidity on photocatalytic removal of *** optimized heterojunction for the removal efficiency of NO was 71.6% at1.07 mg·m-3NO concentration（relative humidity=10%）,and the generation of NO2was only 1.1%.Interestingly,with the increase in relative humidity,it showed a higher inhibition effect on NO2,while the removal of NO decreased slightly（8%）,which might be attributed to the affinity effect of NO2with water molecules and the competitive adsorption of H2O and NO on the surface of the heterojunction ***,the reaction pathways of NO removal at the developed heterojunctions were revealed by in situ DRIFTS *** work provides a novel vision for the development of direct Z-scheme heterojunction photocatalysts to effectively remove NO and inhibit the formation of toxic intermediate NO2under different humidities.

关键词： NO removal Relative humidity Direct Z-scheme Bismuth molybdate Visible-light photocatalysis

Preoperative prognostic nutritional index predicts long-term outcomes of patients with ampullary adenocarcinoma after curative pancreatoduodenectomy

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1291-1300页

作者： Chong-Yuan Sun Xiao-Jie Zhang Zheng Li He Fei Ze-Feng Li dong-bing Zhao Department of Pancreatic and Gastric Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND The prognostic nutritional index(PNI),a marker of immune-nutrition balance,has predictive value for the survival and prognosis of patients with various *** To explore the clinical significance of the preoperative PNI on the prognosis of ampullary adenocarcinoma(AC)patients who underwent curative *** The data concerning 233 patients diagnosed with ACs were extracted and analyzed at our institution from January 1998 to December *** patients were categorized into low and high PNI groups based on the cutoff value determined by receiver operating characteristic curve *** compared disease-free survival(DFS)and overall survival(OS)between these groups and assessed prognostic factors through univariate and multivariate *** The optimal cutoff value for the PNI was established at *** with a PNI≥45.3 were categorized into the PNI-high group,while those with a PNI<45.3 were assigned to the PNI-low *** within the PNI-low group tended to be of advanced age and exhibited higher levels of aspartate transaminase and total bilirubin and a lower creatinine level than were those in the PNI-high *** 5-year OS rates for patients with a PNI≥45.3 and a PNI<45.3 were 61.8%and 43.4%,respectively,while the 5-year DFS rates were 53.5%and 38.3%,*** in the PNI-low group had shorter OS(P=0.006)and DFS(P=0.012).In addition,multivariate analysis revealed that the PNI,pathological T stage and pathological N stage were found to be independent prognostic factors for both OS and *** The PNI is a straightforward and valuable marker for predicting long-term survival after *** PNI should be incorporated into the standard assessment of patients with AC.

关键词： Ampullary carcinoma Prognostic nutritional index Prognosis Pancreaticoduodenectomy

Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-Yong Hou Ni-Yuan Zhang Lu Wang Mei-Yu Lv Xiang-Peng Li Peng Zhang Yue-Ze Wang Lei Shen Xiu-Hai Wu Bo Fu Peng-Yu Guo Zi-Qi Wang dong-bing Cheng Hao Wang Wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University Department of Urology Harbin Medical University Cancer Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like ***, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy

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HAO打卡系统:以组织智能成就智能组织

软件学报 2024年第4期35卷 1914-1933页

作者：吴信东朱晓宇董丙冰嵇圣硙卜晨阳大数据知识工程教育部重点实验室(合肥工业大学) 安徽合肥230009 合肥工业大学计算机与信息学院安徽合肥230601 合肥工业大学大知识科学研究院安徽合肥230009

打卡可能出于私人目的,没有组织关联,比如记录个人的旅行日志;也可能是公事需求,属于组织考勤的一部分,有时还会与多个组织关联.因此,打卡数据的保存、分享和分析需要精细化管理.HAO打卡是一个移动式轻量级打卡平台,以个人和组织为两个... 详细信息

打卡可能出于私人目的,没有组织关联,比如记录个人的旅行日志;也可能是公事需求,属于组织考勤的一部分,有时还会与多个组织关联.因此,打卡数据的保存、分享和分析需要精细化管理.HAO打卡是一个移动式轻量级打卡平台,以个人和组织为两个抓手,以人类智能(HI)、人工智能(AI)和组织智能(OI)相结合的HAO智能为技术驱动,构建HAO打卡知识图谱,通过提出HAO打卡闭环权限管理架构,并辅以从粗粒度到细粒度的隐私权限管理办法,在进行精细化考勤管理的同时保护用户的隐私,从而推动新一代打卡系统的智能化变革.在组织考勤分析方面,提出四要素得分法和四要素考勤报表法,通过打卡数据计算员工考勤得分,生成精准全面的考勤报表,为组织提供决策支持,激发组织和个人的活力,以组织智能成就智能组织.

关键词： HAO打卡系统智能考勤组织智能决策支持

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Analysis of an adult diabetes mellitus caused by a rare mutation of the gene:A case report

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World Journal of Clinical Cases 2024年第19期12卷 3942-3949页

作者： Wen-Xuan Li Li-Li Xu Chuan-Feng Liu bing-Zi dong Yun-Yang Wang Department of Endocrine and Metabolic Diseases The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND This study presents the clinical and genetic mutation characteristics of an unusual case of adult-onset diabetes mellitus occurring in adolescence,featuring a unique mutation in the peroxisome proliferator-activated receptor gamma(PPARG)*** Access Statement:Research data supporting this publication are available from the NN repository at ***/download/.CASE SUMMARY The methodology employed entailed meticulous collection of comprehensive clinical data from the probands and their respective family ***,high-throughput sequencing was conducted to analyze the PPARG genes of the patient,her siblings,and their *** results of this investigation revealed that the patient initially exhibited elevated blood glucose levels during pregnancy,accompanied by insulin resistance and ***,these strains displayed increased susceptibility to diabetic kidney disease without any discernible aggregation *** results from the gene detection process demonstrated a heterozygous mutation of guanine(G)at position 284 in the coding region of exon 2 of PPARG,which replaced the base adenine(A)(exon2c.284A>***95Cys).This missense mutation resulted in the substitution of tyrosine with cysteine at the 95th position of the translated ***,both of her siblings harbored a nucleotide heterozygous variation at the same site,and both were diagnosed with *** The PPARG gene mutation,particularly the ***95Cys mutation,may represent a newly identified subtype of maturity-onset diabetes of the *** subtype is characterized by insulin resistance and lipid metabolism disorders.

关键词： Diabetes Gene mutation Maturity-onset diabetes of the young Peroxisome proliferator-activated receptor gamma Lipid metabolism

高分子表(界)面吸附中的单分子动态学图景教学

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高分子通报 2024年第6期37卷 846-850页

作者：程冬炳沈雷武汉理工大学化学化工与生命科学学院艾克斯马赛学院武汉430070

“高分子表(界)面吸附”是《高分子物理》中聚合物表面与界面章节的重要组成部分,其研究关乎高分子复合材料制备、胶体稳定、废水处理、生命体系等诸多涉及大分子在表(界)面上吸附的领域,具有重要理论与实际意义。为提高本科生对高分子... 详细信息

“高分子表(界)面吸附”是《高分子物理》中聚合物表面与界面章节的重要组成部分,其研究关乎高分子复合材料制备、胶体稳定、废水处理、生命体系等诸多涉及大分子在表(界)面上吸附的领域,具有重要理论与实际意义。为提高本科生对高分子表(界)面吸附现象的认知,本文提出从单分子层面入手,通过展示科研中观察到的高分子单链在表(界)面上的二维扩散运动图景,引入生动实例,阐述其“吸附-扩散-脱附”动态学模型,帮助学生厘清“高分子表(界)面吸附”过程的微观分子机制,突出传统教学中缺乏的动态学思维,培养学生正确的世界观和方法论,这对学生运用正确的高分子物理学科思维解决高分子相关实际问题十分必要。

关键词：高分子表(界)面吸附动态学单分子示踪

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