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Socioeconomic traits and the risk of Barrett’s esophagus and gastroesophageal reflux disease: A Mendelian randomization study

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2631-2645页

作者： Yu-Xin Liu Cheng-Li bin Lu Zhang Wen-Tao Yang bai-Ping An Department of Oncology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Gynecology and Obstetrics Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Endocrine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Cardiovascular Chengdu Integrated TCM&Western Medicine HospitalChengdu 610041Sichuan ProvinceChina

BACKGROUND Previous observational studies have shown that the prevalence of gastroesophageal reflux disease(GERD)and Barrett’s esophagus(BE)is associated with socioeconomic ***,due to the methodological limitations of traditional observational studies,it is challenging to definitively establish *** To explore the causal relationship between the prevalence of these conditions and socioeconomic status using Mendelian randomization(MR).METHODS We initially screened single nucleotide polymorphisms(SNPs)to serve as proxies for eight socioeconomic status phenotypes for univariate MR *** inverse variance weighted(IVW)method was used as the primary analytical method to estimate the causal relationship between the eight socioeconomic status phenotypes and the risk of GERD and *** then collected combinations of SNPs as composite proxies for the eight socioeconomic phenotypes to perform multivariate MR(MVMR)analyses based on the IVW MVMR ***,a two-step MR mediation analysis was used to examine the potential mediation of the associations by body mass index,major depressive disorder(MDD),smoking,alcohol consumption,and sleep *** The study identified three socioeconomic statuses that had a significant impact on *** included household income[odds ratio(OR):0.46;95% confidence interval(95%CI):0.31-0.70],education attainment(OR:0.23;95%CI:0.18-0.29),and the Townsend Deprivation Index at recruitment(OR:1.57;95%CI:1.04-2.37).These factors were found to independently and predominantly influence the genetic causal effect of ***,the mediating effect of educational attainment on GERD was found to be mediated by MDD(proportion mediated:10.83%).Similarly,the effect of educational attainment on BE was mediated by MDD(proportion mediated:10.58%)and the number of cigarettes smoked per day(proportion mediated:3.50%).Additionally,the mediating effect of household income on GERD was observed to be mediated by sleep dur

关键词： Socioeconomic status Gastroesophageal reflux disease Barrett’s esophagus Two-step Mendelian randomization Multivariate Mendelian randomization

Characteristics and suppression of beam distortion in a high repetition rate nanosecond stimulated Brillouin scattering phase conjugation mirror

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High Power Laser Science and Engineering 2024年第2期12卷 69-78页

作者： Yifu Chen Bowen Tan Duo Jin bin Chen Zhenxu bai Kun Wang Yulei Wang Zhiwei Lü School of Astronautics Harbin Institute of TechnologyHarbinChina Center for Advanced Laser Technology Hebei University of TechnologyTianjinChina Hebei Key Laboratory of Advanced Laser Technology and Equipment TianjinChina School of Energy and Environmental Engineering Hebei University of TechnologyTianjinChina

The stimulated Brillouin scattering phase conjugation mirror (SBS-PCM) based on liquid media is widely used in high-power laser systems due to its robust thermal load capacity, high energy conversion efficiency and improved beam quality. Nevertheless, with an increase in the pump repetition rate, thermally-induced blooming and optical breakdown can emerge, leading to distortions in the Stokes beam. In this study, we delved into the thermal effects in liquid SBS-PCMs employing hydrodynamic analysis, establishing a relationship between beam profile distortion and the thermal convection field. We calculated the temperature and convection velocity distribution based on the pump light parameters and recorded the corresponding beam profiles. The intensities of the beam profiles were modulated in alignment with the convection directions, reaching a velocity peak of 2.85 mm/s at a pump pulse repetition rate of 250 Hz. The residual sum of squares (RSS) was employed to quantify the extent of beam profile distortion relative to a Gaussian distribution. The RSS escalated to 7.8, in contrast to 0.7 of the pump light at a pump pulse repetition rate of 500 Hz. By suppressing thermal convection using a high-viscosity medium, we effectively mitigated beam distortion. The RSS was reduced to 0.7 at a pump pulse repetition rate of 500 Hz, coinciding with a twentyfold increase in viscosity, thereby enhancing the beam quality. By integrating hydrodynamic analysis, we elucidated and mitigated distortion with targeted solutions. Our research offers an interdisciplinary perspective on studying thermal effects and contributes to the application of SBS-PCMs in high-repetition-rate laser systems by unveiling the mechanism of photothermal effects.

关键词： beam profile high power high repetition rate stimulated Brillouin scattering phase conjugation mirror thermal convection

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记内蒙古新发现的始新世恐角目(哺乳动物纲)化石

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古脊椎动物学报 2006年第3期44卷 250-261页

作者：白滨中国科学院古脊椎动物与古人类研究所

记述了采自内蒙古二连盆地努和廷勃尔和始新世的Uintatherium sp．和Gobiatherium mirificum两件较破碎的下颌标本。Uintatherium sp．下颌粗壮,下颌突明显,下门齿双叶形,m3下后附尖很小且紧靠下三角座,下次小尖膨大,不与下跟座后脊分离... 详细信息

记述了采自内蒙古二连盆地努和廷勃尔和始新世的Uintatherium sp．和Gobiatherium mirificum两件较破碎的下颌标本。Uintatherium sp．下颌粗壮,下颌突明显,下门齿双叶形,m3下后附尖很小且紧靠下三角座,下次小尖膨大,不与下跟座后脊分离,不具下次小尖脊和下内尖脊。新标本的产出层位在脑木根组的顶部,时代为早始新世早期,是目前已知最早的Uin- tatherium的代表。Gobiatherium mirificum标本产自阿山头组底部,其下颌水平支长且浅,无下颌突,整个下颌显得纤细,m3下后附尖和下后尖距离较远,下后附尖有一脊延伸到下后脊。到目前为止,在内蒙古该种仅分布在阿山头组。

关键词：内蒙古二连盆地始新世脑木根组阿山头组恐角目

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论法教义学:源流、特征及其功能

环球法律评论 2010年第3期32卷 5-17页

作者：白斌浙江大学光华法学院

法教义学乃是一门将现行实在法秩序作为坚定信奉而不加怀疑的前提,并以此为出发点开展体系化与解释工作的规范科学。它研究以规范现象之身份而出现的法,因对现行法秩序的合理性保持确信,故而总是以一国现行实在法秩序为工作的基础及界限... 详细信息

法教义学乃是一门将现行实在法秩序作为坚定信奉而不加怀疑的前提,并以此为出发点开展体系化与解释工作的规范科学。它研究以规范现象之身份而出现的法,因对现行法秩序的合理性保持确信,故而总是以一国现行实在法秩序为工作的基础及界限,并在此背景下开展体系化与解释的工作。在实践方面,它坚持认知主义的立场,主张现实问题的有解性,以实现更多具体细节上的正义为目标。对我国而言,法教义学在体系化和维护法的安定性、减轻负担与制约恣意、解答具体法律问题和促进法治成熟、沟通理论界和实务界以及构建法律共同体等方面的功能应受重视。

关键词：法教义学概念法学法学方法法律方法法理学

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宁夏灵武出土西夏文文献探考

宁夏社会科学 2006年第1期 92-99页

作者：白滨中国社会科学院民族学与人类学研究所北京100081

1917年,宁夏灵武出土一批西夏文佛经,出土后即部分遭到散佚。1929年有一部分辗转入藏北京图书馆,即今国家图书馆,成为今天国内收藏西夏文佛经最富的单位。本文根据当事人留存的著录、研究著作和回忆文章探讨这批西夏文佛经文献出土的时... 详细信息

1917年,宁夏灵武出土一批西夏文佛经,出土后即部分遭到散佚。1929年有一部分辗转入藏北京图书馆,即今国家图书馆,成为今天国内收藏西夏文佛经最富的单位。本文根据当事人留存的著录、研究著作和回忆文章探讨这批西夏文佛经文献出土的时间、地点;出土文献的数量、种类,国内诸家收藏及流失海外的情况;介绍灵武出土西夏文佛经出土之后迄今的著录、整理和研究概况。认为今人对其中已有定论的所谓元刊活字本《大方广佛华严经》的时代问题提出质疑,应当引起研究者注意。

关键词：宁夏灵武西夏文佛经文献

湖北武昌任家湾东吴初年“道士”郑丑墓再研究

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江汉考古 2006年第4期 58-66,72页

作者：白彬四川大学历史文化学院考古系四川成都610064

20世纪50年代湖北武昌任家湾发现的东吴郑丑墓,是我国现存最早的一座道士墓。其墓葬形制、砌筑方法,与同一时期俗人墓相比基本一致,随葬器物既有若干相同或相似之处,但亦有较大的差异。具有明显中原北方地区汉魏墓葬特点的东吴“道士”... 详细信息

20世纪50年代湖北武昌任家湾发现的东吴郑丑墓,是我国现存最早的一座道士墓。其墓葬形制、砌筑方法,与同一时期俗人墓相比基本一致,随葬器物既有若干相同或相似之处,但亦有较大的差异。具有明显中原北方地区汉魏墓葬特点的东吴“道士”郑丑墓在江南地区的出现,证明早在东汉末年,就已经有天师道在江南地区活动;江南地区早期天师道与中原北方地区有密切的渊源关系;中原地区早期天师道应是经由淮河流域传入江南的。

关键词：湖北武昌东吴郑丑墓道士

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基于SVM回归柔性机构的动态可靠性研究

工程力学 2014年第12期31卷 208-216页

作者：韩彦彬白广忱李晓颖白斌北京航空航天大学能源与动力工程学院中国人民解放军93705部队58分队河北联合大学电气工程学院

在柔性机构(Flexibility Mechanism,FM)动态可靠性分析中,为了提高其计算精度和计算效率,通过融合蒙特卡洛和支持向量机回归理论,提出了一种新的SVM回归极值法(SVM Regression Extremum Method,SREM)。该方法借助ADAMS软件抽取FM动态响... 详细信息

在柔性机构(Flexibility Mechanism,FM)动态可靠性分析中,为了提高其计算精度和计算效率,通过融合蒙特卡洛和支持向量机回归理论,提出了一种新的SVM回归极值法(SVM Regression Extremum Method,SREM)。该方法借助ADAMS软件抽取FM动态响应极值的小样本,基于支持向量机回归理论建立FM动态响应极值的代理模型,使用此代理模型进行FM动态响应可靠性分析。最后,利用蒙特卡洛法、SVM回归极值法和另外两种方法对柔性曲柄摇杆机构的摇杆最大摆角可靠度进行分析。结果显示:在小样本情况下,SVM回归极值法的计算精度与MC相当,精度明显高于另外两种方法;SVM回归极值法的计算效率比MC大幅度提高,与另外两种方法计算效率相当。验证了在小样本情况下,SREM在FM动态可靠性分析中高效率和高精度。

关键词：柔性机构支持向量机回归蒙特卡洛法动态可靠性 SVM回归极值法

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Ab initio study of dynamical properties of U-Nb alloy melt

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Chinese Physics B 2021年第12期30卷 515-522页

作者： Yong-Peng Shi Ming-Feng Liu Yun Chen Wen-Lin Mo Dian-Zhong Li Tao Fa bin bai Xiao-Lin Wang Xing-Qiu Chen Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Institute of Materials China Academy of Engineering PhysicsJiangyou 621907China

The U-Nb alloy,as a kind of nuclear material with good corrosion resistance and mechanical properties,plays an important role in the nuclear ***,the experimental measurements and theoretical calculations of many parameters which are essential in describing the dynamical properties of this alloy melt,including density,diffusivity,and viscosity,have not been carried out *** lack of data on the dynamical properties of nuclear materials seriously hinders the high-performance nuclear materials from being developed and *** this work,the dynamical properties of the U-Nb alloy melt are systematically studied by means of ab initio molecular dynamics simulations and their corresponding mathematical models are established,thereby being able to rapidly calculate the densities,diffusion coefficients,viscosities,and their activation energies in the whole U-Nb liquid *** work provides a new idea for investigating the dynamical properties of binary alloy melts,thereby promoting the development of melt research.

关键词： U-Nb alloy melt dynamical properties ab initio study

自适应粒子群优化支持向量回归的工程系统可靠性预测

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机械工程学报 2023年第14期59卷 328-338页

作者：周策白斌叶楠河北工业大学机械工程学院天津300401 三一重工股份有限公司长沙400100

针对可靠性预测精度低的问题提出了一种支持向量机回归预测模型。在可靠性预测过程中,开发了一种结合正弦映射和自适应策略来更新惯性权重的自适应粒子群优化算法,通过增强算法的局部挖掘能力与全局搜索能力,在一定程度上提高了粒子群... 详细信息

针对可靠性预测精度低的问题提出了一种支持向量机回归预测模型。在可靠性预测过程中,开发了一种结合正弦映射和自适应策略来更新惯性权重的自适应粒子群优化算法,通过增强算法的局部挖掘能力与全局搜索能力,在一定程度上提高了粒子群算法的精度和收敛效率。基于8种测试基准函数将提出的算法与其他粒子群算法进行比较验证,结果表明,提出的自适应粒子群算法相比于其他算法具有更好的搜索能力。在此基础上,提出了一种新的自适应粒子群优化-支持向量机回归混合可靠性预测模型,对支持向量机回归的参数进行调整并预测涡轮增压器和工业机器人系统的可靠性,结果表明该混合模型在可靠性预测方面可达到实际工程精度要求。

关键词：可靠性预测支持向量机粒子群算法涡轮增压器工业机器人