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多发性硬化症患者单核细胞激肽B_1受体的表达:T2加权MRI所示病灶体积和临床残疾相关性的研究

世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 22-23页

作者： Prat A. biernacki k. Saroli T. 江山 Neuroimmunology Laboratory and Multiple Sclerosis Clinic Centre Hospitalier de l'Universitéde Montréal-Hpital No-tre-Dame 1560 Sherbrooke E Montréal Que. H2L 4M1 CanadaDr.

Back.round: We have previously shown that the inducible k.nin B1 receptor is expressed on T lymphocytes during relapses and progression in multiple sclerosis. Objective: To evaluate the correlation between the expression of B1 receptor on peripheral blood mononuclear cells derived from patients who have multiple scle rosis with serial, clinical magnetic resonance imaging and immunological study- derived measures. Design: Using frozen samples obtained from a high-frequency m agnetic resonance imaging-immunological study, we analyzed B1 receptor messenge r RNA (mRNA) expression in peripheral blood-deriv- ed mononuclear cells serially collected from 6 patients with multiple sclerosi s and 8 healthy control subjects by semiquantitative radioactive duplex reverse transcriptasepolymerase chain reaction amplification. Timecourse k.nin B1-actin mRNA ratios were subsequently compared with corresponding clinical magnetic res onance imaging and immune parameters. Results: The time-course k.nin B1-actin mRNA ratio correlated positively with the Expanded Disability Status Scale index (P k.n 2 receptor and major histocompatibility complex class II expression on CD4+lymphocytes, but not with gadoliniumenhancin g lesions. The time-course k.nin B1-actin mRNA ratios were 5 to 25 times lower in samples derived from healthy controls. Conclusion: The correlation of k.nin B1 receptor mRNA levels with dynamic clinical and magnetic resonance imaging mea sures suggests that expression of this receptor can serve as an index of disease activity in multiple sclerosis.

关键词：多发性硬化症 B1 T2加权MRI 病灶体积激肽免疫研究免疫学检查复发率 RNA 肌动蛋白

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Effects of combined cannabidiol(CBD)and hops(Humulus lupulus)terpene extract treatment on RAW 264.7 macrophage viability and inflammatory mark.rs

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Natural Products and Bioprospecting 2023年第1期13卷 554-567页

作者： Inga Dammann Claudia k.il Iris Hardewig Elżbieta Sk.zydlewsk. Michałbiernacki Hajo Haase Sanity Group GmbH Jägerstraße 28-3110117 BerlinGermany Department of Food Chemistry and Toxicology Technische Universität BerlinStraße Des 17.Juni 13510623 BerlinGermany Department of Analytical Chemistry Medical University of BialystokA.Mickiewicza 2D15-222 BialystokPoland

This study investigates the potential of cannabidiol(CBD),one major cannabinoid of the plant Cannabis sativa,alone and in combination with a terpene-enriched extract from Humulus lupulus(“Hops 1”),on the LPS-response of RAW 264.7 macrophages as an established in vitro model of *** the present study,we could support earlier findings of the anti-inflammatory potential of CBD,which showed a dose-dependent[0-5μM]reduction in nitric oxide and tumor necrosis factor-alpha(TNF-α)released by LPS-stimulated RAW 264.7 ***,we observed an additive anti-inflammatory effect after combined CBD[5μM]and hops extract[40μg/mL]*** combination of CBD and Hops 1 showed effects in LPS-stimulated RAW 264.7 cells superior to the single sub-stance treatments and ak.n to the control ***,cellular CBD uptak. increased dose-depend-ently in the presence of terpenes from Hops 1 *** anti-inflammatory effect of CBD and its cellular uptak. positively correlated with terpene concentration,as indicated by comparison with a hemp extract containing both CBD and *** findings may contribute to the postulations for the so-called“entourage effect”between cannabinoids and terpenes and support the potential of CBD combined with phytomolecules from a non-cannabi-noid source,such as hops,for the treatment of inflammatory diseases.

关键词： CBD Terpenes Cannabinoids Entourage effect Inflammation

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