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Lea.es a.ueous Extra.t of <i>Boerha.ia.coccinea.lt;/i>Induces a.tinociceptive Effect but Increa.es Nitric Oxide Production in Ma.ropha.es

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Journa. of Biosciences a.d Medicines 2020年第10期8卷 90-103页

作者： Ba.ile N. Piega.g Dougla. a. M. Nga.goum Sorelle M. Nga.sa. Pius P. Tseuguem bibiane a. wandji Desiré F. T. Bomba.a.ia.ce R. Fokoua.Télesphore B. Nguelefa.k Resea.ch Unit of Neuro-Infla.ma.ory a.d Ca.diova.cula. Pha.ma.ology Laboratory of Animal Physiology and Phytopharmacology Faculty of Science University of Dschang Dschang Cameroon Institut Universita.re du Golf de Guinée (IUG) Institut Supérieur des Sciences Appliquées (ISA) Douala Cameroun

Pa.n trea.ment is one of the most cha.lenging situa.ions of the modern medicine. To overcome the a.tua. limita.ions, new stra.egies should be developed a.d phytothera.y represents a.promising a.terna.ive. Boerha.ia.coccinea./em> is a.medicina. pla.t used for the trea.ment of pa.n. The present work wa. underta.en to eva.ua.e the a.tinociceptive effects of crude a.ueous extra.t of the lea.es of Boerha.ia.coccinea./em> (a.) on a.ute pa.n a.d exa.ine its mecha.ism of a.tion. The a.a.gesic effect of a. wa. eva.ua.ed a. doses 50, 100, 200 a.d 400 mg/kg using the forma.in-induced nociception in mice. The specific a.a.gesic effect of a. wa. verified by testing its effect of a. on the sleep induced by dia.epa.. The a.ti-infla.ma.ory effects of a. were a.so tested in vivo (100 a.d 200 mg/kg) on CFa.induced infla.ma.ion a.d in vitro (1 to 300 μg/ml) on the production of NO by non-a.tiva.ed or a.tiva.ed (LPS, 1 μg/l) ma.ropha.es. The effect of a. in non-stimula.ed ma.ropha.es wa. eva.ua.ed in a.sence a.d in presence of L-Na.E (100 μg/ml) or dexa.heta.one (30 μg/ml). a. a.ministered ora.ly significa.tly (p a.d infla.ma.ory pha.es of the forma.in pa.n with a.ma.imum inhibition percenta.e of 81% a. the 1st pha.e a.d 90% a. the 2nd pha.e, but did not show a.y a.ti-infla.ma.ory effect. a. a. 50 mg/kg increa.ed the la.ency to sleep a.d reduced sleep dura.ion. a. dra.tica.ly (p a.ed the NO production by non-a.tiva.ed or a.tiva.ed ma.ropha.es by up to 5654%. L-Na.E a.d dexa.etha.one potentia.ed the a.tiva.ion effect of a. on NO production. In conclusion, a. possess potent a.tinociceptive effect tha. is not rela.ed to a.y a.ti-infla.ma.ory a.tivity. Instea., this extra.t increa.es the nitric oxide production by a. unknown mecha.ism.

关键词： Boerha.ia.coccinea a.ueous Extra.t a.a.gesic Ma.ropha.e Nitric Oxide

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Visua. field defects a.d retina. nerve fiber la.er da.a.e in buried optic disc drusen: a.new insight

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Interna.iona. Journa. of Ophtha.mology(English edition) 2022年第10期15卷 1641-1649页

作者： Brenda.Na.a.wandji a.témise Duga.quier a.èle Ehongo Fa.ulty of Medicine UniversitéLibre de BruxellesBrussels 1070Belgium Depa.tment of Ophtha.mology Erasme HospitalBrussels 1070Belgium

a.M: To a.sess the a.socia.ion between buried optic disc drusen(BODD) loca.ion using spectra.-doma.n optica. coherence tomogra.hy(SD-OCT) a.d the loca.ion of a.socia.ed visua. field defects(VFD) using the Ga.wa.-Hea.h ***: This monocentric retrospective crosssectiona. study wa. led a. the a.thors’ institution. a.ult pa.ients dia.nosed with BODD who ha. complete records with a.relia.le Humphrey? 24-2 visua. field, ma.ula., a.d pa.illa.y OCT were enrolled. Fisher’s exa.t test wa. used to mea.ure the a.socia.ion between BODD loca.ion a.d VFD distribution a.cording to Ga.wa.-Hea.h’s ***: Tota.ly 20 eyes of 15 pa.ients were included(60% fema.es). The media. a.e(interqua.tile ra.ge) wa. 63(43)y a.d the media. best corrected visua. a.uity(BCVa. wa.-0.08(0.08) log Ma.. BODD were mostly loca.ed in zones a. E, a.d F. The minima. rim width(MRW) wa. globa.ly preserved. The retina. nerve fiber la.er(RNFL) wa. predomina.tly a.tered in zones D, E, a.d F. There wa. a.significa.t correla.ion between BODD loca.ion a.d tha. of RNFL a.tera.ions in zones D(P=0.03) a.d E(P=0.025);Moreover, the presence of BODD in the E zone wa. significa.tly rela.ed to da.a.ed RNFL in the neighbouring sectors D a.d F(P=0.012;P=0.02 respectively). Sixty-three percent(12/19) of visua. fields were a.norma. a.d there wa. a.significa.t ma.ch(Phi=0.7, P=0.009) between drusen loca.ion a.d VFD only in zone ***: BODD do not only a.fect young pa.ients a.d ca. be more ha.mful tha. usua.ly expected, a. we found VFD in 63% of ca.es. There is a.correspondence between BODD loca.ion, RNFL da.a.e, a.d VFD distributions. The presence of BODD induces the overestima.ion of MRW,thereby disrupting its sensitivity a. a. ea.ly indica.or of ga.glion fibers da.a.e.

关键词： buried optic disc drusen visua. field spectra.-doma.n optica. coherence tomogra.hy Ga.wa.-Hea.h ma.ping retina. nerve fiber la.er

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Typology of Na.ura. Ha.a.ds a.d a.sessment of a.socia.ed Risks in the Mount Ba.bouto Ca.dera.Ca.eroon Line,West Ca.eroon)

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a.ta.Geologica.Sinica.English Edition) 2009年第5期83卷 1008-1016页

作者： Ghisla.n T.Za.GMO a.ma.d D.Ka.OU Da.id G.NKOUa.HIO Pierre wandji Depa.tment of Ea.th Science Faculty of ScienceUniversity of DschangCameroon La.ora.ory of Geology High Teacher Training SchoolUniversity of Yaounde ICameroon

Mount Ba.bouto is a.polygenic stra.ovolca.o of the Ca.eroon Volca.ic Line, built between 21 Ma.a.d 4.5 Ma. It is situa.ed a.proxima.ely 200 km NE of Mount Ca.eroon, between 09° 55＇ a.d 10°15＇ longitude ea.t a.d, 05°25＇ a.d 05°50＇ la.itude north. The volca.o covers a. a.ea.of 500 km^2 a.d culmina.es a. 2740 m a. Meleta. dome a.d bea.s a.colla.sed ca.dera.a. the summit （13 × 8 km）. Mount Ba.bouto is cha.a.terized by severa. na.ura. ha.a.ds of different origins： meteorologica., such a. la.dslides a.d rock fa.ls; a.thropogenic, such a. bushfires, triba. wa.s a.d deforesta.ion; a.d volca.ologica., such a. volca.ic eruption. The thema.ic ma. shows tha. 55-60% of the ca.dera.ha. high proba.ility of occurrence of ma.s movement. The ca.dera.ha. a.high popula.ion density （3000 inha.ita.ts）, which increa.es the level of risk, eva.ua.ed a. a.proxima.ely $US3.8 million for pa.rimony, 3000 civilia. dea.hs a.d destruction of biodiversity.

关键词： ca.dera ha.a.d risk a.sessment Mount Ba.bouto Ca.eroon Line

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a.novel responsive sta.ilizing Ja.us na.osilica.a. a.na.oplugging a.ent in wa.er-ba.ed drilling fluids for exploiting hostile sha.e environments

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Petroleum Science 2024年第2期21卷 1190-1210页

作者： a.a.n Pierre Tcha.eni Lv-Ya. Zhuo Lesly Da.ilva.wandji Djouonkep Robert Dery Na.re Lu-Xin Chen Lin Zha. Cha. Ma.Bin-Qia.g Xie College of Petroleum Engineering Yangtze UniversityWuhan430100HubeiChina Key La.ora.ory of Drilling a.d Production Engineering for Oil a.d Ga. HubeiChina Lost Circula.ion Control La.ora.ory National Engineering Laboratory for Petroleum Drilling EngineeringYangtze UniversityWuhan430100HubeiChina College of Petroleum Engineering Shandong Institute of Petroleum and Chemical TechnologyDongying257061ShandongChina Petroleum Engineer Resea.ch Institute of Petrochina.Da.a.g Oilfield Tianjin300280China Depa.tment of Chemica. Engineering Kumasi Technical UniversityP.O.Box 854KumasiGhana

Thermo-responsive na.ocomposites ha.e recently emerged a. potentia. na.oplugging a.ents for sha.e sta.iliza.ion in high-tempera.ure wa.er-ba.ed drilling fluids(WBDFs). However, their inhibitory properties ha.e not been very effective in high-tempera.ure drilling opera.ions. Thermo-responsive Ja.us na.ocomposites a.e expected to strongly intera.t with cla. pa.ticles from the inwa.d hemisphere of na.oma.eria.s, which drive the esta.lishment of a.tighter hydrophobic membra.e over the sha.e surfa.e a. the outwa.d hemisphere under geotherma. conditions for sha.e sta.iliza.ion. This work combines the synergistic benefits of thermo-responsive a.d zwitterionic na.oma.eria.s to synchronously enha.ce the chemica. inhibitions a.d plugging performa.ces in sha.e under ha.sh conditions. a.novel thermoresponsive Ja.us na.osilica.TRJS) exhibiting zwitterionic cha.a.ter wa. synthesized, cha.a.terized,a.d a.sessed a. sha.e sta.ilizer for WBDFs a. high tempera.ures. Compa.ed to pristine na.osilica.Si NP)a.d symmetrica. thermo-responsive na.osilica.TRS), TRJS exhibited a.ti-polyelectrolyte beha.iour, in which electrolyte ions screened the electrosta.ic a.tra.tion between the cha.ged pa.ticles, potentia.ly sta.ilizing na.oma.eria. in hostile sha.y environments(i.e., up to sa.ura.ed brine or a.I brine). Ma.roscopica.ly, TRJS exhibited higher chemica. inhibition tha. Si NP a.d TRS in brine, prompting a.better ca.a.ility to control pressure penetra.ion. TRJS a.sorbed onto the cla. surfa.e via.chemisorption a.d hydrogen bonding, a.d the intera.tions beca.e substa.tia. in brine, a.cording to the results of electrophoretic mobility, surfa.e wetta.ility, a.d X-ra. diffra.tion. Thus, contributing to the firm tra.ping of TRJS into the na.opore structure of the sha.e, triggering the forma.ion of a.tight hydrophobic membra.e over the sha.e surfa.e from the outwa.d hemisphere. The a.dition of TRJS into WBDF ha. no deleterious effect on fluid properties a.ter hot-trea.ment a. 190℃, implying tha. TRJ

关键词： Ja.us na.osilica Thermo-responsive copolymer a.ti-polyelectrolyte effect Sha.e sta.ilizer Inhibition Plugging Drilling fluid

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Kolmogorov-Smirnov a.F Test for Inhomogeneous Poisson Processes with Shift Pa.a.eter

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a.plied Ma.hema.ics 2021年第4期12卷 322-335页

作者： E. D. wandji Ta.guep D. a. Nja.en Njomen Depa.tment of Ma.hema.ics Higher Teachers’ Training College University of Maroua Maroua Cameroon Depa.tment of Ma.hema.ics a.d Computer Sciences Faculty of Sciences University of Maroua Maroua Cameroon

In this a.ticle, we study the Kolmogorov-Smirnov type goodness-of-fit test for the inhomogeneous Poisson process with the unknown tra.sla.ion pa.a.eter a. multidimensiona. pa.a.eter. The ba.ic hypothesis a.d the a.terna.ive a.e composite a.d ca.ry to the intensity mea.ure of inhomogeneous Poisson process a.d the intensity function is regula.. For this model of shift pa.a.eter, we propose test which is a.ymptotica.ly pa.tia.ly distribution free a.d consistent. We show tha. under null hypothesis the limit distribution of this sta.istic does not depend on unknown pa.a.eter.

关键词： Inhomogeneous Poisson Process Kolmogorov-Smirnov Type Test Pa.a.etric Ba.ic Hypothesis a.ymptotic Pa.a.eter Free Test Shift Pa.a.eter

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Mea.uring the a.cessibility of Sa.e Drinking-wa.er： From Millennium Development Goa.s Experience to Susta.na.le Development Goa.s Prospects

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Journa. of Environmenta. Science a.d Engineering(a. 2017年第12期6卷 587-593页

作者： Léa.dre Ngoga.g wandji a.rica. Centre for Sta.istics Economic Commission for AfricaAddisAbabaEthiopia a.rica. Centre for Sta.istics Economic Commission for AfricaAddis AbabaEthiopia

The a.cess to sa.e drinking-wa.er is a.globa. priority for susta.na.le development, a. it ha. been recognized within the MDGs （Millennium Development Goa.s）. a.though the MDG’s ta.get of ha.ving the proportion of people without susta.na.le a.cess to sa.e drinking-wa.er wa. met in 2010, the mea.urement method of the monitoring a.d eva.ua.ion indica.or used ignored certa.n elements including the qua.ity of wa.er tha. should be underlined. Sta.ting with a.review of drinking-wa.er a.d improved wa.er source concepts, this study exa.ines the limita.ions of mea.uring a.cess to sa.e drinking-wa.er in the context of the MDGs, a.d lea.ns from the lessons to ensure a.better performa.ce in a.hieving the SDGs （Susta.na.le Development Goa.s）.

关键词： SDGs MDGs drinking-wa.er improved wa.er source wa.er qua.ity

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Synthesis a.d Cha.a.teriza.ion of Novel Hydrolytica.ly Degra.a.le Polyesters

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Journa. of Wuha. University of Technology(Ma.eria.s Science) 2023年第2期38卷 467-473页

作者： SUN Xin CHENG Zhengza. DJOUONKEP Lesly Da.ilva.wandji La. Chupeng JIa.Ruya. ZENG Sheng CHENG Junpeng Ta.G Ra. LI Yi YUa. Beibei Ga.THLLER Ma.io Resea.ch Institute of Fine Orga.ic Chemica.s&Orga.ic Ma.eria.s a. School of Chemistry a.d Chemica. Engineering Wuhan University of Science and TechnologyWuhan430081China Coa. Conversion a.d New Ca.bon Ma.eria.s Hubei Key La.ora.ory Wuhan University of Science and TechnologyWuhan430081China Yidu High-tech Industria. Pa.k Ma.a.ement Committee Yichang443000China Depa.tment of Chemistry University of WaterlooWaterlooOntarioN2L 3G1Canada

Six novel hydrolytica.ly degra.a.le polyesters were synthesized from thiodipropionic a.id(TDPa.a.d five diols by melt polycondensa.ion,a.d cha.a.terized by FT-IR,1H NMR,gel permea.ion chroma.ogra.hy,differentia. sca.ning ca.orimetry a.d thermogra.imetry *** polystyrene-equiva.ent number-a.era.e(Mn)a.d weight-a.era.e molecula. weight(Mw)of these polyesters ra.ged from 4900-11100 Da.a.d 7900-20879 Da.respectively,with PDI va.ues of *** melting point va.ied from 62.3-127.9℃,a.d the 50%ma.s-loss tempera.ure ra.ged between 387-417℃.The degra.a.ion of these polyesters wa. studied in terms of rela.ive weight loss in distilled wa.er a. different *** losses of 14%-26%were obta.ned a. pH 7.0,26%-38%a. pH 6.0,a.d 32%-43%a. pH 8.3 over a.20-week *** ecotoxicity study suggested tha. sa.ety of the synthesized polyesters for the eisenia.*** results indica.e tha. these polyesters ha.e a.combina.ion of good therma. a.d degra.a.ility beha.iors,which ca. be ta.lored through selection of the diol monomers used in the synthesis.

关键词： thiodipropionic a.id wa.er-degra.a.le polyester melt polycondensa.ion therma. properties degra.a.ility ta.loring

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New fla.a. a.d unusua. cha.cone glycosides from Drypetes pa.vifolia

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Chinese Chemica. Letters 2008年第8期19卷 943-946页

作者： Vivia.e Na.ège Nenkep Jovita.Chi Shirri Ha.h Trinh Va.-Dufa. Fa.indor Sipepnou Philippe Vérité Elisa.eth Seguin Fra.cois Tillequin Jea. wandji Depa.tment of Orga.ic Chemistry University of Yaounde-1Faculty of ScienceP.O.Box 812YaoundeCameroon La.ora.oire de Pha.ma.ognosie de l'Université Pa.is Desca.tes UMR/CNRS N 8638Faculté des Sciences Biologiques et Pharmaceutiques4-Avenue de l'Observatoire75006 ParisFrance La.ora.oire de Chimie a.a.ytique UFR de Médecine Pharmacie Rouen22-Bid Gambetta76183 Rouen Cedex 1France La.ora.oire de Pha.ma.ognosie UFR de Médecine Pharmacie Rouen22-Bld Gambetta76183 Rouen Cedex 1France

Two new compounds 7-hydroxy-5-O-（β-D-glucopyra.oside） fla.a. （1） a.d （Z）-4＇,6＇-dihydroxy-2＇-O-（β-D-glucopyra.oside） cha.cone （2）, a.ong with eight known compounds, were isola.ed from the stem ba.k of Drypetes pa.vifolia.（Euphorbia.ea.）. Their structures were esta.lished on the ba.is of spectroscopic a.a.ysis a.d chemica. evidence.

关键词： Drypetes pa.vifolia Fla.onoid glycosides 7-Hydroxy-5-O-(β-D-glucopyra.oside) fla.a. (Z)-4',6'-Dihydroxy-2'-O-(β-D-glucopyr-a.oside) cha.cone

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Ba.ssi–Wa.a.k monogenetic volca.oes, a.a.a.a.Pla.ea.,Ca.eroon: petrogra.hy, minera.ogy a.d geochemistry

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a.ta.Geochimica 2019年第1期38卷 40-67页

作者： a.icet Feudjio Tia.ou Robert Temdjim Pierre wandji Ja.ques-Ma.ie Ba.dintzeff Vivia. Bih Che Edith Eka.a. Ba.e Tiba.g Ca.oline Neh Ngwa.Fra.?ois Xa.ier Ona.a.Meba.a Remote Sensing Unit Faculty of Science Department of Geology University of Buea Depa.tment of Ea.th Sciences Faculty of Science University of Yaoundé 1 La.ora.oire de Géologie Ecole Normale Supérieure de Yaoundé Univ.Pa.is-Sud Sciences de la Terre VolcanologiePlanétologie UMR CNRS 8148 GEOPS Bat.504 Université Paris-Saclay Higher Tea.her Tra.ning College Department of GeologyUniversity of Bamenda Institute for Geologica. a.d Mining Resea.ch (IRGM) Institute for Geologica. a.d Mining Resea.ch (IRGM) Branch of Volcanologic and Geophysics Research (ARGV)

Three monogenetic cones in the Ba.ssi–Wa.a.k a.ea. Nga.undéré, a.a.a.a.Pla.ea. forming pa.t of the Ca.eroon Volca.ic Line(CVL) a.e documented in this study. Ba.a.tic la.a.(a.tered a.ound these vents a.d restricted volca.icla.tic deposits were empla.ed by Ha.a.ia. a.d mild strombolia. style eruptions. The la.a. a.e porphyritic, ma.nly composed of olivine(chrysolite) a.d clinopyroxene(diopside a.d a.gite) phenocrysts a.d pla.iocla.e(a.desine) microphenocrysts. a.cessory minera.s include tita.o-ma.netite a.d tita.o-hema.ite, nepheline,a.a.ite a.d a.phibole xenocrysts. Sa.idine occurs in some sa.ples a.d sodi-pota.sic a.bite in others. Some olivines a.d clinopyroxenes exhibit resorbed ma.gins a.d thin rea.tion rims while pla.iocla.e displa.s oscilla.ory zoning, a.d sieved textures a. a.result of ma.ma.mixing. Whole-rock geochemistry da.a.indica.es tha. the la.a. a.e silica.undersa.ura.ed, composed of ba.a.ites a.d ba.a.ts, showing little compositiona. va.ia.ions(SiO_2: 39.20 wt.%–48.01 wt.%,MgO: 5.29 wt.%–9.70 wt.%). Tra.e elements pa.terns of these la.a. suggest they a.e enriched in LILE including Pb,proba.ly due to crusta. conta.ina.ion. REE pa.terns suggest cogenetic ma.ma. below Ba.ssi 1 a.d Ba.ssi 2 volca.oes,a.d distinct sources below Wa.a.k volca.o a.d nea.by *** la.a. studied show a.finity to high-μ(HIMU), enriched type Ⅰ(EM1) a.d Ocea.ic Isla.d Ba.a.t(OIB)-like ma.tle signa.ures a.d thus indica.e a.heterogeneous ma.tle source undernea.h the vents a. noted a. other monogenetic a.d polygenetic volca.oes a.ong the CVL. Prima.y melts derived from low degrees of pa.tia. melting(0.5%–2%) a.d encountered low ra.es of fra.tiona.ion, a.d crusta. conta.ina.ion coupled with ma.ma.mixing. These melts evolved independently through structura. wea.nesses in the ba.ement.

关键词： Ca.eroon volca.ic line a.a.a.a Pla.ea. Volca.ic field Monogenetic volca.o Ma.ma mixing Petrogenesis

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Nelson-a.len a.d Ka.la.-Meier Estima.ors in Competing Risks

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a.plied Ma.hema.ics 2014年第4期5卷 765-776页

作者： Didier a.a.n Nja.en-Njomen Joseph Nga.chou-wandji Depa.tment of Ma.hema.ics a.d Computer Sciences Faculty of Sciences University of Maroua Maroua Cameroon Depa.tment of Ma.hema.ics Faculty of Sciences University of Yaounde 1 Yaounde Cameroon University of Lorra.ne Lorraine France

In this pa.er, stocha.tic processes developed by a.len [1]?[2] a.e a.a.ted to the Nelson-a.len a.d Ka.la.-Meier?[3] estima.ors in a.context of competing risks. We focus only on the proba.ility distributions of complete downtime individua.s whose ca.ses a.e known a.d which bring us to consider a.pa.tition of individua.s into sub-groups for ea.h ca.se. We then study the a.ymptotic properties of nonpa.a.etric estima.ors obta.ned.

关键词： Censored Da.a Counting Process Competitive Risk Non-Pa.a.etric Estima.ors The Cumula.ive Incidence Function Risk Function Specific Ca.se Conditiona. Distribution Function

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