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Cost-effective low-coverage whole-genome sequencing assay for the risk stratification of gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 690-702页

作者： Li-Ping Ye Xin-Li Mao Xian-bin Zhou Yi Wang Shi-Wen Xu Sai-Qin He Zi-Liang Qian Xiao-Gang Zhang Li-Juan Zhai Jin-Bang Peng bin-bin gu Xiu-Xiu Jin Ya-Qi Song Shao-Wei Li Key Laboratory of Minimally Invasive Techniques&Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Department of Gastroenterology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Institute of Digestive Disease Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Taizhou Hospital of Zhejiang Province Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Suzhou Hongyuan Biotech Inc. Suzhou 215000Zhejiang ProvinceChina Prophet Genomics Inc. CaliforniaCA 95101United States Catcher Bio Inc. Hangzhou 310000Zhejiang ProvinceChina Department of Medicine Catcher Bio Inc.Hangzhou 310000Zhejiang ProvinceChina Taizhou Hospital of Zhejiang Province Zhejiang University School of MedicineLinhai 317000Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC), a multifactorial disease, is caused by pathogens, such as Helicobacter pylori(H. pylori) and Epstein-Barr virus(EBV), and genetic *** To investigate microbiomes and host genome instability by cost-effective,low-coverage wholegenome sequencing,as biomarkers for GC *** Samples from 40 GC patients were collected from Taizhou Hospital,Zhejiang Province,affiliated with Wenzhou Medical *** from the samples was subjected to low-coverage wholegenome sequencing with a median genome coverage of 1.86×(range:1.03×to 3.17×) by Illumina×10,followed by copy number analyses using a customized bioinformatics workflow ultrasensitive chromosomal aneuploidy *** Of the 40 GC samples,20 (50%) were found to be enriched with *** DNA was detected in 5 GC patients (12.5%).*** DNA was found in 15 (37.5%) *** other 20(50%) patients were found to have relatively higher genomic *** number amplifications of the oncogenes,ERBB2 and KRAS,were found in 9 (22.5%) and 7 (17.5%) of the GC samples,*** enrichment was found to be associated with tumors in the gastric cardia and *** enrichment was found to be associated with tumors in the pylorus and *** with elevated genomic instability showed no localization and could be observed in any ***,***-enriched GC was found to be associated with the Borrmann type Ⅱ/Ⅲ and gastritis ***-enriched GC was not associated with *** statistically significant correlation was observed between genomic instability and ***,these three different molecular subtypes showed distinct survival outcomes (P=0.019).EBV-positive tumors had the best prognosis,whereas patients with high genomic instability (CIN+) showed the worst *** with *** infection showed intermediate prognosis compared with the other two *** Thus,using low-coverage whole-ge

关键词： Gastric cancer Whole-genome sequencing Helicobacter pylori infections Epstein-Barr virus infections Genetic components Precision medicine

Low-energy-consumption temperature swing system for CO_(2) capture by combining passive radiative cooling and solar heating

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Green Energy & Environment 2024年第3期9卷 507-515页

作者： Ying-Xi Dang Peng Tan bin Hu Chen gu Xiao-Qin Liu Lin-bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing211816China

Temperature-swing adsorption(TSA)is an effective technique for CO_(2) capture,but the temperature swing procedure is ***,we report a low-energy-consumption system by combining passive radiative cooling and solar heating for the uptake of CO_(2) on commercial activated carbons(CACs).During adsorption,the adsorbents are coated with a layer of hierarchically porous poly(vinylidene fluoride-co-hexafluoropropene)[P(VdF-HFP)HP],which cools the adsorbents to a low temperature under sunlight through radiative *** desorption,CACs with broad absorption of the solar spectrum are exposed to light irradiation for *** heating and cooling processes are completely driven by solar *** tests under mimicked sunlight using the CACs show that the performance of this system is comparable to that of the traditional ***,under real sunlight irradiation,the adsorption capacity of the CACs can be well maintained after multiple *** present work may inspire the development of new temperature swing procedures with little energy consumption.

关键词： CO_(2)capture Solar heating Passive radiative cooling Temperature swing adsorption

Two positive effects with one arrow:Modulating crystal and interfacial decoration towards high-potential cathode material

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Journal of Energy Chemistry 2024年第5期92卷 216-223页

作者： Xuexiu gu Xuan-Wen Gao Dongrun Yang Qinfen gu YSong Hong Chen Tianzhen Ren Wen-bin Luo Institute for Energy Electrochemistry and Urban Mines Metallurgy School of MetallurgyNortheastern UniversityShenyang 110819LiaoningChina Australian Synchrotron(ANSTO) 800 Blackburn RdClaytonVictoria 3168Australia School of Science and Engineering University of DundeeNethergateDundee DD14HNScotlandUK

As the primary suppliers of cyclable sodium ions,O3-type layer-structured manganese-based oxides are recognized as highly competitive cathode candidates for sodium-ion *** advance the development of high-energy sodium-ion batteries,it is crucial to explore cathode materials operating at high voltages while maintaining a stable cycling *** orbital and electronic structure of the octahedral center metal element plays a crucial role in maintaining the octahedra structural integrity and improving Na^(+)ion diffusion by introducing heterogeneous chemical *** by the abundant configuration of extra nuclear electrons and large ion radius,we employed trace amounts of tungsten in this *** obtained cathode material can promote the reversibility of oxygen redox reactions in the high-voltage region and inhibit the loss of lattice ***,the formation of a Na_(2)WO_(4) coating on the material surface can improve the interfacial stability and interface ions *** demonstrates an initial Coulombic efficiency(ICE)of 94.6%along with 168.5 mA h g^(-1 )discharge capacity within the voltage range of 1.9-4.35 *** findings contribute to the advancement of high-energy sodium-ion batteries by providing insights into the benefits of tungsten doping and Na_(2)WO_(4) coating on cathode materials.

关键词： Sodium ion battery Layer-structured manganese-based oxides Cathodematerial Surface modification Elements doping

A new portable open-path instrument for ambient NH_(3) and on-road emission measurements

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Journal of Environmental Sciences 2024年第2期136卷 606-614页

作者： Wenhao Dai Shanshan Wang Sanbao Zhang Jian Zhu Chuanqi gu Zhibin Sun Ruibin Xue bin Zhou Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3) Department of Environmental Science and EngineeringFudan UniversityShanghai 200438China Institute of Eco-Chongming(IEC) Shanghai 202162China Institute of Atmospheric Sciences Fudan UniversityShanghai 200433China

Increased attentions to vehicle emission of NH_(3)have been paid since it is generally regarded as an important source in urban ***,we developed a movable instrument based on Differential Optical Absorption Spectroscopy(DOAS)principle for detecting on-road NH_(3),which can avoid the losses in the sampling process attributed to the non-sampling *** this mobile DOAS,the temporal resolution,detection limit and relative error for NH_(3)were 1 min,2.29 ppbv and 4.57%±2.44%,*** employed to the on-road measurements along the arterial highway in Shanghai,the spatial distributions of NH_(3)and NO were obtained,and their dependence of traffic and road conditions were *** slopes of linear regression between NH_(3)and NO were 0.40,0.02 and 0.07 on the Middle Ring Road,Outer Ring Road and Chongming Island Ring *** indicates that light gasoline vehicles(LGVs)were found to be the main contributor to NH_(3)emissions,while heavy-duty diesel vehicles(HDVs)mainly emitted *** on the measured NH_(3)in the tunnel,the mileagebased NH_(3)emission factor per vehicle was estimated to be 17.9±6.3 mg/*** reported open-path instrument can be broadly used in on-road pollutant monitoring or vehicle emissions,and the measurements can reveal the real situation of emission characteristics,even find the abnormal operations of vehicle catalyst system.

关键词： Ammonia Traffic emissions DOAS Emission factor Mobile measurements

Higher consumption of animal organ meat is associated with a lower prevalence of nonalcoholic steatohepatitis

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 645-657页

作者： Rui Zhang Huai Zhang Yi Wang Liang-Jie Tang Gang Li Ou-Yang Huang Sui-Dan Chen Giovanni Targher Christopher D.Byrne bin-bin gu Ming-Hua Zheng Department of Nutrition the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Biostatistics and Medical Quality Management Office the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina MAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Department of Pathology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Southampton National Institute for Health Research Biomedical Research Centre University Hospital SouthamptonSouthampton General HospitalSouthamptonUK Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province WenzhouChina

Background:Animal organ meat(offal)is a food with high nutrient density that is popular in different parts of the world,but its relationship with nonalcoholic steatohepatitis(NASH)is *** aimed to examine whether daily animal organ meat consumption is associated with the presence of NASH in individuals with nonalcoholic fatty liver disease(NAFLD).Methods:A total of 136 Chinese adults with biopsy-proven NAFLD were *** NASH was defined as NAFLD activity score≥4 and at least one point for steatosis,ballooning,and lobular *** animal organ meat consumption was estimated using a self-administered validated food frequency *** regression analysis was performed to assess the association between animal organ meat intake and liver disease ***:The 136 participants(80.9%men)of the study had a mean±standard deviation(SD)age of 39.0±12.5 years and body mass index of 27.4±3.6 kg/*** of definite NASH was 65.4%.Daily median organ meat consumption was 1.30 g/1,000 *** organ meat consumption was inversely associated with the presence of NASH even after adjustment of demographics,lifestyle variables,metabolic and dietary factors,as well as liver fibrosis stage;adjusted-odds ratios(95%confidence intervals)for NASH were 0.15(0.03,0.69)for the highest tertile and 0.18(0.05,0.70)for the medium tertile,compared to the lowest(reference)tertile of animal organ meat intake(P value for trend=0.024).Conclusions:Our results suggest for the first time that higher animal organ meat consumption is associated with a lower prevalence of NASH in Chinese individuals with biopsy-proven NAFLD.

关键词： Nonalcoholic fatty liver disease(NAFLD) nonalcoholic steatohepatitis(NASH) diet organ meat red meat metabolic dysfunction-associated fatty liver disease(MAFLD)

Nano-frictional mechano-reinforcing porous nanowires scaffolds

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Friction 2024年第5期12卷 968-980页

作者： Licheng HUA Conghu HU Jingkang ZHANG Jin LI Chenjie gu bin HUANG guangyong LI Jianke DU Wanlin guO Smart Materials and Advanced Structures Laboratory School of Mechanical Engineering&MechanicsNingbo UniversityNingbo315211China Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education Nanjing University of Aeronautics and AstronauticsNanjing210016China Key Laboratory of Impact and Safety Engineering Ministry of EducationSchool of mechanical Engineering and MechanicsNingbo UniversityNingbo315211China Department of Microelectronics and Engineering Ningbo UniversityNingbo315211China

Artificial biomaterials with dynamic mechano-responsive behaviors similar to those of biological tissues have been drawing great *** this study,we report a TiO_(2)-based nanowire(TiO_(2)NWs)scaffolds,which exhibit dynamic mechano-responsive behaviors varying with the number and amplitude of nano-deformation *** is found that the elastic and adhesive forces in the TiO_(2)NWs scaffolds can increase significantly after multiple cycles of *** nanofriction experiments show the triboelectric effect of increasing elastic and adhesive forces during the nano-deformation cycles of TiO_(2)NWs *** properties allow the TiO_(2)NW scaffolds to be designed and applied as intelligent artificial biomaterials to simulate biological tissues in the future.

关键词： TiO_(2)NWs scaffolds nano-deformation mechano-reinforcing triboelectric effect intelligent artificial biomaterials

A bibliometric analysis of molybdenum-based nanomaterials in the biomedical field

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Tungsten 2024年第1期6卷 17-47页

作者： Zhi-Qiang Wang Ya-Wen Pan Jing Wu Hong-bin Qi Shuang Zhu Zhan-Jun gu School of Science China University of GeosciencesBeijing 100083China CAS Key Laboratory for Biomedical Eff ects of Nanomaterials and Nanosafety Institute of High Energy PhysicsBeijing 100049China CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaChinese Academy of SciencesBeijing 100190China College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China

Molybdenum(Mo)-based nanomaterials have been widely used in biomedical fields due to their various nanostructures and unique physical/chemical *** various reviews have described the development of Mo-based materials in the biomedical field,an objective and comprehensive summary and analysis of research trends in this field is still ***,we used the bibliometric analysis method to analyze all relevant literature on the biological application of Mobased nanomaterials in recent ***,we use bibliometric tools to analyze the dataset by year,country/region,institution and research hotspot to obtain the research ***,based on objectively identified research hotspots,the biomedical applications of Mo-based nanomaterials are reviewed comprehensively,mainly including sensors,cancer imaging/therapy and antibacterial ***,we discussed the application prospects and challenges of Mo-based *** article provides a new perspective to understand the current research progress and further promote the development of Mobased nanomaterials in biomedical research.

关键词： Molybdenum Nanomaterial Biomedicine Bibliometric analysis

Clinical practice of sepsis-induced immunosuppression:Current immunotherapy and future options

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Chinese Journal of Traumatology 2024年第2期27卷 63-70页

作者： Fei Pei bin gu Shu-Min Miao Xiang-Dong guan Jian-Feng Wu Department of Critical Care Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China guangdong Clinical Research Center for Critical Care Medicine Guangzhou510080China

Sepsis is a potentially fatal condition characterized by the failure of one or more organs due to a disordered host response to *** development of sepsis is closely linked to immune *** a result,immunotherapy has gained traction as a promising approach to sepsis treatment,as it holds the potential to reverse immunosuppression and restore immune balance,thereby improving the prognosis of septic ***,due to the highly heterogeneous nature of sepsis,it is crucial to carefully select the appropriate patient population for *** review summarizes the current and evolved treatments for sepsis-induced immunosuppression to enhance clinicians'understanding and practical application of immunotherapy in the management of sepsis.

关键词： Sepsis Sepsis-induced immunosuppression Immunotherapy Enrichment Classifier

Navigating the future:Embracing resilience and interoperability in the industrial internet

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Fundamental Research 2024年第1期4卷 1-2页

作者： Chaojie gu Chunxiao Jiang Jiming Chen Yang Cong bin Xiao College of Control Science and Engineering Zhejiang UniversityHangzhou 310027China Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China School of Automation Science and Engineering South China University of TechnologyGuangzhou 510641China Division II Department of Information SciencesNational Natural Science Foundation of ChinaBeijing 100085China Chongqing Key Laboratory of Image Cognition School of Computer Science and TechnologyChongqing University of Posts and TelecommunicationsChongqing 400065China

In the midst of the fourth industrial revolution,the convergence of the digital,physical,and biological realms is propelling industrial innovation to new *** the heart of this transformative era lies the Industrial In... 详细信息

关键词： internet network shaping