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Genetic regulation of cell type-specific chromatin accessibility shapes brain disease etiology

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四川生理科学杂志 2024年第5期46卷 1079-1079页

作者： biao zeng 不详

Nucleotide variants in cell type-specific gene regulatory elements in the human brain are risk factors for human *** measured chromatin accessibility in 1932 aliquots of sorted neurons and non-neurons from 616 human postmortem brains and identified 34,539 open chromatin regions with chromatin accessibility quantitative trait loci(caQTLs).Only 10.4%of caQTLs are shared between neurons and non-neurons,which supports cell type-specific genetic regulation of the brain *** allele-specific chromatin accessibility improves statistical fine-mapping and refines molecular mechanisms that underlie disease *** massively parallel reporter assays in induced excitatory neurons,we screened 19,893 brain QTLs and identified the functional impact of 476 regulatory ***,this comprehensive resource captures variation in the human brain regulome and provides insights into disease etiology.

关键词： etiology specific massive

黄河上游水源涵养区植被恢复合理目标及恢复策略

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生态学报 2024年第18期44卷 8219-8233页

作者：曹莹曾彪张富广姜榕沈艳琦兰州大学资源环境学院兰州730000

科学设定植被恢复合理目标,制定适宜可行的恢复策略,充分发挥植被恢复的固碳效益,对提高生态修复效率具有重要的现实意义。以黄河上游水源涵养区这一关键生态功能区作为研究区,以当前实际植被状态为边界条件,利用IBISi(Improved Integra... 详细信息

科学设定植被恢复合理目标,制定适宜可行的恢复策略,充分发挥植被恢复的固碳效益,对提高生态修复效率具有重要的现实意义。以黄河上游水源涵养区这一关键生态功能区作为研究区,以当前实际植被状态为边界条件,利用IBISi(Improved Integrated Biosphere Simulator)模型模拟了近十年平均气候条件下的潜在植被状态,并以该状态下植被净初级生产力为指标,设定了研究区短期植被恢复合理目标,进而估算了区域固碳提升潜力。在此基础上,通过评估植被受损程度,识别了重点恢复区域,并结合生态恢复力及实际植被变化趋势分析,分区分类对植被恢复策略进行了划分。研究结果表明:(1)黄河上游水源涵养区植被净初级生产力恢复目标值平均为295.4 gC m^(-2)a^(-1),可在其植被现状的基础上恢复提升7.18%;(2)在当前恢复目标下,研究区植被恢复固碳提升潜力具有明显的空间差异性,存在提升潜力的区域面积占比约为60%,主要分布在龙羊峡以上以及洮河大夏河流域上游地区;(3)研究区植被恢复策略应以保育保护和自然恢复为主,同时应在吉迈水文站以上黄河北岸、共和盆地、龙羊峡库区、贵南沙地、河湟谷地部分区域等重点恢复区,实施必要的人工辅助修复措施。研究结果可为当地因地制宜开展植被恢复工作提供科学依据和决策支持,同时也可为其他区域生态修复规划提供思路和方法借鉴。

关键词：植被恢复固碳提升潜力 IBISi模型净初级生产力黄河上游

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水泥土加固桩水平循环承载性能足尺试验研究

岩土工程学报 2024年第7期46卷 1453-1461页

作者：杨松松章定文曾彪张爱军成朝恒何凌东南大学交通学院江苏南京211189 交通运输部综合交通运输理论交通运输行业重点实验室(南京现代综合交通实验室) 江苏南京211100 宿迁市高速公路建设指挥部江苏宿迁223800 南京交通工程有限公司江苏南京210019

选取宿迁典型饱和粉土场地,采用水泥土搅拌桩加固钻孔灌注桩桩周土,开展灌注桩水平循环加载足尺试验。探究水泥土加固试验桩(TPI)和未加固试验桩(TPU)在循环水平荷载作用下的滞回特性、弯矩、刚度退化、位移延性、水平承载力与残余变形... 详细信息

选取宿迁典型饱和粉土场地,采用水泥土搅拌桩加固钻孔灌注桩桩周土,开展灌注桩水平循环加载足尺试验。探究水泥土加固试验桩(TPI)和未加固试验桩(TPU)在循环水平荷载作用下的滞回特性、弯矩、刚度退化、位移延性、水平承载力与残余变形能力。试验结果表明:TPI比TPU桩的弯矩减小47%,屈服位移减小41%,水平承载力提升150%,有效刚度提升240%,等效黏滞阻尼比提升233%,桩的开裂荷载提升150%,屈服荷载阶段桩体的残余变形能力减小17%。水泥土搅拌法不仅可以限制桩侧粉土液化,增加桩基础的耗能及位移延性,而且可以显著的降低桩头水平位移和弯矩的发展。从抗震性能的角度分析,水泥土搅拌桩加固既有桩基,有效抑制了加固范围内地基土刚度衰减,增强了桩-土结构的总耗能、等效黏滞阻尼系数与变形恢复能力,提高桩基础在大变形阶段的抗震性能。

关键词：钻孔灌注桩足尺试验水泥土搅拌桩水平循环加载抗震性能

Modified precoding strategy over MIMO double-correlated channels

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The Journal of China Universities of Posts and Telecommunications 2009年第2期16卷 35-38页

作者： JIN Li-biao LI Jian-zeng School of Information Engineering Communication University of China Beijing 100024 China

Double-correlated channels commonly occur due to insufficient scattering around both the transmitting and receiving antennas. In this article, the authors propose a linear precoding strategy with a modified system model over double-correlated channels. In this system model, an inner decorrelation strategy is added combined with precoding. First, a linear precoder that achieves minimum bit error rate （MBER） is proposed and analyzed based on the modified system model. The simulation results show that the bit error rate （BER） performance can be improved by decorrelation. Second, the influence of double correlation on multiple input and multiple output （MIMO） capacity is analyzed and simulated.

关键词： MIMO precoding decorrelation capacity

Rapid Propagation of Rhynchostylis retusa in Vitro

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Phyton-International Journal of Experimental Botany 2021年第3期90卷 987-1001页

作者： Yinkai Xi biao zeng Hengyu Huang Yunnan Breeding and Cultivation Research and Development Center of Endangered and Daodi Chinese Medicinal Materials Yunnan University of Chinese MedicineKunming650000China Chemistry Department Guizhou University of Traditional Chinese MedicineGuiyang550000China Yunnan Academy of Agricultural Science Kunming650000China Qiucheng Breeding Company Ltd. Lijiang674100China

An efficient regeneration system of Rhynchostylis retusa was established to provide technical reference for the application of tissue culture tube seedlings in *** mixtures of callus and protocorm from aseptic germination were used as *** optimal media of each stage was selected for callus proliferation,protocorm occurrence and growth,rejuvenation and rooting via a single,complete combination and orthogonal *** results showed that the optimal medium for callus proliferation,protocorms occurrence and growth was 1/2 Murashige and Skoog(MS)medium adding 50 g·L^(−1) banana puree,0.1 mg·L^(−1)α-naphthaleneacetic acid(NAA),1.5 mg·L^(−1)6-benzylaminopurine(6-BA)and 1.0 mg·L^(−1) kinetin(KT)with 17.33 proliferation coefficient of callus and 19.63 occurrence coefficient of buds after 90 *** the buds occurred from protocorm were cultured on 1/2 MS medium including 100 g·L^(−1) banana puree,1.0 mg·L^(−1) NAA,2.0 mg·L^(−1)6-BA and 0.05 mg·L^(−1) KT,in which the proliferation coefficient of callus was 10.32 and occurrence coefficient of buds reached *** the further subculture,the same medium was simultaneously used for callus proliferation,protocorm occurrence and bud *** plantlets developed roots in 1/2 MS medium containing 70 mL·L^(−1) coconut water and 1.5 mg·L^(−1) NAA with 100%rooting rates after 90 *** survival rate was more than 90%after domestication and *** regeneration protocol will provide technique foundation for protecting wild resource and developing artificial cultivation.

关键词： Rhynchostylis retusa callus protocorm proliferation coefficient rapid propagation

Orthogonal procrustes based semi-blind MIMO channel estimation under space-time block code transmissions

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The Journal of China Universities of Posts and Telecommunications 2011年第4期18卷 20-24页

作者： HU Feng JIN Li-biao LI Jian-zeng School of Information Engineering Communication University of China Beijing 100024 China

This work investigates a novel semi-blind channel estimation for multiple-input multiple-output （MIMO） space-time block coding （STBC） systems. Algorithms for channel estimation based on whitening-rotation （WR） decomposition that provides a combined quality and spatial scalability is utilized. Using a space-time code-constrained input design, our approach exploits the orthogonality of the signal and noise subspaces in conjunction with orthogonal procrustes （OP） technique to obtain an accurate estimate of the unitary rotation matrix and, consequently, of the channel parameters. Unitary rotation matrices are parameterized a much fewer number of parameters, and significant estimation gains can then be achieved by estimation of such orthogonal matrices. Furthermore, the proposed semi-blind MIMO channel estimation approach is conducted to reduce the complexity of system design when the number of the receive antennas is no less than the number of transmit antennas. Computer simulations are conducted to corroborate the effectiveness of the proposed channel estimation, and they demonstrate the improved performance compared to the existing training-based estimation.

关键词： MIMO semi-blind channel estimation STBC orthogonal procrustes singular value decomposition

Genome-wide Transcription Factor Gene Prediction and their Expressional Tissue-Specificities in Maize

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Journal of Integrative Plant Biology 2012年第9期54卷 616-630页

作者： Yi Jiang biao zeng Hainan Zhao Mei Zhang Shaojun Xie Jinsheng Lai State Key Laboratory of Agrobiotechnology and National Maize Improvement Center Department of Plant Genetics and BreedingChina Agricultural UniversityBeijing 100193China

Transcription factors （TFs） are important regulators of gene expression. To better understand TFencoding genes in maize （Zea mays L.）, a genome-wide TF prediction was performed using the updated B73 reference genome. A total of 2 298 TF genes were identified, which can be classified into 56 families. The largest family, known as the MYB superfamily, comprises 322 MYB and MYB-related TF genes. The expression patterns of 2014 （87.64%） TF genes were examined using RNA-seq data, which resulted in the identification of a subset of TFs that are specifically expressed in particular tissues （including root, shoot, leaf, ear, tassel and kernel）. Similarly, 98 kernel-specific TF genes were further analyzed, and it was observed that 29 of the kernel-specific genes were preferentially expressed in the early kernel developmental stage, while 69 of the genes were expressed in the late kernel developmental stage. Identification of these TFs, particularly the tissue-specific ones, provides important information for the understanding of development and transcriptional regulation of maize.

关键词： Genome-wide maize tissue-specific transcription factor.

Application of electrochemistry to single-molecule junctions: from construction to modulation

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Science China Chemistry 2019年第10期62卷 1333-1345页

作者： Gan Wang biao-Feng zeng Shi-Qiang Zhao Qiao-Zan Qian Wenjing Hong Yang Yang Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China

State-of-the-art molecular electronics focus on the measurement of electrical properties of materials at the single-molecule ***, molecular electronics face two primary challenges. One challenge is the reliable construction of single-molecule junctions, and the second challenge is the arbitrary modulation of electron transport through these junctions. Over the past decades, electrochemistry has been widely adopted to meet these challenges, leading to a wealth of novel findings. This review starts from the application of electrochemical methods to the fabrication of nanogaps, which is an essential platform for the construction of single-molecule junctions. The utilization of electrochemistry for the modification of molecular junctions,including terminal groups and structural backbones, is introduced, and finally, recent progress in the electrochemical modulation of single-molecule electron transport is reviewed.

关键词： single-molecule electronics molecular junction electrochemical deposition electrochemical gating

Facile synthesis of zinc-based organic framework for aqueous Hg (Ⅱ) removal: Adsorption performance and mechanism

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Nano Materials Science 2021年第4期3卷 429-439页

作者： biao zeng Wei Wang Sijin He Guo Lin Wenjia Du Jun Chang Zhao Ding The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081PR China Key Laboratory for Ferrous Mtallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081PR China China E-port Data Center Division of Chengdu Chengdu610041PR China Electrochemical Innovation Lab Department of Chemical EngineeringUniversity College London(UCL)LondonWC1E 68TUK College of Material and Chemical Engineering Tongren University Tongren554300GuizhouPR China Department of Mechanical Materials and Aerospace Engineering Illinois Institute of TechnologyChicagoIL60616 USA

Mercury(Hg)ions can lead to a serious impact on the environment;therefore,it was necessary to find an effective method for absorbing these toxic Hg ***,the adsorbent(Zn-AHMT)was synthesized from zinc nitrate and 4-amino 3-hydrazine-5 mercapto-1,2,4-triazole(AHMT)by one-step method and,characterized the microstruc-ture and absorption performance by fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FESEM),X-ray diffraction(XRD),Brunauer-Emmett Teller(BET),Thermal Gravimetric Analyzer(TGA)and X-ray photoelectron spectroscopy(XPS).Through a plethora of measurements,we found that the maximum adsorption capacity was 802.8 mg/g when the optimal pH of Zn-AHMT was *** isothermal and kinetic experiments confirm that the reaction process of Zn-AHMT was chemisorption,while the adsorption process conforms to the Hill model and pseudo second order kinetic *** experiments showed that the adsorption process was spontaneous and *** experiments were performed in the simulated wastewater containing Mn,Mg,Cr,Al,Co,Ni,Hg *** results showed that the Zn-AHMT has a stronger affinity for Hg *** removal rate of Zn-AHMT remained above 98%,indicating that the Zn-AHMT had a good stability validated by three adsorption-desorption repeatable *** to the XPS results,the adsorption reaction of Zn-AHMT was mainly attributed to the chelation and ion *** was further explained by both density functional theory(DFT)calculation and frontier molecular orbital *** therefore propose the adsorption mechanism of *** adsorption reaction facilitates via the synergistic action of S and N ***,the bonding between the adsorbent and the N atom has been proved to be more *** study demonstrated that Zn-AHMT had a promising application prospect in mercury removal.

关键词： Metal-organic frameworks(MOFs) Hg(Ⅱ) Selectivity Adsorption mechanism