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Chemotherapy in non-small cell lung cancer: opportunities for advancement

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Chinese Journal of Cancer 2016年第9期35卷 438-440页

作者： Mani Akhtari Eric H.Bernicker bin s.teh Department of Radiation Oncology Houston Methodist Hospital Cancer Center and Research Institute Weil Cornell Medical College Department of Radiation Oncology The University of Texas Medical Branch at Galveston Cancer Center Thoracic Medical Oncology Houston Methodist Hospital

Locally advanced non-small cell lung cancer(NsCLC) continues to be a challenging disease to treat. With high rates of both local and distant failures, there is signiicant interest in inding more biologically active chemotherapy regimens that can contribute to reduce both failures. The phase III PROCLAIM trial, recently published in the Journal of Clinical Oncology entitled "PROCLAIM: randomized phase III trial of pemetrexed–cisplatin or etoposide–cisplatin plus thoracic radiation therapy followed by consolidation chemotherapy in locally advanced nonsquamous non-small-cell lung cancer", compared two diferent chemotherapy regimens given concurrently with radiotherapy in patients with stage III non-squamous lung cancer: pemetrexed plus cisplatin versus cisplatin plus etoposide. Both groups received consolidation chemotherapy. After enrolling 598 of planned 600 patients, the study was stopped early due to futility as no diference was seen in the primary end-point of overall survival. since PROCLAIM was designed as a superiority trial, these results suggest that pemetrexed regimens do not ofer a clinical advantage over standard cisplatin plus etoposide. There are some subpopulations who might still beneit from pemetrexed, especially if clinicians are concerned about myelosuppression-related adverse events. Future trials are needed to investigate novel biologic agents and irradiation techniques that can result in more durable local and distant disease control in locally advanced NsCLC.

关键词：非小细胞肺癌化疗放射治疗临床医生疾病控制 III 生物活性生物制剂

Long-term outcome of a moderately hypofractionated, intensity-modulated radiotherapy approach using an endorectal balloon for patients with localized prostate cancer

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Cancer Communications 2018年第1期38卷 136-144页

作者： bin s.teh Gary D.Lewis Weiyuan Mai Ramiro Pino Hiromichi Ishiyama Edward Brian Butler Department of Radiation Oncology Houston Methodist HospitalCancer Centerand Research InstituteWeill Cornell Medical College6565 FanninSte#DB1-077HoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical Branch at GalvestonGalvestonTX 77555USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiology and Radiation Oncology Kitasato University School of MedicineSagamihara 252-0374Japan

Background:Technical advances in radiotherapy delivery have simultaneously enabled dose escalation and enhanced bladder and rectal ***,the optimal radiation fractionation regimen for localized prostate cancer is *** and clinical evidence suggest that hypofractionation may improve the therapeutic ratio of *** report our institutional outcomes using moderately hypofractionated,intensity-modulated radio-therapy(IMRT),and an endorectal balloon,with emphasis on long-term biochemical control and treatment-related adverse events in patients with localized prostate ***:Between January 1997 and April 2004,596 patients with cT1-T3 prostate cancer underwent IMRT using a moderate hypofractionation regimen(76.70 Gy at 2.19 Gy/fraction)with an endorectal *** D’Amico clas-sification,226(37.9%),264(44.3%),and 106(17.8%)patients had low-,intermediate-,or high-risk disease,*** majority of intermediate-and high-risk patients received androgen deprivation *** relapse-free survival(bRFs)was evaluated using 2005 Phoenix criteria and estimated using the Kaplan-Meier ***:The median follow-up was 62 *** 5-and 10-year bRFs rates were 92.7%and 87.7%.For low-,intermediate-,and high-risk patients,the 5-year bRFs rates were 96.9%,93.3%,and 82.0%,respectively;the 10-year bRFs rates were 91.4%,89.3%,and 76.2%,***-specific antigen,Gleason score,and T stage were significant predictors of bRFs(all Ps of severe(≥Grade 3)adverse events were very low:1.2%for gastrointestinal events and 1.1%for genitourinary ***:Long-term outcomes after moderately hypofractionated IMRT are *** hypofrac-tionation represents a safe,efficacious,alternative regimen in the treatment of localized prostate cancer.

关键词： Prostate cancer Intensity-modulated radiotherapy Moderate hypofractionation

Prognosis of lymphotropic invasive micropapillary breast carcinoma analyzed by using data from the National Cancer Database

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Cancer Communications 2019年第1期39卷 548-556页

作者： Gary D.Lewis Yan Xing Waqar Haque Tejal Patel Mary schwartz Albert Chen Andrew Farach sandra s.Hatch E.Brian Butler Jenny Chang bin s.teh Department of Radiation Oncology University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Houston Methodist HospitalHoustonTX 77030USA Department of Pathology and Genomic Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical BranchGalvestonTX 77555USA

Background:Invasive micropapillary carcinoma(IMPC)is an uncommon subtype of breast *** studies of this subtype demonstrated a higher propensity for lymph node metastases as compared with invasive ductal carci-noma(IDC).The purpose of the present study was to determine the clinical characteristics,outcomes,and propensity for lymph node metastasis of patients with IMPC of the breast recorded in the National Cancer Database(NCDB).Methods:Records of patients with IMPC diagnosed between 2004 and 2014 were retrieved from the ***-rank test was performed to evaluate associations of clinical characteristics with overall survival(Os).Cox proportional hazards model was used to determine variables associated with ***:Overall,2660 patients with IMPC met the selection criteria;the 5-year Os rate was 87.5%and 24.9%of patients had nodal involvement at *** with≥4 positive lymph nodes had shorter Os than node-negative patients,whereas patients with 1-3 positive nodes had similar Os to node-negative ***s,receipt of radiotherapy,and estrogen receptor positivity were also associated with prolonged *** benefit of radiotherapy was limited to IMPC patients undergoing lumpectomy;there was no benefit for the patients undergoing mastectomy(regardless of nodal positivity/negativity).Conclusions:Favorable prognostic factors of IMPC patients included ages,sitive lymph nodes,receipt of radiotherapy,and estrogen receptor *** results presented herein suggest a survival benefit asso-ciated with radiotherapy in IMPC treatment,though this may be limited to the patients treated with lumpectomy.

关键词： Breast cancer Invasive micropapillary carcinoma Radiotherapy surgery survival Hormone receptor

对局限性前列腺癌患者采用直肠内球囊中度低分割调强放射治疗的长期结局

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癌症 2018年第12期37卷 523-532页

作者： bin s.teh Gary D.Lewis Weiyuan Mai Ramiro Pino Hiromichi Ishiyama Edward Brian Butler Department of Radiation Oncology Houston Methodist Hospital Cancer Center and Research Institute Weill Cornell Medical College Department of Radiation Oncology The University of Texas Medical Branch at Galveston Department of Radiation Oncology Baylor College of Medicine Department of Radiology and Radiation Oncology Kitasato University School of Medicine

背景与目的放射治疗的技术进步使兼顾剂量递增和提升膀胱和直肠保留成为可能。然而,对于局限性前列腺癌的最佳辐射剂量分割方案尚不清楚。实验室和临床证据表明,低分割可提高放疗的治疗率。在此报道我们医院采用中度低分割调强放疗(inte... 详细信息

背景与目的放射治疗的技术进步使兼顾剂量递增和提升膀胱和直肠保留成为可能。然而,对于局限性前列腺癌的最佳辐射剂量分割方案尚不清楚。实验室和临床证据表明,低分割可提高放疗的治疗率。在此报道我们医院采用中度低分割调强放疗(intensity?modulated radiotherapy,IMRT)和直肠内球囊对局限性前列腺癌患者的治疗结局,重点关注患者的长期生化控制和治疗相关不良事件。方法从1997年1月到2004年4月,596例c T1–T3前列腺癌患者使用带直肠内球囊的中度低分割方案(76.70 Gy,2.19 Gy/次)进行IMRT。根据D'Amico分类低风险、中风险或高风险患者分别226(37.9%)例、264(44.3%)例和106(17.8%)例。大多数中、高风险患者接受雄激素剥夺治疗。使用2005年Phoenix标准评估无生化复发生存(biochemical relapse?freesurvival,bRFs),并使用Kaplan?Meier法进行估算。结果中位随访时间为62个月。总的5年bRFs和10年bRFs率分别为92.7%和87.7%。低风险、中风险和高风险患者的5年bRFs率分别为96.9%、93.3%和82.0%,10年bRFs率分别为91.4%、89.3%和76.2%。前列腺特异性抗原、Gleason评分和T分期是bRFs的重要预测因子(均P<0.01)。重度(≥3级)不良事件的5年发生率非常低:胃肠道不良事件和泌尿生殖系统不良事件的发生率分别为1.2%和1.1%。结论中度低分割IMRT后的长期结局令人鼓舞。中度低分割是治疗局限性前列腺癌的安全、有效的替代方案。

关键词：前列腺癌调强放疗中度低分割

采用美国国家癌症数据库数据分析淋巴浸润性微乳头状乳腺癌的预后

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癌症 2020年第2期39卷 77-86页

作者： Gary DLewis Yan Xing Waqar Haque Tejal Patel Mary schwartz Albert Chen Andrew Farach sandra sHatch EBrian Butler Jenny Chang bin s.teh Department of Radiation Oncology University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Houston Methodist HospitalHoustonTX 77030USA Department of Pathology and Genomic Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical BranchGalvestonTX 77555USA.

背景与目的浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)是乳腺癌中一种罕见的亚型。已有研究表明,与浸润性导管癌(invasive ductal carcinoma,IDC)相比,该亚型更易发生淋巴结转移。本研究旨在明确美国国家癌症数据库(Nat... 详细信息

背景与目的浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)是乳腺癌中一种罕见的亚型。已有研究表明,与浸润性导管癌(invasive ductal carcinoma,IDC)相比,该亚型更易发生淋巴结转移。本研究旨在明确美国国家癌症数据库(National Cancer Database,NCDB)中记录的乳腺IMPC患者的临床特征、结局和淋巴结转移倾向性。方法从NCDB中检索2004–2014年之间诊断为IMPC患者的病历,并对其进行log-rank检验以评估临床特征与总生存期(overall survival,Os)的相关性。采用Cox比例风险模型确定Os相关因素。结果本研究共纳入2660例IMPC患者。5年Os率为87.5%,24.9%患者出现淋巴结转移。阳性淋巴结数≥4的患者的Os短于阴性淋巴结的患者,而阳性淋巴结数为1–3的患者的Os与阴性淋巴结患者相似。年龄s延长有关。放疗仅对接受肿块切除术的IMPC患者有效,对进行乳房切除术的患者无效(无论淋巴结阳性/阴性)。结论IMPC患者的有利预后因素包括年龄<65岁、阳性淋巴结数<4、接受放疗和雌激素受体阳性。本研究结果表明,IMPC患者的生存获益与放疗相关,但可能仅限于经肿块切除术治疗的患者。

关键词：乳腺癌浸润性微乳头状癌放疗手术生存激素受体

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前列腺癌的立体定向放射治疗

前列腺癌的立体定向放射治疗

PI3K/AKT抑制剂Perifosine联合照射治疗前列腺癌

中华医学会放射肿瘤治疗学分会六届二次暨中国抗癌协会肿瘤放疗专业委员会二届二次学术会议

作者：高远红王小震 Julie Zhu 麦伟元黄莹 Arnold Paulino Michael ittmann E.Brian Butler bin s.teh The Methodist Hospital Baylor College of Medicine Michael E.DeBakey VA Medical Center 华南肿瘤学国家重点实验室中山大学肿防治中心中国医学科学院中国协医科大学肿瘤医院

目的:立体定向放射治疗(sBRT)日益受到人们重视,它是采用少分次、大分割的放射治疗技术;本研究的目的是通过体外及动物实验模型研究人前列腺癌进行大分割放射治疗的价值。材料与方法:选用人前列腺癌细胞CWR22RV1,分次照射剂量采用5Gy/次...

目的:立体定向放射治疗(sBRT)日益受到人们重视,它是采用少分次、大分割的放射治疗技术;本研究的目的是通过体外及动物实验模型研究人前列腺癌进行大分割放射治疗的价值。材料与方法:选用人前列腺癌细胞CWR22RV1,分次照射剂量采用5Gy/次和1 5Gy/次;应用成克

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PI3K/AKT抑制剂Perifosine联合照射治疗前列腺癌

Designing novel adaptive dynamic event-triggered protocols for uncertain multi-agent systems

中华医学会放射肿瘤治疗学分会六届二次暨中国抗癌协会肿瘤放疗专业委员会二届二次学术会议

作者：高远红王小震 Julie Zhu 麦伟元黄莹 Daniel Floryk Michael Ittmann Timothy C.Thompson E.Brian Butler bin s.teh Department of radiation oncology the Methodist Hospital Department of radiology/radiation oncology Baylor College of Medicine Michael E.DeBakey VA Medical Center 华南肿瘤学国家重点实验室中山大学肿防治中心中国医学科学院中国协医科大学肿瘤医院

目的:前列腺在美国是最常见的非上皮性恶性肿瘤,占其男性癌症死因的第二位。放射治疗是前列腺癌重要的治疗手段。新一代的生物反应修饰剂,如以细胞膜为靶点的烷基化磷脂复合物Perifosine,增强了多种恶性肿瘤的放射效应。本研究的目的是...

目的:前列腺在美国是最常见的非上皮性恶性肿瘤,占其男性癌症死因的第二位。放射治疗是前列腺癌重要的治疗手段。新一代的生物反应修饰剂,如以细胞膜为靶点的烷基化磷脂复合物Perifosine,增强了多种恶性肿瘤的放射效应。本研究的目的是探导Perifosine通过抑制PI3K/AKT信号转导通路是否增强了人前列腺癌的放射效应。

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science China(Information sciences) 2024年第1期67卷 310-311页

作者： bin CHENG bin HE College of Electronics and Information Engineering Tongji University Frontiers science Center for Intelligent Autonomous systems

Multi-agent systems (MAss) have garnered widespread attention and have been investigated by numerous researchers in recent years, primarily due to their broad applications in industry, transportation, agriculture, and astronomy. While studying the cooperative control of MAss, numerous researchers place emphasis on reducing the frequency of communication among neighboring agents.

关键词： Directed graphs

The Immense Impact of Reverse Edges on Large Hierarchical Networks

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Engineering 2024年第5期36卷 240-249页

作者： Haosen Cao bin-bin Hu Xiaoyu Mo Duxin Chen Jianxi Gao Ye Yuan Guanrong Chen Tamás Vicsek Xiaohong Guan Hai-Tao Zhang MOE Engineering Research Center of Autonomous Intelligent Unmanned systems State Key Laboratory of Intelligent Manufacturing Equipment and TechnologySchool of Artificial Intelligence and AutomationHuazhong University of Science and TechnologyWuhan 430074China school of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Jiangsu Key Laboratory of Networked Collective Intelligence School of MathematicsSoutheast UniversityNanjing 210096China Department of Computer science Rensselaer Polytechnic InstituteTroyNY 12180USA Department of Electronic Engineering City University of Hong KongHong Kong 999077China Department of Biological Physics Eötvös UniversityBudapest 1117Hungary MOE Key Laboratory for Intelligent Networks and Network security School of Automation Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Hierarchical networks are frequently encountered in animal groups,gene networks,and artificial engineering systems such as multiple robots,unmanned vehicle systems,smart grids,wind farm networks,and so *** structure of a large directed hierarchical network is often strongly influenced by reverse edges from lower-to higher-level nodes,such as lagging birds’howl in a flock or the opinions of lowerlevel individuals feeding back to higher-level ones in a social *** study reveals that,for most large-scale real hierarchical networks,the majority of the reverse edges do not affect the synchronization process of the entire network;the synchronization process is influenced only by a small part of these reverse edges along specific *** surprisingly,a single effective reverse edge can slow down the synchronization of a huge hierarchical network by over 60%.The effect of such edges depends not on the network size but only on the average in-degree of the involved *** overwhelming majority of active reverse edges turn out to have some kind of“bunching”effect on the information flows of hierarchical networks,which slows down synchronization *** finding refines the current understanding of the role of reverse edges in many natural,social,and engineering hierarchical networks,which might be beneficial for precisely tuning the synchronization rhythms of these *** study also proposes an effective way to attack a hierarchical network by adding a malicious reverse edge to it and provides some guidance for protecting a network by screening out the specific small proportion of vulnerable nodes.

关键词： synchronizability Large hierarchical networks Reverse edges Information flows Complex networks