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列车控制系统的抗拒绝服务攻击弹性控制策略

控制理论与应用 2024年第2期41卷 311-320页

作者：高兵步兵北京交通大学轨道交通控制与安全国家重点实验室北京100044

当遭受拒绝服务(DoS)攻击时,分布式列车控制系统的弹性控制问题受到广泛关注.本文提出了一种基于分布式领导车状态观测器和障碍李雅普诺夫函数的弹性控制策略,不仅可以避免列车碰撞,同时实现了编队控制的目标.首先,给出了一种分布式的... 详细信息

当遭受拒绝服务(DoS)攻击时,分布式列车控制系统的弹性控制问题受到广泛关注.本文提出了一种基于分布式领导车状态观测器和障碍李雅普诺夫函数的弹性控制策略,不仅可以避免列车碰撞,同时实现了编队控制的目标.首先,给出了一种分布式的领导车状态观测器设计方法,用于实时估计领导车的状态.理论分析表明,在DoS攻击满足一定约束的条件下,该状态观测器的估计误差具有指数稳定特性.在此基础上,通过将列车碰撞避免问题转化为状态受限问题,提出一种基于障碍李雅普诺夫函数的状态受限控制律,解决了DoS攻击下确保碰撞避免的车队控制问题.最后,数值仿真证实了本文方法的有效性.

关键词：拒绝服务弹性控制状态估计障碍李雅普诺夫函数列车运行控制碰撞避免

Cell Mechanics Regulates the Dynamic Anisotropic Remodeling of Fibril Matrix at Large Scale

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Research 2024年第3期2023卷 401-415页

作者： Mingxing Ouyang Yanling Hu Weihui Chen Hui Li Yingbo Ji Linshuo Qiu Linlin Zhu Baohua Ji bing bu Linhong Deng Institute of Biomedical Engineering and Health Sciences School of Medical and Health Engineering and School of PharmacyChangzhou UniversityChangzhou213164China Institute of Biomechanics and Applications Department of Engineering MechanicsZhejang UniversityHangzhou310027China.

Living tissues often have anisotropic and heterogeneous organizations, in which developmental processes are coordinated by cells and extracellular matrix modeling. Cells have the capability of modeling matrix in long distance;however, the biophysical mechanism is largely unknown. We investigated the dynamic remodeling of collagen I (COL) fibril matrix by cell contraction with designed patterns of cell clusters. By considering cell dynamic contractions, our molecular dynamics simulations predicted the anisotropic patterns of the observed COL bundling in experiments with various geometrical patterns without spatial limitation. The pattern of COL bundling was closely related to the dynamic remodeling of fibril under cell active contraction. We showed that cell cytoskeletal integrity (actin filaments and microtubules), actomyosin contractions, and endoplasmic reticulum calcium channels acting as force generations and transductions were essential for fiber bundling inductions, and membrane mechanosensory components integrin and Piezo played critical roles as well. This study revealed the underlying mechanisms of the cell mechanics-induced matrix remodeling in large scales and the associated cellular mechanism and should provide important guidelines for tissue engineering in potential biomedical applications.

关键词： contraction Dynamic Matrix

Sensing Traction Strain Induces Cell-Cell Distant Communications

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医用生物力学 2019年第A1期34卷 136-137页

作者： Zhili Qian Yang Jin bing bu Yan Pan Linhong Deng Mingxing Ouyang Institute of Biomedical Engineering and Health Sciences College of Pharmaceutical Engineering and Life ScienceChangzhou University

Mechanobiology has been a highly recognized field in studying the importance of physical forces in physiologies at the molecular,cellular,tissue,organ and *** the intensive work focusing on the fine local biomechanical forces,the long-range force which can propagate through a relatively distant scale(in hundreds of micrometers and beyond)has been an intriguing topic with increasing attentions in recent *** collective functions at cell population level often rely on cell-cell communications with or without direct *** progresses including our own work indicate that the long-range biomechanical force propagating across scales far beyond single cell size may reserve the capability to trigger coordinative biological responses within cell *** and how cells communicate mechanically in a distant manner remains largely to be *** respiratory system,the mechanical property of airway smooth muscle(ASM)is associated with asthma attack with prolonged contraction during airway *** this work,we found that ASM cells rapidly self-assembled into a well-constructed network on 3D matrigel containing type I collagen(COL I),which required the collective functions and coordination of thousands of cells completed within 12-16 *** were assembled with aligned actin stress fibers and elongated *** assembling process relied on the long-range mechanical forces across the matrix to direct cell-cell distant *** further found that single ASM cells could rapidly initiate multiple buds precisely pointing to neighboring cells in distance,which relied on cell traction force and force strain on the *** tracking assay demonstrated the long-range transmission of cellular traction force to distant locations,and modeling of maximum strain distribution on matrix by finite element method predicted the consistency with cell directional protrusions and movements in *** could sense each o

关键词： long-range biomechanical force extracellular matrix cell-cell distant communication cell traction strain sensing cell network assembly

Single-vesicle imaging quantifies calcium’s regulation of nanoscale vesicle clustering mediated by α-synuclein

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Microsystems & Nanoengineering 2020年第1期6卷 775-784页

作者： Bin Cai Jie Liu Yunfei Zhao Xiangyu Xu bing bu Dechang Li Lei Zhang Wei Dong Baohua Ji Jiajie Diao Department of Cancer Biology University of Cincinnati College of MedicineCincinnatiOH 45267USA Biomechanics and Biomaterials Laboratory Department of Applied MechanicsBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province Institute of Cardiovascular ResearchSouthwest Medical UniversityLuzhouSichuan 646000China Institute of Biomedical Engineering and Health Sciences Changzhou UniversityChangzhouJiangsu 213164China Institute of Applied Mechanics Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter(Ministry of Education) School of ScienceXi’an Jiaotong UniversityXi’an 710049China Beijing Advanced Innovation Center for Biomedical Engineering Beijing 100191China

Although numerous studies have shown that the proteinα-synuclein(α-Syn)plays a central role in Parkinson’s disease,dementia with Lewy bodies,and other neurodegenerative diseases,the protein’s physiological function remains poorly ***,despite recent reports suggesting that,under the influence of Ca^(2+),α-Syn can interact with synaptic vesicles,the mechanisms underlying that interaction are far from ***,we used single-vesicle imaging to quantify the extent to which Ca^(2+)regulates nanoscale vesicle clustering mediated by α-*** results revealed not only that vesicle clustering requiredα-Syn to bind to anionic lipid vesicles,but also that different concentrations of Ca^(2+)exerted different effects on howα-Syn induced vesicle *** particular,low concentrations of Ca^(2+)inhibited vesicle clustering by blocking the electrostatic interaction between the lipid membrane and the N terminus of α-Syn,whereas high concentrations promoted vesicle clustering,possibly due to the electrostatic interaction between Ca^(2+)and the negatively charged lipids that is independent of α-*** together,our results provide critical insights intoα-Syn’s physiological function,and how Ca^(2+) regulates vesicle clustering mediated by α-Syn.

关键词： inhibited insight promoted

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传输时延对CBTC影响的分析及消除

铁道学报 2014年第6期36卷 41-46页

作者：步兵唐涛北京交通大学轨道交通控制与安全国家重点实验室北京100044

基于通信的列控系统CBTC利用无线通信传递列车状态信息和控制命令,数据传输时延将引发不必要的列车牵引和制动,降低列控系统的性能。本文提出一种适用于CBTC的列控系统和数据通信系统的一体化设计方法,将CBTC的多列车控制系统等效为网... 详细信息

基于通信的列控系统CBTC利用无线通信传递列车状态信息和控制命令,数据传输时延将引发不必要的列车牵引和制动,降低列控系统的性能。本文提出一种适用于CBTC的列控系统和数据通信系统的一体化设计方法,将CBTC的多列车控制系统等效为网络控制系统,建立一体化模型,分析传输时延对列控系统性能的影响。提出消除传输时延对列控系统影响的改进措施,并通过仿真验证该方法的有效性。

关键词：列车控制车地传输网络控制系统 CBTC

Urban Morphology of Urban Village: A Case Study of Dafen Oil Painting Village in Shenzhen

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Journal of Landscape Research 2017年第4期9卷 37-40,44页

作者： bu bing CHEN Keshi School of Urban Planning and Design Peking University Shenzhen Graduate School

Dafen Oil Painting Village, the largest oil painting village in current China, takes cultural industries like creation and wholesale of oil paintings as the pillar. As one of the urban villages in Shenzhen, Dafen Village not only has the common characteristics of urban morphology as ordinary urban villages, but also has something unique. In this paper, study of the urban morphology of Dafen Oil Painting Village is mainly from 3 aspects: firstly, the formation of street space in Dafen Village; secondly, analysis of the status of urban morphology of Dafen Village; thirdly, the plane layout and public space of Dafen Village. In the end, this paper put forward some suggestions about the future development of urban morphology and space layout in Dafen Village.

关键词： Urban village Cultural industry Urban morphology Public space

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论行政主体对行政契约的单方变更权

南京大学学报（哲学．人文科学．社会科学） 2008年第6期45卷 71-78,140页

作者：步兵东南大学法学院南京210096

公共利益是行政契约得以缔结和履行的重要基础,行政契约的公法属性也决定了行政主体需要享有单方变更权等特权。为了使行政契约的目的得以更好实现,应当承认行政主体为了避免公益之重大损害,有权对行政契约予以单方变更。单方变更权的... 详细信息

公共利益是行政契约得以缔结和履行的重要基础,行政契约的公法属性也决定了行政主体需要享有单方变更权等特权。为了使行政契约的目的得以更好实现,应当承认行政主体为了避免公益之重大损害,有权对行政契约予以单方变更。单方变更权的行使不以合意为前提,但应当受到公共利益需要和比例原则的限制。同时,还需强化对该特权行使的程序控制,完善告知和听取意见、协商等程序性制度,并依据信赖保护原则对相对人的损失予以充分补偿。

关键词：行政契约单方变更程序控制

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行政契约解除研究

东南大学学报（哲学社会科学版） 2010年第4期12卷 66-69页

作者：步兵东南大学法学院江苏南京210096

行政契约缔结后,可由双方当事人协商一致予以解除,也可在符合双方当事人约定解除条件的情况下由契约之一方解除。此外,行政契约还存在通过行使法定解除权以解除契约的情况,这既包括私法契约规则中的法定解除权,也包括行政契约特有的法... 详细信息

行政契约缔结后,可由双方当事人协商一致予以解除,也可在符合双方当事人约定解除条件的情况下由契约之一方解除。此外,行政契约还存在通过行使法定解除权以解除契约的情况,这既包括私法契约规则中的法定解除权,也包括行政契约特有的法定解除权。但多数情形下,行政契约由于其公法属性而存在特殊规则。

关键词：行政契约协商解除约定解除法定解除

基于UPPAAL的FAO系统典型运营场景建模与验证

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铁道学报 2013年第6期35卷 65-71页

作者：彭大天步兵北京交通大学轨道交通控制与安全国家重点实验室

全自动驾驶系统FAO(Fully Automatic Operation)具有安全、可靠、高效的特点,成为未来城市轨道智能交通系统的主要发展方向。FAO系统典型运营场景是1个实时的过程,为发现其逻辑的错误、功能和性能的缺陷,需要在系统设计前,针对系统需求... 详细信息

全自动驾驶系统FAO(Fully Automatic Operation)具有安全、可靠、高效的特点,成为未来城市轨道智能交通系统的主要发展方向。FAO系统典型运营场景是1个实时的过程,为发现其逻辑的错误、功能和性能的缺陷,需要在系统设计前,针对系统需求规范中典型运营场景的实现流程进行形式化分析。本文分析FAO典型运营场景保护区的实现流程,在系统需求规范中提取其功能与性能的需求,采用基于时间自动机理论的UPPAAL构建时间自动机网络模型,进行仿真分析,并验证其功能属性、性能属性与安全属性。通过反例分析、模型修正,增强对FAO系统的理解,减少设计故障,提高安全性,为系统设计与实现打下良好的基础。

关键词：全自动驾驶系统保护区 UPPAAL 时间自动机