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Nano-Micro Letters 2018年第4期10卷 61-69页

作者： Purnima Naresh Manghnani Wenbo Wu Shidang Xu Fang Hu Cathleen teh bin Liu Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Institute of Molecular and Cell Biology Proteos BuildingBiopolis Drive

Photodynamic therapy(PDT) employs accumulation of photosensitizers(PSs) in malignant tumor tissue followed by the light-induced generation of cytotoxic reactive oxygen species to kill the tumor cells. The success of PDT depends on optimal PS dosage that is matched with the ideal power of light. This in turn depends on PS accumulation in target tissue and light administration time and *** theranostic nanomedicine is driven by multifunctional therapeutics that aim to achieve targeted tissue delivery and image-guided therapy, fluorescent PS nanoparticle(NP)accumulation in target tissues can be ascertained through fluorescence imaging to optimize the light dose and administration parameters. In this regard, zebrafish larvae provide a unique transparent in vivo platform to monitor fluorescent PS bio-distribution and their therapeutic efficiency. Using fluorescent PS NPs with unique aggregation-induced emission characteristics, we demonstrate for the first time the real-time visualization of polymeric NP accumulation in tumor tissue and, more importantly, the best time to conduct PDT using transgenic zebrafish larvae with inducible liver hyperplasia as an example.

关键词： Nanomedicine Photodynamic therapy Transgenic zebrafish Aggregation-induced emission Organic nanoparticles

STAT1对人肾透明细胞癌放射敏感性的影响

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中华放射肿瘤学杂志 2009年第3期18卷 238-242页

作者：惠周光骆爱萍毕楠张烨雷明芳麦伟源 teh bin-tean teh bin-sing 中国医学科学院北京协和医学院肿瘤医院放疗科北京100021 中国医学科学院北京协和医学院分子肿瘤国家重点实验室北京100021 美国贝勒医学院放射及放疗科休斯顿77054 美国Van Andel研究所癌症基因实验室 Grand Rapids49503

目的研究人肾透明细胞癌信号传递和转录活化因子1（STAT1）表达情况及抑制STAT1对该肿瘤细胞放射敏感性的影响。方法采用免疫组织化学染色技术对比检测34例人肾透明细胞癌标本和12例正常肾组织标本的STAT1表达。用Western blotting法检... 详细信息

目的研究人肾透明细胞癌信号传递和转录活化因子1（STAT1）表达情况及抑制STAT1对该肿瘤细胞放射敏感性的影响。方法采用免疫组织化学染色技术对比检测34例人肾透明细胞癌标本和12例正常肾组织标本的STAT1表达。用Western blotting法检测离体培养人肾透明细胞癌细胞（CRL-1932）、纤维母细胞（CCL-116）和Wilm’s瘤细胞（CRL-1441）的STAT1表达。用氟达拉滨和siRNA抑制CRL-1932细胞STAT1表达，并通过成克隆法和台盼蓝染色计数法研究抑制STAT1对CRL-1932细胞放射敏感性的影响。结果人肾透明细胞癌标本的总STAT1和磷酸化STAT1表达均明显高于正常肾组织。Western blotting法显示CRL-1932细胞STAT1表达比CRL-1441、CCL-116细胞明显增高；药物氟达拉滨能显著抑制CRL-1932细胞磷酸化STAT1的表达，并显著增加CRL-1932细胞的放射敏感性，且放射增敏程度与药物浓度呈正相关。经STAT1 siRNA处理后CRL-1932细胞总STAT1和磷酸化STAT1的表达均被有效抑制，且细胞在照射后的存活分数显著下降。结论肾透明细胞癌STAT1呈高表达，抑制STATI对该细胞有放射增敏作用。

关键词：细胞系,肾肿瘤照射信号传递和转录活化因子放射增敏剂

氟达拉滨抑制STAT1表达对乳头状细胞癌放射敏感性的影响

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中华放射肿瘤学杂志 2008年第5期17卷 344-348页

作者：惠周光朱晓虹麦伟源 teh bin teh bin Sing 中国医学科学院北京协和医学院肿瘤医院肿瘤研究所放疗科北京100021 美国贝勒医学院放射及放疗科休斯顿77054 49503 Grand Rapids 美国Van Andel研究所癌症基因实验室

目的通过观察氟达拉滨对人肾乳头状细胞癌（RPCC）标本和细胞系STAT1表达的影响，探讨氟达拉滨成为新类型放射增敏剂——基因型放射增敏剂的可能性。方法采用微点阵基因芯片技术对137例人RPCC标本和15例正常肾组织标本进行STAT1表达检... 详细信息

目的通过观察氟达拉滨对人肾乳头状细胞癌（RPCC）标本和细胞系STAT1表达的影响，探讨氟达拉滨成为新类型放射增敏剂——基因型放射增敏剂的可能性。方法采用微点阵基因芯片技术对137例人RPCC标本和15例正常肾组织标本进行STAT1表达检测，利用基因芯片操作系统（GCOS1．4，Affymetfix）以靶信号500作为总体标定值进行质量检验，并利用变性凝胶电泳进行质量评价。用Western印迹法检测人RPCC细胞（SKRC-39）、纤维母细胞（CCL-116）和威尔姆瘤细胞（CRL-1441）株STAT，表达，以及氟达拉滨对SKRC-39细胞±照射后和转染siRNA后的STAT，表达。并用SKRC-39细胞进行成克隆法和台盼蓝染色计数法的氟达拉滨放射增敏实验。结果人RPCC标本和正常肾组织标本的STAT，表达强度分别为821±66和240±35，人RPCC标本STAT，表达显著增高（t=44．38，P=0．000）。Western印迹法检测结果显示SKRC-39细胞表达STAT1比CRL-1441、CCL-116细胞明显增高；与对照组相比氟达拉滨能显著抑制磷酸化STAT。的表达，照射对磷酸化STAT1几乎无影响，而氟达拉滨和照射共同作用时磷酸化STAT，的表达被显著抑制；经STAT1siRNA处理后SKRC-39细胞总STAT1和磷酸化STAT1的表达均被有效抑制。SKRC-39细胞成克隆法放射增敏实验结果显示经氟达拉滨处理后SKRC-39细胞的放射敏感性显著增加，放射增敏程度与药物浓度呈正相关（5、10μmol／L的增敏比分别为1．22、1．39）。结论氟达拉滨通过抑制STAT1表达增加了SKRC-39细胞的放射敏感性，因此属于基因型放射增敏剂。

关键词：细胞系,肿瘤细胞系,纤维母细胞照射 STAT1 表达放射增敏剂

Two-stage Optimal Dispatching of AC/DC Hybrid Active Distribution Systems Considering Network Flexibility

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Journal of Modern Power Systems and Clean Energy 2023年第1期11卷 52-65页

作者： Yi Su Jiashen teh School of Electrical and Electronic Engineering Universiti Sains Malaysia(USM)14300 Nibong TebalPenangMalaysia IEEE

The increasing flexibility of active distribution systems(ADSs)coupled with the high penetration of renewable distributed generators(RDGs)leads to the increase of the *** is of practical significance to achieve the largest amount of RDG penetration in ADSs and maintain the optimal *** study establishes an alternating current(AC)/direct current(DC)hybrid ADS model that considers the dynamic thermal rating,soft open point,and distribution network reconfiguration(DNR).Moreover,it transforms the optimal dispatching into a second-order cone programming *** the different control time scales of dispatchable resources,the following two-stage dispatching framework is proposed.d dispatch uses hourly input data with the goal(1)The day-ahea of minimizing the grid loss and RDG *** obtains the optimal 24-hour schedule to determine the dispatching plans for DNR and the energy storage system.(2)The intraday dispatch uses 15-min input data for 1-hour rolling-plan dispatch but only executes the first 15 min of *** eliminate error between the actual operation and dispatching plan,the first 15 min is divided into three 5-min step-by-step *** goal of each step is to trace the tie-line power of the intraday rolling-plan dispatch to the greatest extent at the minimum *** measured data are used as feedback input for the rolling-plan dispatch after each step is executed.A case study shows that the comprehensive cooperative ADS model can release the line capacity,reduce losses,and improve the penetration rate of ***,the two-stage dispatching framework can handle source-load fluctuations and enhance system stability.

关键词： Two-stage dispatching network flexibility renewable distributed generator second-order cone programming(SOCP) alternating current(AC)/direct current(DC)hybrid active distribution system

Additive direct-write microfabrication for MEMS： A review

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Frontiers of Mechanical Engineering 2017年第4期12卷 490-509页

作者： Kwok Siong teh School of Engineering San Francisco State University San FranciscoCA 94132 USA

Direct-write additive manufacturing refers to a rich and growing repertoire of well-established fabrication techniques that builds solid objects directly from compu- ter-generated solid models without elaborate intermediate fabrication steps. At the macroscale, direct-write techni- ques such as stereolithography, selective laser sintering, fused deposition modeling ink-jet printing, and laminated object manufacturing have significantly reduced concept- to-product lead time, enabled complex geometries, and importantly, has led to the renaissance in fabrication known as the maker movement. The technological premises of all direct-write additive manufacturing are identical--converting computer generated three-dimen- sional models into layers of two-dimensional planes or slices, which are then reconstructed sequentially into three- dimensional solid objects in key differences between the a layer-by-layer format. The various additive manufactur- ing techniques are the means of creating the finished layers and the ancillary processes that accompany them. While still at its infancy, direct-write additive manufacturing techniques at the microscale have the potential to significantly lower the barrier-of-entry--in terms of cost, time and training--for the prototyping and fabrication of MEMS parts that have larger dimensions, high aspect ratios, and complex shapes. In recent years, significant advancements in materials chemistry, laser technology, heat and fluid modeling, and control systems have enabled additive manufacturing to achieve higher resolutions at the micrometer and nanometer length scales to be a viable technology for MEMS fabrication. Compared to traditional MEMS processes that rely heavily on expensive equip- ment and time-consuming steps, direct-write additive manufacturing techniques allow for rapid design-to- prototype realization by limiting or circumventing the need for cleanrooms, photolithography and extensive training. With current direct-write additive

关键词： direct-write additive manufacturing micro-fabrication MEMS

Constitutive modelling of composite laminates under uniaxial compression

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Chinese Journal of Aeronautics 2019年第4期32卷 938-947页

作者： Hsuan-teh HU Lung-Shen KE Department of Civil Engineering ‘‘National" Cheng Kung University

A nonlinear constitutive model for a single lamina is proposed for the failure analysis of composite laminates. In the material model, both fiber and matrix are assumed to behave elasticplastically and the in-plane shear is assumed to behave nonlinearly with a variable shear *** damage onset for individual lamina is detected by a mixed failure criterion, composed of the Tsai-Wu criterion and the maximum stress criterion. After damage takes place within the lamina,the fiber and in-plane shear are assumed to exhibit brittle behavior, and the matrix is assumed to exhibit degrading behavior. The proposed nonlinear material model is tested against experimental data of composite laminates subjected to uniaxial compressive loads, and good agreement is obtained.

关键词： Composite laminates Constitutive model Finite element analysis Nonlinearity Uniaxial compression

Epigenetic alterations in gastric carcinogenesis

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Cell Research 2005年第4期15卷 247-254页

作者： In-Seon CHOI,Tsung-teh WU Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas USA Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas USA

Gastric cancer is believed to result in part from the accumulation of multiple genetic alterations leading to oncogeneoverexpression and tumor suppressor loss. Epigenetic alterations as a distinct and crucial mechanism to silence a varietyof methylated tissue-specific and imprinted genes, have been extensively studied in gastric carcinoma and play impor-tant roles in gastric carcinogenesis. This review will briefly discuss the basic aspects of DNA methylation and CpGisland methylation, in particular the epigenetic alterations of certain critical genes implicated in gastric carcinogenesisand its relevance of clinical implications.

关键词： epigenetic alterations gastric carcinogenesis chronic gastritis intestinal metaplasia dysplasia/adenoma adenocarcinoma.

On Density-Based Data Streams Clustering Algorithms: A Survey

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Journal of Computer Science & Technology 2014年第1期29卷 116-141页

作者： Amineh Amini teh Ying Wah Hadi Saboohi IEEE Department of Information Systems Faculty of Computer Science and Information Technology University of Malaya Kuala Lumpur ACM

Clustering data streams has drawn lots of attention in the last few years due to their ever-growing presence. Data streams put additional challenges on clustering such as limited time and memory and one pass clustering. Furthermore, discovering clusters with arbitrary shapes is very important in data stream applications. Data streams are infinite and evolving over time, and we do not have any knowledge about the number of clusters. In a data stream environment due to various factors, some noise appears occasionally. Density-based method is a remarkable class in clustering data streams, which has the ability to discover arbitrary shape clusters and to detect noise. Furthermore, it does not need the nmnber of clusters in advance. Due to data stream characteristics, the traditional density-based clustering is not applicable. Recently, a lot of density-based clustering algorithms are extended for data streams. The main idea in these algorithms is using density- based methods in the clustering process and at the same time overcoming the constraints, which are put out by data streanFs nature. The purpose of this paper is to shed light on some algorithms in the literature on density-based clustering over data streams. We not only summarize the main density-based clustering algorithms on data streams, discuss their uniqueness and limitations, but also explain how they address the challenges in clustering data streams. Moreover, we investigate the evaluation metrics used in validating cluster quality and measuring algorithms＇ performance. It is hoped that this survey will serve as a steppingstone for researchers studying data streams clustering, particularly density-based algorithms.

关键词： data stream density-based clustering grid-based clustering micro-clustering

Long-term outcome of a moderately hypofractionated, intensity-modulated radiotherapy approach using an endorectal balloon for patients with localized prostate cancer

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Cancer Communications 2018年第1期38卷 136-144页

作者： bin S.teh Gary D.Lewis Weiyuan Mai Ramiro Pino Hiromichi Ishiyama Edward Brian Butler Department of Radiation Oncology Houston Methodist HospitalCancer Centerand Research InstituteWeill Cornell Medical College6565 FanninSte#DB1-077HoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical Branch at GalvestonGalvestonTX 77555USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiology and Radiation Oncology Kitasato University School of MedicineSagamihara 252-0374Japan

Background:Technical advances in radiotherapy delivery have simultaneously enabled dose escalation and enhanced bladder and rectal ***,the optimal radiation fractionation regimen for localized prostate cancer is *** and clinical evidence suggest that hypofractionation may improve the therapeutic ratio of *** report our institutional outcomes using moderately hypofractionated,intensity-modulated radio-therapy(IMRT),and an endorectal balloon,with emphasis on long-term biochemical control and treatment-related adverse events in patients with localized prostate ***:Between January 1997 and April 2004,596 patients with cT1-T3 prostate cancer underwent IMRT using a moderate hypofractionation regimen(76.70 Gy at 2.19 Gy/fraction)with an endorectal *** D’Amico clas-sification,226(37.9%),264(44.3%),and 106(17.8%)patients had low-,intermediate-,or high-risk disease,*** majority of intermediate-and high-risk patients received androgen deprivation *** relapse-free survival(bRFS)was evaluated using 2005 Phoenix criteria and estimated using the Kaplan-Meier ***:The median follow-up was 62 *** 5-and 10-year bRFS rates were 92.7%and 87.7%.For low-,intermediate-,and high-risk patients,the 5-year bRFS rates were 96.9%,93.3%,and 82.0%,respectively;the 10-year bRFS rates were 91.4%,89.3%,and 76.2%,***-specific antigen,Gleason score,and T stage were significant predictors of bRFS(all P<0.01).The 5-year rates of severe(≥Grade 3)adverse events were very low:1.2%for gastrointestinal events and 1.1%for genitourinary ***:Long-term outcomes after moderately hypofractionated IMRT are *** hypofrac-tionation represents a safe,efficacious,alternative regimen in the treatment of localized prostate cancer.

关键词： Prostate cancer Intensity-modulated radiotherapy Moderate hypofractionation

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數字化導板引導游離端牙種植的精準度分析

镜湖医学 2024年第1期24卷 52-53,65,F0003页

作者：鄒德守汪淼澳門鏡湖醫院口腔科中国

目的評估使用數字化導板引導實施牙列遊離端種植的精準度。方法本研究收集2021年12月~2022年12月期間在澳門鏡湖醫院口腔科進行的數字化導板引導的游離端種植牙手術患者16例(植體16枚)。收集同期實施的非游離端種植牙手術患者16例(植體1... 详细信息

目的評估使用數字化導板引導實施牙列遊離端種植的精準度。方法本研究收集2021年12月~2022年12月期間在澳門鏡湖醫院口腔科進行的數字化導板引導的游離端種植牙手術患者16例(植體16枚)。收集同期實施的非游離端種植牙手術患者16例(植體16枚)。使用Blue Sky Plan將患者術前設計數據與術後種植體掃描數據進行交叉比對,測量術前十設計位置與術後實際位置的差異,統計學分析游離端與非游離端植入的植體精準度差異。結果與術前設計植入位置比較,在牙列游離端植入種植體與非游離端植入種植體,其種植精準度相似,無統計學差異(P>0.05)。結論即使在牙列游離端,數字化導板都可以指導手術實現精確植入種植體,值得臨床推廣應用。

关键词：種植牙數字化導板三維精度牙列游離端