检索结果-南通市图书馆

Manipulation of MHC-I/TCR Interaction for Immune Therapy

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2008年第3期5卷 171-182页

作者： Qingjun Liu bin gao Institute of Biotechnology Academy of Military Medical Sciences Beijing100071 China Institute of Microbiology Chinese Academy of Sciences （CAS） Beijing100101 China Institute of Microbiology Chinese Academy of Sciences （CAS） Beijing 100101 China.

Adoptive immunotherapy involving the transfer of autologous tumor or virus-reactive T lymphocytes has been demonstrated to be effective in the eradication of cancer and virally infected cells. Identification of MHC-restricted antigens and progress in generation of adaptive immune responses have provided new direction for such treatment for severe pathologies such as cancer and autoimmune diseases. Here we review the latest development about the molecular basis of MHC-I/TCR interaction, and it＇s manipulation including enhanced MHC-I expression, modification of peptide and engineered TCR for clinical applications such as vaccine design, tumor therapy and autoimmune diseases.

关键词： MHC-I TCR MHC-I/TCR interaction immune therapy

From basic liver immunology to therapeutic opportunities for liver diseases

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第1期18卷 1-3页

作者： Dechun Feng bin gao Laboratory of Liver Diseases National Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMD 20892USA

Five years ago,we launched a special issue in the Cellular&Molecular Immunology with a focus on basic liver immunology,which included eight review articles covering the knowledge about immunological features of the liver.1 To date,these articles have been cited more than 1200 times according to the Google *** the past 5 years,enormous progress has been made in the understanding of liver immunology and the identification of various therapeutic strategies targeting inflammatory mediators for the diagnosis and treatment of liver ***,we are honored and excited to present another follow-up special issue to discuss the updated knowledge of translational liver immunology and the therapeutic targets based on the knowledge we learned from the studies of liver immunology.

关键词： therapeutic diagnosis Immunology

The Complement System in Liver Diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2006年第5期3卷 333-340页

作者： Xuebin Qin bin gao Laboratory for Translational Research Harvard Medical School Cambridge MA 02139 USA Section on Liver Biology Laboratory of Physiologic Studies National Institute on Alcohol Abuse and Alcoholism National Institutes of Health Bethesda MD 20892 USA Laboratory for Translational Research Harvard Medical School One Kendall Square Building 600 3rd Floor Cambridge MA 02139 USA.

The complement system plays an important role in mediating both acquired and innate responses to defend against microbial infection, and in disposing immunoglobins and apoptotic cells. The liver （mainly hepatocytes） is responsible for biosynthesis of about 80-90% of plasma complement components and expresses a variety of complement receptors. Recent evidence from several studies suggests that the complement system is also involved in the pathogenesis of a variety of liver disorders including liver injury and repair, fibrosis, viral hepatitis, alcoholic liver disease, and liver ischemia/reperfusion injury. In this review, we will discuss the potential role of the complement system in the pathogenesis of liver diseases. Cellular ＆ Molecular Immunology.

关键词： immunity complement liver disease

Basic liver immunology

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2016年第3期13卷 265-266页

作者： bin gao Laboratory of Liver Diseases National Institute onAlcohol Abuse and Alcoholism (NIAAA) NationalInstitutes of Health (NIH) Bethesda MD 20892USA

The liver is the largest solid organ in the body and has many unique immunological properties, including induction of immune tolerance, strong innate immunity, poor adaptive immune response versus overreactive autoimmunity and hematopoiesis in the fetal liver. Thus, the liver has been proposed as ＇an immunological organ＇. Although the primary functions of the liver are not traditionally considered to be immunological, the liver also performs many essential immune tasks. For example, hepatocytes are responsible for the production of 80-90% of the circulating innate immunity proteins in the body,

关键词：

New topological semimetai Candidate of nonsymmorphic PdSb2 with unique six-fold degenerate point

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of physics 2019年第4期14卷 1-3页

作者： Guangcun Shan Hai-bin gao School of Instrument Science and Opto-electronic Engineering & Institute of Quantum Sensing Beihang University Beijing 100083 China Max Planck Institute for Chemical Physics of Solids Nothnitzer Str. 40 D-01187 Dresden Germany Institute of Experimental Physics Saarland University 66123 Saarbriicken Germany

Since the discovery of Majorana fermions in condensed matter systems, new quasiparticle predictions of novel fermions have been predicted in solid state systems which exhibit three, six or eight fold degenerate band crossings protected by crystal symmetty in presence of spin orbit coupling and time reversal symmetry [1]. The nontrivial topology in condensed matter systems results from the crossings of conduction and valence bands. And the cases of g = 3, 6, and 8 are of particularly interesting as they can only be found in condensed matter systems, having no high energy analogues as constrained by Poincare symmetry [2].

关键词： discovery fermions time

Fault tolerant control for near space vehicle:a survey and some new results

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2011年第1期22卷 88-94页

作者： Yufei Xu bin Jiang Zhifeng gao Ke Zhang College of Automation Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 P. R. China

A review on fault-tolerant control（FTC） for near space vehicle（NSV） is ***,the concept of near space is introduced,the background of NSV is emphasized,and the model characteristics of NSV in faulty case are ***,a comparison of different existing approaches is briefly carried out,and achievements on the current research in this field are also presented in the view of the practical ***,several existing advanced FTC results for nonlinear flight control systems are ***,the recent literature of NSV are presented to provide an overall view of future developments in this area.

关键词： near space vehicle(NSV) fault-tolerant control(FTC) adaptive sliding mode.

Interleukin-22 from bench to bedside:a promising drug for epithelial repair

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第7期16卷 666-667页

作者： bin gao Xiaogang Xiang Laboratory of Liver Diseases National Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMD 20892USA

Cellular and Molecular Immunology(CMI),the official journal of theChinese Society of Immunology,was established in *** hasnow become one of the leading international journals in the fieldand publishes high-quality original articles and *** veryfirst research article published in the inaugural issue of CMI wasfrom our group and described,for the first time,the protectiveeffect of interleukin-22(IL-22)on the epithelium in the liver.1Fascinatingly,14 years later,the first-in-human phase I clinicalstudy of human IL-22-Fc dimer(F-652)in healthy subjects is alsopublished in CMI.2 We are very excited to see these interestingstudies of IL-22 from bench to bedside published in CMI alongsideits strong growth as a journal over the last 14 years.

关键词： Immunology protective Interleukin

Investigation of the synaptic device based on the resistive switching behavior in hafnium oxide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2015年第1期25卷 47-50页

作者： bin gao Lifeng Liu Jinfeng Kang Institute of Microelectronics Peking University

Metal-oxide based electronics synapse is promising for future neuromorphic computation application due to its simple structure and fabfriendly materials. Hf Oxresistive switching memory has been demonstrated superior performance such as high speed, low voltage, robust reliability, excellent repeatability, and so on. In this work, the Hf Oxsynaptic device was investigated based on its resistive switching phenomenon. Hf Oxresistive switching device with different electrodes and dopants were fabricated. Ti N/Gd:Hf Ox/Pt stack exhibited the best synaptic performance, including controllable multilevel ability and low training energy consumption. The training schemes for memory and forgetting were developed.

关键词： Hafnium oxide(HfOx) Resistive switching Memristor Multilevel cell(MLC) Synapse

Hepatocytes： a key cell type for innate immunity

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2016年第3期13卷 301-315页

作者： Zhou Zhou Ming-Jiang Xu bin gao Laboratory of Liver Diseases National Institute on Alcohol Abuse and Alcoholism National Institutes of Health Bethesda MD USA

Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism, detoxification, and protein synthesis. Hepatocytes also activate innate immunity against invading microorganisms by secreting innate immunity proteins. These proteins include bactericidal proteins that directly kill bacteria, opsonins that assist in the phagocytosis of foreign bacteria, iron-sequestering proteins that block iron uptake by bacteria, several soluble factors that regulate lipopolysaccharide signaling, and the coagulation factor fibrinogen that activates innate immunity. In this review, we summarize the wide variety of innate immunity proteins produced by hepatocytes and discuss liver-enriched transcription factors （e.g. hepatocyte nuclear factors and CCAAT/enhancer-binding proteins）, pro-inflammatory mediators （e.g. interleukin （IL）-6, IL-22, IL-lp and tumor necrosis factor-a）, and downstream signaling pathways （e.g. signal transducer and activator of transcription factor 3 and nuclear factor-KB） that regulate the expression of these innate immunity proteins. We also briefly discuss the dysregulation of these innate immunity proteins in chronic liver disease, which may contribute to an increased susceDtibilitv to bacterial infection in oatients with cirrhosis.

关键词： Liver acute phase protein cytokine infection transcription factor