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A Security Trade-Off Scheme of Anomaly Detection System in IoT to Defend against Data-Tampering Attacks

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Computers, Materials & Continua 2024年第3期78卷 4049-4069页

作者： bing liu Zhe Zhang Shengrong Hu Song Sun Dapeng liu Zhenyu Qiu Zhejiang Institute of Industry and Information Technology Hangzhou310000China Digital Economy Development Center of Zhejiang Hangzhou310000China College of Computer and Information Science Chongqing Normal UniversityChongqing401331China Bank of Suzhou Suzhou215000China Hangzhou Hikvision Digital Technology Co. Ltd.Hangzhou310051China

Internet of Things(IoT)is vulnerable to data-tampering(DT)attacks.Due to resource limitations,many anomaly detection systems(ADSs)for IoT have high false positive rates when detecting DT attacks.This leads to the misreporting of normal data,which will impact the normal operation of IoT.To mitigate the impact caused by the high false positive rate of ADS,this paper proposes an ADS management scheme for clustered IoT.First,we model the data transmission and anomaly detection in clustered IoT.Then,the operation strategy of the clustered IoT is formulated as the running probabilities of all ADSs deployed on every IoT device.In the presence of a high false positive rate in ADSs,to deal with the trade-off between the security and availability of data,we develop a linear programming model referred to as a security trade-off(ST)model.Next,we develop an analysis framework for the ST model,and solve the ST model on an IoT simulation platform.Last,we reveal the effect of some factors on the maximum combined detection rate through theoretical analysis.Simulations show that the ADS management scheme can mitigate the data unavailability loss caused by the high false positive rates in ADS.

关键词： Network security Internet of Things data-tampering attack anomaly detection

Doppler-resilient waveform design in integrated MIMO radar-communication systems

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Science China(Information Sciences) 2024年第1期67卷 187-202页

作者： Zhengchun ZHOU bing liu bingsheng SHEN Avik Ranjan ADHIKARY Pingzhi FAN Institute of Mobile Communications Southwest Jiaotong University Department of Mathematics Southwest Jiaotong University

In recent years,the increased high-rate wireless services(5G and 6G) and reliable sensing capabilities(automotive radar,air traffic control,geophysical monitoring),have led to more serious spectrum congestion.Conventionally,radars and communication systems are often seen to be “competing” for the same resources.In this scenario,an integrated platform for radar and communication systems seems to be an optimal solution to address the problem.In this paper,we propose a preamble waveform design based on zero-correlation zone(ZCZ) and zero odd-correlation zone(ZOCZ) sequence sets,which are Doppler resilient in multiple-input,multiple-output(MIMO) radar.The preamble waveforms can be simultaneously used for channel estimation and radar sensing in RadCom systems.The ambiguity function of the proposed waveforms displays low/zero sidelobes within a time-delay correlation zone.Finally,we give some numerical results to show the efficiency of the proposed waveforms in radar sensing and channel estimation.

关键词： ambiguity function correlation channel estimation integrated radar and communication (RadCom) systems MIMO radar zero correlation zone (ZCZ) sequence set zero odd-correlation zone (ZOCZ) sequence set

Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway

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Science China(Life Sciences) 2024年第4期67卷 663-679页

作者： Yanfang liu Yan Wang bing liu Wenzhong liu Yuanyuan Ma Yiren Cao Shi Yan Panpan Zhang Lixin Zhou Qimin Zhan Nan Wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Surgery IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Oncology IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China Peking University International Cancer Institute Beijing 100191China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518132China

Chemoresistance is a significant barrier to effective cancer treatment.Potential mechanisms for chemoresistance include reactive oxygen species(ROS)accumulation and expression of chemoresistance-promoting genes.Here,we report a novel function of lncRNA16 in the inhibition of ROS generation and the progression of chemoresistance.By analyzing the serum levels of lncRNA16 in a cohort of 35 patients with non-small cell lung cancer(NSCLC)and paired serum samples pre-and post-treatment from 10 NSCLC patients receiving neoadjuvant platinum-based chemotherapy,performing immunohistochemistry(IHC)assays on 188 NSCLC tumor samples,using comprehensive identification of RNA-binding proteins by mass spectrometry(ChIRP-MS)assays,as well as RNA immunoprecipitation(RIP)and RNA pull-down analyses,we discovered that patients with increased serum levels of lncRNA16 exhibited a poor response to platinum-based chemotherapy.The expression of hemoglobin subunit beta(HBB)and NDUFAF5 significantly increases with the development of chemoresistance.LncRNA16 binds to HBB and promotes HBB accumulation by inhibiting autophagy.LncRNA16 can also inhibit ROS generation via the HBB/NDUFAF5 axis and function as a scaffold to facilitate the colocalization of HBB and NDUFAF5 in the mitochondria.Importantly,preclinical studies in mouse models of chemo-resistant NSCLC have suggested that lncRNA16 targeting by trivalent N-acetylgalactosamine(GalNAc)-conjugated siRNA restores chemosensitivity and results in tumor growth inhibition with no detectable toxicity in vivo.Overall,lncRNA16 is a promising therapeutic target for overcoming chemoresistance,and the combination of first-line platinum-based chemotherapy with lncRNA16 intervention can substantially enhance anti-tumor efficacy.

关键词： chemoresistance lncRNARNA interference ROs chemosensitizer

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Long-range Pt-Ni dual sites boost hydrogen evolution through optimizing the adsorption configuration

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Nano Research 2024年第5期17卷 3700-3706页

作者： Cong liu Pengfang Zhang bing liu Qian Meng Xuzhao Yang Yakun Li Jingli Han Yao Wang Henan Province Engineering Research Center of Catalysis and Separation of Cyclohexanol College of Materials and Chemical EngineeringZhengzhou University of Light IndustryZhengzhou 450001China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology Liaocheng UniversityLiaocheng 252000China Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringInternational Joint Research Center for Photoresponsive Molecules and MaterialsJiangnan UniversityWuxi 214122China

Elaborated design of catalytic systems with a specifically tailored site distance to match the intermediates could substantially improve reaction kinetics and boost catalytic activity under unfavorable reaction conditions.Considering the lower energy barriers of water splitting upon the synergy of dual sites,constructing synergistic Pt-M(M:transition metal)dual sites is an effective way to boost Pt with highly catalytic hydrogen evolution reaction(HER)performance.An unconventional“Ni(OH)_(2)-coated high-index Pt facets”was constructed to obtain long-range Pt-Ni dual sites,in which Ni composition as a water dissociation synergistic site can protect Pt from electrolyte corrosion and ensure efficient proton donation to Pt sites.The obtained long-range Pt-Ni dual sites present 3.84 mA·cm^(-1) of current density,which is 7.5 times specific activity higher than that of commercial Pt/C towards alkaline HER.The enhanced HER performance is attributed to synergistic catalysis on Pt-Ni dual sites accompanied by unconventional electron coupling.This work illustrates a new strategy to construct the long-range dual sites by unconventional strategy for fundamental electrocatalytic study of alkaline HER.

关键词： long-range Pt-Ni dual sites electron transfer hydrogen evolution reaction sites synergy

Eu-MOF-Based Fluorescent Ratiometric Sensor by Detecting 3,4,5-Trihydroxybenzoic for Fingerprint Visualization on Porous Objects

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Photonic Sensors 2024年第1期14卷 85-98页

作者： Muwen LIANG Yabin ZHAO Yaping LUO Bin DU Wei HU bing liu Xihui MU Zhaoyang TONG Department of Investigation People's Public Security University of ChinaBejing 100038China State Key Laboratory of NBC Protection for Civilian Beijing 102205China

Latent fingerprints(LFPs)at the crime scene are served as important clues to locate the trajectory of criminal behavior and portray the characteristics of the suspect.Therefore,visualizing LFPs is of considerable significance.In this work,the europium metal-organic framework(Eu-MOF)sensor was successfully constructed for sensitive detection of gallic acid(3,4,5-trihydroxybenzoic acid,GA)and visualization of the sweat LFPs.The boric-acid-modified Eu-MOF was prepared by using the simple one-pot solvothermal method using Eu as the metal i ion center and 3,5-dicarboxybenzeneboronic acid(BBDC)as the organic ligand.The sensor showed desirable photoluminescent performance through the chelating of BBDC with Eu3+.The sensor exhibited the satisfactory linear relationship to GA in the range of 1 nM to 20 nM with a low detection limit of 0.34 nM under the optimized conditions.The prepared sensor with ideal selectivity to GA was successfully applied for visualizing LFPs on porous substrates with the high contrast and superior stability.Given the good performance of the sensor,all fingerprint images obtained from 1200 samples presented clear friction ridges and met the identification criteria.Notably,the sensor had less impact on the subsequent deoxyribonucleic acid(DNA)detection,displaying a promising perspective for applications in extracting physical evidence of site investigation.

关键词： Europium metal-organic framework(Eu-MOF) photoluminescence 3,4,5-trihydroxybenzoic latent fingerprints(LFPs)development

Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

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Oncology Research 2024年第4期32卷 769-784页

作者： HUAN GAO JIE ZHANG TONY GKLEIJN ZHAOYONG WU bing liu YUJIN MA BAOYUE DING DONGFENG YIN Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics Department of PharmaceuticsCollege of MedicineJiaxing UniversityJiaxing314001China Department of Pharmacy The General Hospital of Xinjiang Military RegionUrumqi830000China Department of Pathology and Medical Biology University Medical Center GroningenUniversity of GroningenGroningen9713 GZThe Netherlands Department of Pathology Laboratory of Experimental OncologyErasmus MCRotterdam3015 GDThe Netherlands Department of Pharmacy Jiaxing Maternal and Child Health Care HospitalAffiliated Hospital of Jiaxing UniversityJiaxing314001China Qinghai Enlu Biotechnology Co. Ltd.Haidong810700China

Bone metastasis secondary to breast cancer negatively impacts patient quality of life and survival.The treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic effect.To improve the treatment efficacy,we developed Pluronic P123(P123)-based polymeric micelles dually decorated with alendronate(ALN)and cancer-specific phage protein DMPGTVLP(DP-8)for targeted drug delivery to breast cancer bone metastases.Doxorubicin(DOX)was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity(3.44%).The DOX-loaded polymeric micelles were spherical,123 nm in diameter on average,and exhibited a narrow size distribution.The in vitro experiments demonstrated that a pH decrease from 7.4 to 5.0 markedly accelerated DOX release.The micelles were well internalized by cultured breast cancer cells and the cell death rate of micelle-treated breast cancer cells was increased compared to that of free DOX-treated cells.Rapid binding of the micelles to hydroxyapatite(HA)microparticles indicated their high affinity for bone.P123-ALN/DP-8@DOX inhibited tumor growth and reduced bone resorption in a 3D cancer bone metastasis model.In vivo experiments using a breast cancer bone metastasis nude model demonstrated increased accumulation of the micelles in the tumor region and considerable antitumor activity with no organ-specific histological damage and minimal systemic toxicity.In conclusion,our study provided strong evidence that these pH-sensitive dual ligand-targeted polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis.

关键词： Pluronic micelles Targeted nanotherapeutics Nanoparticulate drug delivery system Breast cancer with bone metastasis Therapeutic efficacy

Tuning the local coordination environment of silver(Ⅰ) coordination networks with counterions for enhanced electrocatalytic CO_(2) reduction

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Science China Chemistry 2024年第5期67卷 1524-1530页

作者： Xiaofeng Cui Xueting Wang Cong Fu bing liu Mei-Yan Gao Tingting Kong Yujie Xiong Anhui Engineering Research Center of Carbon Neutrality The Key Laboratory of Functional Molecular SolidsMinistry of EducationAnhui Laboratory of Molecular-Based MaterialsCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China Department of Chemical Sciences Bernal InstituteUniversity of LimerickLimerick V94 T9PXRepublic of Ireland School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China School of Chemical and Material Engineering Jiangnan UniversityWuxi 214122China

Very recently, the local coordination environment of active sites has been found to strongly influence their performance in electrocatalytic CO_(2) reduction by tuning the intrinsic kinetics of CO_(2) activation and intermediate stabilization. It is imperative to elucidate the mechanism for such an influence towards the rational design of efficient catalysts;however, the complex interactions between the multiple factors involved in the system make it challenging to establish a clear structure–performance relationship. In this work, we chose ion-intercalated silver(I)-based coordination networks(AgCNs) with a well-defined structure as a model platform, which enables us to understand the regulation mechanism of counterions as the counterions are the only tuning factor involved in such a system. We prepared two isostructural Ag CNs with different intercalation ions or counterions of BF_(4)^(-) and ClO_(4)^(-)(named as AgCNs-BF_(4) and AgCNs-ClO_(4)) and found that the former has a more competitive CO_(2) electroreduction performance than the latter. AgCNs-BF_(4) achieves the highest Faradaic efficiency for CO_(2) to CO of 87.1% at-1.0 V(vs. RHE) with a higher partial current density, while AgCNs-ClO_(4) exhibits only 77.2% at the same applied potential.Spectroscopic characterizations and theoretical calculation reveal that the presence of BF_(4)^(-)is more favorable for stabilizing the COOH^(*) intermediate by weakening hydrogen bonds, which accounts for the superior activity of Ag CNs-BF_(4).

关键词： electrocatalytic CO_(2) reduction coordination networks local environment counterions intercalation ions

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Intermolecular hydrogen-bonding as a robust tool toward significantly improving the photothermal conversion efficiency of a NIR-II squaraine dye

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Chinese Chemical Letters 2024年第4期35卷 310-315页

作者： Songtao Cai liuying Wu Yuan Li Soham Samanta Jinying Wang bing liu Feihu Wu Kaitao Lai Yingchao liu Junle Qu Zhigang Yang Center for Biomedical Photonics&Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

The photothermal therapy(PTT) has come across as a promising noninvasive therapeutic strategy for tumor treatment. However, low photothermal conversion efficiency(PCE) and hydrophobicity may impede the therapeutic efficacy of organic photothermal agents and an efficient PTT-agent must overcome these two major challenges. In this work, we developed a new strategy to promote higher PCE wherein the intermolecular hydrogen-bonding interaction between the single dye molecule and water facilitated the transformation of the absorbed energy into the heat. A hydrophilic squaraine dye(SCy1) with the second near-infrared region(NIR-II) absorption and extremely low emission were designed to exhibit much higher PCE than that of the analogues of pentamethine-dyes(PCy1, PCy2). The presence of the ‘–O-' at middle of squaric cycle enabled the intermolecular H-bonding formation between the SCy1 and water to promote the energy dissipation channel. Moreover, the introduction of long-chain phenylsulfonate groups helped in to improve the water solubility apart from serving as an additional means of further enhancing PCE through fluorescence quenching. Therefore, SCy1 with a squaraine backbone and long-chain sulfonate moieties revealed outstanding photothermal stability and anti-aggregation activity apart from showing exceptionally high PCE(74%) in water. SCy1 demonstrated excellent therapeutic efficacy when applied in the PTT treatment of tumor-bearing mice under a laser irradiation of 915 nm.

关键词： Squaraine-based cyanine Hydrogen bonds High PCE Anti-aggregation Photothermal therapy

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Development of a clinical nomogram for prediction of response to neoadjuvant chemotherapy in patients with advanced gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 396-408页

作者： bing liu Yu-Jie Xu Feng-Ran Chu Guang Sun Guo-Dong Zhao Sheng-Zhong Wang Department of Gastrointestinal Surgery Central South University Xiangya School of Medicine Affiliated Haikou HospitalHaikou 570208Hainan ProvinceChina Clinical College Hainan Medical UniversityHaikou 571199Hainan ProvinceChina

BACKGROUND The efficacy of neoadjuvant chemotherapy(NAC)in advanced gastric cancer(GC)is still a controversial issue.AIM To find factors associated with chemosensitivity to NAC treatment and to provide the optimal therapeutic strategies for GC patients receiving NAC.METHODS The clinical information was collected from 230 GC patients who received NAC treatment at the Central South University Xiangya School of Medicine Affiliated Haikou Hospital from January 2016 to December 2020.Least absolute shrinkage and selection operator logistic regression analysis was used to find the possible predictors.A nomogram model was employed to predict the response to NAC.RESULTS In total 230 patients were finally included in this study,including 154 males(67.0%)and 76 females(33.0%).The mean age was(59.37±10.60)years,ranging from 24 years to 80 years.According to the tumor regression grade standard,there were 95 cases in the obvious response group(grade 0 or grade 1)and 135 cases in the poor response group(grade 2 or grade 3).The obvious response rate was 41.3%.Least absolute shrinkage and selection operator analysis showed that four risk factors significantly related to the efficacy of NAC were tumor location(P<0.001),histological differentiation(P=0.001),clinical T stage(P=0.008),and carbohydrate antigen 724(P=0.008).The C-index for the prediction nomogram was 0.806.The calibration curve revealed that the predicted value exhibited good agreement with the actual value.Decision curve analysis showed that the nomogram had a good value in clinical application.CONCLUSION A nomogram combining tumor location,histological differentiation,clinical T stage,and carbohydrate antigen 724 showed satisfactory predictive power to the response of NAC and can be used by gastrointestinal surgeons to determine the optimal treatment strategies for advanced GC patients.

关键词： Advanced gastric cancer Predictor Neoadjuvant chemotherapy Nomogram Tumor regression grade