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Reversal of multidrug resistance and antitumor promoting activity of 3-oxo-6β-hydroxy-β-amyrin isolated from Pistacia integerrima

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BIOCELL 2021年第1期45卷 139-147页

作者： ABDUR RAUF SAUD BAWAZEER MUSLIM RAZA EMAN EL-SHARKAWY MD.HABIBUR RAHMAN MOHAMED A.EL-ESAWI GHIAS UDDIN bina ssiddiqui ANEES AHMED KHALIL JOSEPH MOLNAR AKOS CSONKA DIÁNA SZABÓ HAROON KHAN MOHAMMAD SMUBARAK TAIBI BEN HADDA MUDYAWATI KAMARUDDIN SEEMA PATEL Department of Chemistry University of SwabiAnbar23561Khyber Pakhtunkhwa Pakistan Department of Pharmaceutical Chemistry Faculty of PharmacyUmm Al-Qura UniversityMakkah24211Saudi Arabia State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China Chemical Departments Faculty of ScienceNorthern Borders UniversityArar91431Saudi Arabia Department of Pharmacy Southeast UniversityBanani-1213DhakaBangladesh Department of Global Medical Science Wonju College of MedicineYonsei UniversitySeoulSouth Korea Botany Department Faculty of ScienceTanta UniversityTanta31527Egypt Institute of Chemical Sciences University of PeshawarPeshawar25120Pakistan H.E.J.Research Institute of Chemistry International Center for Chemical and Biological SciencesUniversity of KarachiKarachi75270Pakistan University Institute of Diet and Nutritional Sciences Faculty of Allied Health SciencesThe University of LahoreLahore54000Pakistan Department of Medical Microbiology and Immunobiology Faculty of MedicineUniversity of SzegedSzeged6700Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery Faculty of MedicineUniversity of SzegedSzeged6700Hungary Department of Pharmacy Abdul Wali Khan UniversityMardan23200Pakistan Department of Chemistry The University of JordanAmman11942Jordan LCM Laboratory Faculty of SciencesMohamed First UniversityOujda60000Morocco Institution of Health Science of Tahirah Al Baeti Bulukumba South Sulawesi92352Indonesia Bioinformatics and Medical Informatics Research Center San Diego State UniversitySan Diego92182USA

The bioactive triterpenoid 3-oxo-6-β-hydroxy-β-amyrin(1)has been isolated from multiple plant *** this study,chloroform fraction of Pistacia integerrima extract was processed for the isolation of the *** compound identity was confirmed by advanced spectroscopy technique.X-ray crystallography was applied for molecular structure *** addition,compound 1 was screen for its activity on reversal of MDR(multidrug resistance)mediated by P-gp(P-glycoprotein).This was accomplished by using rhodamine123 exclusion on multidrug-resistant human ABCB1 gene transfected mouse T-lymphoma cell *** revealed that MDR reversing effect was comparable to verapamil as positive control in *** of TPA-induced tumor promotion with 3-oxo-6β-hydroxy-β-amyrin led to reduction in the applied anti-tumor promotion *** chemo-preventive effect of 3-oxo-6β-hydroxy-β-amyrin was comparable to curcumin as positive control based on the reduction of immediate early tumor antigen *** docking by applying Autodock Vina 1 and i-GEMDOCK v 2.1 tools indicated that compound 1 gives good docking results,as determined by their fitness score and ***,results showed that compound 1 isolated from Pistacia integerrima precisely attached to a region where co-crystallized ligand for receptor previously *** findings may explain the use of Pistacia integerrima plant extracts as an anticancer agent in folk medicine.

关键词： Pistacia integerrima Anti-tumor properties X-ray crystallography POM Molecular docking

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