检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

红景天苷对力竭大鼠心肌收缩力的影响

解放军医学杂志 2018年第6期43卷 472-477页

作者：齐江莉李泱解亚楠曹雪滨石家庄市第二医院重症医学科石家庄050000 解放军总医院心内科北京100853 解放军252医院心内科河北保定071000

目的探讨红景天苷对力竭大鼠心肌收缩力的影响,为临床力竭心脏损伤防护提供新的思路。方法40只雄性SD大鼠随机分为4组(n=10):对照组,力竭组,红景天苷A、B组。Thomas方法制备力竭大鼠模型。红景天苷A、B组分别给予15、3.mg/(kg·d)红景... 详细信息

目的探讨红景天苷对力竭大鼠心肌收缩力的影响,为临床力竭心脏损伤防护提供新的思路。方法40只雄性SD大鼠随机分为4组(n=10):对照组,力竭组,红景天苷A、B组。Thomas方法制备力竭大鼠模型。红景天苷A、B组分别给予15、3.mg/(kg·d)红景天苷溶液,对照组、力竭组给予等体积0.9%NaCl溶液,腹腔注射2周。ELISA法检测各组血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、肌钙蛋白I(TnI)含量的变化。采用Langendorff装置分离大鼠心室肌细胞,以Ion Optix细胞收缩和钙离子浓度同步测定系统检测大鼠心肌细胞的收缩功能和钙瞬变,激光共聚焦显微镜线扫描成像技术记录心肌细胞自发性钙火花及肌质网钙含量。结果与对照组比较,力竭组大鼠心肌细胞钙瞬变、最大收缩幅度分别降低41%和45%(P3.%,最大收缩幅度分别增加了25%、54%(P<0.01),钙火花发生率明显降低(P<0.01),心肌细胞肌质网钙离子含量明显增加(P<0.01);且红景天苷B组各指标均明显优于红景天苷A组(P<0.05或P<0.01)。结论红景天苷可改善力竭运动造成的心肌细胞收缩力减弱,其机制与细胞内钙离子调控有关。

关键词：力竭运动红景天苷钙瞬变钙火花

Designing novel adaptive dynamic event-triggered protocols for uncertain multi-agent systems

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第1期67卷 310-311页

作者： bin CHENG bin HE College of Electronics and Information Engineering Tongji University Frontiers Science Center for Intelligent Autonomous Systems

Multi-agent systems (MASs) have garnered widespread attention and have been investigated by numerous researchers in recent years, primarily due to their broad applications in industry, transportation, agriculture, and astronomy. While studying the cooperative control of MASs, numerous researchers place emphasis on reducing the frequency of communication among neighboring agents.

关键词： Directed graphs

桃主要性状的分子标记与功能基因定位研究进展

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

果树学报 2018年第3期35卷 334-346页

作者：连晓东谭彬郑先波陈谭星王婷栗焕楠冯建灿河南农业大学林学院郑州450002 河南农业大学园艺学院郑州450002 河南省果树瓜类生物学重点实验室郑州450002

综述了桃果实、花、树体及抗根结线虫等主要性状的功能基因定位和分子标记开发的最新研究成果,阐述了决定果皮茸毛有无、果肉颜色(黄/白)、果肉质地与核黏离性、短枝型矮化和柱型等质量性状的功能基因定位,分析了1个与成熟期主效位点相... 详细信息

综述了桃果实、花、树体及抗根结线虫等主要性状的功能基因定位和分子标记开发的最新研究成果,阐述了决定果皮茸毛有无、果肉颜色(黄/白)、果肉质地与核黏离性、短枝型矮化和柱型等质量性状的功能基因定位,分析了1个与成熟期主效位点相关的重要候选基因,同时对决定果实糖、酸含量变化的QTL以及根结线虫(Meloidogyne incognita)、蚜虫(Myzus persicae Sulzer.)抗性相关位点的研究进展进行总结,为桃性状定位和整个发育期调控糖、酸含量的基因及其作用模式研究提供参考。在此基础上,对功能基因和分子标记在辅助选择育种和种质资源鉴定中的应用及发展方向进行展望。

关键词：桃性状定位功能基因分子标记

Protein acetylation sites with complex-valued polynomial model

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第3期18卷 217-226页

作者： Wenzheng BAO bin YANG School of Information Engineering Xuzhou University of TechnologyXuzhou 221018China School of Information Science and Engineering Zaozhuang UniversityZaozhuang 277160China

Protein acetylation refers to a process of adding acetyl groups(CH3.O-)to lysine residues on protein *** one of the most commonly used protein post-translational modifications,lysine acetylation plays an important role in different *** our study,we developed a humanspecific method which uses a cascade classifier of complexvalued polynomial model(CVPM),combined with sequence and structural feature descriptors to solve the problem of imbalance between positive and negative *** gene expression programming and differential evolution are utilized to search the optimal CVPM *** also made a systematic and comprehensive analysis of the acetylation data and the prediction *** performances of our proposed method are 79.15%in Sp,78.17%in Sn,78.66%in ACC 78.76%in F1,and 0.573. in MCC,which performs better than other state-of-the-art methods.

关键词： protein acetylation complex-valued polynomial model machine learning

Comprehensive Assessment of STGSA Generated Skeletal Mechanism for the Application in Flame-Wall Interaction and Flame-Flow Interaction

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第5期33卷 1946-1960页

作者： YU Chunkan YANG bin Institute of Technical Thermodynamics Karlsruhe Institute of TechnologyKarlsruhe 76131Germany Center for Combustion Energy Tsinghua UniversityBeijing 100084China

In this study,we conduct a thorough evaluation of the STGSA-generated skeletal mechanism for C_(2)H_4/*** STGSA-reduced mechanisms are taken into account,incorporating basic combustion models such as the homogeneous reactor model,one-dimensional flat premixed flame,and non-premixed counterflow ***,these models are applied to more complex combustion systems,considering factors like flame-flow interaction and flame-wall *** considerations take into account additional physical parameters and processes such as mixing frequency and *** results indicate that the skeletal mechanism adeptly captures the behavior of these complex combustion ***,it is suggested to incorporate strain rate considerations in generating the skeletal mechanism,especially when the combustion system operates under high turbulent intensity.

关键词： Species-Targeted Global Sensitivity Analysis(STGSA) mechanism reduction Partially Stirred Reactor(PaSR) spark ignition Head-on Quenching(HoQ)

Collective Molecular Machines: Multidimensionality and Reconfigurability

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第8期16卷 309-340页

作者： bin Wang Yuan Lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical *** the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense *** progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and ***,individual molecular machines are only capable of producing nanometer work and generally have only a single *** order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new *** this review,we comprehensively discuss recent developments in the collective behaviors of molecular *** particular,collective behavior is divided into two *** is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional *** other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale *** discuss design strategies for both modes and focus on the modulation of features and ***,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

An Icy Worlds life detection strategy based on Exo-AUV

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第11期67卷 3515-3535页

作者： bin WANG Hongde QIN National Key Laboratory of Autonomous Marine Vehicle Technology Harbin Engineering University Shipbuilding Engineering College Harbin Engineering University

In the solar system, Icy Worlds such as Europa and Enceladus hold great potential for extraterrestrial life and may provide humanity an answer, within this century, to the age-old question of life beyond Earth. Exo-AUV technology shows promise in life detection in the icy shell, at the ice-water interface and on the seafloor of exo-ocean. Space agencies, including NASA and DLR, are enthusiastic about deploying Exo-AUVs to explore life in these regions. However, the where and how to find life, the technologies to be utilized and the goals to be achieved are crucial aspects for future Exo-AUV life detection missions on Icy Worlds. This study delves into a hypothetical mission of life detection on Europa, discussing science goals,detectable objects, potential regions and biogenic analysis for Icy Worlds. It proposes a life detection strategy for Icy Worlds based on Exo-AUVs, presents key contextual elements for Exo-AUV operations, outlines technological requirements for hull,payloads and autonomy, introduces the current state of Exo-AUV research and addresses existing challenges. This study also suggests a roadmap for conceptual development of Exo-AUV and a Concept of Operations for Multiple Exo-AUV System(ConOps for MEAS). This system aims to assist planetary scientists and astrobiologists in exploring Icy Worlds, identifying robust biosignatures and potentially discovering extant organisms, even prebiotic chemical systems.

关键词： Icy Worlds Europa Life detection Biological potential Exo-AUV

Feasibility of medical radioisotope production based on the proton beams at China Spallation Neutron Source

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第6期35卷 26-39页

作者： bing Jiang bin-bin Tian Han-Tao Jing Qi-Fan Dong Spallation Neutron Source Science Center Dongguan 523803China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The utilization of a proton beam from the China Spallation Neutron Source(CSNS)for producing medical radioisotopes is appealing owing to its high current intensity and high *** medical isotope production based on the proton beam at the CSNS is significant for the development of future radiopharmaceuticals,particularly for theα-emitting *** production yield and activity of typical medical isotopes were estimated using the FLUKA *** results indicate that the 3.0-MeV proton beam with a power of 100 kW at CSNS-II is highly suitable for proof-of-principle studies of most medical *** particular,this proton beam offers tremendous advantages for the large-scale production of alpha radioisotopes,such as 225Ac,whose theoretical production yield can reach approximately 57 Ci/*** on these results,we provide perspectives on the use of CSNS proton beams to produce radioisotopes for medical applications.

关键词： CSNS proton beam Medical isotope production α-Emitting radionuclides Nuclidic purity analysis

Evaluation of frictional pressure drop correlations for air-water and air-oil two-phase flow in pipeline-riser system

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1305-1319页

作者： Nai-Liang Li bin Chen School of Low-carbon Energy and Power Engineering China University of Mining and TechnologyXuzhou221116JiangsuChina State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049ShaanxiChina

Accurate prediction of the frictional pressure drop is important for the design and operation of subsea oil and gas transporting system considering the length of the pipeline. The applicability of the correlations to pipeline-riser flow needs evaluation since the flow condition in pipeline-riser is quite different from the original data where they were derived from. In the present study, a comprehensive evaluation of 24prevailing correlation in predicting frictional pressure drop is carried out based on experimentally measured data of air-water and air-oil two-phase flows in pipeline-riser. Experiments are performed in a system having different configuration of pipeline-riser with the inclination of the downcomer varied from-2°to-5°to investigated the effect of the elbow on the frictional pressure drop in the riser. The inlet gas velocity ranges from 0.03.to 6.2 m/s, and liquid velocity varies from 0.02 to 1.3.m/s. A total of885 experimental data points including 782 on air-water flows and 103.on air-oil flows are obtained and used to access the prediction ability of the correlations. Comparison of the predicted results with the measured data indicate that a majority of the investigated correlations under-predict the pressure drop on severe slugging. The result of this study highlights the requirement of new method considering the effect of pipe layout on the frictional pressure drop.

关键词： Frictional pressure drop Pipeline-riser Gas-liquid two-phase flow Severe slugging Correlation