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The Prevalence and Clinical Manifestations of Co-Infection in Pediatric Infectious Mononucleosis: A Single-Centered, Retrospective Study

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Open Journal of Pediatrics 2024年第3期14卷 459-475页

作者： Abdishakur Abdukadir Muse Zakaria Ahmed Mohamed Pu Yang Lihong Liao bibek dhar shrestha Agness Nicholaus Kanusya Paul Mwale Youping Deng Dongchi Zhao Department of Pediatrics Zhongnan Hospital of Wuhan University Wuhan China Department of Ophthalmology Zhongnan Hospital of Wuhan University Wuhan China

Background: Recent studies indicate that the incidence of infectious mononucleosis (IM) has increased in China. Furthermore, it has been shown that children diagnosed with IM are prone to acquiring other pathogens. However, there is limited research on the prevalence of these co-infections in children with IM. Thus, we conducted this study to determine the prevalence of coinfections and common pathogens, as well as to compare clinical manifestations in children with and without coinfections. Methods: This retrospective observational study was conducted at the Department of Pediatrics Zhongnan Hospital of Wuhan University, Wuhan, China, with data from January 2018 to January 2023. Data, including demographics, symptoms, lab results, and complications, were collected from the hospital’s electronic database and analyzed. The statistical analysis included descriptive statistics, independent samples t-tests and Mann-Whitney tests to compare the means of continuous variables. Statistical significance was determined by p-values less than 0.05. Results: The study involved 216 participants diagnosed with IM, predominantly males (61.6%) aged 0 - 4 years (50.9%). Coinfection was detected in 39.8% of children, with multiple pathogens present in 33.72% of these cases. Among coinfection cases, 40% occurred in children under 5 years old, and females made up 54.2% of these cases. Mycoplasma pneumoniae (MP) was the most prevalent pathogen, accounting for 18.1% of cases. Influenza B (IFB) and Influenza A (IFA) viruses were found in 16.7% and 13.9% of participants, respectively, indicating a notable occurrence of respiratory pathogen coinfections. Male gender, fever, tonsillopharyngitis, lower HGB levels, higher ESR, CRP, and AST levels were correlated with coinfections. Conclusion: In summary, the study revealed a high prevalence of coinfections among children diagnosed with IM, particularly involving Mycoplasma pneumoniae and influenza viruses. These coinfections were notably

关键词： Prevalence Mononucleosis Coinfection Children Epstein-Barr Virus Features

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The Prevalence and Clinical Manifestations of Co-Infection in Pediatric Infectious Mononucleosis: A Single-Centered, Retrospective Study

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Open Journal of Pediatrics（儿科学期刊） 2024年第3期 459页

作者： Abdishakur Abdukadir Muse Zakaria Ahmed Mohamed Pu Yang Lihong Liao bibek dhar shrestha Agness Nicholaus Kanusya Paul Mwale Youping Deng Dongchi Zhao

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